Standard name
Human Ortholog
Description Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.11 – 0.05 0 0 0 – 0 0.05 0 0 0.13 0.2 0.21 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0.16 0 0 0 – 0 0.07 0.07 0.11 0 0.05 0.05 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.09 0.2 – 0.11 0.1 0 0.1 – 0.13 0.23 0.18 0.14 0.37 0.53 0.59 0 0 0 0 0.08 0.1 0 0 0
Cytoplasm 0.25 0.32 – 0.79 0.47 0.72 0.79 – 0.87 0.89 0.95 0.88 0.45 0.35 0.27 0.15 0.25 0.19 0 0.05 0 0 0 0
Endoplasmic Reticulum 0.5 0.45 – 0.05 0.28 0.09 0.11 – 0.08 0 0 0 0.25 0.18 0.16 0 0 0.06 0.28 0.29 0.25 0.18 0.15 0
Endosome 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 0.05
Golgi 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Mitochondria 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.09 0 – 0 0.07 0.07 0 – 0 0 0 0 0 0 0 0.23 0.17 0.18 0 0 0 0 0 0
Nuclear Periphery 0 0 – 0.05 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0
Nucleolus 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.13 0 – 0 0.26 0.13 0.09 – 0 0.07 0 0.06 0 0 0 0.62 0.58 0.64 0.58 0.45 0.35 0.7 0.69 0.83
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 8 28 – 1 0 3 7 – 3 10 2 5 25 68 77 2 2 1 3 10 1 3 13 1
Bud 1 3 – 3 1 2 1 – 4 12 7 13 4 18 18 3 0 0 0 1 0 0 2 3
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 4 23 1 4 5 2
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 18 50 – 2 7 1 21 – 17 41 18 17 69 184 219 2 1 2 9 27 2 0 7 0
Cytoplasm 50 79 – 15 34 55 161 – 109 162 93 107 84 120 102 15 40 26 3 15 1 5 6 8
Endoplasmic Reticulum 103 113 – 1 20 7 22 – 10 3 2 2 47 62 61 2 6 8 74 95 7 43 58 19
Endosome 1 0 – 0 0 0 0 – 0 0 0 0 2 2 1 0 5 2 1 3 1 4 18 21
Golgi 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 3 8 6 3 0 0 0 2 3
Mitochondria 5 3 – 0 0 0 0 – 2 0 0 0 0 0 1 3 3 3 9 2 0 4 1 5
Nucleus 19 8 – 0 5 5 9 – 2 2 1 5 1 0 0 23 28 25 0 0 0 0 0 2
Nuclear Periphery 0 0 – 1 0 0 0 – 1 0 0 0 0 1 0 0 0 1 2 1 1 1 3 4
Nucleolus 0 0 – 0 0 1 1 – 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 1 – 0 1 0 0 1 4 1 0 1 1 0 0 0 0 0 0
Vac/Vac Membrane 27 6 – 0 19 10 19 – 2 12 1 7 2 4 1 61 94 89 153 151 9 168 276 368
Unique Cell Count 204 250 19 72 76 203 126 182 98 121 186 346 371 99 161 139 267 335 28 239 399 445
Labelled Cell Count 232 290 23 86 84 242 150 243 124 156 235 463 482 114 188 166 267 335 28 239 399 445


Cytoplasm, Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.6 10.3 – 7.6 12.0 7.8 10.5 – 8.6 9.2 8.1 9.0 9.4 9.9 10.2 15.2 16.2 17.4 8.8 8.8 9.4
Std Deviation (1e-4) 1.4 1.5 – 1.2 1.8 1.6 1.8 – 1.5 1.6 1.4 1.8 1.3 2.0 1.6 4.6 4.9 4.8 1.7 2.0 2.3
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70005101520HU80HU120HU16005101520rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.4445 3.435 2.9387 3.0019 2.5293 3.0943 4.922 6.8387 6.1237 5.8693 5.7976 6.511 6.104 7.0021 6.1659 6.1434 5.8969 6.815
Actin 0.0141 0.0001 0.0021 0.0003 0.0009 0.0004 0.024 0.0001 0.0032 0.0142 0.0004 0.0051 0.0163 0.0001 0.0011 0.0172 0 0.0001
Bud 0.0008 0.0036 0.0013 0.0022 0.001 0.0006 0.0008 0.0004 0.0009 0.0012 0.0009 0.0004 0.0004 0.0008 0.001 0.0005 0.0005 0.0004
Bud Neck 0.004 0.0019 0.0016 0.0008 0.0009 0.0037 0.0131 0.0061 0.0035 0.0024 0.0037 0.0094 0.0027 0.0024 0.0025 0.002 0.0013 0.0046
Bud Periphery 0.0024 0.0031 0.0021 0.0135 0.0024 0.0027 0.0028 0.0016 0.0035 0.0043 0.0057 0.003 0.0016 0.0027 0.0027 0.0013 0.0029 0.0021
Bud Site 0.004 0.0128 0.0042 0.0013 0.0024 0.0014 0.0096 0.0143 0.0099 0.0121 0.0038 0.0011 0.0035 0.0089 0.0089 0.0031 0.0013 0.0009
Cell Periphery 0.0211 0.0233 0.0168 0.0086 0.0094 0.018 0.109 0.0802 0.0693 0.0584 0.0852 0.1015 0.0361 0.0216 0.0152 0.0148 0.0119 0.0226
Cytoplasm 0.0206 0.0299 0.0155 0.0045 0.013 0.0124 0.0486 0.0573 0.0678 0.0355 0.0134 0.0219 0.0368 0.0261 0.017 0.0027 0.0041 0.0263
Cytoplasmic Foci 0.0105 0.0051 0.0101 0.0029 0.0099 0.0083 0.0343 0.006 0.0092 0.0079 0.0119 0.0046 0.0112 0.0051 0.0086 0.0049 0.0009 0.0034
Eisosomes 0.0003 0 0 0 0 0 0.0002 0 0 0.0001 0 0 0.0003 0 0 0.0002 0 0
Endoplasmic Reticulum 0.0237 0.0229 0.0131 0.0044 0.0041 0.0107 0.0196 0.0324 0.034 0.0183 0.008 0.0144 0.0354 0.0239 0.0204 0.0043 0.0068 0.0178
Endosome 0.1328 0.1061 0.1111 0.0908 0.1144 0.0812 0.0859 0.0407 0.0726 0.0591 0.0983 0.0302 0.1052 0.0845 0.1349 0.0725 0.0604 0.0658
Golgi 0.0085 0.0034 0.0041 0.0029 0.0072 0.0046 0.0138 0.0014 0.0058 0.0173 0.0151 0.0076 0.01 0.0033 0.0059 0.0059 0.0008 0.0019
Lipid Particles 0.0265 0.004 0.0086 0.0016 0.014 0.0074 0.0797 0.0323 0.028 0.0292 0.0094 0.0175 0.0367 0.0082 0.0121 0.0172 0.0026 0.0089
Mitochondria 0.0131 0.0011 0.0046 0.0088 0.0051 0.0064 0.0155 0.0002 0.0019 0.0025 0.0034 0.0035 0.0042 0.0036 0.0058 0.0038 0.0005 0.0009
None 0.0086 0.0005 0.0116 0.001 0.0006 0.0031 0.0054 0.0005 0.0009 0.0003 0.0001 0.0001 0.0134 0.0003 0.0007 0.0004 0.0001 0.007
Nuclear Periphery 0.0068 0.0066 0.0063 0.0027 0.0032 0.0044 0.0064 0.0038 0.0055 0.0024 0.0018 0.002 0.0116 0.0066 0.0053 0.0026 0.0061 0.0031
Nucleolus 0.0016 0.0014 0.0021 0.0013 0.0008 0.0013 0.0012 0.0017 0.0017 0.0006 0.001 0.0009 0.0027 0.0029 0.002 0.0016 0.0012 0.001
Nucleus 0.0032 0.004 0.0069 0.0027 0.0021 0.0036 0.0032 0.003 0.0031 0.0017 0.0018 0.0019 0.0118 0.0043 0.0031 0.002 0.0048 0.0035
Peroxisomes 0.0056 0.0001 0.0033 0.0003 0.0019 0.0004 0.0055 0.0001 0.0009 0.0016 0.0012 0.0007 0.0029 0.0002 0.0019 0.0019 0.0001 0.0001
Punctate Nuclear 0.0031 0.0001 0.001 0.0001 0.001 0.0003 0.0111 0.0002 0.0003 0.0003 0.0002 0.0002 0.0018 0.0001 0.0003 0.0009 0.0001 0.0001
Vacuole 0.6456 0.7306 0.7121 0.78 0.7697 0.7848 0.5028 0.7119 0.6667 0.7204 0.7282 0.7675 0.6317 0.7545 0.701 0.7895 0.8374 0.7954
Vacuole Periphery 0.0433 0.0395 0.0615 0.0693 0.0358 0.0445 0.0074 0.0059 0.0114 0.0103 0.0064 0.0062 0.0236 0.04 0.0497 0.0506 0.0564 0.0341

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.4313 20.2573 18.5007 24.0389 21.4705 36.5856 22.0577 29.2432 31.6396 29.0996
Translational Efficiency 0.8016 0.9167 0.7899 0.8561 0.6953 0.5031 1.0395 1.1834 1.0009 0.6295

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
249 1235 206 1707 1684 2286 323 1873 1933 3521 529 3580

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 917.44 1040.55 1215.71 932.61 797.41 986.40 1207.90 1049.20 812.87 1005.39 1210.94 993.61
Standard Deviation 185.35 344.03 130.02 130.32 110.89 123.73 141.35 135.42 129.44 228.30 137.10 145.20
Intensity Change Log 2 — 0.181661 0.406113 0.023660 — 0.306851 0.599107 0.395896 — 0.241228 0.499075 0.208736

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000069 0.001772 0.041640 0.004633 0.000145 0.001354 0.016711 0.005591 0.000135 0.001500 0.026419 0.005134
Bud Neck 0.002440 0.058279 0.076470 0.016571 0.028346 0.073574 0.066778 0.044906 0.025009 0.068209 0.070552 0.031396
Bud Site 0.016020 0.042656 0.125769 0.076055 0.018616 0.026365 0.076238 0.096618 0.018282 0.032079 0.095526 0.086813
Cell Periphery 0.007842 0.145525 0.295604 0.001297 0.009644 0.251330 0.197678 0.015427 0.009412 0.214219 0.235812 0.008690
Cytoplasm 0.016720 0.132795 0.105615 0.077921 0.060462 0.083881 0.142850 0.105758 0.054827 0.101038 0.128351 0.092485
Cytoplasmic Foci 0.006488 0.007815 0.008995 0.063928 0.015240 0.004944 0.011071 0.030935 0.014112 0.005951 0.010262 0.046667
Eisosomes 0.000014 0.000975 0.010672 0.000089 0.000109 0.001092 0.004782 0.000668 0.000097 0.001051 0.007075 0.000392
Endoplasmic Reticulum 0.002790 0.031674 0.095684 0.005587 0.009471 0.036707 0.070116 0.016532 0.008610 0.034941 0.080073 0.011313
Endosome 0.019007 0.017279 0.009751 0.204907 0.037311 0.012164 0.014253 0.107187 0.034953 0.013958 0.012500 0.153782
Golgi 0.002245 0.002300 0.005186 0.020700 0.001553 0.002946 0.003101 0.009585 0.001642 0.002720 0.003913 0.014885
Lipid Particles 0.001886 0.003429 0.043522 0.002722 0.001516 0.004755 0.024314 0.009950 0.001563 0.004290 0.031794 0.006504
Mitochondria 0.000818 0.000340 0.000124 0.002121 0.000673 0.002851 0.000040 0.001708 0.000691 0.001970 0.000073 0.001905
Mitotic Spindle 0.000347 0.000050 0.000193 0.001297 0.000024 0.000111 0.000150 0.002866 0.000065 0.000089 0.000167 0.002118
None 0.000110 0.000421 0.000015 0.000094 0.000067 0.000037 0.000004 0.000236 0.000072 0.000171 0.000008 0.000168
Nuclear Periphery 0.000138 0.000069 0.000207 0.000084 0.000065 0.000091 0.000151 0.000102 0.000075 0.000083 0.000173 0.000093
Nuclear Periphery Foci 0.001863 0.000648 0.006031 0.000613 0.000148 0.000552 0.005766 0.000869 0.000369 0.000586 0.005869 0.000747
Nucleolus 0.000371 0.000253 0.000023 0.000214 0.000214 0.000286 0.000057 0.000317 0.000234 0.000274 0.000044 0.000268
Nucleus 0.005938 0.003554 0.003558 0.001322 0.002572 0.001419 0.002254 0.002189 0.003006 0.002168 0.002762 0.001776
Peroxisomes 0.000375 0.001045 0.001632 0.005109 0.000654 0.001786 0.001630 0.003885 0.000618 0.001526 0.001631 0.004469
Vacuole 0.864643 0.545178 0.168798 0.486885 0.803105 0.489966 0.361175 0.528936 0.811032 0.509332 0.286261 0.508885
Vacuole Periphery 0.049878 0.003945 0.000513 0.027850 0.010065 0.003790 0.000881 0.015734 0.015193 0.003844 0.000737 0.021511

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.52 -7.11 -5.19 -3.11 6.27 -3.78 -9.15 -9.11 -6.22 5.87 -6.00 -10.17 -9.54 -6.34 8.10
Bud Neck -16.62 -8.68 -13.07 11.87 6.95 -13.88 -6.53 -6.27 8.49 3.73 -16.55 -9.10 -3.34 14.98 7.98
Bud Site -5.43 -8.41 -11.92 -7.39 3.84 -3.35 -7.99 -19.40 -16.63 -2.49 -6.65 -11.52 -24.15 -18.15 1.25
Cell Periphery -23.65 -15.58 4.63 25.49 15.99 -46.13 -16.10 -3.25 44.08 15.56 -50.38 -21.93 0.79 50.66 22.02
Cytoplasm -15.44 -8.88 -10.74 7.57 2.67 -5.05 -9.48 -9.48 -4.75 3.91 -11.10 -10.94 -10.11 1.65 5.09
Cytoplasmic Foci -0.58 -0.96 -17.06 -20.73 -17.13 7.41 1.70 -7.96 -15.52 -8.08 6.56 1.98 -17.49 -25.95 -17.85
Eisosomes -6.15 -8.81 -6.30 5.66 8.75 -12.14 -9.10 -5.69 3.50 7.90 -12.51 -12.06 -5.59 7.33 11.52
Endoplasmic Reticulum -12.24 -8.16 -3.86 11.01 7.91 -13.40 -8.55 -4.52 9.19 7.52 -16.13 -11.46 -2.50 14.79 11.05
Endosome 0.39 2.02 -27.15 -34.09 -35.22 11.82 9.08 -17.17 -25.79 -23.59 10.83 10.50 -32.05 -41.90 -40.85
Golgi -0.05 -2.58 -10.37 -12.22 -9.81 -2.24 -3.12 -7.69 -5.81 -6.02 -2.28 -5.13 -14.24 -12.71 -11.65
Lipid Particles -1.00 -6.80 -0.58 1.70 6.85 -6.76 -7.00 -9.47 -5.26 4.26 -6.99 -9.81 -9.32 -3.94 8.13
Mitochondria 1.12 1.62 -2.71 -7.97 -8.89 -3.43 3.16 -3.36 1.80 -7.24 -2.95 3.36 -4.98 0.20 -11.44
Mitotic Spindle 0.99 0.52 -2.05 -3.24 -2.90 -2.48 -1.44 -4.36 -4.24 -4.12 -0.52 -1.53 -5.27 -5.23 -4.97
None -1.59 1.43 0.17 1.70 -1.52 0.88 1.86 -1.23 -1.51 -1.76 -1.41 2.11 -1.21 0.10 -2.20
Nuclear Periphery 0.95 -0.89 0.67 -1.58 5.52 -2.07 -5.58 -2.84 -1.73 2.81 -0.59 -5.81 -1.58 -2.01 5.98
Nuclear Periphery Foci 0.81 -2.61 0.78 -0.28 10.45 -4.50 -12.87 -6.26 -2.44 10.69 -1.05 -14.40 -2.03 -2.02 14.84
Nucleolus 0.65 2.06 0.85 0.32 -13.65 -2.35 11.30 -4.11 -1.12 -10.26 -1.01 7.78 -1.65 -0.19 -15.00
Nucleus 0.52 0.69 1.39 2.98 3.77 2.86 0.66 0.33 -3.30 -0.39 0.93 0.30 1.86 1.24 2.74
Peroxisomes -3.36 -4.72 -10.67 -9.55 -7.55 -5.81 -5.22 -6.96 -4.27 -4.62 -6.42 -6.77 -12.12 -8.83 -8.43
Vacuole 18.51 36.78 22.68 4.79 -22.78 37.22 30.05 29.39 -4.00 -10.87 40.50 45.11 39.73 0.05 -19.27
Vacuole Periphery 6.86 7.38 3.29 -19.43 -23.18 8.93 13.98 -4.77 -11.31 -14.53 10.45 13.57 -4.67 -21.67 -26.44
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
Localization
Cell Percentages vacuole (74%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Rcr2

Rcr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rcr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available