Standard name
Human Ortholog
Description Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.35 0.5 0.57 0.62 0.44 0.5 0.37 0.22 0.3 – 0.23 0.24 0.48 0.44 0.51 0.4 0.33 0.29 0.44 0.41 0.59 0.51 0.59 0.69
Bud 0 0 0.05 0.07 0.07 0.06 0.05 0 0.05 – 0.08 0.06 0 0 0.06 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0.07 0.05 0.05 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 0 0.08 0 0 0.05 0 0.05 0 0 – 0 0 0.05 0 0 0.09 0.11 0.15 0 0 0 0 0 0
Endoplasmic Reticulum 0.55 0.61 0.66 0.38 0.37 0.4 0.4 0.36 0.27 – 0.16 0.14 0.57 0.49 0.37 0.06 0 0.07 0.17 0.25 0.1 0.12 0.14 0.07
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.87 0.55 0.63 0.59 0.71 0.52 0.48 0.34 0.2 – 0.2 0.14 0.7 0.79 0.59 0.88 0.88 0.78 0.36 0.28 0.28 0.33 0.23 0.2
Mitochondria 0.11 0.08 0.28 0.63 0.46 0.59 0.57 0.69 0.86 – 0.9 0.9 0.18 0.22 0.47 0.05 0.14 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 131 112 237 192 146 194 200 121 121 – 66 101 88 102 137 114 59 74 170 95 243 71 146 161
Bud 4 4 21 22 23 25 26 18 19 – 23 24 6 7 15 7 2 11 1 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 10 7 20 21 18 19 11 3 10 – 7 16 5 3 3 6 8 12 0 0 0 0 2 3
Cytoplasm 13 19 10 9 17 15 30 24 12 – 6 10 10 6 11 25 20 37 2 2 0 0 2 0
Endoplasmic Reticulum 209 138 275 116 124 157 221 198 112 – 45 60 104 113 99 16 5 17 66 57 42 16 35 16
Endosome 0 0 1 0 1 0 1 1 2 – 0 0 1 0 1 1 0 2 0 0 1 1 0 0
Golgi 328 124 263 181 235 204 262 190 80 – 56 60 128 183 159 254 159 198 139 64 115 45 56 46
Mitochondria 42 18 118 194 153 230 311 382 351 – 256 377 32 51 126 15 25 16 4 3 0 0 1 0
Nucleus 0 0 0 0 0 0 1 1 0 – 1 0 0 0 1 0 0 0 1 0 0 0 0 0
Nuclear Periphery 1 0 1 0 2 3 8 7 4 – 5 11 0 0 1 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 0 1 1 0 0 2 1 – 0 1 0 0 2 1 2 1 0 0 0 0 0 0
Peroxisomes 0 0 0 1 1 1 5 1 0 – 3 4 0 0 1 0 0 0 0 0 4 0 0 2
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 9 1 1 1 0 1 1 6 0 – 0 0 0 0 1 6 1 3 0 2 0 1 0 0
Unique Cell Count 378 226 418 309 332 390 546 552 410 286 417 182 231 268 288 181 253 390 231 413 140 248 235
Labelled Cell Count 748 423 947 738 721 849 1077 954 712 468 665 374 465 557 445 281 371 390 231 413 140 248 235


ER to Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 36.3 33.4 22.4 21.9 22.1 20.4 19.8 18.4 17.1 – 15.9 15.3 29.6 29.1 26.9 33.3 36.4 39.1 29.2 32.3 31.9
Std Deviation (1e-4) 9.1 6.9 3.9 4.7 5.0 4.0 4.4 4.2 4.2 – 3.7 3.7 6.9 7.5 7.4 11.8 12.9 14.5 6.3 7.9 8.4
Intensity Change (Log2) – – – -0.03 -0.02 -0.13 -0.18 -0.28 -0.39 – -0.49 -0.55 0.4 0.38 0.26 0.57 0.7 0.8 0.38 0.52 0.51

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.5 -3.5 -2.0 -6.2 -11.1 -7.9 – -8.8 -9.6 -1.9 -3.1 -1.4 -4.5 -5.4 -6.9
Bud 1.2 1.1 0.8 -0.2 -1.4 -0.3 – 1.6 0.5 -0.9 -1.2 0.3 -1.7 -2.3 -0.4
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 1.2 0.4 0.1 -2.4 -4.3 -1.8 – -1.6 -0.7 -1.1 -2.3 -2.6 -1.9 -0.2 0
Cytoplasm 0.4 2.0 1.2 2.4 1.6 0.5 – -0.3 0 1.9 0.2 1.3 3.8 4.5 6.0
Endoplasmic Reticulum -7.6 -7.8 -7.3 -7.8 -9.2 -11.1 – -13.1 -15.2 -2.0 -4.2 -7.4 -16.0 -14.2 -15.0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi -1.2 2.3 -3.1 -4.6 -8.8 -12.7 – -11.3 -14.4 1.8 4.3 -0.9 7.5 6.1 4.2
Mitochondria 9.3 5.1 8.8 8.9 12.6 16.7 – 16.0 18.3 -2.8 -1.7 5.0 -7.7 -3.8 -6.9
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 2.9 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 39.6986 47.6429 43.9242 47.6415 41.6402 47.3913 33.2173 44.5992 41.7452 39.8984 41.9118 41.1318 31.0069 39.8802 39.9198 37.8099 33.1209 36.3534
Actin 0.1774 0.0943 0.0845 0.0064 0.0458 0.0341 0.1339 0.068 0.0628 0.0394 0.0113 0.0327 0.1888 0.1687 0.2098 0.3256 0.0424 0.1237
Bud 0.0001 0 0 0 0 0 0.0005 0.0001 0.0001 0.0004 0 0.0006 0.0007 0.0002 0 0 0.0002 0
Bud Neck 0.001 0.0003 0.0008 0.0001 0.0002 0.0002 0.0006 0.0006 0.0009 0.0002 0.0002 0.0002 0.0005 0.0006 0.0005 0.0008 0.0003 0.0003
Bud Periphery 0.0002 0 0 0 0 0 0.0005 0.0001 0.0002 0.0003 0 0.0004 0.0011 0.0002 0 0.0001 0.0002 0.0001
Bud Site 0.0003 0.0001 0 0 0 0 0.0026 0.0002 0.0003 0.002 0 0.0006 0.0029 0.0004 0.0001 0 0.0005 0.0001
Cell Periphery 0.0009 0.0004 0.0007 0.0004 0.0002 0.0004 0.0006 0.0009 0.0005 0.0007 0.0007 0.0004 0.0005 0.0006 0.0005 0.0004 0.0004 0.0002
Cytoplasm 0.0001 0.0004 0.0001 0 0 0 0.0036 0.0023 0.0029 0.0036 0 0.004 0.0021 0.0002 0.0001 0.0001 0.0003 0.0012
Cytoplasmic Foci 0.002 0.0024 0.0012 0.0005 0.0008 0.0005 0.0105 0.0029 0.0013 0.0033 0.0008 0.0012 0.0144 0.0022 0.0011 0.001 0.0146 0.0034
Eisosomes 0.0597 0.0428 0.0459 0.0212 0.0519 0.0173 0.0641 0.0245 0.0552 0.0432 0.0459 0.0228 0.0393 0.0168 0.039 0.1851 0.0731 0.0098
Endoplasmic Reticulum 0.0016 0.0021 0.0024 0.0013 0.001 0.0023 0.0053 0.0038 0.003 0.0056 0.0032 0.0035 0.0116 0.0012 0.0017 0.0017 0.0014 0.0053
Endosome 0.0079 0.0057 0.0053 0.0027 0.0029 0.0034 0.0272 0.0091 0.0091 0.0074 0.003 0.0092 0.0238 0.0037 0.0026 0.0051 0.005 0.0094
Golgi 0.7168 0.8453 0.8459 0.9625 0.8926 0.9279 0.6879 0.874 0.842 0.8731 0.9211 0.9177 0.6148 0.7567 0.7387 0.4747 0.7721 0.8365
Lipid Particles 0.0206 0.0034 0.0094 0.0038 0.0039 0.002 0.0224 0.0072 0.0039 0.0125 0.0127 0.003 0.016 0.0121 0.0043 0.003 0.0142 0.0035
Mitochondria 0.009 0.0011 0.0015 0.0004 0.0004 0.0099 0.0266 0.0039 0.0028 0.0035 0.0004 0.0018 0.0371 0.0147 0.001 0.0016 0.0581 0.0044
None 0.0001 0 0 0 0 0 0.0009 0.0001 0.008 0.001 0 0.0002 0.0069 0.0003 0 0 0.0013 0.0001
Nuclear Periphery 0.0005 0.0002 0.0007 0.0003 0.0001 0.0006 0.0041 0.0009 0.0027 0.0015 0.0002 0.0005 0.0095 0.0028 0.0002 0.0001 0.0002 0.0009
Nucleolus 0 0 0 0 0 0 0.0011 0 0.0001 0 0 0 0.0007 0.0057 0 0 0.0029 0
Nucleus 0 0 0 0 0 0 0.0008 0 0.0009 0.0002 0 0.0003 0.0013 0.0105 0 0 0.0006 0.0001
Peroxisomes 0.0004 0.0006 0 0 0 0 0.0017 0.0004 0.0001 0.0005 0.0001 0.0001 0.0034 0.0004 0.0001 0.0001 0.0103 0.0004
Punctate Nuclear 0 0 0 0 0 0 0.0008 0.0001 0.0001 0.0003 0 0.0002 0.0214 0.0012 0 0 0.0004 0
Vacuole 0.0002 0.0001 0.0001 0 0 0.0001 0.0017 0.0003 0.0021 0.0003 0 0.0002 0.0013 0.0001 0 0.0001 0.0006 0.0002
Vacuole Periphery 0.0012 0.0007 0.0013 0.0004 0.0002 0.0013 0.0025 0.0006 0.0011 0.0009 0.0003 0.0005 0.0019 0.0007 0.0002 0.0003 0.001 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 147.9578 142.7174 113.3712 136.6231 129.8855 120.3205 133.3418 116.4146 115.973 149.8794
Translational Efficiency 1.3922 1.3061 1.3091 1.0282 1.2094 1.5319 1.1107 1.0361 1.2065 1.1244

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1848 125 191 1239 1687 1857 1623 2873 3535 1982 1814 4112

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1907.02 2333.64 3447.05 1782.54 1557.01 1649.04 3238.40 2301.43 1739.99 1692.22 3260.37 2145.08
Standard Deviation 826.44 598.93 1673.12 1205.47 622.35 848.31 780.58 1415.26 756.61 851.22 918.69 1376.22
Intensity Change Log 2 — 0.291262 0.854042 -0.097386 — 0.082848 1.056503 0.563752 — 0.201288 0.948573 0.237521

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.153858 0.175965 0.116673 0.104489 0.298538 0.291269 0.090835 0.226227 0.222903 0.283997 0.093555 0.189546
Bud Neck 0.002638 0.005237 0.033411 0.006664 0.003539 0.007303 0.003912 0.004454 0.003068 0.007173 0.007018 0.005120
Bud Site 0.029877 0.010937 0.018813 0.076229 0.026666 0.066753 0.007732 0.080615 0.028345 0.063233 0.008899 0.079294
Cell Periphery 0.002507 0.001181 0.013014 0.007811 0.001595 0.001641 0.004269 0.007890 0.002072 0.001612 0.005190 0.007866
Cytoplasm 0.063473 0.020629 0.025639 0.132744 0.040644 0.120800 0.004849 0.097490 0.052578 0.114482 0.007038 0.108112
Cytoplasmic Foci 0.011555 0.021437 0.009273 0.009617 0.011866 0.036907 0.000885 0.004515 0.011704 0.035931 0.001769 0.006053
Eisosomes 0.116328 0.300593 0.106333 0.070864 0.236446 0.108450 0.169327 0.072090 0.173652 0.120568 0.162694 0.071721
Endoplasmic Reticulum 0.083058 0.088030 0.185294 0.129224 0.039803 0.061026 0.207977 0.131723 0.062416 0.062729 0.205588 0.130970
Endosome 0.008647 0.007931 0.016471 0.021316 0.005495 0.012883 0.011983 0.019756 0.007143 0.012571 0.012455 0.020226
Golgi 0.398184 0.294884 0.184996 0.175307 0.240089 0.189550 0.377612 0.187224 0.322737 0.196193 0.357331 0.183633
Lipid Particles 0.093549 0.059023 0.127802 0.157366 0.068331 0.063232 0.109299 0.116717 0.081514 0.062966 0.111247 0.128965
Mitochondria 0.007163 0.001911 0.004644 0.008793 0.004848 0.005317 0.001939 0.017584 0.006059 0.005102 0.002224 0.014936
Mitotic Spindle 0.000674 0.000380 0.003232 0.021142 0.001049 0.005225 0.000511 0.010945 0.000853 0.004920 0.000797 0.014017
None 0.015896 0.001684 0.000997 0.003767 0.009058 0.002494 0.000545 0.003808 0.012633 0.002443 0.000592 0.003795
Nuclear Periphery 0.000207 0.000250 0.006011 0.000885 0.000195 0.000203 0.000806 0.000479 0.000201 0.000206 0.001354 0.000601
Nuclear Periphery Foci 0.000347 0.000194 0.001967 0.000763 0.000308 0.000285 0.000159 0.000283 0.000329 0.000279 0.000349 0.000428
Nucleolus 0.000254 0.000148 0.000618 0.000454 0.000334 0.000315 0.000013 0.000223 0.000292 0.000305 0.000077 0.000293
Nucleus 0.007826 0.001400 0.078406 0.040649 0.008346 0.013311 0.002665 0.008672 0.008074 0.012560 0.010640 0.018307
Peroxisomes 0.000668 0.004163 0.000230 0.000888 0.000745 0.002354 0.000405 0.001619 0.000705 0.002469 0.000386 0.001399
Vacuole 0.002136 0.003294 0.055138 0.028260 0.001454 0.009273 0.003016 0.006196 0.001811 0.008896 0.008504 0.012844
Vacuole Periphery 0.001154 0.000730 0.011038 0.002766 0.000652 0.001408 0.001262 0.001489 0.000914 0.001366 0.002291 0.001873

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.93 3.46 8.34 4.10 1.26 0.68 20.11 7.89 7.41 -15.34 -6.19 17.52 6.70 11.82 -12.12
Bud Neck -2.45 -8.07 -6.57 -1.33 6.82 -6.53 -0.90 -3.27 3.73 -1.90 -7.71 -6.35 -6.71 2.94 2.01
Bud Site 2.75 0.63 -9.01 -8.60 -6.46 -9.08 6.03 -14.77 -4.20 -21.97 -9.00 7.50 -17.43 -4.92 -24.07
Cell Periphery 3.38 -6.23 -5.41 -7.07 3.48 -0.31 -7.97 -15.40 -15.67 -6.57 2.68 -8.53 -14.53 -16.58 -4.35
Cytoplasm 4.38 2.09 -14.31 -14.52 -13.21 -12.48 9.50 -15.35 -1.05 -25.33 -10.56 13.47 -19.33 -4.73 -32.16
Cytoplasmic Foci -1.03 -1.13 -0.52 0.95 0.96 -8.86 7.51 4.50 12.83 -9.00 -9.52 8.40 4.16 11.95 -7.54
Eisosomes -6.50 1.94 9.93 8.80 3.00 14.65 7.08 21.36 7.35 14.93 8.12 1.86 21.95 10.49 15.89
Endoplasmic Reticulum -0.43 -5.26 -2.06 -0.53 4.33 -5.73 -29.88 -19.49 -13.07 14.01 0.06 -26.58 -14.44 -12.54 15.96
Endosome 0.73 -5.60 -7.29 -6.45 -0.10 -8.27 -13.17 -17.57 -5.04 -8.77 -6.72 -12.66 -17.82 -5.32 -8.36
Golgi 3.89 14.45 26.55 6.48 1.91 5.52 -13.29 8.27 2.29 23.43 15.43 -3.38 24.52 5.16 24.64
Lipid Particles 3.03 -1.42 -2.95 -4.56 -0.30 1.15 -7.51 -7.21 -8.99 0.56 4.64 -6.01 -6.53 -10.56 0.08
Mitochondria 3.88 0.88 -0.83 -4.38 -1.49 -0.52 3.44 -9.04 -8.42 -11.33 1.11 4.88 -7.90 -8.37 -11.68
Mitotic Spindle 1.25 -2.34 -9.70 -9.80 -5.37 -3.95 0.39 -10.52 -5.78 -10.74 -4.25 -1.41 -14.48 -8.58 -13.43
None 6.22 7.34 5.89 -1.49 -3.18 4.80 6.38 3.56 -2.15 -5.85 8.19 9.94 6.83 -2.57 -7.11
Nuclear Periphery -1.19 -8.74 -16.29 -15.59 7.09 -0.43 -11.12 -12.00 -11.45 4.77 -0.27 -12.54 -18.69 -18.75 6.39
Nuclear Periphery Foci 1.23 -5.15 -4.25 -4.17 4.10 0.38 2.39 0.36 -0.05 -2.93 1.05 -1.40 -2.20 -3.59 -0.22
Nucleolus 0.88 -2.50 -2.09 -2.24 1.58 0.21 4.01 0.56 0.46 -2.10 -0.20 3.02 -0.44 -0.30 -2.23
Nucleus 5.14 -5.98 -15.55 -17.03 1.57 -2.53 2.80 -4.10 -1.62 -7.21 -2.91 -3.07 -14.50 -11.28 -7.47
Peroxisomes -1.16 1.83 -0.23 1.14 -1.25 -4.79 2.62 -2.09 1.96 -3.09 -4.83 2.56 -2.09 2.86 -3.26
Vacuole -0.75 -7.60 -15.27 -14.39 -0.08 -6.96 -3.72 -9.93 -1.83 -7.22 -6.69 -7.45 -17.29 -11.47 -9.63
Vacuole Periphery 1.28 -4.96 -2.32 -4.02 4.37 -2.31 -4.97 -5.39 -0.06 -1.17 -1.34 -4.80 -3.63 -0.89 2.14
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
Localization
Cell Percentages ER (74%)
Cell Cycle Regulation No
Subcompartmental Group ER-1

Sec31

Sec31


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec31-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available