Standard name
Human Ortholog
Description Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.13 0 0 0 0 0 0 0.19 0.13 0.13
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.12 0.17 0.13 0.14 0.06 0.08 0.06 0.08 0 0 0.06 0 0 0 0 0 0 0 0 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0 0 0 0.05 0 0 0.26 0.13 0.23 0.13 0 0 0 0.12 0.08 0.09 0 0 0 0 0 0.08
Nucleus 0.48 0.53 0.3 0 0.16 0.13 0.11 0.12 0.2 0.16 0.26 0.26 0.13 0.08 0.07 0.24 0.3 0.32 0.22 0.32 0.14 0.13 0.11 0.05
Nuclear Periphery 0.06 0.08 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0.05
Nucleolus 0.46 0.4 0.64 0.91 0.79 0.75 0.75 0.74 0.65 0.69 0.59 0.62 0.82 0.83 0.78 0.76 0.7 0.65 0.61 0.54 0.68 0.45 0.44 0.34
Peroxisomes 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.05 0.41 0.23 0.34 0.29 0.31 0.14 0.24 0.13 0.22 0.18 0.28 0.2 0 0 0 0 0 0 0 0.06 0.07
Vac/Vac Membrane 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.08 0 0.08 0.08 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2
Bud 0 0 0 0 1 0 5 6 4 7 10 8 0 1 0 0 0 0 4 2 2 2 6 6
Bud Neck 0 0 0 17 2 1 3 4 3 1 5 1 4 11 5 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 4 0 5 2 3 25 17 10 27 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 4 11
Cytoplasm 6 4 7 5 2 9 5 13 8 10 5 5 9 26 46 1 5 4 0 0 0 33 51 52
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 5
Endosome 2 1 10 8 44 91 93 121 36 57 32 53 4 11 20 2 2 0 1 1 3 1 12 25
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 0 0 0 1 6
Mitochondria 0 8 4 5 4 25 18 32 167 93 128 87 6 7 1 17 10 12 1 1 7 5 15 29
Nucleus 72 89 98 12 59 68 78 104 128 118 142 167 22 24 25 35 37 43 39 68 56 22 44 20
Nuclear Periphery 9 14 24 1 10 9 11 20 27 20 19 23 1 2 1 1 1 0 8 5 26 6 12 19
Nucleolus 69 68 211 310 291 402 536 620 414 496 326 401 142 257 279 109 87 87 108 115 277 79 173 132
Peroxisomes 0 1 0 17 1 18 10 13 2 7 0 10 3 6 9 1 0 0 0 0 0 0 1 3
SpindlePole 0 0 18 140 86 181 206 260 86 172 71 144 32 88 73 3 0 2 3 1 12 0 24 29
Vac/Vac Membrane 7 7 17 0 6 8 23 32 15 18 17 17 1 2 4 4 4 7 8 17 17 13 33 36
Unique Cell Count 150 169 329 341 369 533 711 841 633 721 550 645 174 309 359 143 124 133 178 215 406 178 397 391
Labelled Cell Count 165 192 389 519 506 817 990 1228 915 1016 765 943 224 435 465 173 146 156 178 215 406 178 397 391


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.4 11.4 13.6 12.2 11.1 8.7 8.2 8.2 6.4 7.0 6.6 6.9 13.1 13.1 12.3 17.4 19.4 22.9 21.9 19.3 20.3
Std Deviation (1e-4) 3.6 3.1 3.3 4.0 2.7 2.1 1.7 2.0 1.8 1.7 1.9 1.8 6.6 6.9 6.6 5.6 7.1 8.7 12.0 10.8 12.1
Intensity Change (Log2) – – – -0.15 -0.29 -0.65 -0.73 -0.73 -1.09 -0.96 -1.04 -0.99 -0.06 -0.05 -0.15 0.36 0.52 0.75 0.69 0.5 0.58

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 4.1 0 0 0 0 0 0 0 0 0 3.5 0 0 0 0
Bud Site 0 0 0 0 0 3.7 2.8 0 3.8 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.6 0 -0.5 0 -0.7 -1.0 -0.9 0 0 1.9 3.6 5.3 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.6 4.4 6.2 5.0 5.5 1.8 3.0 1.9 3.1 0 0.4 1.6 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 2.7 1.4 2.3 9.7 6.1 8.9 6.2 0 1.0 0 5.2 0 0
Nucleus -9.2 -4.4 -6.2 -7.5 -7.1 -3.3 -5.0 -1.3 -1.3 -4.3 -7.1 -7.8 -1.2 0 0.5
Nuclear Periphery -4.8 -2.8 -4.2 -4.8 -4.0 -2.0 -3.4 -2.6 -2.6 -3.3 -4.2 -4.9 -2.9 -2.7 -3.2
Nucleolus 8.3 4.3 3.6 3.8 3.3 0.4 1.5 -1.4 -0.6 4.1 5.4 3.9 2.6 1.2 0.3
Peroxisomes 4.1 0 3.4 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 10.8 6.6 9.6 8.6 9.2 3.8 7.2 3.5 6.7 4.6 7.8 5.7 -1.6 0 -1.9
Vacuole -4.3 -2.6 -3.1 -1.5 -1.0 -2.3 -2.2 -1.5 -2.0 -2.6 -3.4 -3.1 -1.1 -0.9 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.5431 10.5264 9.5033 8.8931 9.7245 9.6572 10.9297 12.6156 11.8052 10.1854 10.8607 11.7281 9.3332 10.8086 10.536 10.542 9.2078 10.0475
Actin 0.0113 0.0001 0.0081 0.0004 0.0001 0.0002 0.0188 0.0002 0.0003 0.0002 0.0008 0.0001 0.0117 0.0051 0.0116 0.0001 0.0203 0.0002
Bud 0.0003 0.0001 0.0001 0.0001 0.0001 0 0.0003 0.0001 0.0001 0.0001 0.0003 0 0.0002 0.0002 0.0001 0.0001 0.0003 0.0001
Bud Neck 0.0006 0.0007 0.0007 0.0004 0.0006 0.0006 0.0005 0.0003 0.0002 0.0008 0.0009 0.0003 0.0016 0.0005 0.0002 0.0004 0.0008 0.0005
Bud Periphery 0.001 0.0005 0.0003 0.0003 0.0015 0.0005 0.0006 0.0004 0.0002 0.0005 0.0007 0.0003 0.0006 0.0006 0.0002 0.0004 0.0006 0.0004
Bud Site 0.0013 0.0004 0.0003 0.0001 0.0001 0.0001 0.0016 0.0002 0.0011 0.0001 0.0011 0.0001 0.0024 0.0009 0.0012 0.0002 0.0015 0.0001
Cell Periphery 0.0007 0.0011 0.0003 0.0002 0.0012 0.0008 0.0006 0.0004 0.0003 0.0007 0.0007 0.0005 0.0011 0.0008 0.0002 0.0002 0.0003 0.0004
Cytoplasm 0.0009 0.0001 0.0003 0.0001 0 0 0.0013 0 0.0016 0.0001 0.0004 0 0.0018 0.0001 0.0001 0 0.0005 0
Cytoplasmic Foci 0.0072 0.0005 0.009 0.0004 0.0004 0.001 0.0181 0.0007 0.0067 0.0024 0.0135 0.0004 0.0088 0.0038 0.0014 0.0036 0.0056 0.0005
Eisosomes 0.0011 0 0.0006 0 0.0001 0.0001 0.0004 0 0 0 0.0002 0.0001 0.0015 0.0001 0.0001 0 0.0002 0.0001
Endoplasmic Reticulum 0.0018 0.0001 0.0003 0.0006 0.0004 0.0001 0.0011 0 0.0009 0.0002 0.0002 0.0001 0.0005 0.0001 0 0.0001 0.0009 0.0001
Endosome 0.0095 0.0007 0.002 0.001 0.0002 0.0003 0.0089 0.0002 0.0051 0.0008 0.0025 0.0001 0.0033 0.0049 0.0003 0.0003 0.0154 0.0002
Golgi 0.004 0.0003 0.0019 0.0002 0.0002 0.0005 0.004 0.0002 0.0011 0.0009 0.0014 0.0002 0.0008 0.0024 0.0006 0.0006 0.0232 0.0003
Lipid Particles 0.0319 0.0058 0.0367 0.0033 0.0134 0.024 0.04 0.0078 0.0191 0.0521 0.0355 0.0116 0.0107 0.0112 0.004 0.0528 0.0074 0.0223
Mitochondria 0.0183 0.001 0.005 0.0006 0.0044 0.0082 0.0099 0.0043 0.001 0.001 0.0275 0.0023 0.0097 0.005 0.0019 0.0019 0.0087 0.0085
None 0.0053 0.0001 0.0025 0.0002 0.0002 0.0002 0.0058 0.0001 0.0015 0.0002 0.0012 0.0001 0.0035 0.0002 0.0002 0.0001 0.0004 0.0001
Nuclear Periphery 0.0981 0.0472 0.0734 0.2706 0.1477 0.1627 0.0829 0.0554 0.0628 0.2811 0.1919 0.1461 0.0256 0.0384 0.0019 0.0329 0.2281 0.1771
Nucleolus 0.6505 0.7964 0.7361 0.5404 0.6847 0.6547 0.6056 0.7586 0.8035 0.4861 0.4923 0.7141 0.766 0.7277 0.8508 0.7764 0.4337 0.6154
Nucleus 0.1139 0.1191 0.0955 0.1464 0.1209 0.1096 0.1042 0.1578 0.0689 0.1408 0.1577 0.1008 0.1146 0.1694 0.1183 0.1165 0.219 0.1477
Peroxisomes 0.0058 0.0001 0.0077 0.0001 0.0006 0.0002 0.0065 0.0002 0.0023 0.0004 0.0019 0.0001 0.0007 0.007 0.0035 0.0025 0.0023 0.0002
Punctate Nuclear 0.0184 0.0169 0.0141 0.0212 0.0098 0.014 0.0557 0.0058 0.0177 0.0099 0.0351 0.0068 0.0188 0.0038 0.0014 0.0072 0.015 0.0076
Vacuole 0.0042 0.0041 0.0014 0.0009 0.0032 0.0026 0.0027 0.0011 0.0015 0.0037 0.0049 0.0013 0.0049 0.0096 0.0005 0.0008 0.0013 0.0016
Vacuole Periphery 0.0138 0.0048 0.0037 0.0122 0.0102 0.0196 0.0304 0.006 0.0041 0.0177 0.0296 0.0145 0.0111 0.0081 0.0013 0.0028 0.0148 0.0165

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 44.8217 40.0678 41.1002 35.1756 52.131 46.1144 37.8316 30.9622 24.9777 48.2196
Translational Efficiency 2.9381 3.1781 2.2344 2.1049 2.2138 1.6984 2.0526 2.0586 2.0101 1.9455

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1051 735 208 1512 1970 1954 2419 1651 3021 2689 2627 3163

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 962.27 1183.84 1653.44 1770.06 1002.69 1302.17 1617.43 1955.44 988.63 1269.83 1620.28 1866.82
Standard Deviation 193.78 283.83 278.24 513.68 211.65 256.85 319.91 488.95 206.51 269.70 316.96 509.41
Intensity Change Log 2 — 0.298960 0.780957 0.879285 — 0.377042 0.689828 0.963618 — 0.339332 0.735174 0.922934

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000923 0.000933 0.000769 0.001518 0.000494 0.000558 0.001057 0.001240 0.000643 0.000661 0.001034 0.001373
Bud Neck 0.001360 0.002241 0.003068 0.010582 0.001591 0.001862 0.003373 0.006552 0.001510 0.001965 0.003349 0.008478
Bud Site 0.000316 0.000554 0.000592 0.002823 0.000279 0.000284 0.000204 0.000942 0.000292 0.000358 0.000234 0.001841
Cell Periphery 0.000067 0.000088 0.000018 0.000342 0.000051 0.000040 0.000039 0.000100 0.000057 0.000053 0.000038 0.000216
Cytoplasm 0.000667 0.000512 0.000028 0.002864 0.000666 0.000133 0.000083 0.000548 0.000667 0.000237 0.000079 0.001655
Cytoplasmic Foci 0.000422 0.000988 0.000667 0.004055 0.000447 0.000803 0.000154 0.003478 0.000439 0.000854 0.000194 0.003754
Eisosomes 0.000051 0.000078 0.000061 0.000092 0.000077 0.000084 0.000099 0.000114 0.000068 0.000083 0.000096 0.000103
Endoplasmic Reticulum 0.002608 0.001459 0.000660 0.000947 0.001551 0.000916 0.000694 0.000337 0.001919 0.001064 0.000691 0.000629
Endosome 0.000310 0.000347 0.000113 0.001582 0.000821 0.000588 0.000059 0.000728 0.000643 0.000522 0.000063 0.001136
Golgi 0.000377 0.000695 0.000368 0.001708 0.000267 0.000644 0.000075 0.001085 0.000305 0.000658 0.000098 0.001383
Lipid Particles 0.000994 0.000255 0.000090 0.000372 0.000137 0.000312 0.000013 0.000287 0.000435 0.000297 0.000019 0.000327
Mitochondria 0.002035 0.003959 0.002618 0.008126 0.001526 0.002490 0.002250 0.008409 0.001703 0.002892 0.002279 0.008274
Mitotic Spindle 0.001344 0.002604 0.015911 0.012910 0.001301 0.002656 0.000910 0.006083 0.001316 0.002642 0.002098 0.009346
None 0.002390 0.002619 0.000266 0.004140 0.001233 0.000968 0.000412 0.001175 0.001635 0.001419 0.000401 0.002592
Nuclear Periphery 0.010812 0.008229 0.048180 0.042133 0.011144 0.007771 0.021263 0.038937 0.011028 0.007897 0.023394 0.040465
Nuclear Periphery Foci 0.006226 0.007530 0.017082 0.010907 0.010079 0.005305 0.003510 0.015130 0.008738 0.005913 0.004584 0.013111
Nucleolus 0.513559 0.586610 0.747131 0.532871 0.601471 0.609805 0.529404 0.645166 0.570887 0.603465 0.546643 0.591486
Nucleus 0.444971 0.365678 0.133300 0.315261 0.357945 0.353293 0.420621 0.204752 0.388221 0.356679 0.397872 0.257578
Peroxisomes 0.004137 0.006435 0.023782 0.010614 0.004678 0.005276 0.003546 0.013435 0.004489 0.005593 0.005149 0.012087
Vacuole 0.001863 0.002528 0.001377 0.006981 0.001340 0.001757 0.001195 0.007268 0.001522 0.001968 0.001210 0.007131
Vacuole Periphery 0.004568 0.005658 0.003918 0.029172 0.002903 0.004454 0.011039 0.044237 0.003483 0.004783 0.010475 0.037035

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.07 0.46 -5.30 -5.46 -3.60 -2.36 -15.78 -14.69 -13.32 -3.19 -0.34 -7.98 -13.91 -15.02 -7.05
Bud Neck -3.72 -3.48 -13.56 -12.14 -9.40 -1.18 -7.46 -12.69 -11.47 -7.81 -2.62 -8.60 -18.00 -16.39 -12.59
Bud Site -1.12 -0.91 -6.18 -5.03 -4.00 -0.06 1.03 -4.75 -4.55 -5.25 -0.84 0.58 -7.50 -6.90 -7.63
Cell Periphery -0.68 3.62 -3.72 -3.34 -4.44 1.13 1.16 -3.10 -4.01 -4.08 0.43 2.25 -4.44 -4.54 -5.01
Cytoplasm 0.08 2.03 -3.29 -3.14 -4.44 1.46 1.57 0.13 -2.99 -3.29 1.42 2.17 -2.63 -4.33 -5.06
Cytoplasmic Foci -1.44 -1.35 -5.83 -4.71 -5.46 -1.26 1.71 -4.72 -4.10 -5.05 -1.77 1.63 -7.36 -6.24 -7.77
Eisosomes -4.06 -2.02 -7.52 -1.89 -4.09 -0.97 -2.29 -4.39 -4.93 -1.76 -2.69 -3.65 -6.27 -4.58 -1.06
Endoplasmic Reticulum 4.43 3.88 6.64 1.71 -0.71 5.43 7.74 11.60 9.07 7.03 7.49 11.24 10.88 4.12 -0.10
Endosome -0.33 2.41 -4.03 -3.85 -4.62 0.71 2.67 0.22 -0.45 -2.47 0.54 3.09 -1.80 -2.66 -5.22
Golgi -0.79 -0.06 -2.11 -1.44 -2.17 -1.21 3.80 -1.80 -0.79 -2.23 -1.38 2.82 -2.85 -1.61 -3.48
Lipid Particles 1.19 1.45 0.99 -0.92 -2.67 -1.07 2.64 -1.67 0.16 -3.53 0.57 1.93 0.45 -0.31 -5.84
Mitochondria -1.70 -1.84 -9.15 -3.12 -7.61 -2.36 -4.23 -11.29 -8.23 -9.97 -2.78 -3.85 -14.62 -8.76 -12.97
Mitotic Spindle -0.94 -2.89 -5.89 -4.80 0.42 -1.52 0.66 -4.24 -2.66 -4.49 -1.76 -1.35 -7.38 -5.63 -6.31
None -0.26 4.04 -1.66 -1.21 -4.18 0.76 4.45 0.17 -0.70 -5.52 0.55 5.55 -1.96 -2.15 -4.87
Nuclear Periphery 1.18 -3.69 -8.00 -8.83 0.73 2.23 -5.05 -9.02 -10.43 -5.28 2.52 -6.37 -12.03 -13.71 -5.78
Nuclear Periphery Foci -0.73 -3.16 -3.18 -1.57 1.90 4.71 7.61 -3.53 -8.00 -10.67 3.27 5.87 -4.16 -7.28 -10.29
Nucleolus -5.44 -12.08 -0.28 5.21 11.93 -1.04 8.46 -4.07 -3.08 -11.23 -4.66 3.17 -1.27 3.02 -4.06
Nucleus 6.03 22.05 9.65 2.95 -14.04 0.58 -7.41 17.85 16.87 23.27 4.59 -1.32 17.19 12.48 16.07
Peroxisomes -3.39 -7.21 -8.10 -5.02 4.68 -1.12 2.39 -10.61 -11.00 -13.76 -2.69 -1.78 -12.94 -11.98 -12.17
Vacuole -0.98 0.35 -6.29 -5.25 -5.35 -1.25 0.75 -11.07 -9.45 -11.72 -1.42 1.55 -11.61 -10.13 -12.61
Vacuole Periphery -0.75 0.58 -9.83 -9.31 -10.73 -2.13 -10.25 -15.45 -14.64 -12.10 -1.90 -9.10 -18.49 -17.52 -14.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles
Localization
Cell Percentages nucleus (20%), nucleolus (18%), mixed (38%)
Cell Cycle Regulation Yes
nucleus - MA (0.00019)
Subcompartmental Group N/A

Rrp1

Rrp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rrp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available