Standard name
Human Ortholog
Description Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.83 0.85 0.93 0.79 0.94 0.89 0.88 0.84 0.73 0.79 0.66 0.7 0.82 0.93 0.98 0.79 0.69 0.7 0.8 0.78 0.85 0.76 0.62 0.53
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.08 0.1 0.14 0 0 0 0 0 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.05 0.08 0.34 0.19 0.34 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0 0.08 0.09 0.11
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0.08 0.1
Vac/Vac Membrane 0.21 0.19 0.13 0.27 0 0.11 0.1 0.13 0.08 0.08 0.12 0.11 0.24 0.11 0 0.25 0.41 0.28 0.05 0.05 0 0 0.06 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 4 2 1 3 2
Bud 0 1 0 0 0 0 0 1 3 1 5 3 0 0 0 0 0 0 5 2 1 1 15 16
Bud Neck 0 0 0 0 0 0 2 2 0 1 0 1 0 0 0 1 0 0 3 3 0 2 12 7
Bud Site 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 1 2 2 0 0 0 0 0 0
Cytoplasm 418 363 263 184 273 334 393 309 329 297 327 294 376 327 407 351 266 270 441 362 263 229 361 222
Endoplasmic Reticulum 2 1 3 0 0 0 1 0 0 2 0 1 0 0 0 32 18 13 0 0 0 1 5 5
Endosome 3 1 3 2 0 4 5 1 0 2 7 7 24 6 2 35 37 54 10 8 4 6 23 28
Golgi 1 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 1 2 3 0 2 0 5 2
Mitochondria 2 12 0 3 10 17 21 28 153 71 170 105 1 0 1 18 4 1 3 9 7 7 8 8
Nucleus 7 3 0 1 3 8 11 7 17 16 11 19 1 1 0 1 6 5 36 35 8 25 52 45
Nuclear Periphery 0 1 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 2 2
Nucleolus 3 0 0 0 1 0 0 0 1 1 0 1 1 0 0 5 3 5 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 3 5 5 0 0 0 0 2 0
SpindlePole 5 0 0 1 1 0 2 1 2 2 0 0 3 2 1 16 19 23 14 4 6 9 44 40
Vac/Vac Membrane 105 80 36 62 11 41 46 48 36 31 62 46 108 40 9 110 159 108 25 25 6 11 33 22
Unique Cell Count 503 425 284 232 290 377 445 369 448 377 497 423 458 351 416 445 387 387 553 464 310 303 587 419
Labelled Cell Count 546 462 306 253 299 404 481 397 544 425 582 481 516 377 421 573 520 488 553 464 310 303 587 419


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 5.1 6.5 6.2 4.9 4.9 4.9 5.1 3.9 4.4 4.2 4.4 6.6 6.3 5.6 5.5 6.7 7.3 6.6 6.8 6.9
Std Deviation (1e-4) 0.9 0.8 1.1 1.7 1.4 1.3 1.3 1.4 0.7 0.8 0.7 0.7 1.5 1.6 1.2 1.4 1.5 1.7 1.4 1.7 2.0
Intensity Change (Log2) – – – -0.06 -0.41 -0.41 -0.41 -0.35 -0.74 -0.56 -0.63 -0.57 0.03 -0.05 -0.21 -0.23 0.04 0.17 0.02 0.07 0.1

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -4.4 0.7 -1.7 -1.9 -3.4 -6.4 -4.9 -8.4 -7.4 -4.0 0.3 3.4 -5.0 -7.5 -7.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 3.8 2.6 1.9
Endosome 0 0 0 0 0 0 0 0 0 3.0 0 0 4.0 4.6 5.9
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.6 3.7 4.7 0 0 0 0 0 0 0 3.4 0 0
Nucleus 0 0 0 0 0 3.3 3.5 0 3.6 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 3.2 3.8 4.2
Vacuole 4.0 -3.9 -0.7 -1.0 0.1 -2.1 -1.9 -0.1 -0.7 3.7 -0.5 -5.6 4.0 8.0 4.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9324 2.8335 2.4801 2.1356 2.0653 2.5344 7.3082 6.947 7.0277 7.2779 5.9692 6.7082 3.5735 4.355 4.2129 4.2713 4.3998 4.1659
Actin 0.0284 0.0005 0.0049 0.001 0.0686 0.0007 0.0287 0.001 0.0184 0.0007 0.0013 0.0026 0.0007 0.0011 0.0011 0.0008 0.0139 0.0006
Bud 0.0008 0.0002 0.0011 0.0002 0.0005 0.0006 0.0032 0.0013 0.003 0.0004 0.0005 0.0008 0.0001 0.0012 0.0005 0.0002 0.0004 0.0003
Bud Neck 0.0036 0.0004 0.0009 0.0009 0.0009 0.0048 0.0171 0.0006 0.0022 0.0008 0.001 0.0085 0.0007 0.0013 0.0011 0.0013 0.0011 0.005
Bud Periphery 0.0014 0.0001 0.0008 0.0001 0.0006 0.0004 0.0054 0.0005 0.0056 0.0007 0.0003 0.0015 0.0001 0.0011 0.0003 0.0001 0.0003 0.0002
Bud Site 0.0048 0.0016 0.0016 0.0003 0.0017 0.0006 0.01 0.0096 0.0108 0.0007 0.0002 0.0011 0.0006 0.0043 0.0016 0.0002 0.0008 0.0003
Cell Periphery 0.0004 0.0001 0.0002 0.0001 0.0001 0 0.0005 0.0001 0.0003 0.0016 0 0.0001 0 0.0001 0 0 0 0
Cytoplasm 0.3974 0.6484 0.5986 0.6088 0.6649 0.5116 0.3467 0.6232 0.5488 0.5736 0.7617 0.4263 0.3896 0.4858 0.4569 0.5198 0.495 0.3504
Cytoplasmic Foci 0.0387 0.0053 0.0103 0.0051 0.0161 0.0066 0.0437 0.0107 0.0098 0.0095 0.0088 0.0073 0.0083 0.006 0.0074 0.0057 0.0189 0.0066
Eisosomes 0.001 0 0.0001 0 0.0003 0 0.0002 0.0005 0.0002 0 0 0 0 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0101 0.0083 0.0087 0.0061 0.0055 0.0042 0.0096 0.0044 0.0074 0.0056 0.0052 0.0059 0.0027 0.0027 0.0025 0.0034 0.0046 0.0016
Endosome 0.017 0.0045 0.0099 0.0026 0.0093 0.0054 0.0367 0.0088 0.0079 0.0053 0.0047 0.0145 0.0058 0.0038 0.0039 0.0031 0.0077 0.0045
Golgi 0.0047 0.0002 0.0015 0.0001 0.0056 0.0002 0.0128 0.0026 0.005 0.0002 0.0005 0.0026 0.0002 0.0002 0.0001 0.0001 0.0043 0.0012
Lipid Particles 0.015 0.0003 0.0048 0.0003 0.0053 0.0002 0.0109 0.0004 0.0006 0.0004 0.0002 0.0014 0.0007 0.0001 0.0001 0.0001 0.0015 0.0005
Mitochondria 0.0099 0.0004 0.003 0.0005 0.0022 0.0006 0.0146 0.0015 0.0036 0.0007 0.0493 0.0031 0.0006 0.0008 0.0009 0.0007 0.0031 0.0008
None 0.2305 0.175 0.2083 0.2278 0.1607 0.1124 0.1422 0.1578 0.1777 0.2488 0.1137 0.0733 0.2406 0.1342 0.2315 0.2701 0.2979 0.142
Nuclear Periphery 0.0172 0.0089 0.0114 0.0056 0.0034 0.0082 0.0253 0.0079 0.013 0.0078 0.0104 0.0161 0.0084 0.0091 0.0085 0.009 0.0082 0.0053
Nucleolus 0.0021 0.0007 0.0009 0.0003 0.0002 0.0011 0.002 0.0008 0.0013 0.0006 0.0002 0.0028 0.0012 0.0014 0.001 0.0006 0.0011 0.002
Nucleus 0.175 0.136 0.1097 0.135 0.0325 0.3262 0.2298 0.1536 0.1549 0.1187 0.0312 0.3962 0.3122 0.3178 0.258 0.1664 0.1043 0.4454
Peroxisomes 0.029 0.0001 0.0054 0.0001 0.0161 0.0002 0.0243 0.0022 0.0019 0.0003 0.0002 0.0011 0.0008 0.0003 0.0007 0.0002 0.0161 0.0013
Punctate Nuclear 0.0088 0.0064 0.0152 0.0035 0.0042 0.0135 0.0239 0.0088 0.024 0.0176 0.0079 0.0303 0.0251 0.0262 0.022 0.0161 0.0196 0.0309
Vacuole 0.0027 0.0025 0.0023 0.0013 0.0012 0.0022 0.0096 0.0031 0.0031 0.0054 0.0021 0.0035 0.0015 0.0022 0.0015 0.0015 0.0011 0.0012
Vacuole Periphery 0.0014 0.0003 0.0006 0.0002 0.0003 0.0003 0.0028 0.0005 0.0007 0.0005 0.0006 0.0009 0.0002 0.0003 0.0003 0.0003 0.0003 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.0447 11.7046 20.5289 13.4207 10.8029 9.5171 11.8345 8.3505 8.9073 14.808
Translational Efficiency 1.0522 1.165 0.7139 0.8966 1.2828 1.5645 1.6139 1.8809 1.2026 1.1087

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1217 1290 2673 1284 2431 1751 1695 1158 3648 3041 4368 2442

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 719.52 846.77 959.46 1070.97 733.44 878.86 955.65 1057.29 728.80 865.25 957.98 1064.48
Standard Deviation 116.50 110.42 136.00 168.99 87.75 109.83 144.26 161.32 98.50 111.22 139.28 165.54
Intensity Change Log 2 — 0.234935 0.415188 0.573811 — 0.260954 0.381803 0.527620 — 0.248128 0.398432 0.550679

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000127 0.000489 0.000211 0.000855 0.000067 0.000311 0.000480 0.000847 0.000087 0.000387 0.000315 0.000851
Bud Neck 0.005919 0.007487 0.011371 0.027721 0.005998 0.020221 0.017244 0.026766 0.005972 0.014819 0.013650 0.027268
Bud Site 0.002514 0.010146 0.009678 0.044270 0.002056 0.012471 0.015409 0.054507 0.002209 0.011485 0.011902 0.049124
Cell Periphery 0.000106 0.000142 0.000136 0.000302 0.000080 0.000248 0.000290 0.000214 0.000089 0.000203 0.000196 0.000260
Cytoplasm 0.535034 0.535132 0.376820 0.145009 0.555844 0.428259 0.314407 0.082520 0.548902 0.473595 0.352601 0.115377
Cytoplasmic Foci 0.127964 0.055936 0.003689 0.045242 0.062769 0.085296 0.012874 0.057925 0.084518 0.072842 0.007253 0.051257
Eisosomes 0.000071 0.000047 0.000019 0.000028 0.000037 0.000069 0.000036 0.000027 0.000048 0.000059 0.000026 0.000028
Endoplasmic Reticulum 0.000861 0.002318 0.001492 0.003006 0.000417 0.000918 0.003611 0.004364 0.000565 0.001512 0.002315 0.003650
Endosome 0.006557 0.003853 0.001082 0.005491 0.002210 0.009829 0.007832 0.016423 0.003660 0.007294 0.003702 0.010675
Golgi 0.000565 0.001797 0.000138 0.005071 0.000413 0.002367 0.002043 0.013411 0.000464 0.002125 0.000877 0.009026
Lipid Particles 0.004340 0.002121 0.000355 0.000852 0.001403 0.004119 0.000913 0.001290 0.002383 0.003271 0.000571 0.001060
Mitochondria 0.002304 0.002199 0.001249 0.005376 0.001620 0.008061 0.002479 0.004172 0.001848 0.005575 0.001727 0.004805
Mitotic Spindle 0.000316 0.006931 0.013442 0.436497 0.001526 0.012492 0.092864 0.561279 0.001123 0.010133 0.044262 0.495669
None 0.008895 0.007177 0.008681 0.019249 0.004599 0.006479 0.017756 0.005698 0.006032 0.006775 0.012202 0.012823
Nuclear Periphery 0.000580 0.000760 0.001847 0.002364 0.000465 0.000998 0.001495 0.001246 0.000503 0.000897 0.001710 0.001834
Nuclear Periphery Foci 0.001152 0.001621 0.000295 0.007270 0.000238 0.000457 0.001315 0.004502 0.000543 0.000951 0.000691 0.005957
Nucleolus 0.001869 0.001560 0.000617 0.013918 0.000718 0.002952 0.004675 0.013750 0.001102 0.002361 0.002192 0.013838
Nucleus 0.252504 0.321993 0.549347 0.196434 0.336654 0.335929 0.462204 0.090536 0.308581 0.330017 0.515532 0.146217
Peroxisomes 0.002576 0.002669 0.000115 0.009289 0.001447 0.008378 0.002106 0.018477 0.001824 0.005957 0.000888 0.013646
Vacuole 0.045113 0.035001 0.019287 0.029982 0.021248 0.059022 0.038161 0.034021 0.029209 0.048832 0.026611 0.031897
Vacuole Periphery 0.000633 0.000619 0.000129 0.001774 0.000190 0.001123 0.001805 0.008025 0.000338 0.000909 0.000780 0.004738

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.82 -3.93 -13.07 -4.94 -10.59 -4.44 -13.37 -9.29 -5.87 -2.43 -6.70 -12.77 -15.62 -8.11 -8.84
Bud Neck -1.90 -6.92 -15.11 -13.38 -9.97 -9.10 -10.66 -14.11 -6.68 -5.16 -8.92 -12.19 -20.42 -12.30 -10.99
Bud Site -5.45 -5.63 -17.26 -12.62 -14.13 -7.39 -10.96 -19.19 -14.94 -13.11 -9.21 -11.67 -25.75 -19.38 -19.57
Cell Periphery -3.67 -1.01 -10.04 -6.16 -9.39 -2.16 -11.64 -10.93 0.25 0.13 -2.63 -9.68 -15.39 -0.79 -7.39
Cytoplasm 0.78 26.43 48.75 46.83 27.77 15.85 44.05 74.19 43.41 20.04 12.52 49.93 87.84 61.78 35.02
Cytoplasmic Foci 13.28 26.93 16.63 4.70 -11.66 -6.08 21.08 1.43 6.03 -11.66 3.58 35.21 11.94 8.41 -16.78
Eisosomes 4.71 16.76 9.48 2.44 -10.35 -7.02 -1.88 -0.62 6.57 1.09 -3.75 12.40 5.03 6.77 -7.38
Endoplasmic Reticulum -7.47 -10.51 -9.20 -3.13 -3.51 -7.69 -8.95 -4.04 -3.16 1.94 -10.72 -14.13 -8.08 -4.78 0.08
Endosome 3.30 7.53 3.60 0.28 -8.46 -7.81 -2.44 -6.63 2.05 -3.01 -5.55 3.59 -3.56 2.68 -6.77
Golgi -2.09 5.35 -3.29 -0.68 -4.32 -4.18 -2.10 -4.78 -2.50 -3.97 -4.53 0.01 -5.81 -2.31 -5.80
Lipid Particles 4.86 9.63 7.00 2.97 -11.36 -4.58 1.87 -0.00 4.57 -1.80 -2.29 10.71 5.83 5.18 -9.62
Mitochondria 0.21 1.04 -0.63 -1.10 -3.19 -4.59 -1.56 -1.50 4.16 -0.05 -4.15 -0.10 -1.71 3.47 -2.89
Mitotic Spindle -4.14 -9.67 -35.46 -34.46 -33.27 -5.88 -17.31 -41.51 -40.00 -27.99 -7.03 -18.98 -53.89 -52.06 -44.50
None 1.27 0.64 -1.63 -3.41 -3.15 -2.33 -8.96 -2.80 0.17 6.56 -0.83 -6.32 -3.87 -2.96 1.12
Nuclear Periphery -3.02 -23.32 -17.09 -15.99 -3.09 -7.78 -23.13 -12.16 -7.99 2.99 -8.41 -34.91 -21.31 -16.76 -0.22
Nuclear Periphery Foci -2.30 3.45 -7.81 -7.33 -8.36 -2.80 -6.47 -6.73 -6.37 -3.46 -4.25 -5.38 -10.51 -9.83 -8.96
Nucleolus 1.25 1.92 -10.71 -11.02 -11.15 -6.01 -8.41 -11.88 -10.42 -6.59 -5.15 -7.60 -16.21 -14.90 -12.91
Nucleus -7.75 -42.24 0.25 6.91 35.21 0.18 -17.67 19.24 16.90 30.52 -3.64 -42.24 14.40 16.16 47.85
Peroxisomes 0.05 7.21 -3.88 -3.52 -10.10 -6.32 0.24 -7.88 -1.54 -7.98 -5.99 5.20 -9.13 -2.08 -11.73
Vacuole 1.69 3.38 -4.70 -5.94 -7.19 -12.99 -12.45 -6.72 3.45 3.61 -10.51 -8.71 -9.56 -1.41 -3.44
Vacuole Periphery 0.11 2.31 -0.05 -0.26 -4.93 -5.64 -2.90 -2.79 -1.49 -1.82 -4.34 -0.47 -2.95 -1.36 -2.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
Localization
Cell Percentages cytoplasm (56%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pph3

Pph3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pph3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available