Standard name
Human Ortholog
Description Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.06 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.06 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 1.0 0.97 0.98 0.95 0.94 0.87 0.73 0.75 0.66 0.6 0.5 0.51 0.98 1.0 0.99 0.96 0.9 0.92 0.97 0.92 0.92 0.67 0.8 0.81
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.07 0.27 0.34 0.27 0.47 0.55 0.61 0.65 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 0 0 0 1 0 0 1 1 1 2 0 0 0 0 0 1 0 2 1 13 14 6
Bud 1 3 1 0 3 2 9 5 2 1 8 8 0 0 1 0 0 1 0 2 1 4 4 7
Bud Neck 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 3 2 7 7 4
Bud Site 0 0 1 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 13 7 12 3 10 6 8 13 17 13 13 2 5 7 3 11 14 0 0 3 0 1 0
Cytoplasm 238 383 327 202 220 309 316 292 193 220 159 180 204 262 322 359 253 249 234 376 300 80 184 160
Endoplasmic Reticulum 0 6 2 2 0 7 3 13 11 5 11 6 1 1 0 15 9 6 0 3 2 0 2 2
Endosome 0 0 0 0 4 1 5 10 0 2 1 1 0 0 0 4 1 3 1 5 2 3 1 0
Golgi 0 2 0 0 0 0 0 0 0 0 0 0 0 0 1 1 3 1 0 1 0 0 0 1
Mitochondria 4 3 2 6 16 94 148 103 139 202 197 229 1 0 0 11 5 4 0 2 2 4 5 2
Nucleus 0 1 2 0 1 1 0 4 3 3 3 0 0 0 1 8 5 11 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 2 2 2 4 2 2 0 0 1 0 1 1 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 3 0 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 1 0 0 0 1 1 1 0 1
Vac/Vac Membrane 0 0 0 5 4 2 14 6 7 9 14 13 2 0 0 10 19 6 0 4 1 2 2 5
Unique Cell Count 239 395 332 212 234 354 432 388 294 366 321 350 208 262 326 375 280 272 242 410 325 120 230 197
Labelled Cell Count 244 413 342 227 251 427 505 446 371 466 410 457 211 268 334 412 307 297 242 410 325 120 230 197


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.5 7.1 6.4 6.6 6.3 5.5 5.0 5.2 5.1 4.5 4.9 4.7 6.8 6.7 6.7 7.8 9.4 9.0 6.0 6.2 7.2
Std Deviation (1e-4) 0.6 0.8 1.5 2.7 1.6 1.1 1.4 1.4 1.1 1.1 1.5 1.4 0.9 0.9 1.2 1.6 1.6 1.5 1.1 1.1 1.4
Intensity Change (Log2) – – – 0.04 -0.03 -0.23 -0.36 -0.3 -0.33 -0.5 -0.39 -0.45 0.07 0.05 0.05 0.28 0.54 0.48 -0.11 -0.05 0.16

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2.2 0 0.6 -0.8 0 1.6 0 1.4 0 0 -0.2 0 0 1.3 2.0
Cytoplasm -2.2 -2.9 -5.6 -9.5 -8.9 -10.9 -12.3 -14.3 -14.1 -0.4 2.0 0.3 -2.2 -4.5 -4.0
Endoplasmic Reticulum 0 0 0 0 2.6 2.7 0 2.6 0 0 0 0 2.9 2.4 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 4.2 9.8 11.6 9.8 14.0 0 16.9 0 0 0 0 2.3 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.9
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.3 0 0 0 3.8 3.5 0 0 0 0 4.8 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.249 1.5613 1.7823 1.4577 1.7366 1.9755 3.9406 4.5403 4.2166 4.3554 4.317 4.2688 4.8786 5.3232 5.2782 5.7642 5.2913 5.3003
Actin 0.0197 0.0018 0.0098 0.0009 0.0002 0.001 0.0174 0.004 0.0097 0.0023 0.0295 0.0152 0.0263 0.001 0.0206 0.0259 0.0258 0.0029
Bud 0.0004 0.0001 0.0011 0.0002 0 0.0001 0.0012 0.0012 0.0009 0.0021 0.0016 0.0019 0.0009 0.0019 0.0105 0.0005 0.0005 0.0013
Bud Neck 0.0021 0.0004 0.0014 0.0002 0.0001 0.0059 0.0059 0.0005 0.003 0.0005 0.002 0.0052 0.009 0.0002 0.0064 0.0037 0.001 0.0031
Bud Periphery 0.0011 0.0001 0.0015 0.0003 0 0.0001 0.0022 0.0015 0.0009 0.0037 0.0029 0.0026 0.0009 0.0015 0.0079 0.0008 0.0005 0.0019
Bud Site 0.0023 0.0097 0.0013 0.0003 0 0.0001 0.0105 0.0089 0.0067 0.002 0.0059 0.0013 0.0033 0.0101 0.0102 0.0016 0.0007 0.002
Cell Periphery 0.0031 0.001 0.0005 0.0005 0.0001 0.0003 0.001 0.0008 0.0003 0.0002 0.0006 0.0002 0.0006 0.0004 0.0008 0.0004 0.0001 0.0002
Cytoplasm 0.518 0.7499 0.6553 0.8468 0.8213 0.838 0.7077 0.7292 0.7438 0.812 0.6539 0.7428 0.6192 0.8119 0.7113 0.6691 0.7157 0.772
Cytoplasmic Foci 0.0077 0.0066 0.0098 0.0037 0.0046 0.0063 0.0156 0.0109 0.0095 0.0172 0.0545 0.0239 0.0247 0.0081 0.0118 0.0172 0.0333 0.0049
Eisosomes 0.0016 0.0001 0.0001 0 0 0 0.0002 0.0003 0.0002 0 0.0003 0.0001 0.0005 0.0001 0.0005 0.0002 0.0002 0.0003
Endoplasmic Reticulum 0.025 0.0136 0.0089 0.0064 0.0024 0.0062 0.0072 0.0026 0.0041 0.0017 0.0035 0.0024 0.0096 0.0025 0.0062 0.0031 0.0044 0.0029
Endosome 0.0081 0.0176 0.0072 0.0024 0.0026 0.0026 0.0156 0.0037 0.0067 0.0189 0.0195 0.0066 0.0313 0.0019 0.0074 0.023 0.0277 0.0023
Golgi 0.0033 0.0014 0.0014 0.0003 0.0002 0.0003 0.0031 0.0006 0.0037 0.0011 0.0053 0.0039 0.0055 0.0003 0.0023 0.0015 0.0098 0.0003
Lipid Particles 0.0034 0.0003 0.0009 0.0001 0.0001 0.0003 0.0021 0.0003 0.0017 0.0001 0.0113 0.0024 0.0044 0.0003 0.0014 0.0009 0.0037 0.0004
Mitochondria 0.0016 0.0002 0.0004 0.0001 0.0001 0.0002 0.007 0.0004 0.0029 0.0008 0.0025 0.0011 0.0022 0.0025 0.0062 0.0003 0.0021 0.0002
None 0.3922 0.1909 0.2919 0.1335 0.1669 0.1363 0.19 0.2295 0.1954 0.1312 0.157 0.1814 0.2071 0.1489 0.182 0.2446 0.1591 0.2006
Nuclear Periphery 0.0038 0.0017 0.0021 0.0009 0.0002 0.0004 0.0025 0.0006 0.001 0.0006 0.0025 0.0011 0.025 0.0004 0.0015 0.0006 0.0021 0.0008
Nucleolus 0.0005 0.0001 0.0001 0 0 0 0.0004 0.0002 0.0003 0.0001 0.0018 0.0001 0.001 0.0039 0.0006 0.0001 0.0001 0.0005
Nucleus 0.0021 0.0014 0.002 0.0012 0.0003 0.0006 0.0025 0.0017 0.0015 0.0014 0.0028 0.0014 0.0089 0.0016 0.0021 0.0007 0.001 0.0013
Peroxisomes 0.0005 0.0001 0.0003 0 0 0.0001 0.0014 0.0004 0.003 0.0006 0.0154 0.0034 0.002 0.0003 0.0051 0.0009 0.006 0.0001
Punctate Nuclear 0.001 0.0003 0.0008 0.0003 0.0001 0.0002 0.003 0.0006 0.0028 0.0009 0.0243 0.0018 0.0125 0.0005 0.001 0.0018 0.0011 0.001
Vacuole 0.002 0.0024 0.0026 0.0015 0.0007 0.001 0.0033 0.0021 0.0015 0.0021 0.0027 0.0009 0.004 0.0014 0.0035 0.0027 0.0041 0.0008
Vacuole Periphery 0.0006 0.0004 0.0004 0.0001 0.0001 0.0001 0.0004 0.0002 0.0003 0.0004 0.0005 0.0002 0.0012 0.0002 0.0007 0.0005 0.0011 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.1971 13.3811 10.875 13.6722 11.09 12.1108 10.3083 13.0451 15.3212 14.6656
Translational Efficiency 1.6161 0.9711 0.9976 0.7269 0.9821 1.0846 1.0276 0.8457 0.671 0.8889

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2658 255 1317 115 2198 1622 1977 119 4856 1877 3294 234

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 765.19 868.92 947.80 1046.18 802.04 839.80 1013.27 1008.73 781.87 843.76 987.09 1027.13
Standard Deviation 86.97 113.87 116.06 159.50 94.57 111.61 124.45 134.34 92.33 112.36 125.34 148.43
Intensity Change Log 2 — 0.183405 0.308765 0.451241 — 0.066372 0.337273 0.330794 — 0.124699 0.323424 0.390858

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000165 0.001181 0.000272 0.002623 0.000161 0.000611 0.000268 0.000361 0.000163 0.000688 0.000269 0.001473
Bud Neck 0.008777 0.020078 0.002446 0.004266 0.008391 0.015122 0.002586 0.002971 0.008602 0.015796 0.002530 0.003607
Bud Site 0.008882 0.052680 0.013658 0.063305 0.006664 0.029479 0.011241 0.028289 0.007878 0.032631 0.012207 0.045498
Cell Periphery 0.000138 0.000208 0.000098 0.000237 0.000113 0.000155 0.000084 0.000121 0.000127 0.000162 0.000090 0.000178
Cytoplasm 0.673815 0.412009 0.732448 0.478627 0.629895 0.538690 0.698039 0.435309 0.653935 0.521479 0.711797 0.456598
Cytoplasmic Foci 0.138800 0.313869 0.025440 0.039277 0.163073 0.224103 0.016017 0.032941 0.149787 0.236298 0.019784 0.036055
Eisosomes 0.000089 0.000158 0.000024 0.000082 0.000106 0.000137 0.000026 0.000056 0.000097 0.000140 0.000025 0.000068
Endoplasmic Reticulum 0.001019 0.001241 0.001165 0.001613 0.000707 0.001141 0.001299 0.001977 0.000878 0.001155 0.001245 0.001798
Endosome 0.007136 0.037873 0.002528 0.007501 0.011613 0.032528 0.002321 0.039784 0.009163 0.033254 0.002404 0.023918
Golgi 0.003092 0.008420 0.000119 0.000473 0.002178 0.009573 0.000149 0.016061 0.002678 0.009416 0.000137 0.008400
Lipid Particles 0.002496 0.002885 0.000765 0.001566 0.002567 0.003043 0.000711 0.001243 0.002528 0.003022 0.000733 0.001402
Mitochondria 0.001669 0.002313 0.000224 0.000114 0.001001 0.002908 0.000393 0.000329 0.001367 0.002827 0.000325 0.000223
Mitotic Spindle 0.000772 0.000663 0.010125 0.043456 0.002865 0.007867 0.013845 0.032994 0.001720 0.006888 0.012357 0.038136
None 0.003832 0.000247 0.003922 0.005014 0.001662 0.001107 0.004317 0.001916 0.002850 0.000990 0.004159 0.003438
Nuclear Periphery 0.000108 0.000136 0.000531 0.000460 0.000132 0.000085 0.000617 0.000572 0.000118 0.000092 0.000583 0.000517
Nuclear Periphery Foci 0.000347 0.001411 0.002111 0.002768 0.000508 0.000547 0.001884 0.003226 0.000420 0.000665 0.001975 0.003001
Nucleolus 0.000470 0.001221 0.000144 0.000103 0.000386 0.000421 0.000126 0.000199 0.000432 0.000530 0.000133 0.000151
Nucleus 0.067946 0.015493 0.110759 0.052306 0.061568 0.017909 0.120356 0.057268 0.065059 0.017581 0.116519 0.054829
Peroxisomes 0.001306 0.015748 0.000495 0.000564 0.001841 0.005733 0.000203 0.000387 0.001548 0.007094 0.000320 0.000474
Vacuole 0.078108 0.109219 0.092575 0.295042 0.103877 0.106711 0.125152 0.340984 0.089772 0.107052 0.112127 0.318406
Vacuole Periphery 0.001032 0.002946 0.000153 0.000605 0.000692 0.002130 0.000366 0.003012 0.000878 0.002241 0.000281 0.001829

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.84 -3.44 -2.37 -0.09 -1.96 -4.67 -2.64 -3.42 2.50 -0.93 -5.88 -3.94 -2.76 -0.36 -2.09
Bud Neck -3.30 9.68 6.08 4.81 -1.61 -5.75 9.81 9.52 12.26 0.47 -6.70 14.07 10.70 12.29 -1.29
Bud Site -8.09 -1.82 -2.76 1.69 -2.37 -13.20 -1.29 -2.13 4.92 -1.63 -14.80 -1.85 -3.23 1.79 -2.84
Cell Periphery -3.30 4.69 -2.38 0.48 -4.02 -4.72 5.60 1.32 4.36 -1.43 -4.36 7.84 -1.32 1.21 -4.28
Cytoplasm 14.87 2.92 13.01 2.96 11.85 10.53 5.60 10.08 6.27 8.17 18.26 7.55 16.47 8.87 13.88
Cytoplasmic Foci -12.79 36.75 23.31 20.52 -1.17 -10.37 41.75 23.22 29.77 -3.42 -17.19 56.56 32.53 38.51 -3.76
Eisosomes -4.27 15.51 1.28 4.51 -5.57 -2.52 15.43 7.89 6.69 -5.15 -4.10 22.00 5.60 6.61 -7.32
Endoplasmic Reticulum -0.56 -3.15 -2.50 -1.03 -0.57 -1.88 -5.23 -2.31 -0.70 0.22 -1.30 -5.32 -3.28 -1.45 -0.23
Endosome -7.34 12.22 5.32 8.27 -0.57 -12.05 14.33 1.05 5.50 -1.18 -15.63 18.87 1.84 10.48 -1.28
Golgi -3.37 11.03 10.61 5.35 -1.19 -8.36 7.06 0.04 3.47 -1.01 -8.65 12.92 1.49 6.56 -1.04
Lipid Particles -0.46 7.93 0.28 0.56 -2.47 -1.43 10.01 5.96 5.47 -3.53 -1.64 12.39 2.25 3.04 -3.23
Mitochondria -0.47 5.43 6.02 1.75 4.85 -2.23 1.61 1.98 3.71 3.20 -2.06 4.50 5.18 4.08 5.27
Mitotic Spindle 0.28 -4.57 -1.69 -1.71 -0.32 -2.66 -3.92 -1.11 -0.05 0.30 -3.47 -6.31 -2.05 -0.67 -0.06
None 10.58 1.08 1.62 -2.87 1.07 1.75 -5.64 -1.34 -2.38 2.35 6.58 -2.45 0.84 -2.93 2.31
Nuclear Periphery -0.49 -17.43 -5.83 -5.01 0.26 4.06 -27.44 -8.17 -8.64 1.26 1.87 -31.83 -9.81 -10.13 1.36
Nuclear Periphery Foci -4.04 -12.69 -5.32 -2.98 -1.27 -0.89 -9.11 -4.72 -4.60 -1.02 -4.45 -14.54 -7.15 -6.36 -1.68
Nucleolus -1.00 10.53 12.94 1.53 4.74 -0.36 4.20 4.16 4.69 0.41 -0.81 9.19 10.02 3.75 2.77
Nucleus 21.26 -15.22 1.74 -6.03 10.19 24.79 -23.42 -0.95 -6.29 9.51 36.98 -27.68 0.37 -8.61 14.12
Peroxisomes -6.62 4.35 4.81 7.05 0.05 -6.74 5.40 4.70 10.99 -1.97 -10.15 7.32 6.61 12.91 -1.64
Vacuole -3.70 -12.68 -15.18 -13.44 -12.47 -0.83 -18.10 -14.47 -14.31 -10.03 -5.52 -23.19 -21.00 -19.88 -15.66
Vacuole Periphery -2.00 13.76 9.38 2.93 -0.35 -8.17 6.04 0.70 4.35 -0.73 -6.84 12.21 3.11 7.29 -0.76
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ste7

Ste7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ste7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available