Standard name
Human Ortholog
Description Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.99 0.98 0.99 0.9 0.9 – 0.8 0.79 0.64 0.77 0.99 0.99 0.99 0.95 0.91 0.96 0.94 0.91 0.96 0.97 0.94 0.85
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.25 0.06 – 0.28 0.31 0.46 0.33 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.06 – 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 3 0 2 0 1 0 0 0 1
Bud 0 1 0 1 0 2 0 – 4 2 6 4 0 1 0 1 0 1 0 0 0 0 4 6
Bud Neck 0 0 0 0 0 1 1 – 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 3 4 7 5 2 12 – 8 4 2 7 1 3 6 4 4 2 0 0 0 0 0 0
Cytoplasm 119 237 159 213 268 178 338 – 257 292 134 203 253 499 444 201 140 133 116 227 155 207 392 213
Endoplasmic Reticulum 0 2 0 2 0 0 0 – 0 0 0 0 1 0 0 12 6 4 0 0 0 1 3 2
Endosome 0 0 0 1 0 0 5 – 4 5 2 2 1 3 4 4 6 1 0 0 0 0 1 5
Golgi 1 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 1 1 2 0 1 1 1
Mitochondria 0 5 0 5 5 49 21 – 90 113 98 86 0 0 3 7 1 0 3 6 1 0 3 6
Nucleus 0 0 0 0 0 0 1 – 3 1 3 1 1 1 0 1 3 1 0 0 0 0 0 0
Nuclear Periphery 1 0 0 0 0 1 0 – 0 1 0 0 0 0 0 0 1 0 0 0 0 0 1 0
Nucleolus 0 1 0 0 0 0 0 – 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 2 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 2 0 7 – 2 2 4 2 0 0 1 2 6 1 0 0 0 0 2 5
Vac/Vac Membrane 1 2 1 2 4 2 23 – 19 9 4 5 0 0 0 2 1 3 0 7 0 0 0 5
Unique Cell Count 122 243 160 218 270 198 375 322 369 211 264 256 503 449 212 154 139 125 251 162 213 418 252
Labelled Cell Count 123 251 164 232 284 235 408 389 431 255 311 258 508 459 237 168 149 125 251 162 213 418 252


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 5.5 6.0 6.3 6.2 4.6 5.4 – 4.7 4.6 4.7 4.5 5.9 6.1 6.3 5.8 6.1 6.1 5.5 5.7 6.1
Std Deviation (1e-4) 0.8 1.1 1.0 2.8 1.4 2.8 1.5 – 1.4 1.4 1.7 0.8 1.2 1.1 1.8 1.0 1.4 1.2 1.5 1.6 2.0
Intensity Change (Log2) – – – 0.07 0.06 -0.37 -0.15 – -0.35 -0.38 -0.36 -0.42 -0.01 0.03 0.08 -0.05 0.04 0.02 -0.12 -0.08 0.02

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.3 -0.1 -3.8 -3.8 – -5.9 -6.0 -8.4 -6.4 -0.6 -0.2 -0.5 -2.5 -3.5 -2.1
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 3.1 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 3.1 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.8 – 2.7 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.4033 -0.1144 -0.1573 -0.47 -0.5375 -0.3058 2.1106 1.8186 2.0223 0.8028 1.4749 1.5219 3.2793 4.2243 2.8155 3.0361 3.1821 2.8816
Actin 0.0173 0.001 0.0252 0.0002 0.0332 0.0044 0.0307 0.0073 0.0114 0.0002 0.0021 0.0023 0.1203 0.0126 0.0002 0.0012 0.025 0.0015
Bud 0.0006 0.0016 0.0012 0.0001 0.0003 0.0001 0.0006 0.0041 0.0018 0.0001 0.0011 0.0002 0.0007 0.0004 0 0 0.0007 0
Bud Neck 0.0017 0.0002 0.0035 0.0001 0.0004 0.0004 0.0004 0.0002 0.0011 0.0001 0.0004 0.0002 0.0076 0.0026 0 0.0001 0.0001 0.0001
Bud Periphery 0.0013 0.0016 0.0023 0 0.0004 0 0.0007 0.0022 0.0022 0 0.0032 0.0005 0.0006 0.0003 0 0 0.0012 0
Bud Site 0.0013 0.0073 0.005 0 0.0005 0 0.0011 0.006 0.0027 0.0001 0.0003 0 0.0575 0.1476 0.0001 0 0.0004 0
Cell Periphery 0.0002 0.0003 0.0002 0 0.0001 0 0.0004 0.0002 0.0004 0.0001 0.0001 0.0001 0.0003 0.0007 0.0001 0 0.0001 0
Cytoplasm 0.2552 0.382 0.2907 0.5187 0.3725 0.3701 0.4557 0.6061 0.5475 0.817 0.6931 0.6112 0.0527 0.5287 0.4356 0.4178 0.3348 0.5593
Cytoplasmic Foci 0.0803 0.006 0.0232 0.0064 0.0123 0.0163 0.0053 0.0087 0.0088 0.0082 0.0215 0.004 0.1023 0.004 0.0019 0.0078 0.0224 0.0095
Eisosomes 0.0002 0.0001 0.0002 0 0.0001 0 0.0002 0.0001 0.0001 0.0001 0 0 0.001 0.0001 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0061 0.0019 0.0075 0.0059 0.0014 0.0008 0.0229 0.0038 0.0108 0.0063 0.0057 0.0057 0.0018 0.0026 0.003 0.0016 0.001 0.0015
Endosome 0.0376 0.0018 0.0145 0.0051 0.0145 0.0027 0.0104 0.0016 0.0056 0.0062 0.0129 0.0019 0.0234 0.0007 0.0005 0.0007 0.0038 0.001
Golgi 0.0129 0.0001 0.0028 0.0002 0.0353 0.0002 0.0016 0.0004 0.001 0.0004 0.0008 0.0001 0.0093 0.0004 0.0001 0.0001 0.0126 0.0003
Lipid Particles 0.0166 0.0002 0.0089 0.0002 0.0078 0.0003 0.001 0.0004 0.0007 0.0047 0.0011 0.0001 0.0356 0.0002 0.0001 0.0001 0.0011 0.0029
Mitochondria 0.0075 0.0001 0.0014 0.0002 0.0078 0.0002 0.0022 0.0003 0.0009 0.0003 0.0041 0.0006 0.0028 0.0001 0.0001 0.0001 0.0041 0.0002
None 0.5167 0.5922 0.5888 0.4597 0.4867 0.6018 0.4181 0.3536 0.3812 0.1511 0.1919 0.3581 0.5225 0.2968 0.5566 0.5686 0.5633 0.4136
Nuclear Periphery 0.0157 0.0007 0.0062 0.0009 0.0004 0.0003 0.0168 0.001 0.0078 0.0012 0.017 0.0103 0.0093 0.0004 0.0005 0.0003 0.0002 0.0002
Nucleolus 0.0007 0.0001 0.0003 0 0.0001 0 0.0003 0.0001 0.0003 0.0001 0.0008 0 0.0006 0 0 0 0 0
Nucleus 0.0047 0.0011 0.0018 0.0008 0.0006 0.0006 0.0227 0.0009 0.0093 0.0009 0.031 0.0028 0.0011 0.0005 0.0005 0.0005 0.0002 0.0003
Peroxisomes 0.0095 0.0001 0.0087 0 0.0239 0.0006 0.001 0.0008 0.0003 0.0001 0.0005 0.0001 0.017 0.0002 0 0.0005 0.0282 0.0082
Punctate Nuclear 0.0092 0.0005 0.0047 0.0004 0.0007 0.0006 0.0026 0.0012 0.0038 0.0004 0.0008 0.0008 0.0325 0.0003 0.0002 0.0002 0.0002 0.0011
Vacuole 0.0027 0.001 0.0019 0.0009 0.0007 0.0004 0.0036 0.0007 0.0018 0.0021 0.006 0.0005 0.0005 0.0005 0.0003 0.0003 0.0004 0.0002
Vacuole Periphery 0.0018 0.0001 0.0012 0.0002 0.0003 0.0001 0.0014 0.0001 0.0005 0.0003 0.0056 0.0003 0.0005 0 0 0 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 0.9335 3.338 1.2385 4.5288 2.4207 1.866 5.4844 3.9864 4.459 5.6578
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
103 750 106 1952 1494 2408 340 1593 1597 3158 446 3545

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 655.66 786.08 1084.94 866.73 712.03 809.34 1006.23 905.13 708.39 803.82 1024.94 883.99
Standard Deviation 79.35 107.75 130.58 111.79 83.49 98.19 123.30 122.94 84.37 101.03 129.48 118.48
Intensity Change Log 2 — 0.261728 0.726595 0.402635 — 0.184808 0.498950 0.346187 — 0.222195 0.612569 0.373523

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000224 0.000325 0.001056 0.000474 0.000120 0.000387 0.000509 0.001657 0.000127 0.000372 0.000639 0.001006
Bud Neck 0.031962 0.011265 0.003873 0.004871 0.014069 0.017057 0.002834 0.008147 0.015223 0.015681 0.003081 0.006343
Bud Site 0.009983 0.014696 0.004952 0.025351 0.004745 0.013765 0.004047 0.039872 0.005083 0.013986 0.004262 0.031876
Cell Periphery 0.000429 0.000119 0.000321 0.000098 0.000108 0.000114 0.000189 0.000315 0.000129 0.000115 0.000221 0.000196
Cytoplasm 0.390692 0.573117 0.278973 0.593223 0.551030 0.611965 0.482597 0.593591 0.540689 0.602739 0.434202 0.593389
Cytoplasmic Foci 0.343927 0.194980 0.017588 0.030045 0.200063 0.104705 0.012782 0.037367 0.209341 0.126145 0.013924 0.033335
Eisosomes 0.000378 0.000060 0.000104 0.000037 0.000109 0.000052 0.000053 0.000035 0.000127 0.000054 0.000065 0.000036
Endoplasmic Reticulum 0.000678 0.001464 0.012150 0.002264 0.000709 0.000569 0.010100 0.001000 0.000707 0.000781 0.010587 0.001696
Endosome 0.009303 0.016761 0.009608 0.006865 0.009160 0.007065 0.004675 0.008053 0.009169 0.009368 0.005847 0.007399
Golgi 0.005409 0.001583 0.000208 0.002237 0.001746 0.001295 0.000174 0.002761 0.001982 0.001363 0.000182 0.002473
Lipid Particles 0.010092 0.003155 0.004385 0.000988 0.004203 0.001892 0.001915 0.000903 0.004583 0.002192 0.002502 0.000950
Mitochondria 0.010793 0.002211 0.000427 0.004969 0.003512 0.004759 0.000428 0.005856 0.003982 0.004154 0.000428 0.005368
Mitotic Spindle 0.000132 0.002289 0.002513 0.046425 0.003643 0.006799 0.002426 0.063608 0.003417 0.005728 0.002447 0.054146
None 0.001292 0.002615 0.001629 0.005837 0.001739 0.003497 0.007882 0.005447 0.001710 0.003287 0.006396 0.005662
Nuclear Periphery 0.000352 0.000684 0.002923 0.001034 0.000434 0.000538 0.001816 0.000742 0.000429 0.000573 0.002079 0.000903
Nuclear Periphery Foci 0.000228 0.001019 0.011094 0.002453 0.000306 0.000190 0.006203 0.001743 0.000301 0.000387 0.007366 0.002134
Nucleolus 0.001435 0.000802 0.000875 0.000361 0.000651 0.000882 0.000307 0.000628 0.000702 0.000863 0.000442 0.000481
Nucleus 0.138548 0.085081 0.388908 0.105142 0.152184 0.161879 0.301794 0.098976 0.151305 0.143640 0.322498 0.102371
Peroxisomes 0.016750 0.005462 0.000401 0.001293 0.003018 0.002640 0.000227 0.004306 0.003904 0.003310 0.000268 0.002647
Vacuole 0.026500 0.080968 0.257675 0.163239 0.047793 0.058431 0.158497 0.122441 0.046420 0.063783 0.182068 0.144906
Vacuole Periphery 0.000896 0.001343 0.000338 0.002794 0.000658 0.001521 0.000545 0.002552 0.000673 0.001479 0.000496 0.002685

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.40 -5.45 -1.94 0.00 4.87 -1.24 -8.82 -2.62 -0.95 -0.03 -1.50 -10.35 -3.66 -0.59 2.63
Bud Neck 2.81 3.70 3.71 4.69 -0.20 -2.09 8.66 4.16 6.71 -5.66 -0.36 9.22 7.44 9.89 -4.04
Bud Site -1.32 1.34 -1.27 0.11 -5.16 -6.78 -1.47 -8.80 -3.31 -8.41 -7.83 -1.06 -9.86 -2.16 -9.75
Cell Periphery 3.28 1.12 3.75 5.69 6.65 -0.43 -6.48 -0.40 -0.24 1.12 0.85 -6.08 1.27 0.67 4.58
Cytoplasm -6.88 5.36 -4.66 5.22 -14.29 -6.63 12.61 7.42 14.48 -7.71 -7.09 15.94 5.94 15.70 -13.10
Cytoplasmic Foci 6.14 14.14 13.65 23.68 -4.77 16.45 36.66 31.59 21.08 -10.19 14.54 38.60 35.33 31.76 -12.06
Eisosomes 5.81 4.80 6.20 6.19 6.87 7.50 5.07 10.00 2.40 6.82 9.19 5.60 11.67 4.00 9.64
Endoplasmic Reticulum -3.57 -7.58 -2.29 -0.20 6.76 1.44 -6.00 -5.93 -6.84 5.52 -0.95 -8.29 -3.39 -2.94 7.37
Endosome -3.59 0.06 3.54 7.58 4.53 2.84 5.20 4.45 2.34 -1.27 -0.16 4.48 6.37 7.56 1.07
Golgi 1.65 2.24 1.96 2.09 -2.59 1.36 6.62 2.33 1.02 -2.91 1.92 6.73 3.47 1.83 -3.91
Lipid Particles 2.38 1.92 3.05 5.25 5.79 6.71 5.22 8.36 2.77 5.40 6.37 4.40 9.07 5.99 8.23
Mitochondria 1.27 1.52 1.29 0.17 -2.50 -1.03 3.30 1.49 3.02 -2.34 -0.12 3.63 1.94 3.02 -3.42
Mitotic Spindle -2.71 -1.63 -10.04 -8.86 -8.01 -2.06 -2.05 -13.18 -12.54 -9.99 -1.80 -1.98 -15.00 -14.51 -10.43
None -2.41 0.06 -4.81 -2.94 -5.31 -3.52 -5.48 -10.66 -4.56 -2.04 -3.82 -5.00 -8.57 -3.97 -2.43
Nuclear Periphery -1.22 -8.89 -10.00 -3.88 4.52 -0.92 -13.71 -15.42 -10.94 2.74 -1.31 -16.04 -17.41 -10.88 5.48
Nuclear Periphery Foci -7.28 -7.35 -5.10 -2.99 5.68 3.37 -5.88 -8.91 -9.30 3.74 -2.21 -7.87 -8.88 -8.51 5.56
Nucleolus 0.86 1.02 0.93 0.58 -0.41 -1.74 -0.11 -4.87 -3.10 -2.63 -1.43 0.08 -3.66 -1.80 -1.76
Nucleus 2.78 -6.07 0.10 -8.38 7.20 -1.65 -11.58 3.51 5.66 13.37 1.19 -13.10 3.42 2.66 15.18
Peroxisomes 1.93 2.87 2.77 3.93 -3.14 0.84 8.01 1.38 0.66 -5.90 0.96 7.33 4.47 4.46 -6.74
Vacuole -5.08 -11.13 -20.45 -23.50 3.53 -4.12 -15.12 -27.80 -25.86 2.11 -7.00 -18.56 -42.55 -38.52 2.95
Vacuole Periphery -1.58 2.50 -0.23 0.74 -1.68 -2.45 3.51 -0.45 1.74 -1.97 -2.94 4.33 -0.88 1.56 -2.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (54%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Rtr2

Rtr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available