Standard name
Human Ortholog
Description Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.13 0.15 0.11 0.12 0.1 0.1 0.12 0.12 0.19 0.14 0.13 0.08 0.16 0.12 0.05 0.1 0.09 0.09 0.08 0.1 0.14 0.28 0.2 0.22
Bud 0.07 0.08 0.07 0.07 0.11 0.12 0.12 0.16 0.15 0.14 0.14 0.12 0.06 0.06 0 0 0 0 0.35 0.33 0.31 0.33 0.32 0.23
Bud Neck 0.3 0.34 0.22 0.29 0.35 0.21 0.24 0.15 0.19 0.23 0.23 0.25 0.3 0.24 0.17 0.19 0.16 0.14 0.44 0.43 0.38 0.27 0.33 0.37
Bud Site 0.27 0.2 0.22 0.27 0.16 0.24 0.14 0.11 0.17 0.16 0.14 0.12 0.13 0.1 0.05 0.09 0 0.07 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.05 0.1 0 0.05 0 0 0 0 0 0 0.07
Cytoplasm 0.12 0.11 0.11 0 0.07 0.07 0.09 0.06 0.07 0 0.09 0.08 0.08 0.15 0.21 0.2 0.2 0.25 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.09 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.15 0.17 0 0 0 0 0 0
Mitochondria 0.05 0 0 0 0 0.09 0.11 0.12 0.18 0.22 0.24 0.29 0 0 0 0.07 0.09 0.08 0 0 0 0 0 0
Nucleus 0 0 0 0.05 0.05 0.05 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.29 0.15 0.15 0.2 0.19 0.21 0.26 0.36 0.23 0.26 0.23 0.25 0.15 0.17 0.18 0.16 0.19 0.22 0 0 0 0 0 0
Peroxisomes 0 0 0.13 0.11 0.12 0.16 0.13 0.09 0.12 0.1 0.09 0.07 0.12 0.11 0.16 0.05 0.06 0 0 0 0 0 0 0
SpindlePole 0 0.06 0.07 0.07 0.11 0.1 0.11 0.09 0.08 0.09 0.05 0.06 0.1 0.11 0.12 0.24 0.16 0.11 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 22 27 44 21 32 45 58 63 76 68 24 19 46 36 16 22 9 9 18 24 83 107 121 129
Bud 12 14 30 12 36 53 57 85 59 69 25 27 17 18 7 5 2 2 77 83 176 125 192 139
Bud Neck 50 59 88 53 109 92 114 81 73 115 42 59 90 72 52 44 17 15 96 110 219 102 198 220
Bud Site 45 35 90 48 50 106 65 61 66 79 26 28 39 31 16 20 2 7 – – – – – –
Cell Periphery 3 5 12 8 3 17 14 13 20 15 7 9 11 14 31 4 5 1 1 1 4 6 17 40
Cytoplasm 20 19 44 8 22 30 41 33 27 20 16 19 25 46 64 47 21 26 4 5 8 5 3 5
Endoplasmic Reticulum 3 1 9 3 2 7 2 4 11 9 5 5 2 2 6 2 1 5 0 2 9 0 4 10
Endosome 5 7 11 7 11 12 21 23 7 12 3 5 14 22 28 6 2 2 2 4 7 6 9 7
Golgi 2 0 3 1 1 0 2 2 1 0 1 2 2 3 2 26 16 18 0 2 4 3 3 3
Mitochondria 9 3 8 8 14 38 51 63 71 109 45 67 1 1 2 16 9 8 2 2 5 7 15 20
Nucleus 5 5 17 9 17 20 16 23 13 26 6 10 9 12 9 8 1 3 0 3 1 0 0 0
Nuclear Periphery 0 0 1 0 1 0 1 1 1 4 1 1 0 0 1 0 0 0 1 0 2 2 6 1
Nucleolus 48 26 59 36 60 92 125 190 91 127 43 59 45 51 55 37 20 23 3 3 8 0 0 0
Peroxisomes 5 7 54 19 39 70 61 46 48 49 17 16 36 34 49 11 6 4 2 1 11 5 15 11
SpindlePole 3 11 30 12 35 42 55 49 33 45 9 13 30 34 36 56 17 11 5 4 23 2 3 3
Vac/Vac Membrane 1 1 14 3 5 3 7 12 4 1 1 3 5 9 7 5 5 1 0 1 2 1 0 2
Unique Cell Count 167 176 402 180 315 436 480 533 394 494 185 234 296 299 302 231 104 104 220 256 578 383 596 602
Labelled Cell Count 233 220 514 248 437 627 690 749 601 748 271 342 372 385 381 309 133 135 220 256 578 383 596 602


Bud Neck, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.3 14.0 13.1 11.6 11.0 9.9 9.2 8.9 9.2 8.3 8.6 8.1 13.6 13.5 13.4 17.6 21.9 20.2 11.0 11.6 12.3
Std Deviation (1e-4) 3.7 3.2 2.9 2.3 3.9 3.1 2.9 2.7 2.7 2.5 2.3 2.5 3.2 4.1 4.0 5.6 8.7 7.9 1.8 2.1 2.2
Intensity Change (Log2) – – – -0.18 -0.24 -0.39 -0.5 -0.55 -0.51 -0.66 -0.6 -0.68 0.06 0.04 0.04 0.43 0.75 0.63 -0.24 -0.17 -0.09

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.3 -0.3 -0.3 0.5 0.4 3.3 1.3 0.7 -1.2 1.8 0.5 -2.7 -0.6 -0.7 -0.7
Bud -0.3 1.8 2.3 2.2 3.9 3.4 3.1 2.3 1.7 -0.9 -0.7 -3.0 -2.8 -2.1 -2.1
Bud Neck 2.0 3.8 -0.3 0.7 -2.6 -1.2 0.5 0.2 1.0 2.6 0.7 -1.5 -0.8 -1.2 -1.7
Bud Site 1.1 -2.2 0.7 -3.4 -4.5 -2.0 -2.4 -2.4 -3.3 -3.1 -4.2 -6.3 -4.4 -4.8 -3.6
Cell Periphery 0.9 -1.9 0.7 -0.1 -0.5 1.5 0 0.5 0.6 0.5 1.2 4.0 -1.0 0 0
Cytoplasm -2.5 -1.8 -2.1 -1.2 -2.6 -2.0 -4.0 -0.9 -1.2 -1.1 1.7 3.7 3.2 2.5 3.7
Endoplasmic Reticulum 0 0 -0.7 -2.4 -1.9 0.5 -0.4 0 -0.1 0 0 -0.2 0 0 0
Endosome 0.7 0.6 0 1.3 1.3 -0.9 -0.3 0 -0.5 1.4 2.9 3.8 -0.1 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 6.1 0 0
Mitochondria 0 1.9 4.3 5.1 5.6 7.6 8.9 8.8 10.0 0 0 0 3.1 0 0
Nucleus 0.4 0.7 0.3 -0.7 0.1 -0.7 0.7 -0.6 0 -0.8 -0.1 -0.9 -0.5 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.6 1.6 2.4 4.1 7.2 3.0 4.0 2.5 3.3 0.2 0.9 1.3 0.5 1.1 1.8
Peroxisomes -1.0 -0.4 1.1 -0.3 -2.4 -0.5 -1.6 -1.5 -2.6 -0.5 -0.8 1.0 -3.5 -2.2 -2.7
SpindlePole -0.3 1.7 1.1 2.0 0.9 0.5 0.9 -1.2 -0.9 1.2 1.8 2.0 5.9 2.8 1.0
Vacuole -1.2 -1.6 -2.9 -2.0 -1.1 -2.3 -3.8 0 -1.7 -1.4 -0.3 -0.9 -0.9 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.8028 9.443 10.4046 9.7159 8.1196 9.6973 10.346 11.6112 11.8572 10.4677 10.0636 12.2293 10.1627 11.9972 12.5869 13.3027 12.5925 12.5714
Actin 0.0977 0.0261 0.0263 0.0401 0.0118 0.1743 0.1359 0.0434 0.0447 0.0089 0.0487 0.1785 0.1424 0.0849 0.0459 0.0002 0.0633 0.0709
Bud 0.0156 0.0135 0.0054 0.001 0.0018 0.0047 0.0085 0.0177 0.0103 0.0309 0.0056 0.0033 0.0081 0.0093 0.0058 0.0003 0.0011 0.0045
Bud Neck 0.1542 0.0288 0.6315 0.8356 0.8034 0.7587 0.1637 0.0434 0.5114 0.6712 0.6667 0.7791 0.2201 0.0644 0.6587 0.9814 0.8293 0.8905
Bud Periphery 0.0158 0.0121 0.0055 0.0013 0.0029 0.0108 0.0079 0.0142 0.0107 0.0552 0.0062 0.0091 0.0067 0.0115 0.0094 0.0003 0.0016 0.0132
Bud Site 0.4893 0.839 0.2697 0.0528 0.0184 0.0177 0.4196 0.7857 0.3232 0.0579 0.0704 0.0072 0.3907 0.6651 0.2204 0.002 0.0042 0.0096
Cell Periphery 0.0038 0.0039 0.0036 0.0014 0.0021 0.0025 0.003 0.004 0.0052 0.0034 0.002 0.0019 0.0025 0.0105 0.0056 0.001 0.0018 0.0027
Cytoplasm 0.0054 0.0132 0.0008 0.0003 0.0016 0.0009 0.0108 0.0584 0.0009 0.0015 0.0031 0.0009 0.0071 0.0004 0.0021 0.0001 0.0002 0.0009
Cytoplasmic Foci 0.0927 0.0164 0.0138 0.0049 0.0193 0.0089 0.0322 0.002 0.0173 0.0084 0.0691 0.0038 0.091 0.0006 0.0039 0.0019 0.0046 0.0015
Eisosomes 0.003 0.0002 0.0004 0.0017 0.0008 0.0005 0.0018 0.0005 0.0003 0.0001 0.0005 0.0005 0.0011 0.0004 0.0002 0 0.0004 0.0002
Endoplasmic Reticulum 0.0037 0.0002 0.0002 0.0001 0.0027 0.0001 0.0079 0.0004 0.0002 0.0009 0.001 0.0001 0.0012 0.0001 0.0004 0 0 0.0002
Endosome 0.0127 0.0012 0.0014 0.0028 0.0202 0.0006 0.0203 0.0005 0.0091 0.0432 0.0247 0.001 0.0131 0.0008 0.0189 0.0001 0.0002 0.0008
Golgi 0.0064 0.0003 0.0018 0.006 0.0121 0.0018 0.0266 0.0005 0.0128 0.033 0.0344 0.0028 0.0038 0.0003 0.0034 0.0002 0.0012 0.0015
Lipid Particles 0.0092 0.001 0.0073 0.0062 0.0137 0.0027 0.0291 0.0004 0.003 0.0039 0.0103 0.0053 0.0075 0.0006 0.001 0.0005 0.0008 0.0003
Mitochondria 0.0066 0.0009 0.0023 0.0147 0.0369 0.0014 0.0099 0.002 0.0189 0.0657 0.0042 0.0014 0.0091 0.0015 0.001 0.0001 0.001 0.0002
None 0.0129 0.0002 0.0065 0.0009 0.0041 0.0001 0.0371 0.0003 0.0003 0.0002 0.0022 0.0001 0.0091 0.0001 0.0002 0 0 0
Nuclear Periphery 0.0061 0.0012 0.0002 0.0001 0.0047 0.0001 0.0189 0.0032 0.0001 0.0003 0.0004 0.0001 0.0259 0.0001 0.0004 0 0 0.0001
Nucleolus 0.0072 0.0194 0.0111 0.0079 0.0091 0.0029 0.0074 0.0029 0.0086 0.0026 0.0135 0.0013 0.0171 0.0968 0.0074 0.0094 0.0844 0.0005
Nucleus 0.0063 0.0072 0.0017 0.0016 0.0027 0.0011 0.0117 0.0148 0.0013 0.0016 0.0046 0.0003 0.0049 0.0249 0.0027 0.0015 0.0039 0.0005
Peroxisomes 0.0303 0.0021 0.0061 0.0193 0.0212 0.0064 0.0128 0.0015 0.0195 0.002 0.0082 0.0023 0.0213 0.0007 0.0026 0.0003 0.0008 0.0004
Punctate Nuclear 0.0185 0.0011 0.0036 0.0007 0.003 0.0009 0.0286 0.0005 0.0006 0.0004 0.0219 0.0003 0.0047 0.0004 0.0005 0.0003 0.0007 0.0003
Vacuole 0.0018 0.0113 0.0009 0.0005 0.0033 0.0026 0.0048 0.0023 0.0013 0.0068 0.0018 0.0006 0.0103 0.0229 0.0081 0.0003 0.0003 0.0012
Vacuole Periphery 0.0008 0.0008 0.0001 0.0002 0.0041 0.0004 0.0016 0.0014 0.0002 0.0017 0.0005 0.0001 0.0025 0.0036 0.0014 0 0 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 30.317 30.3775 25.1934 34.7198 27.6447 26.6375 33.8765 31.502 31.2962 34.5386
Translational Efficiency 2.0533 1.9915 1.9467 1.5394 1.8785 2.1281 1.6588 1.4765 1.6104 1.6431

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
280 1368 1748 1589 173 2072 1357 2855 453 3440 3105 4444

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1067.90 1253.84 1451.72 1678.66 1109.62 1190.76 1430.28 1717.74 1083.83 1215.85 1442.35 1703.77
Standard Deviation 147.58 221.87 260.17 332.49 172.79 212.73 249.21 386.27 158.98 218.61 255.66 368.42
Intensity Change Log 2 — 0.231577 0.442987 0.652533 — 0.101817 0.366232 0.630446 — 0.166912 0.404384 0.641320

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.009056 0.009745 0.015622 0.011293 0.023452 0.006088 0.006315 0.004838 0.014554 0.007542 0.011555 0.007146
Bud Neck 0.253127 0.189549 0.198751 0.163718 0.199442 0.230200 0.205346 0.175473 0.232625 0.214034 0.201633 0.171270
Bud Site 0.613655 0.661928 0.662795 0.703598 0.681776 0.634584 0.670831 0.675278 0.639670 0.645458 0.666307 0.685404
Cell Periphery 0.009056 0.008441 0.007985 0.006364 0.009391 0.010596 0.005285 0.008355 0.009184 0.009739 0.006805 0.007643
Cytoplasm 0.024898 0.037560 0.039498 0.047625 0.026946 0.040359 0.038100 0.079534 0.025680 0.039246 0.038887 0.068124
Cytoplasmic Foci 0.027163 0.028908 0.037897 0.026183 0.019178 0.025248 0.035675 0.016405 0.024114 0.026704 0.036926 0.019901
Eisosomes 0.003417 0.003498 0.002003 0.001625 0.002290 0.003531 0.002639 0.001617 0.002986 0.003518 0.002281 0.001620
Endoplasmic Reticulum 0.000657 0.000360 0.000747 0.000191 0.000510 0.000256 0.000345 0.000171 0.000601 0.000297 0.000571 0.000178
Endosome 0.007795 0.003047 0.002183 0.001384 0.005023 0.004428 0.001389 0.001234 0.006736 0.003879 0.001836 0.001287
Golgi 0.005215 0.002721 0.001200 0.001100 0.002949 0.002860 0.000662 0.001094 0.004350 0.002805 0.000965 0.001096
Lipid Particles 0.000285 0.000280 0.000322 0.001291 0.000178 0.000640 0.000187 0.000105 0.000244 0.000497 0.000263 0.000529
Mitochondria 0.012869 0.016333 0.004102 0.009119 0.003570 0.011657 0.004096 0.008130 0.009318 0.013517 0.004099 0.008484
Mitotic Spindle 0.001053 0.002627 0.002286 0.004209 0.001255 0.003281 0.003247 0.005328 0.001130 0.003021 0.002706 0.004928
None 0.000268 0.000487 0.000242 0.000562 0.000120 0.000587 0.000228 0.000612 0.000211 0.000547 0.000236 0.000594
Nuclear Periphery 0.000020 0.000041 0.000047 0.000059 0.000036 0.000033 0.000042 0.000039 0.000026 0.000036 0.000045 0.000046
Nuclear Periphery Foci 0.000516 0.000629 0.000474 0.000332 0.001226 0.000816 0.000502 0.000203 0.000787 0.000742 0.000486 0.000249
Nucleolus 0.000659 0.003200 0.001969 0.001813 0.000547 0.001686 0.001320 0.001893 0.000616 0.002288 0.001685 0.001865
Nucleus 0.000981 0.001952 0.002523 0.001980 0.001254 0.001342 0.001963 0.002654 0.001085 0.001585 0.002278 0.002413
Peroxisomes 0.019146 0.016149 0.005947 0.006452 0.010561 0.012343 0.007209 0.005474 0.015867 0.013857 0.006499 0.005824
Vacuole 0.008800 0.010529 0.012487 0.009878 0.008580 0.008614 0.013888 0.010475 0.008716 0.009376 0.013099 0.010261
Vacuole Periphery 0.001364 0.002018 0.000918 0.001225 0.001717 0.000851 0.000730 0.001087 0.001499 0.001315 0.000836 0.001136

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.23 -2.05 -0.74 -0.69 1.58 2.64 2.57 2.85 1.06 1.02 2.29 0.96 2.42 0.33 3.00
Bud Neck 3.75 3.51 5.51 3.66 4.62 -1.54 -0.03 1.45 8.48 3.88 1.49 2.80 5.12 8.87 5.68
Bud Site -2.44 -2.12 -4.59 -3.98 -5.13 2.16 0.90 0.75 -3.97 -0.44 -0.32 -1.19 -2.66 -5.36 -3.32
Cell Periphery 0.29 0.46 1.26 1.83 1.88 -0.49 1.53 0.44 2.70 -3.68 -0.36 1.40 0.99 3.13 -1.11
Cytoplasm -2.31 -3.31 -4.28 -3.08 -1.58 -2.15 -2.48 -8.83 -11.63 -9.95 -3.27 -4.14 -10.49 -11.73 -9.90
Cytoplasmic Foci -0.41 -2.84 -0.12 0.45 4.13 -1.33 -3.65 0.36 4.03 7.32 -0.83 -4.33 0.89 3.44 8.92
Eisosomes -0.07 1.69 2.10 3.13 1.70 -1.63 -0.40 0.99 5.77 3.74 -0.79 1.25 2.33 6.11 3.85
Endoplasmic Reticulum 1.28 -0.20 2.11 2.26 1.37 1.05 0.52 1.38 2.93 1.47 1.82 0.07 2.57 3.46 1.72
Endosome 2.52 2.95 3.43 4.01 2.48 0.33 1.98 2.07 5.95 0.62 2.09 3.58 4.03 7.17 2.73
Golgi 1.26 2.14 2.19 2.19 0.39 0.07 1.76 1.43 3.30 -2.02 1.18 2.68 2.58 3.92 -0.61
Lipid Particles -0.01 -0.59 -1.77 -1.81 -1.64 -1.36 -0.44 0.43 1.61 1.86 -1.15 -0.65 -1.37 -0.22 -1.12
Mitochondria -0.70 2.00 0.84 2.94 -3.96 -3.59 -0.28 -2.26 2.29 -3.99 -1.38 1.86 0.32 3.74 -5.62
Mitotic Spindle -4.42 -3.54 -5.27 -2.24 -1.67 -2.47 -2.21 -5.21 -3.41 -2.61 -4.57 -3.98 -7.94 -4.13 -3.50
None -2.43 0.04 -1.32 -0.31 -1.38 -5.53 -2.20 -6.37 -0.44 -6.09 -5.23 -0.95 -4.09 -0.55 -4.00
Nuclear Periphery -2.75 -6.34 -4.28 -1.86 0.03 0.08 -1.18 -0.70 -2.23 1.24 -1.32 -4.12 -3.17 -2.82 1.18
Nuclear Periphery Foci -0.95 -0.04 1.89 2.69 2.71 0.67 1.17 1.68 3.39 4.70 0.18 1.12 2.24 4.22 5.89
Nucleolus -3.16 -2.73 -2.84 1.62 0.31 -2.23 -2.40 -3.27 -0.34 -1.51 -3.80 -3.50 -4.27 0.90 -0.48
Nucleus -2.47 -4.53 -3.79 -0.80 1.93 -0.20 -1.65 -2.17 -4.63 -1.07 -1.48 -4.38 -4.24 -4.22 0.52
Peroxisomes 0.77 3.65 3.51 5.79 -0.56 -0.50 1.03 1.54 5.43 1.92 0.75 3.65 3.91 7.91 1.03
Vacuole -0.90 -2.88 -1.10 -0.20 2.71 -0.09 -3.10 -1.62 -3.73 2.56 -0.54 -4.26 -2.15 -2.98 3.42
Vacuole Periphery -0.86 0.66 0.12 1.35 -1.05 0.90 0.99 0.63 -1.12 -1.45 0.33 1.19 0.61 0.56 -1.54
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Shs1

Shs1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Shs1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available