Standard name
Human Ortholog
Description Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.05 0.06 0.05 – 0 0.09 0 0 0 0 0 0.09 0 0 0 0 0 0
Cytoplasm 1.0 0.97 1.0 0.97 0.97 0.98 0.91 0.87 0.84 – 0.83 0.74 0.99 0.99 1.0 0.98 0.95 0.97 0.97 0.91 0.95 0.89 0.93 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0.07 0.05 – 0 0.07 0 0 0 0.06 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0.05 – 0.06 0.12 0 0 0 0 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 5 1 – 3 8 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 2 0 0 0 0 0 0 – 0 1 1 0 0 0 0 0 0 3 0 0 1 6
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 1 2 8 5 13 18 13 – 6 27 5 6 4 5 7 13 0 0 0 0 0 1
Cytoplasm 205 136 186 149 182 228 250 247 200 – 172 228 349 426 523 195 159 144 196 134 183 102 388 402
Endoplasmic Reticulum 0 1 1 3 3 4 15 20 11 – 6 22 1 3 1 11 1 9 0 0 2 3 12 7
Endosome 0 0 0 0 0 0 0 2 0 – 0 0 0 0 0 0 0 0 0 2 0 0 0 0
Golgi 0 1 0 0 1 0 0 0 0 – 1 0 1 1 0 0 1 0 1 0 1 0 2 1
Mitochondria 1 0 0 3 1 0 4 2 10 – 17 10 0 1 0 1 1 0 0 0 0 2 2 2
Nucleus 1 1 1 0 0 0 1 3 1 – 0 3 1 1 0 0 0 2 0 2 0 0 0 1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 1 0 0 1 0 0 0 0 0 1 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 1 – 0 0 0 1 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 1 0 0 0 0 0 0 0
Vac/Vac Membrane 0 2 0 1 2 1 1 9 13 – 12 38 1 0 1 6 8 5 0 1 0 4 5 4
Unique Cell Count 206 140 186 154 187 233 274 284 237 206 307 352 432 525 199 167 149 202 148 194 115 418 435
Labelled Cell Count 208 141 191 158 197 238 284 306 250 218 338 359 440 529 218 180 173 202 148 194 115 418 435


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.8 10.5 9.3 9.1 15.8 16.2 16.6 17.0 15.5 – 14.8 17.5 10.0 11.8 13.5 20.0 20.8 20.4 8.9 9.2 10.4
Std Deviation (1e-4) 1.6 5.4 1.9 1.6 2.9 3.9 3.5 4.2 4.2 – 4.7 5.6 2.2 2.7 3.7 6.0 7.7 6.1 1.7 3.3 2.7
Intensity Change (Log2) – – – -0.03 0.77 0.8 0.84 0.88 0.74 – 0.68 0.92 0.11 0.35 0.54 1.11 1.17 1.14 -0.06 -0.0 0.17

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 2.6 3.1 2.8 – 0 3.8 0 0 0 0 0 3.7
Cytoplasm -2.5 -2.2 -2.0 -4.1 -5.1 -5.6 – -5.8 -7.5 -1.3 -1.6 -0.8 -1.9 -3.0 -2.5
Endoplasmic Reticulum 0 0 0 2.8 3.3 2.5 – 0 3.4 0 0 0 2.8 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 4.0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 3.2 – 3.3 5.0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.4136 9.5019 7.8849 7.3736 6.3905 8.6075 6.026 8.9373 7.4342 6.5267 6.8904 8.742 8.2833 9.9496 8.716 6.2575 7.5111 8.9037
Actin 0.0206 0.0003 0.0017 0.002 0.0002 0.0002 0.0089 0.0005 0.0169 0.0003 0.0001 0.0006 0.0044 0.0007 0.0103 0.0223 0.031 0.0024
Bud 0.0004 0.0001 0.0003 0.0008 0.0001 0.0002 0.0006 0.0002 0.0022 0.0001 0.0006 0.0001 0.0002 0.0002 0.0002 0.0006 0.0004 0.0001
Bud Neck 0.0005 0.0001 0.0004 0.0006 0.0006 0.0008 0.0005 0.0001 0.0005 0.0003 0.0005 0.0006 0.0003 0.0001 0.0003 0.0005 0.0007 0.0007
Bud Periphery 0.0003 0 0.0002 0.0003 0 0.0001 0.0004 0 0.0022 0.0001 0.0001 0 0.0001 0.0001 0.0002 0.0004 0.0005 0.0001
Bud Site 0.001 0.0002 0.0012 0.001 0.0001 0 0.002 0.0003 0.0026 0.0001 0.0004 0 0.0004 0.0007 0.0006 0.0008 0.0003 0
Cell Periphery 0.0001 0 0.0001 0.0003 0.0001 0 0.0001 0 0.0001 0 0 0 0.0001 0.0001 0.0001 0.0001 0.0001 0
Cytoplasm 0.8194 0.9887 0.9062 0.8872 0.938 0.9713 0.8058 0.9926 0.9132 0.9165 0.9123 0.9874 0.9252 0.991 0.9412 0.769 0.7922 0.9744
Cytoplasmic Foci 0.0286 0.0016 0.0224 0.0104 0.004 0.0037 0.0454 0.0021 0.0144 0.009 0.0185 0.0034 0.0183 0.0018 0.013 0.0202 0.0125 0.0037
Eisosomes 0.0001 0 0 0.0001 0 0 0.0001 0 0.0001 0 0 0 0 0 0.0002 0.0001 0.0004 0
Endoplasmic Reticulum 0.0078 0.0023 0.0042 0.0068 0.0036 0.0035 0.0042 0.0004 0.0013 0.0017 0.0013 0.0013 0.0084 0.0011 0.0069 0.0016 0.0113 0.0034
Endosome 0.0487 0.0015 0.0169 0.0248 0.0118 0.0101 0.057 0.0009 0.0186 0.0441 0.0469 0.0037 0.0178 0.0008 0.0124 0.0868 0.0565 0.0049
Golgi 0.0109 0.0001 0.0038 0.0042 0.0003 0.0013 0.0087 0.0001 0.009 0.0167 0.0054 0.0008 0.0054 0.0002 0.0021 0.0559 0.0262 0.0016
Lipid Particles 0.0147 0 0.0011 0.0348 0.0024 0.0001 0.0089 0 0.0065 0.0015 0.0021 0 0.0013 0 0.0009 0.0113 0.0134 0.0011
Mitochondria 0.0126 0.0001 0.0186 0.005 0.0006 0.0036 0.0176 0.0001 0.0046 0.0035 0.0008 0.0004 0.0013 0.0001 0.0048 0.0141 0.0383 0.0011
None 0.0105 0.0025 0.0032 0.002 0.0019 0.0005 0.006 0.0016 0.0012 0.0009 0.0006 0.0005 0.0058 0.0017 0.0023 0.0018 0.0015 0.0012
Nuclear Periphery 0.0039 0.0005 0.005 0.0032 0.0203 0.0009 0.0117 0.0002 0.0007 0.0006 0.0005 0.0002 0.002 0.0002 0.0012 0.0007 0.0036 0.0026
Nucleolus 0.0002 0 0.0002 0.0002 0.0006 0 0.0005 0 0.0001 0 0.0001 0 0 0 0 0 0.0001 0
Nucleus 0.0027 0.001 0.0037 0.0016 0.0059 0.0015 0.005 0.0006 0.0013 0.0007 0.001 0.0005 0.0015 0.0007 0.001 0.001 0.0018 0.0012
Peroxisomes 0.0115 0 0.0061 0.0078 0.0001 0 0.0057 0 0.002 0.0003 0.0006 0.0001 0.0049 0 0.0007 0.0066 0.0013 0.0003
Punctate Nuclear 0.002 0.0001 0.0008 0.0007 0.0016 0.0001 0.0047 0.0001 0.0004 0.0001 0.0001 0 0.0015 0.0001 0.0003 0.0004 0.0004 0.0004
Vacuole 0.0026 0.0005 0.0032 0.0049 0.0051 0.0015 0.0043 0.0002 0.0016 0.0024 0.0057 0.0002 0.001 0.0004 0.0009 0.0038 0.0056 0.0004
Vacuole Periphery 0.0009 0.0001 0.0007 0.0014 0.0027 0.0007 0.0017 0 0.0006 0.001 0.0023 0.0001 0.0002 0 0.0004 0.0022 0.002 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 35.215 26.6706 24.0085 49.3019 40.5847 43.0168 30.1717 45.3525 58.7168 43.1388
Translational Efficiency 1.1895 1.0011 1.0529 0.9297 0.793 1.0883 1.1255 0.7886 0.8199 0.798

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1863 891 1248 1409 1228 1097 135 81 3091 1988 1383 1490

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1023.48 1047.90 1510.69 1666.51 914.10 1122.29 1639.25 1788.00 980.03 1088.95 1523.24 1673.11
Standard Deviation 173.62 168.77 263.84 446.58 143.31 171.46 347.85 454.53 170.86 174.23 275.83 447.86
Intensity Change Log 2 — 0.034018 0.561725 0.703347 — 0.296022 0.842612 0.967923 — 0.163565 0.701068 0.834225

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000104 0.000222 0.000245 0.001372 0.000268 0.000231 0.000568 0.000370 0.000169 0.000227 0.000276 0.001318
Bud Neck 0.000819 0.000981 0.000947 0.003045 0.001010 0.001648 0.004137 0.003749 0.000895 0.001349 0.001259 0.003083
Bud Site 0.006957 0.010889 0.002799 0.022312 0.006888 0.012438 0.013256 0.015619 0.006930 0.011744 0.003819 0.021948
Cell Periphery 0.000057 0.000060 0.000126 0.000448 0.000084 0.000077 0.000217 0.000666 0.000068 0.000070 0.000135 0.000460
Cytoplasm 0.885281 0.812253 0.809349 0.768138 0.782989 0.803860 0.576925 0.795342 0.844642 0.807622 0.786661 0.769617
Cytoplasmic Foci 0.058474 0.102341 0.011655 0.024128 0.102944 0.110347 0.036219 0.029037 0.076141 0.106759 0.014052 0.024394
Eisosomes 0.000006 0.000011 0.000002 0.000007 0.000016 0.000013 0.000023 0.000007 0.000010 0.000012 0.000004 0.000007
Endoplasmic Reticulum 0.000492 0.000574 0.000234 0.000655 0.001873 0.000459 0.000855 0.001565 0.001041 0.000511 0.000295 0.000705
Endosome 0.001398 0.003912 0.000681 0.009352 0.004843 0.005378 0.005161 0.001810 0.002766 0.004721 0.001119 0.008942
Golgi 0.002758 0.001182 0.000890 0.009429 0.001452 0.002967 0.000458 0.000561 0.002239 0.002167 0.000848 0.008947
Lipid Particles 0.000269 0.000580 0.000746 0.003804 0.001161 0.000596 0.002136 0.004251 0.000624 0.000589 0.000881 0.003828
Mitochondria 0.000382 0.000157 0.000182 0.001411 0.001724 0.001954 0.000066 0.000098 0.000915 0.001148 0.000171 0.001340
Mitotic Spindle 0.001451 0.004336 0.006400 0.035090 0.002917 0.003211 0.007591 0.001455 0.002034 0.003715 0.006516 0.033262
None 0.003758 0.000788 0.005884 0.001694 0.001577 0.001245 0.002208 0.001323 0.002891 0.001040 0.005525 0.001674
Nuclear Periphery 0.000021 0.000063 0.000179 0.000502 0.000117 0.000034 0.000560 0.000901 0.000059 0.000047 0.000216 0.000523
Nuclear Periphery Foci 0.000485 0.001187 0.002070 0.003663 0.002637 0.000960 0.008683 0.005980 0.001340 0.001061 0.002715 0.003789
Nucleolus 0.000081 0.000126 0.000088 0.000565 0.000280 0.000214 0.000148 0.000493 0.000160 0.000174 0.000094 0.000561
Nucleus 0.022005 0.017570 0.141059 0.025026 0.030739 0.011427 0.055942 0.014989 0.025475 0.014180 0.132750 0.024480
Peroxisomes 0.000464 0.000661 0.000050 0.001808 0.000847 0.000776 0.000330 0.000221 0.000616 0.000724 0.000077 0.001722
Vacuole 0.013930 0.041486 0.016232 0.081561 0.052696 0.041231 0.284253 0.115211 0.029331 0.041345 0.042394 0.083391
Vacuole Periphery 0.000807 0.000619 0.000183 0.005991 0.002939 0.000935 0.000265 0.006352 0.001654 0.000794 0.000191 0.006010

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.52 -6.95 -2.57 -1.81 -0.63 0.49 -3.80 -1.36 -1.79 2.56 -2.06 -6.20 -2.25 -1.84 -0.45
Bud Neck -1.70 -5.62 -9.67 -9.03 -3.59 -2.90 -5.34 -2.63 -1.85 1.43 -3.53 -6.99 -9.97 -6.98 -2.70
Bud Site -4.28 2.67 -5.14 -2.41 -6.88 -4.93 -4.90 -4.77 -1.63 -0.14 -6.27 1.65 -5.78 -1.90 -6.49
Cell Periphery -1.12 -8.20 -2.84 -2.76 -0.72 1.12 -6.79 -2.72 -2.77 -1.16 -0.71 -8.86 -3.01 -2.96 -0.79
Cytoplasm 10.78 21.73 19.81 6.99 0.36 -2.53 12.60 1.29 2.09 -7.51 7.20 18.61 14.48 8.15 -2.58
Cytoplasmic Foci -8.68 18.18 14.75 17.19 -4.21 -1.32 12.70 9.77 10.30 -0.71 -8.18 26.38 22.83 24.94 -3.63
Eisosomes -5.63 1.71 1.38 6.76 -0.44 1.93 -3.57 5.18 3.20 6.97 -2.52 4.70 7.70 8.65 2.94
Endoplasmic Reticulum -0.52 1.44 1.98 2.18 1.09 4.66 3.35 2.83 -0.06 0.96 3.55 4.96 5.29 1.98 1.57
Endosome -4.90 2.48 -3.83 0.21 -4.87 -0.69 0.57 5.51 5.26 4.65 -4.54 6.88 -1.36 1.71 -4.28
Golgi 2.64 3.03 -0.22 -2.34 -2.71 -3.62 5.57 5.42 6.29 0.79 0.30 3.41 -0.74 -0.96 -2.72
Lipid Particles -3.11 -8.85 -8.34 -7.25 -5.11 3.77 -5.96 -3.40 -4.00 -1.11 0.26 -7.45 -7.88 -7.92 -5.02
Mitochondria 1.98 1.47 -0.40 -1.99 -1.59 -0.20 2.54 2.64 2.09 2.25 -0.39 2.70 1.59 1.33 -1.61
Mitotic Spindle -1.71 -4.84 -6.12 -3.95 -2.59 -0.17 -2.11 -0.74 -0.66 1.67 -1.56 -4.79 -5.82 -4.72 -2.12
None 8.08 -3.08 6.54 -3.62 13.39 1.33 -0.77 1.16 0.46 1.53 7.60 -5.79 6.23 -2.06 13.31
Nuclear Periphery -4.09 -16.87 -5.60 -4.60 1.24 4.36 -10.28 -1.28 -1.66 2.42 0.83 -16.97 -5.08 -5.24 2.15
Nuclear Periphery Foci -4.24 -11.91 -7.25 -4.08 0.32 4.71 -7.24 -2.58 -3.98 2.45 1.34 -8.92 -4.80 -5.73 1.69
Nucleolus -1.12 -5.06 -2.39 -1.74 -2.02 0.50 1.63 0.90 0.53 -0.09 -0.48 1.40 -1.42 -1.11 -2.00
Nucleus 2.32 -32.19 -8.00 -9.17 28.69 11.16 -6.56 4.55 -2.36 8.27 10.38 -31.60 -5.35 -13.54 28.95
Peroxisomes -1.26 2.74 -0.89 -0.24 -2.67 0.29 2.09 2.25 6.82 0.73 -0.74 3.90 -0.26 0.15 -2.61
Vacuole -10.75 -11.67 -27.00 -17.39 -18.42 3.63 -11.93 -4.35 -4.91 5.83 -6.95 -10.55 -23.97 -20.33 -11.89
Vacuole Periphery 1.75 7.44 -1.97 -2.35 -3.15 2.16 2.97 0.58 -0.51 -0.93 2.33 4.07 -0.43 -2.10 -3.25
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Nth1

Nth1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nth1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available