Standard name
Human Ortholog
Description NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0.05 0.06 0.06 0.1 0 0 0 0.08 0.12 0.16 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.98 1.0 0.97 0.96 0.89 0.88 0.91 0.89 0.84 0.79 0.99 0.98 0.98 0.82 0.81 0.77 0.96 0.96 0.92 0.89 0.86 0.83
Endoplasmic Reticulum 0 0 0 0 0 0.05 0.1 0.09 0.05 0.07 0.12 0.12 0 0 0 0.07 0 0 0 0 0 0 0 0.06
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 5 5 4 13 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 2 0 0 0 1 3 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 1 1 4 3 18 13 15 17 19 32 0 0 4 6 6 13 0 0 0 0 0 0
Cytoplasm 79 188 293 268 333 328 382 383 281 270 247 250 214 251 234 61 42 61 73 179 289 148 204 249
Endoplasmic Reticulum 0 1 3 0 7 16 41 41 16 22 35 38 1 5 1 5 0 3 0 2 8 2 8 18
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Golgi 0 0 2 0 1 0 0 2 0 0 1 4 0 1 1 1 4 0 0 0 3 0 1 10
Mitochondria 0 0 0 0 0 0 0 1 1 1 0 0 0 0 1 3 0 1 0 0 1 1 1 2
Nucleus 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 1 1 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 1 0 1 0 1 0 2 1 0 2 2 0 0 2 3 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 2
Vac/Vac Membrane 0 1 0 0 0 0 0 0 0 0 1 0 2 0 1 0 3 2 1 1 4 3 4 3
Unique Cell Count 79 190 298 268 345 342 429 435 310 304 295 318 217 255 240 74 52 79 76 187 314 167 238 301
Labelled Cell Count 79 192 300 269 346 347 443 442 321 317 308 339 220 257 242 78 58 84 76 187 314 167 238 301


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 187.4 175.1 146.0 149.1 145.4 127.8 118.8 101.6 90.0 87.4 81.0 73.1 167.8 150.8 130.9 266.1 294.6 310.9 182.7 164.6 185.1
Std Deviation (1e-4) 46.0 42.6 40.8 38.5 40.0 33.2 30.6 30.9 29.5 24.9 22.1 21.5 52.2 40.0 35.9 73.3 105.8 82.3 54.5 52.8 46.5
Intensity Change (Log2) – – – 0.03 -0.01 -0.19 -0.3 -0.52 -0.7 -0.74 -0.85 -1.0 0.2 0.05 -0.16 0.87 1.01 1.09 0.32 0.17 0.34


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 3.5 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 3.2 2.6 3.5 3.8 4.1 5.4 0 0 0 0 0 0
Cytoplasm 2.1 -1.4 -1.8 -4.8 -5.1 -4.1 -4.7 -6.2 -7.6 0.3 0.1 -0.7 -5.7 -5.8 -7.0
Endoplasmic Reticulum 0 0 2.7 4.8 4.7 2.9 3.8 5.4 5.4 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.0158 19.7678 16.9113 19.7561 13.8152 17.5277 14.6878 21.0788 18.4719 16.6614 17.8009 17.727 15.4665 24.5547 18.0097 17.4911 16.4462 19.926
Actin 0.0332 0.0004 0.0182 0.0045 0.0097 0.0034 0.0088 0.0002 0.0037 0.0014 0.0125 0.0022 0.0063 0.0013 0.0076 0.0005 0.0056 0.0093
Bud 0.0021 0.0015 0.0022 0.0021 0.0016 0.0009 0.0009 0.0005 0.0018 0.0018 0.0123 0.0008 0.0016 0.0015 0.0017 0.0015 0.0008 0.0005
Bud Neck 0.0013 0.0005 0.0027 0.0008 0.0034 0.0019 0.0031 0.0002 0.0007 0.001 0.0007 0.0011 0.0004 0.0004 0.0008 0.0006 0.0008 0.0014
Bud Periphery 0.0029 0.0007 0.0026 0.0018 0.0028 0.0011 0.0006 0.0001 0.0023 0.001 0.0077 0.0015 0.0027 0.0006 0.0007 0.0005 0.0004 0.0003
Bud Site 0.0042 0.0019 0.0068 0.0011 0.0076 0.0004 0.0056 0.0006 0.002 0.003 0.0019 0.0003 0.0021 0.0025 0.0014 0.0019 0.0011 0.0001
Cell Periphery 0.0026 0.002 0.0014 0.0006 0.0006 0.0005 0.0006 0.0001 0.0003 0.0005 0.0002 0.0004 0.0006 0.0006 0.0006 0.0002 0.0001 0.0002
Cytoplasm 0.7204 0.928 0.8479 0.7604 0.6438 0.8965 0.8039 0.9573 0.8668 0.7699 0.8517 0.9013 0.842 0.8876 0.8962 0.8645 0.8418 0.9133
Cytoplasmic Foci 0.012 0.0045 0.007 0.0148 0.0385 0.0093 0.0278 0.0052 0.0138 0.0239 0.0145 0.0078 0.0168 0.0274 0.0165 0.0139 0.0275 0.0079
Eisosomes 0.001 0 0.0003 0.0002 0.0005 0.0001 0.0001 0 0 0 0.0001 0 0.0001 0 0.0002 0 0 0
Endoplasmic Reticulum 0.0472 0.01 0.0198 0.0065 0.0228 0.0229 0.0267 0.0042 0.0123 0.0085 0.0049 0.0183 0.0346 0.0031 0.0129 0.0313 0.0201 0.0128
Endosome 0.0333 0.0056 0.0185 0.0216 0.0537 0.0139 0.0458 0.006 0.0328 0.0845 0.0426 0.0283 0.0266 0.0275 0.0175 0.0478 0.0631 0.0315
Golgi 0.007 0.0006 0.0022 0.0017 0.0082 0.0026 0.0093 0.0008 0.0045 0.0044 0.0048 0.0055 0.0073 0.0031 0.0028 0.0028 0.006 0.0055
Lipid Particles 0.0071 0.0001 0.0013 0.005 0.0189 0.0004 0.0021 0 0.0019 0.001 0.0069 0.0014 0.0107 0.0023 0.0032 0.0005 0.003 0.0001
Mitochondria 0.0179 0.0003 0.0081 0.013 0.066 0.0081 0.0026 0.0003 0.0077 0.0028 0.0018 0.0029 0.0043 0.002 0.0011 0.0005 0.0072 0.0054
None 0.012 0.0007 0.0009 0.0047 0.0105 0.0005 0.0052 0.0005 0.0012 0.0023 0.0017 0.0006 0.005 0.0011 0.0036 0.0007 0.0031 0.0005
Nuclear Periphery 0.0124 0.0018 0.0041 0.0064 0.0091 0.0025 0.0093 0.0018 0.0062 0.0063 0.0041 0.0027 0.0044 0.0009 0.0028 0.005 0.0047 0.001
Nucleolus 0.0005 0.0001 0.0021 0.0109 0.0024 0.0001 0.0007 0 0.0001 0.0005 0.0002 0.0002 0.0002 0.0003 0.0012 0.0001 0.0001 0
Nucleus 0.0058 0.0021 0.0039 0.0046 0.0066 0.0022 0.0045 0.0016 0.0028 0.0083 0.0017 0.002 0.0029 0.0024 0.0023 0.0016 0.002 0.0011
Peroxisomes 0.0032 0.0001 0.0005 0.0013 0.0088 0.0025 0.0024 0.0001 0.0048 0.0007 0.0021 0.0003 0.0084 0.0004 0.0004 0.0001 0.0013 0.0002
Punctate Nuclear 0.0011 0.0001 0.0003 0.0009 0.007 0.0001 0.0073 0 0.001 0.0029 0.0025 0.0016 0.0008 0.0002 0.0018 0.0002 0.001 0.0001
Vacuole 0.0599 0.0363 0.0439 0.1183 0.065 0.0239 0.028 0.0189 0.03 0.0655 0.02 0.0183 0.0192 0.0312 0.0222 0.0212 0.0074 0.0064
Vacuole Periphery 0.0128 0.0027 0.0054 0.0189 0.0126 0.0063 0.0046 0.0014 0.0034 0.0099 0.0051 0.0026 0.003 0.0035 0.0026 0.0045 0.0028 0.0023

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 43.9141 27.9759 22.5451 23.3694 18.9788 48.0938 28.8947 31.3058 31.5576 32.1669
Translational Efficiency 0.9378 0.8103 0.6282 0.7192 0.7289 0.8589 0.9349 0.6573 0.6572 0.7013

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1993 1300 1942 1078 1533 1483 110 86 3526 2783 2052 1164

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 8069.36 8662.47 2401.73 1235.94 8551.79 9021.89 1740.10 1352.98 8279.11 8854.00 2366.26 1244.59
Standard Deviation 2458.49 2351.01 798.34 247.62 2521.16 2485.29 646.33 242.55 2497.41 2430.12 804.85 249.13
Intensity Change Log 2 — 0.102324 -1.748380 -2.706846 — 0.077203 -2.297056 -2.660086 — 0.089454 -2.004680 -2.682598

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000381 0.000063 0.000133 0.000640 0.000061 0.000102 0.001111 0.002849 0.000242 0.000083 0.000186 0.000804
Bud Neck 0.001773 0.000421 0.001037 0.001940 0.000276 0.000930 0.008077 0.003490 0.001122 0.000692 0.001415 0.002055
Bud Site 0.031010 0.002720 0.008189 0.033136 0.001844 0.003310 0.047231 0.048414 0.018329 0.003035 0.010281 0.034265
Cell Periphery 0.009164 0.011026 0.001764 0.000422 0.019095 0.011543 0.003188 0.001833 0.013481 0.011301 0.001840 0.000526
Cytoplasm 0.759469* 0.829970* 0.883524* 0.790598* 0.772174* 0.802497* 0.539495* 0.687777* 0.764993* 0.815330* 0.865081* 0.783001*
Cytoplasmic Foci 0.079395 0.005736 0.014738 0.063767 0.004632 0.011630 0.111663 0.087797 0.046890 0.008877 0.019934 0.065542
Eisosomes 0.000003 0.000001 0.000001 0.000008 0.000002 0.000002 0.000021 0.000030 0.000003 0.000002 0.000002 0.000010
Endoplasmic Reticulum 0.000241 0.000185 0.000351 0.000201 0.001006 0.000278 0.001738 0.005450 0.000574 0.000235 0.000426 0.000588
Endosome 0.001324 0.000251 0.001104 0.004461 0.000295 0.000501 0.019277 0.006984 0.000876 0.000384 0.002078 0.004647
Golgi 0.028645 0.025337 0.017201 0.005087 0.035125 0.031344 0.021570 0.010564 0.031463 0.028538 0.017436 0.005491
Lipid Particles 0.008412 0.007676 0.002765 0.002766 0.011112 0.012078 0.011083 0.006635 0.009586 0.010021 0.003211 0.003052
Mitochondria 0.000261 0.000116 0.000181 0.000297 0.000151 0.000273 0.000038 0.000011 0.000213 0.000200 0.000173 0.000276
Mitotic Spindle 0.002020 0.000589 0.005118 0.009765 0.000418 0.002571 0.006488 0.000264 0.001324 0.001645 0.005191 0.009063
None 0.003624 0.003483 0.002622 0.000388 0.003775 0.003806 0.000112 0.000062 0.003690 0.003655 0.002487 0.000364
Nuclear Periphery 0.000272 0.000455 0.000206 0.000044 0.000669 0.000655 0.000411 0.000029 0.000444 0.000561 0.000217 0.000043
Nuclear Periphery Foci 0.005986 0.007804 0.005459 0.001753 0.009926 0.009714 0.010542 0.002170 0.007699 0.008822 0.005732 0.001784
Nucleolus 0.000151 0.000078 0.000076 0.000082 0.000059 0.000083 0.000074 0.000052 0.000111 0.000081 0.000076 0.000080
Nucleus 0.009688 0.016938 0.015973 0.004862 0.007983 0.022067 0.007555 0.002624 0.008947 0.019671 0.015522 0.004697
Peroxisomes 0.000285 0.000021 0.000034 0.001425 0.000019 0.000022 0.000944 0.002325 0.000170 0.000022 0.000083 0.001491
Vacuole 0.029626 0.055982 0.021825 0.075674 0.075106 0.060681 0.197519 0.127723 0.049399 0.058486 0.031243 0.079520
Vacuole Periphery 0.028270 0.031149 0.017699 0.002685 0.056273 0.025913 0.011864 0.002918 0.040445 0.028359 0.017386 0.002702

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.64 1.02 -0.82 -6.06 -3.62 -2.41 -6.35 -1.84 -1.80 -0.94 1.41 0.16 -2.74 -5.19 -3.47
Bud Neck 6.76 2.94 0.08 -5.05 -2.25 -6.31 -2.99 -4.66 -3.22 1.93 2.66 -1.83 -2.72 -4.26 -1.10
Bud Site 13.99 10.62 0.80 -11.40 -8.54 -2.94 -7.44 -6.64 -6.37 0.18 12.76 5.49 -4.77 -12.50 -8.49
Cell Periphery -1.98 10.80 13.24 14.27 7.89 5.30 12.33 13.88 10.95 1.83 2.42 17.89 20.56 20.21 7.91
Cytoplasm -7.15 -14.98 -1.86 5.35 12.89 -2.15 8.60 3.73 4.51 -3.20 -6.47 -13.97 -0.32 5.21 11.52
Cytoplasmic Foci 18.10 15.33 3.85 -20.74 -16.16 -8.15 -10.19 -9.02 -8.13 1.41 15.40 9.95 -4.62 -20.71 -15.19
Eisosomes 1.97 2.19 -3.96 -11.77 -12.35 -2.84 -7.59 -2.62 -2.53 -0.52 1.22 0.67 -6.49 -8.61 -8.15
Endoplasmic Reticulum 1.80 -2.13 2.20 0.24 3.30 2.05 -1.14 -0.87 -1.08 -0.70 2.18 0.88 0.34 -0.89 -0.15
Endosome 7.79 1.08 -6.29 -9.46 -6.95 -3.87 -6.77 -5.22 -5.01 4.06 5.78 -5.90 -8.51 -9.99 -4.99
Golgi 1.57 6.29 14.22 12.27 9.42 1.71 3.00 5.43 4.59 1.42 1.92 9.39 18.88 16.19 9.34
Lipid Particles 0.73 5.81 5.84 5.84 0.46 -1.07 0.18 2.97 3.70 1.86 -0.65 8.77 8.88 9.89 0.80
Mitochondria 2.98 1.49 0.43 -1.31 -0.43 -1.46 3.06 4.84 3.24 2.08 0.21 0.99 0.07 -0.06 -0.36
Mitotic Spindle 2.73 -4.12 -2.79 -3.61 -1.12 -3.12 -2.40 2.58 3.31 2.45 -0.79 -6.11 -3.15 -2.91 -0.88
None 0.37 2.33 7.85 8.81 8.65 -0.03 8.87 9.09 6.19 2.47 0.13 3.53 10.53 8.62 8.76
Nuclear Periphery -4.66 2.15 10.10 11.31 9.35 -0.40 1.08 14.38 9.41 2.40 -3.09 7.40 16.57 12.85 9.34
Nuclear Periphery Foci -2.38 0.91 7.55 8.34 6.27 -0.03 -0.54 10.00 8.91 4.90 -2.12 3.55 11.89 12.14 6.99
Nucleolus 2.03 2.08 2.05 0.08 -0.11 -2.62 -1.97 1.51 3.36 2.94 1.53 1.79 1.81 0.90 0.18
Nucleus -5.96 -7.12 5.31 9.20 11.85 -10.93 -0.66 6.96 14.46 3.81 -12.08 -8.53 5.75 15.38 12.28
Peroxisomes 6.04 5.70 -6.08 -8.02 -7.93 -0.46 -6.85 -6.02 -6.01 -3.03 5.88 3.24 -7.78 -8.91 -8.47
Vacuole -7.00 3.16 -15.04 -7.50 -17.32 2.26 -6.92 -3.84 -4.39 1.57 -3.55 6.21 -11.45 -8.73 -15.37
Vacuole Periphery -1.09 4.57 13.12 12.53 10.44 8.83 11.51 16.89 10.67 2.58 5.48 11.02 21.40 16.89 10.69
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Gdh2

Gdh2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gdh2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available