Standard name
Human Ortholog
Description GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; contains a PH-like domain
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Bud 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.89 0.86 0.94 0.95 0.93 0.86 0.71 0.68 0.5 0.57 0.44 0.52 0.91 0.94 0.94 0.77 0.69 0.76 0.81 0.8 0.83 0.79 0.75 0.78
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0 0 0 0.05 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0.06 0 0 0 0 0 0 0.05 0 0 0 0.05 0 0 0 0.08 0.1 0 0.08 0.06 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.07 0.15 0.06 0.37 0.28 0.5 0.32 0 0 0 0 0 0 0 0 0.05 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.06 0.22 0.17 0.16 0.09 0.12 0 0 0 0.13 0.15 0.24 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 1 5 5 4 5 15 11 2 6 2 9 1 0 1 1 6 1 3 1 3 2 3 6
Bud 0 7 7 1 2 1 13 5 12 12 10 10 3 1 0 0 1 0 1 1 0 1 3 9
Bud Neck 0 0 1 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 1 2 2 3 2
Bud Site 0 0 0 0 0 0 0 0 1 0 2 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 11 1 4 8 3 4 5 10 4 7 1 2 2 3 1 1 0 0 0 0 0 0
Cytoplasm 121 125 275 256 315 313 278 308 158 224 119 163 167 271 261 92 68 19 115 132 267 90 169 218
Endoplasmic Reticulum 2 5 4 5 8 13 20 11 11 15 13 12 5 2 5 6 3 0 2 0 2 2 9 6
Endosome 8 3 4 3 8 6 13 23 10 7 1 15 7 10 11 10 10 1 11 9 9 1 5 9
Golgi 0 0 0 0 0 0 1 3 1 0 1 0 1 0 0 3 5 1 0 0 1 0 2 2
Mitochondria 2 4 1 1 5 26 58 29 116 110 133 99 1 1 2 1 0 0 0 6 17 3 7 4
Nucleus 0 1 0 2 1 1 4 7 4 3 4 9 0 0 1 0 1 1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 2 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 1 0 0 0 0 0 0 2 1 1 0 0 0 0 4 1 0 0 0 0 0 1 0
Peroxisomes 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
SpindlePole 3 0 4 1 4 2 8 9 2 6 0 5 2 1 1 5 6 0 3 5 5 2 7 7
Vac/Vac Membrane 0 4 2 3 5 13 22 99 54 61 25 36 1 9 1 16 15 6 0 3 7 4 8 4
Unique Cell Count 136 145 294 269 340 362 389 454 315 392 268 312 183 289 278 120 99 25 143 167 322 114 227 280
Labelled Cell Count 144 152 314 278 356 388 435 509 382 457 316 367 189 297 285 141 118 30 143 167 322 114 227 280


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.0 6.0 6.6 6.4 7.2 6.0 6.0 6.8 5.6 5.6 5.3 5.8 6.9 7.4 7.4 11.7 12.1 11.3 6.1 6.9 8.1
Std Deviation (1e-4) 1.0 1.5 0.9 1.1 1.1 1.1 1.2 1.2 1.3 1.2 1.2 1.1 1.0 1.1 1.3 4.8 2.8 1.9 1.1 1.6 1.9
Intensity Change (Log2) – – – -0.04 0.11 -0.14 -0.14 0.03 -0.23 -0.25 -0.33 -0.2 0.05 0.15 0.15 0.82 0.86 0.77 -0.12 0.06 0.29

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 1.7 0.7 0 0 0 1.0 0 0 0 0 0 0
Bud 0 0 0 0.7 0 1.0 0.5 0.9 0.6 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.8 -2.1 -1.2 -2.7 -2.7 -1.7 -0.9 -1.7 -1.1 0 -2.5 -2.4 0 0 0
Cytoplasm 0.8 -0.4 -3.0 -7.3 -8.3 -11.8 -10.6 -12.7 -11.3 -0.9 0.1 0.2 -4.9 -6.4 -3.1
Endoplasmic Reticulum 0 0.9 1.8 2.7 1.0 1.7 1.9 2.4 1.9 0 0 0 0 0 0
Endosome 0 0.9 0 1.6 2.7 1.5 0 0 2.4 0 1.7 1.9 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.4 6.7 4.1 11.4 9.8 13.7 10.4 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.7 0.6 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 2.5 3.5 8.3 7.0 6.7 4.8 5.5 0 2.2 0 5.7 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8532 2.2601 1.7421 1.388 1.9702 1.9564 1.9324 2.4708 2.1566 1.938 1.2574 2.2513 1.8021 2.7028 1.9979 2.1095 1.4947 2.1286
Actin 0.0394 0.0079 0.0286 0.0362 0.0508 0.0351 0.0184 0.014 0.0158 0.0077 0.0001 0.0021 0.0239 0.0137 0.0051 0.0013 0.0058 0.0079
Bud 0.005 0.0015 0.0008 0.0022 0.001 0.0009 0.0005 0.0012 0.0017 0.0003 0.0001 0.0001 0.0006 0.0007 0.0006 0.0003 0.0005 0.0001
Bud Neck 0.0025 0.0039 0.0183 0.0019 0.0029 0.0242 0.0006 0.0004 0.0028 0.0005 0.0004 0.0031 0.0014 0.0003 0.0004 0.0003 0.0005 0.0013
Bud Periphery 0.0029 0.0011 0.0006 0.0018 0.0012 0.0008 0.0004 0.0006 0.0064 0.0002 0 0 0.0005 0.0005 0.0002 0.0001 0.0002 0.0001
Bud Site 0.0067 0.0115 0.0081 0.02 0.0048 0.0019 0.002 0.0077 0.0051 0.0007 0.0001 0.0001 0.0032 0.0118 0.0009 0.0003 0.0003 0.0001
Cell Periphery 0.0006 0.0003 0.0004 0.0002 0.0005 0.0002 0.0002 0.0002 0.0006 0 0 0.0001 0.0008 0.0003 0.0001 0 0.0001 0
Cytoplasm 0.5258 0.7563 0.6351 0.5887 0.5332 0.6738 0.6869 0.8892 0.8259 0.7931 0.9736 0.8571 0.7278 0.8589 0.7752 0.675 0.8055 0.8134
Cytoplasmic Foci 0.1227 0.1078 0.1175 0.0883 0.064 0.1057 0.0903 0.0256 0.037 0.1099 0.0067 0.0696 0.0797 0.0407 0.1118 0.1338 0.0353 0.061
Eisosomes 0.0004 0.0001 0.0007 0.0001 0.0002 0.0001 0.0001 0 0.0002 0 0 0 0.0003 0.0001 0.0001 0 0 0.0001
Endoplasmic Reticulum 0.0121 0.0053 0.0051 0.0148 0.0102 0.0058 0.0086 0.0026 0.0024 0.0025 0.002 0.0032 0.0144 0.0028 0.0063 0.0043 0.0081 0.0041
Endosome 0.0511 0.0178 0.0391 0.0221 0.0742 0.0306 0.0346 0.0091 0.0095 0.0275 0.0032 0.0201 0.0267 0.0132 0.0315 0.0437 0.0373 0.0147
Golgi 0.0141 0.0061 0.009 0.0128 0.0246 0.0086 0.0221 0.0029 0.0046 0.0086 0.0001 0.0016 0.0051 0.0063 0.0055 0.0196 0.0281 0.003
Lipid Particles 0.0183 0.0018 0.0162 0.0056 0.0142 0.0071 0.0102 0.0002 0.0025 0.0082 0 0.0003 0.0101 0.0008 0.0019 0.0035 0.0032 0.0113
Mitochondria 0.0103 0.0018 0.0202 0.0132 0.0645 0.0024 0.0087 0.0005 0.0073 0.0011 0.0001 0.0003 0.0012 0.0068 0.0125 0.0004 0.011 0.0049
None 0.1096 0.055 0.0734 0.1078 0.0141 0.0602 0.0906 0.0399 0.0715 0.0216 0.0099 0.0352 0.0703 0.024 0.0396 0.1086 0.0222 0.0578
Nuclear Periphery 0.0207 0.0013 0.0033 0.0028 0.0382 0.0023 0.0037 0.0007 0.0006 0.0011 0.0005 0.0003 0.0125 0.0006 0.0011 0.0011 0.0016 0.0006
Nucleolus 0.0029 0.0004 0.001 0.0003 0.0011 0.0006 0.0002 0.0001 0.0001 0.0001 0 0 0.0002 0 0 0 0 0.0001
Nucleus 0.0213 0.0029 0.0025 0.0033 0.0207 0.0077 0.0017 0.0014 0.0011 0.001 0.0021 0.0008 0.0029 0.0008 0.0012 0.0016 0.0016 0.0016
Peroxisomes 0.0151 0.011 0.0148 0.0691 0.0545 0.0068 0.0122 0.0009 0.0023 0.0109 0 0.0043 0.0091 0.0164 0.0034 0.0036 0.0357 0.0036
Punctate Nuclear 0.0126 0.0042 0.0022 0.0065 0.0135 0.0226 0.0059 0.0008 0.0013 0.004 0.0003 0.0007 0.0058 0.0005 0.0007 0.0009 0.0006 0.0137
Vacuole 0.004 0.0019 0.002 0.0019 0.0079 0.0021 0.0014 0.0018 0.0013 0.0008 0.0006 0.0007 0.0024 0.0007 0.0016 0.0012 0.0017 0.0005
Vacuole Periphery 0.0018 0.0003 0.0012 0.0004 0.0038 0.0004 0.0007 0.0002 0.0002 0.0003 0.0001 0.0002 0.0012 0.0003 0.0003 0.0003 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.3551 7.0424 7.8386 12.231 9.8949 19.1919 13.2398 16.2199 13.7975 12.277
Translational Efficiency 1.0211 1.206 1.092 0.7653 0.6297 0.6783 0.9497 0.6597 0.961 0.763

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1258 1247 227 1326 1547 1564 1539 437 2805 2811 1766 1763

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 745.90 850.21 1243.08 1085.62 791.04 858.91 1022.70 1529.19 770.80 855.05 1051.03 1195.57
Standard Deviation 84.64 129.35 157.39 168.38 102.76 134.06 124.15 405.51 97.68 132.06 148.51 314.27
Intensity Change Log 2 — 0.188837 0.736865 0.541465 — 0.118756 0.370560 0.950945 — 0.153193 0.559947 0.766645

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002014 0.004786 0.056717 0.034877 0.002605 0.003248 0.007697 0.008299 0.002340 0.003930 0.013998 0.028289
Bud Neck 0.018579 0.015638 0.013273 0.010385 0.018379 0.023328 0.009426 0.022098 0.018469 0.019917 0.009920 0.013288
Bud Site 0.018462 0.053481 0.113845 0.118604 0.026735 0.048925 0.035004 0.049887 0.023025 0.050947 0.045138 0.101571
Cell Periphery 0.000296 0.000144 0.000716 0.000190 0.000213 0.000167 0.000200 0.000052 0.000250 0.000157 0.000266 0.000156
Cytoplasm 0.372911 0.377377 0.312244 0.251676 0.404125 0.313342 0.502865 0.373199 0.390126 0.341749 0.478363 0.281799
Cytoplasmic Foci 0.381424 0.322505 0.097737 0.208033 0.339527 0.320853 0.112749 0.181445 0.358317 0.321586 0.110819 0.201443
Eisosomes 0.000314 0.000142 0.000162 0.000107 0.000282 0.000188 0.000086 0.000046 0.000296 0.000167 0.000096 0.000092
Endoplasmic Reticulum 0.002961 0.002124 0.009749 0.001148 0.004039 0.001921 0.002521 0.000126 0.003556 0.002011 0.003450 0.000895
Endosome 0.022347 0.042616 0.015642 0.037750 0.032357 0.067378 0.017069 0.039526 0.027868 0.056393 0.016886 0.038190
Golgi 0.022102 0.020056 0.002588 0.010695 0.017355 0.027538 0.002476 0.020055 0.019484 0.024219 0.002491 0.013015
Lipid Particles 0.015730 0.004750 0.012545 0.006433 0.009649 0.007152 0.003885 0.003710 0.012377 0.006086 0.004998 0.005758
Mitochondria 0.014967 0.005313 0.000355 0.001973 0.006872 0.010685 0.000495 0.007066 0.010503 0.008302 0.000477 0.003235
Mitotic Spindle 0.003333 0.013177 0.054549 0.077701 0.003376 0.009859 0.020495 0.076588 0.003357 0.011331 0.024873 0.077425
None 0.003592 0.001175 0.000861 0.000253 0.001908 0.001258 0.001954 0.000447 0.002663 0.001221 0.001814 0.000301
Nuclear Periphery 0.000274 0.000186 0.000821 0.000337 0.000224 0.000194 0.000762 0.000220 0.000246 0.000191 0.000770 0.000308
Nuclear Periphery Foci 0.000885 0.001831 0.013555 0.002015 0.001110 0.001193 0.005230 0.000236 0.001009 0.001476 0.006300 0.001574
Nucleolus 0.001541 0.001346 0.000210 0.000296 0.000558 0.001560 0.000865 0.000725 0.000999 0.001465 0.000781 0.000403
Nucleus 0.049892 0.018565 0.109256 0.007632 0.033803 0.018646 0.082632 0.010975 0.041019 0.018610 0.086054 0.008461
Peroxisomes 0.030672 0.033520 0.016532 0.117250 0.023480 0.035924 0.030817 0.101608 0.026706 0.034857 0.028981 0.113373
Vacuole 0.034282 0.077452 0.168276 0.108790 0.069795 0.101203 0.162313 0.101996 0.053868 0.090667 0.163080 0.107106
Vacuole Periphery 0.003420 0.003816 0.000366 0.003853 0.003607 0.005436 0.000460 0.001697 0.003523 0.004718 0.000448 0.003319

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.09 -4.88 -9.42 -8.13 1.50 -1.01 -3.67 -1.96 -1.66 -0.39 -2.99 -6.16 -9.54 -8.63 -4.85
Bud Neck 1.64 1.05 5.59 4.35 3.63 -2.55 6.00 -1.57 0.40 -6.01 -0.93 6.86 4.80 6.17 -2.62
Bud Site -10.76 -7.31 -17.72 -9.02 -0.58 -7.41 -1.33 -3.23 1.61 -2.34 -12.66 -5.93 -17.23 -8.68 -11.34
Cell Periphery 3.46 -6.39 2.67 -2.46 10.30 2.50 1.89 11.57 9.47 8.94 4.21 0.11 4.68 0.95 6.14
Cytoplasm -0.46 3.96 7.13 7.22 0.55 8.95 -5.68 0.68 -4.66 4.15 6.26 -6.01 8.11 2.61 12.43
Cytoplasmic Foci 6.51 29.62 24.51 17.53 -10.55 2.28 34.04 16.52 14.69 -6.12 6.08 46.04 29.90 23.91 -13.08
Eisosomes 5.76 6.55 10.95 2.04 2.51 2.26 5.08 6.16 8.56 6.33 4.88 8.73 9.30 6.04 1.93
Endoplasmic Reticulum 1.08 -5.18 3.31 1.70 7.54 3.89 2.82 7.95 7.55 15.04 3.33 0.31 7.07 3.70 11.08
Endosome -7.25 4.22 -2.53 4.98 -6.14 -10.78 9.57 -0.25 7.64 -5.57 -12.94 10.01 -0.66 11.22 -8.95
Golgi 1.25 13.29 9.42 7.93 -7.44 -4.83 12.49 1.05 4.12 -4.77 -2.90 17.44 8.78 10.84 -7.82
Lipid Particles 9.32 1.95 7.68 -2.78 4.28 2.65 7.49 6.83 4.58 0.25 8.51 10.70 8.69 0.24 -1.98
Mitochondria 5.29 8.45 7.78 5.37 -3.08 -2.48 6.71 0.72 2.76 -3.86 1.98 10.69 7.92 7.10 -4.75
Mitotic Spindle -4.65 -3.72 -13.20 -10.50 -3.32 -3.75 -7.30 -7.50 -6.64 -5.06 -5.94 -8.27 -15.25 -12.93 -9.10
None 3.25 3.78 4.56 3.27 4.68 1.10 0.20 3.06 1.72 5.78 3.11 2.26 5.65 3.27 7.15
Nuclear Periphery 1.47 -8.72 -2.08 -3.73 7.41 0.53 -14.34 -2.33 -2.67 6.58 1.44 -16.29 -3.40 -4.72 10.98
Nuclear Periphery Foci -2.60 -11.17 -4.19 -1.40 9.64 -0.45 -7.51 6.43 3.80 8.95 -2.25 -10.59 -3.45 -1.48 8.03
Nucleolus 0.41 4.06 3.84 2.31 -1.01 -2.19 -3.06 -3.56 1.07 -0.92 -1.37 0.94 3.20 2.93 2.96
Nucleus 12.35 -7.80 15.20 3.30 11.23 8.12 -17.19 7.44 1.09 21.31 14.55 -17.32 17.44 3.81 26.35
Peroxisomes -0.73 5.79 -10.10 -9.80 -14.25 -3.99 0.55 -7.30 -5.72 -7.49 -3.46 2.53 -13.28 -11.36 -14.37
Vacuole -12.04 -14.12 -23.26 -14.41 3.22 -7.56 -23.13 -7.97 -4.47 6.22 -13.12 -29.42 -22.06 -14.05 5.96
Vacuole Periphery -0.55 7.52 1.42 1.92 -3.56 -2.47 7.45 4.61 6.60 -4.59 -2.40 10.47 2.57 4.41 -4.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; contains a PH-like domain
Localization
Cell Percentages cytoplasm (60%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Gyp7

Gyp7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gyp7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available