Standard name
Human Ortholog
Description Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.95 0.99 0.98 0.95 0.91 0.9 0.88 0.79 0.82 0.74 0.73 0.99 0.97 0.99 0.92 0.99 0.93 0.95 0.93 0.95 0.89 0.88 0.82
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.27 0.14 0.24 0.2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.08 0.1 0.1 0.07 0.1 0.07 0.14 0 0.07 0 0.08 0 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 0 1 0 0 1 1 0 0 0 0 0 0 0 2 0 1 0 3
Bud 1 0 0 1 6 2 3 3 12 11 7 6 0 0 0 0 0 0 1 0 2 1 5 3
Bud Neck 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 2 3 3 7 7 5 5 9 5 11 1 1 0 2 2 2 0 0 0 0 0 0
Cytoplasm 223 393 486 369 486 691 863 874 654 627 498 647 173 340 335 134 112 96 216 390 471 202 235 207
Endoplasmic Reticulum 1 4 2 1 2 0 1 3 1 0 2 3 0 1 1 4 6 2 0 0 0 2 2 2
Endosome 0 1 1 0 0 2 1 0 0 2 0 2 0 3 0 0 0 0 1 6 4 7 6 8
Golgi 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 1 0 1 2 3 0 2 1
Mitochondria 1 6 0 5 9 31 32 26 225 105 158 181 0 0 0 5 0 1 1 6 3 2 2 6
Nucleus 2 1 3 1 2 9 15 21 10 15 22 16 1 2 2 4 2 1 0 2 0 0 0 3
Nuclear Periphery 0 2 0 0 0 0 2 2 1 2 1 2 0 0 0 0 0 0 0 1 0 1 2 0
Nucleolus 0 0 0 0 1 0 0 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 1 0 1 3 0 0 0 1 0 0 1 0 0 0 1 0 1 2 2 2
Vac/Vac Membrane 0 13 3 10 19 59 95 99 57 80 50 124 5 25 11 12 3 8 1 2 1 0 2 5
Unique Cell Count 227 412 489 378 510 759 963 992 828 766 671 883 175 352 339 146 113 103 229 420 495 227 268 253
Labelled Cell Count 230 421 497 390 530 801 1020 1039 966 851 746 996 181 372 350 162 126 110 229 420 495 227 268 253


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.5 6.2 7.4 7.2 6.5 6.5 6.4 6.6 5.1 5.8 5.3 5.6 8.4 8.2 8.0 7.1 9.1 9.9 8.0 8.4 8.6
Std Deviation (1e-4) 1.0 0.9 1.2 1.1 1.5 1.3 1.2 1.3 1.1 0.9 1.0 1.0 1.3 1.2 1.5 1.5 1.6 2.5 1.4 1.7 2.1
Intensity Change (Log2) – – – -0.06 -0.2 -0.19 -0.21 -0.18 -0.53 -0.36 -0.48 -0.4 0.17 0.14 0.1 -0.06 0.3 0.41 0.1 0.17 0.21

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -2.2 -4.0 -6.2 -6.9 -7.5 -10.5 -9.6 -11.8 -12.2 -0.7 -3.0 -0.9 -5.3 -0.3 -4.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.5 4.1 3.6 12.7 8.6 11.5 10.7 0 0 0 0 0 0
Nucleus 0 0 0 1.5 2.2 0 2.0 3.1 1.8 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.4 3.4 5.7 6.6 6.7 5.3 6.8 5.5 8.2 0 5.2 2.9 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.1157 7.8099 6.9285 6.5048 6.3805 6.8378 9.5742 11.2047 10.5381 10.1404 9.917 10.402 8.343 9.8186 8.7906 8.4071 8.1116 8.7135
Actin 0.0306 0.0172 0.0155 0.0008 0.0004 0.0005 0.0321 0.0002 0.0171 0.0008 0.0623 0.0004 0.0043 0.0003 0.0029 0.0014 0.0179 0.0017
Bud 0.0006 0.0014 0.0026 0.0001 0.0001 0.0001 0.0006 0.0001 0.0002 0.0001 0.0006 0.0001 0.0005 0.0013 0.0002 0.0025 0.0004 0.0003
Bud Neck 0.0053 0.0005 0.0013 0.0009 0.0006 0.0015 0.0069 0.0002 0.0006 0.0004 0.0023 0.0017 0.0011 0.0004 0.0006 0.0008 0.0011 0.0016
Bud Periphery 0.0005 0.0006 0.001 0.0002 0 0 0.0004 0 0.0002 0 0.001 0 0.0004 0.0003 0.0001 0.0041 0.0006 0.0002
Bud Site 0.004 0.0008 0.0019 0.0002 0.0001 0.0001 0.0047 0.0002 0.0014 0.0001 0.0004 0.0001 0.001 0.0068 0.0003 0.0085 0.0009 0.0001
Cell Periphery 0.0002 0.0001 0.0001 0.0001 0 0 0.0002 0 0.0001 0 0.0002 0 0.0001 0.0001 0 0.0002 0 0
Cytoplasm 0.8138 0.9014 0.8521 0.9133 0.9573 0.9146 0.8195 0.9703 0.9028 0.924 0.8926 0.9194 0.8315 0.9021 0.9157 0.8297 0.7992 0.8685
Cytoplasmic Foci 0.0215 0.0051 0.0081 0.0022 0.0025 0.0051 0.0264 0.0009 0.0035 0.0016 0.0029 0.0024 0.0277 0.0019 0.0034 0.0025 0.0399 0.0043
Eisosomes 0.0008 0.0002 0.0002 0 0 0 0.0002 0 0.0001 0 0.0005 0 0 0 0 0 0.0001 0
Endoplasmic Reticulum 0.005 0.0022 0.0027 0.0018 0.003 0.0023 0.0055 0.0013 0.0027 0.0021 0.0065 0.0024 0.0034 0.0019 0.0029 0.0019 0.0025 0.0018
Endosome 0.0114 0.0087 0.005 0.0035 0.0017 0.0015 0.0138 0.0005 0.0059 0.0006 0.005 0.0013 0.0172 0.0034 0.0036 0.0028 0.0148 0.0057
Golgi 0.0042 0.0016 0.0041 0.0025 0 0.0001 0.0046 0 0.0027 0.0001 0.0036 0.0001 0.0051 0.0003 0.0011 0.0004 0.0096 0.0015
Lipid Particles 0.0044 0.0001 0.0019 0.0014 0 0 0.0069 0 0.0028 0 0.0005 0 0.0023 0.0003 0.0006 0.0003 0.0194 0.0012
Mitochondria 0.0032 0.0024 0.013 0.0282 0.0001 0.0002 0.0038 0.0001 0.0008 0.0001 0.0014 0.0001 0.0097 0.0002 0.0014 0.0023 0.0069 0.0009
None 0.0352 0.0018 0.0104 0.003 0.0085 0.0065 0.0205 0.0016 0.0043 0.0415 0.0017 0.0062 0.0102 0.0039 0.0045 0.0312 0.0059 0.0093
Nuclear Periphery 0.0053 0.0028 0.0087 0.0032 0.0044 0.003 0.0076 0.0014 0.0041 0.0027 0.0066 0.0033 0.0084 0.0027 0.0032 0.0031 0.0061 0.0041
Nucleolus 0.0008 0.0003 0.0001 0.0001 0 0 0.0008 0 0.0001 0 0.0001 0 0.0001 0.0001 0 0.0008 0.0002 0.0001
Nucleus 0.0285 0.0493 0.0604 0.0349 0.0195 0.0625 0.0324 0.0225 0.0408 0.0245 0.0088 0.0604 0.0585 0.0719 0.0543 0.0995 0.0443 0.0904
Peroxisomes 0.0136 0.0001 0.008 0.0007 0 0.0001 0.0051 0 0.0076 0.0001 0.0002 0 0.0091 0.0001 0.0028 0.0004 0.0243 0.0014
Punctate Nuclear 0.0097 0.0017 0.0019 0.0015 0.0012 0.0011 0.0067 0.0004 0.0018 0.001 0.0017 0.0016 0.0081 0.0011 0.0017 0.0019 0.0048 0.0061
Vacuole 0.0012 0.0013 0.0008 0.0009 0.0004 0.0006 0.001 0.0003 0.0005 0.0002 0.0006 0.0004 0.0009 0.0011 0.0004 0.0049 0.0007 0.0004
Vacuole Periphery 0.0003 0.0002 0.0003 0.0005 0.0001 0.0001 0.0004 0 0.0002 0.0001 0.0006 0.0001 0.0003 0.0001 0.0001 0.0008 0.0004 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 90.6644 71.2766 87.0131 87.0575 95.8744 95.1127 85.1445 82.7679 85.3845 96.0615
Translational Efficiency 2.4647 2.6111 1.7235 2.1395 2.1613 2.5653 1.8524 1.953 1.9383 1.882

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1036 670 2646 1366 1833 2276 2726 1590 2869 2946 5372 2956

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 707.50 909.18 1008.98 1203.32 754.99 953.50 1062.69 1237.49 737.84 943.42 1036.23 1221.70
Standard Deviation 84.57 122.34 129.18 170.13 98.27 118.09 147.11 184.90 96.30 120.51 141.15 179.04
Intensity Change Log 2 — 0.361836 0.512096 0.766218 — 0.336775 0.493191 0.712887 — 0.348953 0.502367 0.738933

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000078 0.000508 0.000329 0.006651 0.000080 0.000224 0.000184 0.005584 0.000079 0.000288 0.000256 0.006077
Bud Neck 0.006879 0.004418 0.004468 0.005930 0.002661 0.008732 0.005590 0.007884 0.004184 0.007750 0.005037 0.006981
Bud Site 0.004348 0.012238 0.010194 0.043371 0.002945 0.010452 0.006130 0.035024 0.003452 0.010858 0.008131 0.038882
Cell Periphery 0.000172 0.000116 0.000068 0.000331 0.000069 0.000071 0.000072 0.000095 0.000106 0.000082 0.000070 0.000204
Cytoplasm 0.599398 0.656581 0.706006 0.482440 0.687843 0.668544 0.674480 0.611533 0.655905 0.665823 0.690008 0.551878
Cytoplasmic Foci 0.222061 0.122570 0.009646 0.023072 0.070416 0.096105 0.009692 0.011403 0.125175 0.102124 0.009670 0.016795
Eisosomes 0.000129 0.000045 0.000012 0.000027 0.000028 0.000040 0.000020 0.000013 0.000065 0.000041 0.000016 0.000020
Endoplasmic Reticulum 0.001375 0.001656 0.000796 0.001510 0.000829 0.000799 0.000557 0.000547 0.001026 0.000994 0.000675 0.000992
Endosome 0.006647 0.009562 0.001461 0.018565 0.002396 0.006924 0.001189 0.004819 0.003931 0.007524 0.001323 0.011171
Golgi 0.001850 0.001905 0.000288 0.017781 0.000672 0.002124 0.000189 0.007619 0.001097 0.002075 0.000238 0.012315
Lipid Particles 0.005962 0.002949 0.000467 0.001590 0.001333 0.001636 0.000465 0.000570 0.003005 0.001935 0.000466 0.001041
Mitochondria 0.001828 0.000531 0.000831 0.006622 0.000777 0.003876 0.000724 0.003199 0.001156 0.003115 0.000777 0.004781
Mitotic Spindle 0.000079 0.002730 0.015801 0.144541 0.002096 0.009778 0.019017 0.055542 0.001367 0.008175 0.017433 0.096669
None 0.005047 0.003028 0.005089 0.009607 0.004743 0.002068 0.006144 0.010789 0.004853 0.002286 0.005624 0.010243
Nuclear Periphery 0.000208 0.000283 0.000879 0.001815 0.000300 0.000247 0.000557 0.000500 0.000267 0.000255 0.000716 0.001108
Nuclear Periphery Foci 0.000512 0.002493 0.000826 0.004408 0.000731 0.000408 0.000535 0.001373 0.000652 0.000882 0.000678 0.002776
Nucleolus 0.000548 0.000634 0.000361 0.000941 0.000490 0.000585 0.000497 0.000146 0.000511 0.000596 0.000430 0.000513
Nucleus 0.110036 0.086929 0.173092 0.129949 0.190004 0.099783 0.184737 0.185361 0.161127 0.096859 0.179001 0.159755
Peroxisomes 0.001517 0.003833 0.000882 0.001945 0.000922 0.002890 0.000572 0.004364 0.001137 0.003104 0.000725 0.003246
Vacuole 0.030445 0.086062 0.067481 0.091061 0.030295 0.083806 0.088243 0.051998 0.030349 0.084319 0.078017 0.070050
Vacuole Periphery 0.000882 0.000930 0.001022 0.007843 0.000368 0.000909 0.000408 0.001636 0.000554 0.000914 0.000711 0.004504

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.65 -2.96 -3.16 -1.93 -2.40 -5.65 -2.32 -2.09 -1.80 -1.79 -7.32 -3.75 -3.43 -2.76 -2.78
Bud Neck 2.32 2.97 3.53 1.04 1.00 -8.16 -3.33 -2.42 5.94 0.87 -5.39 -0.23 0.86 6.46 1.26
Bud Site -4.47 -3.18 -5.57 -1.12 -3.66 -6.44 -2.53 -6.21 -0.54 -4.83 -7.50 -4.50 -8.46 -1.51 -5.81
Cell Periphery 5.29 13.10 1.41 -1.49 -4.46 -0.16 3.32 -7.88 -7.04 -10.57 5.57 11.51 -1.90 -4.77 -7.29
Cytoplasm -3.79 -2.57 12.14 13.60 16.61 2.88 11.80 19.89 17.01 9.75 -0.79 7.85 23.80 23.37 18.61
Cytoplasmic Foci 12.49 35.56 35.52 20.09 0.51 -7.12 26.89 27.04 32.88 0.95 6.24 39.52 39.58 38.18 1.11
Eisosomes 10.84 15.90 15.11 8.01 -4.84 -5.93 6.22 7.60 14.13 0.91 7.46 16.39 15.77 15.47 -2.52
Endoplasmic Reticulum -1.10 1.03 1.98 5.22 3.14 0.16 0.83 1.16 0.69 1.08 0.13 0.95 2.03 1.50 3.33
Endosome -2.38 8.71 4.35 5.64 -2.54 -9.30 6.77 5.22 12.97 -0.35 -7.30 10.68 5.29 11.26 -2.47
Golgi 0.10 8.86 -0.44 -0.44 -2.54 -3.21 2.44 -0.54 1.84 -1.74 -2.62 5.91 -0.92 0.87 -3.07
Lipid Particles 2.55 8.43 7.07 1.40 -8.36 -0.67 3.33 0.62 1.22 -9.29 2.46 8.75 6.07 1.66 -12.23
Mitochondria 3.93 3.59 1.45 -1.97 -1.54 -4.11 1.05 0.05 4.16 -1.11 -3.28 3.15 0.84 3.61 -1.87
Mitotic Spindle -1.87 -9.21 -9.78 -8.56 -5.60 -4.37 -7.58 -7.12 -3.60 -0.94 -5.05 -11.05 -11.87 -7.95 -4.95
None 1.60 0.50 -3.32 -4.02 -6.02 4.36 -2.10 -7.70 -16.42 -6.31 4.72 -1.21 -7.73 -14.53 -8.94
Nuclear Periphery -2.79 -15.82 -12.72 -11.34 -1.14 0.74 -13.24 -12.77 -19.81 0.10 -0.23 -18.99 -16.91 -19.03 -0.84
Nuclear Periphery Foci -7.67 -5.18 -6.31 1.56 -4.22 2.03 0.69 -4.28 -10.31 -7.92 -2.21 -1.32 -7.01 -5.86 -7.23
Nucleolus -0.39 3.20 2.73 1.67 0.23 -0.39 1.23 3.80 2.66 4.79 -0.45 2.54 4.27 2.77 2.84
Nucleus 4.08 -20.52 -10.97 -14.02 7.53 18.12 -5.60 -6.53 -25.30 -1.70 16.89 -14.10 -9.45 -27.52 3.49
Peroxisomes -2.41 3.04 7.17 3.68 0.42 -4.94 2.63 0.79 5.05 -1.08 -5.39 3.39 2.79 6.93 -0.49
Vacuole -11.96 -23.36 -31.54 -18.30 -18.45 -16.88 -25.63 -25.91 -14.95 -7.68 -21.04 -34.07 -40.06 -24.67 -18.56
Vacuole Periphery -0.03 1.15 -0.47 -0.38 -1.07 -3.04 0.99 0.92 4.17 0.00 -2.36 0.99 -0.35 1.19 -0.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (82%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Grx3

Grx3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Grx3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available