Standard name
Human Ortholog
Description Nuclear protein with a role in protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; DNA-binding protein with preference for UV-damaged DNA; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.25 0.19 0.36 0.25 0.29 0.31 0.29 0.19 0.21 0.23 0.14 0.11 0.47 0.62 0.6 0.45 0.39 0.35 0.15 0.13 0.15 0.31 0.46 0.41
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.12 0.05 0 0 0 0 0 0
Endosome 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.1 0.14 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.46 0.13 0.21 0.5 0.34 0.52 0.67 0.73 0.73 0.75 0.83 0.81 0 0 0 0.06 0 0 0 0.05 0.08 0 0.05 0
Nucleus 0.42 0.37 0.25 0.28 0.27 0.25 0.2 0.3 0.28 0.3 0.26 0.32 0.26 0.12 0.08 0.27 0.24 0.21 0.46 0.43 0.31 0.11 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.07 0.05 0 0 0.06 0.07 0.09
Vac/Vac Membrane 0.15 0.33 0.23 0.2 0.24 0.18 0.12 0 0.08 0.09 0.07 0.11 0.37 0.36 0.44 0.21 0.32 0.37 0.24 0.27 0.28 0.33 0.26 0.3
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 1 1 0 2
Bud 0 1 0 1 1 1 1 1 6 3 4 2 0 0 0 0 0 0 6 7 5 4 3 4
Bud Neck 0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 1 1 2 0 3
Bud Site 0 0 0 0 0 0 1 1 6 5 3 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0
Cytoplasm 62 66 43 24 40 44 58 29 48 58 34 23 74 130 170 181 72 73 47 64 24 38 76 84
Endoplasmic Reticulum 1 2 2 0 0 0 1 1 0 0 1 0 1 1 2 28 22 10 1 3 2 2 2 1
Endosome 0 35 4 4 3 0 1 1 0 0 0 0 5 6 6 33 19 30 2 5 2 4 6 7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 0 0 2 0 3 1 1 0 5
Mitochondria 116 44 25 48 47 74 135 112 164 193 200 168 1 5 1 22 2 6 6 21 13 2 8 6
Nucleus 107 128 30 27 37 35 40 46 62 78 62 67 41 25 23 106 45 44 142 209 50 13 6 5
Nuclear Periphery 0 3 0 0 0 0 0 3 1 1 1 3 0 0 0 0 0 1 0 0 0 0 1 0
Nucleolus 0 0 0 1 0 1 2 1 1 1 1 0 0 0 1 3 3 6 2 2 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 1 1 1 0 0 1 1 1 1 1 2 2 0 1 20 12 15 16 19 6 7 12 18
Vac/Vac Membrane 38 114 27 19 33 25 25 5 17 24 16 22 57 77 123 82 59 76 74 131 44 40 42 62
Unique Cell Count 253 343 118 96 139 142 202 154 225 256 240 207 156 211 281 399 185 208 312 481 161 124 167 205
Labelled Cell Count 324 396 132 125 161 180 265 201 306 364 323 292 184 244 330 477 235 263 312 481 161 124 167 205


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.6 4.4 4.5 3.8 4.2 3.8 3.3 3.5 3.6 3.4 3.3 3.2 5.1 4.8 5.0 5.6 6.7 6.2 4.5 4.3 5.2
Std Deviation (1e-4) 0.5 0.7 1.6 1.1 1.9 1.8 1.5 1.5 1.8 1.8 1.3 1.3 1.5 1.5 1.7 1.6 1.9 1.9 1.4 1.3 1.7
Intensity Change (Log2) – – – -0.23 -0.09 -0.24 -0.45 -0.35 -0.33 -0.41 -0.45 -0.48 0.2 0.11 0.17 0.33 0.58 0.47 0.02 -0.05 0.22

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – -0.5 1.7 2.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.8047 2.0733 2.1448 1.9999 1.6337 2.2292 2.471 2.9657 3.078 3.2779 2.3094 3.0507 5.1172 3.3208 3.7842 3.7529 4.3412 3.4463
Actin 0.0597 0.0238 0.0022 0.0002 0.0003 0.0007 0.0004 0.0003 0.0001 0.0358 0.0005 0.0051 0.0656 0.0001 0.0114 0.0041 0.0008 0.0002
Bud 0.0008 0.0003 0.0002 0.0001 0 0.0002 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0013 0.0001 0.0001 0.003 0.0001 0.0001
Bud Neck 0.0041 0.0009 0.0003 0.0013 0.0016 0.0032 0.0008 0.0005 0.0004 0.0005 0.0008 0.0063 0.024 0.0005 0.0005 0.0115 0.0007 0.0026
Bud Periphery 0.0012 0.0002 0.0002 0.0001 0 0.0003 0.0003 0 0 0.0001 0.0001 0.0002 0.0034 0.0001 0.0001 0.0041 0.0001 0.0001
Bud Site 0.0037 0.0024 0.0012 0.0005 0.0001 0.0005 0.0006 0.001 0.0001 0.0004 0.0002 0.0003 0.0086 0.0006 0.0003 0.0133 0.0003 0.0002
Cell Periphery 0.0004 0.0002 0.0001 0 0 0.0001 0.0001 0 0 0 0 0 0.0006 0 0 0.0002 0.0001 0
Cytoplasm 0.0542 0.0987 0.0086 0.0296 0.038 0.05 0.0321 0.0391 0.0149 0.025 0.0418 0.0255 0.0596 0.0326 0.0075 0.0282 0.0287 0.0387
Cytoplasmic Foci 0.0437 0.0026 0.0017 0.0004 0.0017 0.0029 0.0087 0.0012 0.0007 0.0088 0.0116 0.0019 0.0301 0.0007 0.0008 0.0059 0.0117 0.0018
Eisosomes 0.0005 0.0016 0.0002 0 0 0.0001 0 0 0 0.0003 0 0 0.0011 0 0.0001 0.0001 0.0002 0
Endoplasmic Reticulum 0.0155 0.003 0.001 0.0007 0.0008 0.0023 0.0014 0.001 0.0003 0.0016 0.0008 0.0008 0.0124 0.0008 0.0003 0.0017 0.0019 0.0006
Endosome 0.0423 0.0026 0.0052 0.0007 0.0021 0.004 0.0039 0.0009 0.0004 0.0031 0.0023 0.0012 0.0329 0.0006 0.0022 0.0023 0.0043 0.001
Golgi 0.0114 0.0005 0.0044 0 0 0.0002 0.0005 0 0 0.0016 0.0002 0.0002 0.0098 0 0.0023 0.0009 0.0002 0
Lipid Particles 0.0217 0.0009 0.0007 0.0001 0.0002 0.0011 0.0041 0.0001 0 0.0016 0.0003 0.0003 0.0268 0.0001 0.0027 0.0007 0.0021 0.0004
Mitochondria 0.0052 0.0016 0.0025 0.0007 0.0009 0.0008 0.0022 0.0004 0.0002 0.001 0.0008 0.0002 0.0038 0.0004 0.01 0.0016 0.0009 0.0003
None 0.2022 0.2008 0.0959 0.095 0.1552 0.1041 0.0782 0.103 0.0647 0.1491 0.0909 0.0851 0.0954 0.0663 0.0307 0.1201 0.2638 0.0994
Nuclear Periphery 0.0318 0.027 0.0163 0.0093 0.0151 0.0091 0.01 0.0074 0.006 0.0112 0.0116 0.0075 0.047 0.0096 0.0047 0.0104 0.0167 0.0057
Nucleolus 0.014 0.0152 0.0071 0.0072 0.0177 0.0158 0.0075 0.0075 0.0056 0.0066 0.0092 0.0108 0.0115 0.0084 0.0062 0.0112 0.0104 0.0115
Nucleus 0.374 0.5912 0.8417 0.7931 0.7135 0.7404 0.7781 0.7809 0.8626 0.6455 0.6738 0.745 0.4916 0.8302 0.8992 0.734 0.5608 0.7914
Peroxisomes 0.0538 0.0028 0.0002 0 0.0001 0.0008 0.0023 0.0001 0 0.0017 0.0012 0.0007 0.0081 0 0.0021 0.0019 0.0005 0.0001
Punctate Nuclear 0.055 0.0207 0.0086 0.0602 0.0517 0.0609 0.066 0.0558 0.0435 0.1054 0.1528 0.1082 0.0572 0.0481 0.0182 0.0434 0.0933 0.0453
Vacuole 0.0032 0.0024 0.0009 0.0007 0.0006 0.0021 0.002 0.0005 0.0002 0.0003 0.0008 0.0005 0.0068 0.0006 0.0003 0.0011 0.002 0.0006
Vacuole Periphery 0.0016 0.0007 0.0005 0.0002 0.0003 0.0003 0.0006 0.0001 0.0001 0.0002 0.0003 0.0001 0.0027 0.0002 0.0002 0.0003 0.0004 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.6586 5.658 7.464 13.1733 13.677 13.3544 8.899 7.0788 13.4366 16.5257
Translational Efficiency 1.2167 0.9002 0.7357 0.9873 0.8407 1.3866 0.6255 0.8662 0.7133 0.8867

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
582 1708 1095 1108 315 1988 135 118 897 3696 1230 1226

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 626.80 696.30 796.88 802.15 707.94 695.77 867.56 867.83 655.29 696.01 804.64 808.47
Standard Deviation 67.46 101.98 107.44 129.80 78.14 100.88 91.54 130.42 81.22 101.39 108.09 131.29
Intensity Change Log 2 — 0.151704 0.346357 0.355867 — -0.025017 0.293336 0.293785 — 0.060673 0.318478 0.323272

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000076 0.000260 0.000282 0.001272 0.000108 0.000329 0.000797 0.001987 0.000087 0.000297 0.000339 0.001341
Bud Neck 0.001460 0.012790 0.011148 0.026285 0.002185 0.021843 0.003240 0.015111 0.001714 0.017659 0.010280 0.025210
Bud Site 0.000882 0.002993 0.006009 0.015335 0.000334 0.010548 0.000958 0.026833 0.000690 0.007056 0.005455 0.016442
Cell Periphery 0.000152 0.000133 0.000487 0.000229 0.000142 0.000223 0.000115 0.000210 0.000148 0.000181 0.000446 0.000227
Cytoplasm 0.158193 0.173259 0.079491 0.041622 0.152020 0.180409 0.015693 0.106749 0.156025 0.177105 0.072489 0.047890
Cytoplasmic Foci 0.022489 0.032669 0.003418 0.001558 0.048167 0.045484 0.000422 0.005408 0.031506 0.039562 0.003089 0.001929
Eisosomes 0.000040 0.000038 0.000044 0.000031 0.000070 0.000056 0.000053 0.000039 0.000051 0.000048 0.000045 0.000032
Endoplasmic Reticulum 0.000303 0.003064 0.002999 0.007085 0.002091 0.002688 0.009478 0.006043 0.000931 0.002861 0.003710 0.006985
Endosome 0.001371 0.002460 0.001596 0.001550 0.001774 0.005377 0.000671 0.008725 0.001513 0.004029 0.001494 0.002240
Golgi 0.000235 0.000623 0.000091 0.000247 0.000227 0.001916 0.000062 0.001102 0.000232 0.001319 0.000088 0.000329
Lipid Particles 0.002688 0.003751 0.000596 0.000598 0.006976 0.006313 0.000875 0.004762 0.004194 0.005129 0.000627 0.000999
Mitochondria 0.003423 0.006190 0.001471 0.003729 0.001309 0.017300 0.000624 0.005268 0.002681 0.012166 0.001378 0.003877
Mitotic Spindle 0.000849 0.003107 0.005839 0.098205 0.000070 0.015185 0.000335 0.193109 0.000576 0.009604 0.005235 0.107339
None 0.008318 0.012393 0.012186 0.011091 0.007003 0.014439 0.004240 0.017751 0.007856 0.013493 0.011314 0.011732
Nuclear Periphery 0.000807 0.002385 0.001142 0.002206 0.001486 0.002371 0.001078 0.013450 0.001045 0.002377 0.001135 0.003289
Nuclear Periphery Foci 0.000105 0.000649 0.000204 0.002946 0.000698 0.001046 0.000562 0.017186 0.000313 0.000863 0.000244 0.004317
Nucleolus 0.002397 0.006882 0.002114 0.014171 0.003819 0.009633 0.002323 0.021042 0.002896 0.008362 0.002137 0.014832
Nucleus 0.791510 0.723086 0.861731 0.754819 0.758451 0.640763 0.946517 0.530445 0.779901 0.678806 0.871037 0.733224
Peroxisomes 0.001693 0.004251 0.000273 0.001846 0.002776 0.008821 0.000224 0.001420 0.002073 0.006709 0.000268 0.001805
Vacuole 0.002670 0.008283 0.008249 0.014814 0.009981 0.013094 0.011613 0.021521 0.005237 0.010870 0.008618 0.015460
Vacuole Periphery 0.000339 0.000734 0.000627 0.000359 0.000313 0.002162 0.000119 0.001836 0.000330 0.001502 0.000571 0.000501

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.49 -4.42 -17.17 -16.24 -15.76 -3.67 -6.71 -6.06 -5.34 -2.23 -4.81 -7.25 -18.89 -16.67 -15.18
Bud Neck -9.80 -6.60 -19.36 -14.00 -13.33 -11.83 -2.48 -5.41 0.49 -2.96 -15.45 -6.87 -19.78 -12.25 -13.61
Bud Site -3.35 -3.86 -13.02 -11.93 -9.36 -8.61 -2.95 -3.07 -1.53 -2.48 -8.71 -4.43 -13.51 -9.81 -9.71
Cell Periphery 0.58 -3.06 -2.62 -5.89 2.27 -3.97 0.50 -1.04 2.27 -1.41 -1.63 -3.13 -3.46 -2.90 2.21
Cytoplasm -1.45 8.73 14.52 25.64 8.60 -2.22 12.84 7.05 10.68 -2.26 -2.61 11.47 17.89 35.04 7.63
Cytoplasmic Foci -3.65 9.24 8.07 12.29 -1.18 0.72 10.67 9.96 16.90 -1.98 -3.01 13.36 12.07 19.56 -1.41
Eisosomes 0.35 -0.23 -4.01 -6.11 -2.57 2.56 -1.12 -1.14 -3.05 0.25 0.89 0.62 -2.64 -4.49 -2.38
Endoplasmic Reticulum -12.95 -11.95 -20.26 -10.94 -9.04 -0.79 -7.61 -4.86 -4.91 1.49 -6.72 -9.71 -16.00 -13.15 -6.94
Endosome -2.25 -0.26 -2.54 -0.02 -1.73 -5.98 0.27 -1.83 0.56 -1.86 -5.85 -0.03 -3.30 3.53 -2.19
Golgi -1.76 1.11 -6.55 -2.65 -13.21 -4.71 -0.45 -3.26 2.37 -2.65 -4.85 1.34 -8.34 0.64 -13.34
Lipid Particles -2.12 4.51 3.87 9.84 -2.50 0.82 5.45 3.47 3.72 -0.74 -1.49 7.29 6.48 13.04 -2.28
Mitochondria -1.34 0.97 -0.24 2.58 -6.41 -10.96 2.37 -1.22 8.64 -1.92 -6.21 0.98 -0.83 9.21 -6.76
Mitotic Spindle -2.92 -3.18 -18.68 -18.32 -17.60 -7.78 -1.55 -6.80 -6.35 -6.34 -8.00 -3.70 -19.84 -18.59 -18.62
None -2.49 -1.24 -1.82 1.04 -0.07 -4.07 2.20 -1.44 0.98 -2.82 -4.64 -1.25 -2.64 2.19 -0.64
Nuclear Periphery -7.15 -3.81 -11.67 -4.32 -10.20 -1.78 0.26 -1.41 -1.17 -1.45 -6.51 -1.60 -7.39 -3.97 -7.12
Nuclear Periphery Foci -6.89 -2.24 -8.70 -8.34 -8.61 -0.92 -1.48 -2.49 -2.44 -1.10 -3.05 -1.43 -8.84 -8.46 -7.83
Nucleolus -3.21 0.78 -15.25 -14.65 -15.84 -5.98 -0.76 -3.65 -3.12 -3.36 -6.00 0.77 -15.78 -14.52 -16.07
Nucleus 5.50 -5.95 13.38 10.37 21.38 7.17 -6.43 5.90 3.24 9.15 10.10 -8.60 14.59 8.41 23.21
Peroxisomes -2.64 1.75 -1.02 2.33 -5.53 -4.57 1.23 1.10 6.95 -0.46 -5.51 2.74 -0.61 6.09 -5.40
Vacuole -7.77 -5.20 -7.75 -4.95 -4.10 -1.44 -3.18 -2.67 -2.50 -1.25 -6.75 -4.45 -7.03 -4.80 -4.03
Vacuole Periphery -1.81 -0.70 -0.11 3.95 0.78 -5.41 2.82 -1.00 2.87 -1.41 -5.13 -0.72 -0.44 5.79 0.55
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nuclear protein with a role in protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; DNA-binding protein with preference for UV-damaged DNA; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions
Localization
Cell Percentages nucleus (75%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Cmr1

Cmr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cmr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available