Standard name
Human Ortholog
Description Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.1 0 0 0 0 – 0 0 0 0.07 0.07 0.11 0.06 0.11 0.13 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.07 0.06 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0.06 0 0 0 – 0 0 0 0 0 0 0.06 0.06 0 0 0 0 0 0.05 0.09
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.19 0.39 0.42 0.39 0.29 0.54 0.63 0.6 – 0.77 0.78 0.75 0 0 0 0.12 0.13 0.1 0 0.06 0 0.06 0.12 0.15
Nucleus 0.06 0.07 0 0 0.05 0.06 0.06 0.08 – 0.07 0.11 0.09 0.09 0.09 0.07 0.1 0.11 0 0 0 0 0 0 0
Nuclear Periphery 0.63 0.6 0.65 0.68 0.64 0.59 0.51 0.4 – 0.49 0.38 0.49 0.57 0.6 0.51 0.5 0.44 0.49 0.85 0.79 0.87 0.82 0.72 0.62
Nucleolus 0 0 0 0 0 0.06 0.08 0.1 – 0.12 0.07 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.51 0.54 0.38 0.22 0.31 0.18 0.17 0.13 – 0.09 0.1 0.09 0.56 0.54 0.59 0.5 0.5 0.49 0.06 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 0 – 0 0 0 2 2 2 0 0 0 0 1 1 0 6 4
Bud 0 0 1 0 1 0 3 5 – 9 6 7 1 1 3 0 0 0 1 2 3 2 3 3
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 3 0 0 0 0 0 1 0 1 0
Bud Site 0 1 0 0 0 2 5 5 – 7 5 12 0 0 1 0 1 0 – – – – – –
Cell Periphery 0 0 0 0 1 0 0 1 – 0 0 0 4 4 1 0 0 1 0 0 0 0 0 0
Cytoplasm 1 1 16 35 11 22 13 23 – 12 9 12 77 77 156 8 43 17 0 0 0 0 0 2
Endoplasmic Reticulum 2 4 1 0 3 4 0 0 – 1 1 1 1 2 7 10 25 10 0 1 3 4 8 5
Endosome 1 0 10 2 27 9 14 22 – 7 2 7 24 24 25 8 25 5 3 3 12 10 35 61
Golgi 0 0 1 1 1 0 0 0 – 0 0 0 0 0 2 0 0 0 0 0 2 2 12 25
Mitochondria 24 75 185 139 140 264 495 498 – 669 319 475 7 7 7 16 52 12 4 12 13 24 82 97
Nucleus 7 14 16 15 22 29 49 68 – 57 47 56 98 98 92 13 44 5 1 5 3 3 3 2
Nuclear Periphery 79 114 288 241 310 292 400 335 – 429 156 308 655 691 693 67 178 62 117 155 403 319 492 410
Nucleolus 2 2 6 9 21 30 64 84 – 105 28 72 3 3 9 6 9 5 0 0 0 1 0 1
Peroxisomes 0 0 0 0 1 0 0 3 – 2 0 1 0 0 0 0 0 0 0 0 1 3 8 8
SpindlePole 0 1 0 0 0 2 5 8 – 5 3 2 13 11 28 1 3 0 0 1 2 1 4 5
Vac/Vac Membrane 64 103 166 80 152 87 134 105 – 74 41 58 636 618 805 67 199 62 7 11 9 11 18 22
Unique Cell Count 126 190 442 356 485 491 787 830 868 411 632 1142 1145 1367 135 401 126 139 198 462 388 682 657
Labelled Cell Count 180 316 690 522 690 741 1182 1157 1377 617 1011 1521 1538 1834 196 579 179 139 198 462 388 682 657


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 5.8 6.0 6.4 6.0 5.3 4.8 5.1 – 4.5 4.6 4.6 8.1 8.1 8.2 5.5 5.9 6.8 8.3 8.2 8.4
Std Deviation (1e-4) 0.9 1.0 1.2 2.1 1.4 1.5 1.2 1.3 – 1.1 1.3 1.2 1.3 1.3 1.5 1.0 1.3 1.3 1.4 1.3 1.3
Intensity Change (Log2) – – – 0.1 0.01 -0.18 -0.33 -0.23 – -0.43 -0.37 -0.39 0.44 0.44 0.44 -0.14 -0.04 0.18 0.47 0.45 0.48


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 3.6 -1.2 0.7 -2.2 -0.8 – -2.6 -1.2 -1.7 2.4 2.4 4.9 1.2 4.0 4.2
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 0 5.0 0
Endosome -2.0 2.6 -0.5 0 0.4 – 0 0 0 -0.2 -0.2 -0.6 0 2.9 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria -0.8 -4.1 3.6 0 6.2 – 0 0 0 -22.6 -22.6 -24.5 -6.4 -9.3 -6.7
Nucleus 0.4 0.7 1.6 2.0 3.1 – 2.2 4.4 3.4 3.4 3.4 2.4 2.8 4.1 0
Nuclear Periphery 0.8 -0.4 -1.8 0 -8.4 – 0 0 0 -2.8 -1.8 -5.3 -3.2 -6.1 -3.2
Nucleolus 1.2 2.7 3.8 0 5.8 – 0 0 0 0 0 0 0 1.0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 3.0 0 0 0
Vacuole -4.6 -2.0 -6.8 -8.0 -10.3 – -12.8 -9.4 -11.3 6.5 5.9 7.8 2.5 3.5 2.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4019 4.2192 3.853 3.6133 3.8253 4.0494 2.6214 3.017 2.5646 2.4451 2.3392 2.4939 1.3152 2.2093 2.0624 1.9329 1.5529 1.7294
Actin 0.0092 0.0004 0.0002 0.0003 0.001 0.0014 0.0309 0.0002 0.0005 0.0022 0.0028 0.0001 0.019 0.0018 0.001 0.0046 0.041 0.0003
Bud 0.0001 0.004 0.0001 0.0001 0 0.0002 0.0004 0 0 0 0.0001 0 0.0001 0.0001 0 0.0001 0.0001 0
Bud Neck 0.0023 0.0002 0.0001 0 0.0001 0.0003 0.0005 0 0 0 0.0001 0 0.0007 0.0001 0 0.0001 0.0001 0
Bud Periphery 0.0003 0.0005 0 0 0 0.0003 0.0012 0.0001 0.0001 0.0002 0.0006 0 0.0002 0.0003 0.0002 0.0007 0.0002 0
Bud Site 0.0008 0.0022 0.0002 0.0001 0 0 0.001 0 0 0 0.0001 0 0.0005 0.0003 0.0001 0.0001 0.0002 0
Cell Periphery 0.0002 0.0002 0 0 0 0 0.0002 0 0 0 0.0001 0 0.0001 0.0001 0.0001 0.0001 0 0
Cytoplasm 0.0044 0.0131 0.0047 0.0013 0.0006 0.0075 0.0008 0.0003 0.0003 0.0002 0.0001 0 0.0209 0.0002 0.0011 0.0007 0.0001 0.0002
Cytoplasmic Foci 0.0073 0.0018 0.0005 0.0028 0.0003 0.0012 0.0146 0 0.0001 0.0001 0.0016 0.0001 0.048 0.0025 0.0078 0.0002 0.0025 0.0001
Eisosomes 0.0009 0 0 0 0 0 0.0006 0 0 0 0.0002 0 0.0004 0.0004 0.0001 0.0002 0.0002 0
Endoplasmic Reticulum 0.0081 0.0057 0.0039 0.0048 0.0022 0.0031 0.0054 0.0065 0.0065 0.0048 0.0055 0.0013 0.007 0.0135 0.0077 0.0385 0.0059 0.0017
Endosome 0.0206 0.0047 0.0019 0.0018 0.005 0.004 0.0128 0.001 0.0017 0.0017 0.0023 0.0006 0.0106 0.0038 0.0043 0.0038 0.0027 0.0015
Golgi 0.0034 0.0001 0.0001 0.0001 0.0005 0.0005 0.01 0.0002 0.0002 0.0003 0.0041 0.0002 0.0026 0.0012 0.0029 0.0013 0.0027 0.0001
Lipid Particles 0.0059 0.001 0.0004 0.0004 0.0027 0.0009 0.0432 0.0015 0.0016 0.0014 0.1156 0.0149 0.0161 0.0315 0.0153 0.0025 0.0136 0.0008
Mitochondria 0.0022 0.0025 0.0009 0.0014 0.0012 0.0014 0.0204 0.0022 0.0024 0.0035 0.0221 0.0003 0.0044 0.0395 0.0042 0.0229 0.0077 0.0009
None 0.011 0.0083 0.0005 0.0013 0.0007 0.0014 0.0068 0.0002 0.0004 0.0006 0.0009 0.0001 0.0753 0.0005 0.0017 0.0031 0.0007 0.0002
Nuclear Periphery 0.8434 0.7593 0.8321 0.8309 0.8822 0.8547 0.7716 0.8953 0.9092 0.9286 0.7989 0.9598 0.6513 0.8117 0.8844 0.8542 0.8431 0.9671
Nucleolus 0.0031 0.0056 0.0027 0.0027 0.0011 0.0024 0.0053 0.0002 0.0002 0.0002 0.0006 0.0001 0.0047 0.0011 0.0002 0.0005 0.0003 0.0002
Nucleus 0.0301 0.1103 0.0854 0.0296 0.0159 0.0715 0.0081 0.0188 0.0169 0.0047 0.0057 0.0039 0.0421 0.0108 0.0129 0.0107 0.0033 0.0061
Peroxisomes 0.0024 0.0001 0 0.0001 0.0002 0 0.015 0 0 0.0001 0.0013 0 0.0401 0.0017 0.0037 0.0002 0.0379 0
Punctate Nuclear 0.0217 0.0546 0.0427 0.0972 0.0659 0.035 0.0059 0.0003 0.0004 0.0008 0.0011 0.0006 0.0203 0.0021 0.0012 0.0012 0.0018 0.0011
Vacuole 0.0026 0.004 0.0012 0.0007 0.0012 0.0015 0.0019 0.0017 0.0023 0.0007 0.0012 0.0002 0.0028 0.0036 0.001 0.0018 0.0009 0.0003
Vacuole Periphery 0.02 0.0215 0.0225 0.0243 0.019 0.0124 0.0435 0.0714 0.0569 0.0498 0.035 0.0178 0.0329 0.0732 0.0502 0.0526 0.035 0.0194

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.083 14.0301 16.2954 16.5525 18.5794 12.958 16.9613 15.8187 17.4923 18.2481
Translational Efficiency 1.1822 1.3695 1.0419 0.9804 0.9864 1.3309 0.9044 0.7624 0.8268 0.9217

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
84 818 1298 1028 322 572 1831 1408 406 1390 3129 2436

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1053.22 796.50 905.99 926.18 681.84 813.44 941.82 935.96 758.68 803.47 926.96 931.83
Standard Deviation 184.92 144.91 109.29 132.94 103.79 114.19 122.38 130.13 195.58 133.39 118.45 131.41
Intensity Change Log 2 — -0.403061 -0.217240 -0.185442 — 0.254603 0.466018 0.457014 — -0.107979 0.090831 0.101976

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000376 0.000269 0.000150 0.000310 0.000273 0.000137 0.000099 0.000104 0.000294 0.000215 0.000120 0.000191
Bud Neck 0.002049 0.000775 0.001151 0.002637 0.000975 0.000187 0.000525 0.000967 0.001198 0.000533 0.000784 0.001671
Bud Site 0.001346 0.000799 0.000225 0.001873 0.000502 0.000234 0.000310 0.000724 0.000677 0.000566 0.000275 0.001209
Cell Periphery 0.000088 0.000091 0.000025 0.000058 0.000093 0.000037 0.000032 0.000032 0.000092 0.000069 0.000029 0.000043
Cytoplasm 0.002851 0.009171 0.001221 0.012679 0.003541 0.002476 0.002930 0.002335 0.003398 0.006416 0.002221 0.006700
Cytoplasmic Foci 0.022656 0.003355 0.000221 0.005564 0.000699 0.001925 0.000662 0.003310 0.005242 0.002766 0.000479 0.004261
Eisosomes 0.000010 0.000009 0.000003 0.000008 0.000009 0.000005 0.000002 0.000004 0.000010 0.000007 0.000002 0.000006
Endoplasmic Reticulum 0.028885 0.016928 0.005831 0.009531 0.021933 0.017465 0.005897 0.006790 0.023372 0.017149 0.005870 0.007947
Endosome 0.044977 0.006562 0.001920 0.010760 0.004656 0.004189 0.001759 0.007863 0.012998 0.005586 0.001826 0.009085
Golgi 0.015415 0.001037 0.000093 0.003550 0.000263 0.001735 0.000215 0.002882 0.003398 0.001324 0.000164 0.003164
Lipid Particles 0.006194 0.010110 0.000702 0.004223 0.023220 0.014459 0.000453 0.003136 0.019697 0.011900 0.000556 0.003595
Mitochondria 0.002606 0.005437 0.001803 0.005880 0.006523 0.006286 0.001759 0.003082 0.005713 0.005787 0.001777 0.004263
Mitotic Spindle 0.081893 0.010076 0.014679 0.134317* 0.004926 0.006222 0.013837 0.072524 0.020850 0.008490 0.014186 0.098601
None 0.000078 0.006720 0.000751 0.001029 0.005651 0.001057 0.000639 0.000620 0.004498 0.004390 0.000686 0.000793
Nuclear Periphery 0.378503* 0.332683* 0.451620* 0.285728* 0.329076* 0.377162* 0.537134* 0.317906* 0.339302* 0.350986* 0.501660* 0.304327*
Nuclear Periphery Foci 0.356116* 0.541393* 0.488730* 0.463276* 0.544665* 0.548193* 0.403132* 0.555335* 0.505655* 0.544191* 0.438641* 0.516486*
Nucleolus 0.002807 0.013462 0.007349 0.005463 0.020433 0.003845 0.003728 0.002286 0.016786 0.009505 0.005230 0.003627
Nucleus 0.016049 0.030774 0.014605 0.025971 0.028987 0.008748 0.019641 0.004631 0.026310 0.021710 0.017552 0.013636
Peroxisomes 0.001027 0.000529 0.000124 0.000664 0.000744 0.000632 0.000066 0.000154 0.000803 0.000571 0.000090 0.000369
Vacuole 0.028355 0.005756 0.004925 0.020501 0.001443 0.002239 0.004807 0.009863 0.007011 0.004309 0.004856 0.014352
Vacuole Periphery 0.007721 0.004063 0.003873 0.005980 0.001387 0.002768 0.002374 0.005452 0.002698 0.003530 0.002996 0.005675

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.64 1.32 -0.09 -1.76 -3.64 1.78 2.25 2.23 1.40 0.01 1.12 2.46 0.93 -0.31 -3.32
Bud Neck 1.42 1.01 -1.11 -4.75 -4.10 1.27 0.57 -0.22 -5.94 -2.76 1.25 0.68 -1.49 -5.46 -4.89
Bud Site 0.75 1.71 -1.40 -2.67 -3.83 0.42 0.45 -0.66 -1.82 -1.77 0.13 1.18 -2.05 -2.81 -4.19
Cell Periphery -0.11 1.65 0.62 1.76 -3.43 2.51 2.59 2.72 0.68 0.21 1.12 3.17 2.37 2.60 -2.22
Cytoplasm -3.60 1.40 -6.97 -3.87 -8.16 0.15 -0.14 0.59 0.42 1.20 -2.62 0.67 -4.99 -2.23 -6.89
Cytoplasmic Foci 1.71 2.02 1.52 -1.51 -5.17 -1.93 -0.03 -3.78 -1.61 -3.40 0.96 2.01 0.38 -1.69 -6.06
Eisosomes 0.28 1.48 -0.79 -2.37 -5.60 2.79 4.92 3.35 0.85 -2.10 1.54 4.56 1.13 -0.62 -5.78
Endoplasmic Reticulum 1.39 2.69 2.18 3.88 -3.67 1.20 4.75 4.57 5.25 -0.72 1.88 5.49 4.77 6.99 -3.04
Endosome 2.39 2.69 2.12 -2.65 -7.65 0.36 2.52 -2.19 -2.79 -5.76 2.05 3.18 1.04 -3.31 -9.27
Golgi 1.41 1.51 1.19 -2.41 -3.72 -1.85 0.42 -2.80 -0.92 -2.85 0.95 1.53 0.15 -2.25 -4.43
Lipid Particles -1.54 2.47 0.66 3.08 -3.81 1.82 5.62 4.89 3.99 -3.84 2.18 5.86 4.82 5.26 -5.41
Mitochondria -1.64 0.46 -1.49 -0.14 -2.80 0.16 4.76 2.94 2.07 -1.74 -0.08 4.55 1.41 1.61 -3.29
Mitotic Spindle 2.94 2.71 -2.43 -15.43 -14.74 -1.01 -4.32 -12.46 -11.17 -10.38 2.05 0.93 -11.54 -18.74 -17.75
None -5.18 -2.05 -5.34 4.15 -1.30 3.25 3.55 3.49 1.04 -0.09 0.14 3.37 3.15 4.38 -1.00
Nuclear Periphery 1.23 -2.12 3.04 5.26 16.84 -2.69 -13.59 0.86 4.74 24.00* -0.77 -11.57 3.06 6.29 29.02
Nuclear Periphery Foci -5.88 -4.30 -2.48 7.79 4.48 -0.07 8.90 -0.36 -0.35 -15.65 -2.37 4.66 0.27 4.37 -8.39
Nucleolus -3.76 -2.08 -2.02 2.69 0.07 3.98 4.07 4.43 1.08 1.87 2.11 3.47 3.74 3.56 1.12
Nucleus -1.29 0.08 -2.04 -1.53 -5.49 3.62 1.10 4.44 1.48 6.51 0.84 1.36 1.28 0.63 -0.14
Peroxisomes 0.73 1.37 0.21 -1.00 -2.38 0.48 4.17 3.49 2.80 -1.46 1.06 3.80 1.48 0.71 -2.68
Vacuole 2.59 2.68 0.33 -6.89 -7.35 -1.41 -3.34 -6.18 -4.62 -3.39 1.15 0.99 -4.03 -7.81 -7.90
Vacuole Periphery 1.26 1.35 0.77 -1.29 -1.63 -1.98 -1.95 -5.05 -2.60 -3.37 -0.97 -0.37 -3.32 -2.46 -3.66
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination
Localization
Cell Percentages nuclear periphery (73%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Gle1

Gle1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gle1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available