Standard name
Human Ortholog
Description S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated unfolded protein response; regulates HAC1 mRNA translocation, splicing and translation with KIN2 during ER stress; direct phosphorylation of the substrate Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the plasma membrane; activation loop phosphorylation (T302) required for full kinase activity; orthologous to MARK/PAR-1, AMP-activated protein kinase (AMPK) family members

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.11 0.08 0.06 0
Bud 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0.08 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0.05 0.1 0.07 0 0.06 0.05 0.05 0.05 0.11 0.13 0.13 0.11 0.1 0 0 0 0 0.05 0 0 0
Cytoplasm 0.94 0.93 0.92 0.92 0.88 0.83 0.73 0.72 0.65 0.62 0.58 0.96 0.96 0.93 0.86 0.91 0.88 0.78 0.84 0.68 0.68 0.76 0.81
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0.05 0.09 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0 0 0.08 0.2 0.19 0.2 0.31 0.34 0.3 0 0 0 0.07 0 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.12 0.11 0.08 0.09 0.11 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 11 2 18 7 7 2 9 6 9 4 18 8 8 4 1 1 0 26 6 65 27 28 21
Bud 9 7 21 8 10 15 25 20 23 22 32 8 8 7 1 0 0 4 4 9 11 16 13
Bud Neck 2 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 31 8 24 27 18 10
Bud Site 0 1 1 0 1 3 1 1 1 2 1 0 0 0 0 0 0
Cell Periphery 10 1 30 33 35 22 48 42 34 22 61 45 45 30 4 0 0 7 1 30 11 9 9
Cytoplasm 367 255 544 308 461 515 581 571 430 296 334 340 340 259 36 42 15 333 248 408 232 389 418
Endoplasmic Reticulum 13 9 8 9 10 22 15 17 39 16 30 4 6 10 2 4 1 4 1 20 6 9 9
Endosome 0 0 6 2 13 5 12 6 0 7 9 0 0 0 0 0 0 5 2 11 2 4 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 1 1 2
Mitochondria 0 13 10 15 40 124 153 160 203 163 174 0 0 0 3 2 1 3 6 14 12 11 10
Nucleus 0 1 1 2 2 3 3 6 4 0 1 0 0 3 1 2 0 0 3 0 0 0 0
Nuclear Periphery 0 1 1 0 1 1 1 0 5 0 4 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 0 3 0 0 0 0 6 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 2 1 0 2 4 1 1 0 3 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 7 0 3 0 1 1 1 0 4 1 1 0 3 0 2 0 1 4 0 2 3
Vac/Vac Membrane 0 1 6 3 17 10 96 86 54 45 66 0 0 0 0 0 0 8 5 2 5 7 3
Unique Cell Count 391 275 594 335 524 619 800 789 657 474 575 355 354 278 42 46 17 428 294 602 342 509 518
Labelled Cell Count 412 292 658 388 600 724 949 923 805 577 739 407 408 313 51 51 19 428 294 602 342 509 518


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.0 5.5 5.5 5.8 6.2 5.9 6.2 6.4 5.7 5.8 6.2 7.5 7.5 7.7 5.9 5.6 7.6 7.0 7.2 7.8
Std Deviation (1e-4) 0.7 1.1 1.3 1.4 1.7 1.2 1.5 1.5 1.5 1.5 1.7 0.8 0.8 0.9 0.9 1.0 1.4 1.3 1.4 1.7
Intensity Change (Log2) 0.06 0.17 0.1 0.15 0.22 0.04 0.08 0.17 0.44 0.44 0.48 0.09 0.02 0.46 0.34 0.38 0.5


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.9 -1.9 -3.7 -2.6 -3.2 -2.0 -2.5 0.1 -0.7 -0.7 -1.4 0 0 0
Bud -1.0 -1.7 -1.1 -0.4 -1.1 0 0.9 1.7 -1.1 -1.1 -0.8 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2.8 1.2 -1.3 0.8 0.2 0.1 -0.3 3.5 4.2 4.2 3.1 0 0 0
Cytoplasm 0.2 -2.0 -4.4 -8.9 -8.9 -11.1 -11.5 -13.2 2.5 2.6 0.8 -1.3 -0.1 -0.5
Endoplasmic Reticulum 1.5 0.7 2.5 0.8 1.1 4.3 2.2 3.7 0 0.4 2.2 0 0 0
Endosome 0 1.9 -0.4 0.8 -0.5 0 0.7 0.8 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.5 4.8 10.2 10.0 10.4 13.7 14.4 13.4 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 -0.9 0 0 0 0 0 0
Vacuole 0 2.6 0.9 7.8 7.3 6.0 6.5 7.4 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.6763 3.6131 3.2294 2.8124 3.2517 3.3916 3.5901 4.5922 4.1554 3.7797 3.5354 4.3858 2.1365 3.5758 3.0248 3.0318 2.9109 3.1307
Actin 0.0548 0.011 0.039 0.0134 0.1438 0.0255 0.0145 0.0126 0.0252 0.0473 0.0225 0.0142 0.1293 0.0471 0.0236 0.023 0.1154 0.0066
Bud 0.0061 0.0051 0.0423 0.0053 0.0044 0.0015 0.0099 0.0044 0.0409 0.0319 0.0023 0.0014 0.0209 0.0009 0.0311 0.0306 0.0171 0.0011
Bud Neck 0.0146 0.0011 0.0119 0.001 0.0052 0.2063 0.0099 0.0024 0.0015 0.0014 0.0217 0.2184 0.0027 0.0039 0.0008 0.0003 0.0024 0.2389
Bud Periphery 0.0191 0.0068 0.1027 0.0118 0.009 0.0029 0.0133 0.0056 0.075 0.0921 0.0038 0.0012 0.0231 0.0005 0.0718 0.2932 0.0309 0.0016
Bud Site 0.0341 0.039 0.0287 0.0012 0.0045 0.0018 0.0376 0.0941 0.0193 0.0143 0.0046 0.0018 0.0419 0.1215 0.0033 0.0012 0.003 0.0004
Cell Periphery 0.0085 0.0023 0.0039 0.0025 0.0033 0.0018 0.0079 0.0062 0.0031 0.0044 0.0027 0.0016 0.0048 0.0028 0.002 0.0102 0.0045 0.0028
Cytoplasm 0.6293 0.8329 0.6178 0.8494 0.6165 0.6705 0.7389 0.7844 0.6881 0.6591 0.829 0.6379 0.6572 0.7483 0.6438 0.5889 0.778 0.6804
Cytoplasmic Foci 0.0221 0.0053 0.0226 0.0127 0.0276 0.0075 0.013 0.008 0.0089 0.0064 0.005 0.0132 0.0215 0.0091 0.0223 0.0038 0.0086 0.0021
Eisosomes 0.0004 0.0001 0.0003 0.0002 0.0004 0.0001 0.0005 0.0001 0.0021 0.0006 0.0001 0.0001 0.0006 0.0005 0.0002 0.0001 0.0002 0
Endoplasmic Reticulum 0.0082 0.0029 0.0039 0.0072 0.007 0.0019 0.0051 0.0025 0.003 0.0082 0.0037 0.002 0.0046 0.0028 0.0036 0.006 0.0064 0.0022
Endosome 0.0175 0.0014 0.0107 0.0113 0.0368 0.0033 0.0009 0.001 0.0024 0.0028 0.0012 0.0018 0.029 0.0006 0.0134 0.0013 0.0017 0.0009
Golgi 0.0077 0.0007 0.0075 0.0032 0.0189 0.0021 0.0007 0.0008 0.0014 0.0022 0.0009 0.0006 0.006 0.001 0.0071 0.0007 0.0019 0.0002
Lipid Particles 0.0181 0.0002 0.0073 0.0021 0.0141 0.0014 0.0006 0.0002 0.0005 0.0007 0.0002 0.0003 0.0147 0.0007 0.0159 0.0005 0.0006 0.0001
Mitochondria 0.0131 0.0003 0.0126 0.0124 0.0096 0.0007 0.0002 0.0002 0.0007 0.0009 0.0002 0.0001 0.0007 0.0001 0.0031 0.0001 0.0003 0.0003
None 0.0789 0.083 0.0706 0.0517 0.0589 0.0576 0.1425 0.0741 0.1224 0.12 0.0981 0.1021 0.009 0.0555 0.1308 0.0375 0.0266 0.0594
Nuclear Periphery 0.0115 0.0013 0.0012 0.0026 0.0139 0.004 0.0005 0.0003 0.0006 0.0012 0.0006 0.0004 0.0096 0.0007 0.0005 0.0006 0.0006 0.0011
Nucleolus 0.0013 0.0003 0.0004 0.0003 0.0004 0.0007 0.0002 0.0001 0.0002 0.0003 0.0001 0.0001 0.0003 0.0001 0.0002 0 0 0
Nucleus 0.012 0.0026 0.0016 0.0022 0.0034 0.0026 0.0011 0.0011 0.0015 0.0023 0.0014 0.0008 0.0011 0.0008 0.0006 0.0005 0.0004 0.0011
Peroxisomes 0.0161 0.0011 0.0089 0.0036 0.0136 0.0021 0.0004 0.0007 0.0008 0.0006 0.0002 0.0004 0.0036 0.0009 0.0231 0 0.0005 0.0001
Punctate Nuclear 0.0217 0.0013 0.0031 0.0022 0.0055 0.0048 0.0009 0.0004 0.0012 0.0007 0.0007 0.0011 0.018 0.0021 0.0009 0.0002 0.0004 0.0001
Vacuole 0.0037 0.0012 0.0025 0.0031 0.0018 0.0007 0.0011 0.0008 0.001 0.0023 0.001 0.0004 0.0009 0.0002 0.0015 0.0012 0.0005 0.0004
Vacuole Periphery 0.0011 0.0001 0.0006 0.0007 0.0014 0.0004 0.0001 0.0001 0.0001 0.0002 0.0001 0 0.0005 0 0.0004 0.0001 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.2108 13.2752 21.076 35.4018 22.1644 35.2066 26.3768 35.3944 37.886 34.4998
Translational Efficiency 0.7082 0.8959 0.6985 0.5924 0.6913 0.6432 0.5328 0.4343 0.5456 0.5353

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
189 997 1877 1388 1172 1653 1598 2094 1361 2650 3475 3482

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 974.24 828.21 1057.47 1050.68 722.11 817.55 924.33 962.41 757.12 821.56 996.24 997.60
Standard Deviation 145.81 116.89 129.40 184.99 126.22 108.56 111.75 133.79 155.80 111.89 138.53 162.09
Intensity Change Log 2 -0.234281 0.118268 0.108974 0.179088 0.356189 0.414433 -0.043680 0.224378 0.246978

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.014009 0.001660 0.009257 0.013339 0.008205 0.002684 0.002193 0.002397 0.009011 0.002299 0.006008 0.006759
Bud Neck 0.023194 0.037091 0.036349 0.024143 0.091113 0.074193 0.041976 0.037958 0.081681 0.060234 0.038937 0.032451
Bud Site 0.080706 0.044434 0.238093* 0.173488* 0.241618* 0.063593 0.059138 0.148936* 0.219272* 0.056385 0.155800* 0.158723*
Cell Periphery 0.001102 0.000296 0.000711 0.001714 0.008776 0.000668 0.000369 0.000459 0.007711 0.000528 0.000554 0.000959
Cytoplasm 0.294969* 0.534118* 0.545296* 0.431207* 0.434819* 0.516468* 0.694658* 0.556153* 0.415398* 0.523109* 0.613981* 0.506347*
Cytoplasmic Foci 0.065882 0.165555 0.038091 0.031904 0.113576 0.167681 0.015481 0.020587 0.106953 0.166881 0.027694 0.025098
Eisosomes 0.000271 0.000264 0.000161 0.000424 0.002050 0.000817 0.000153 0.000131 0.001803 0.000609 0.000157 0.000248
Endoplasmic Reticulum 0.003317 0.000748 0.001449 0.003317 0.004480 0.000652 0.000409 0.000609 0.004318 0.000688 0.000971 0.001689
Endosome 0.011485 0.014351 0.001908 0.007316 0.007098 0.014017 0.001686 0.004052 0.007707 0.014143 0.001806 0.005353
Golgi 0.017471 0.003326 0.000665 0.005793 0.007683 0.007031 0.000350 0.003010 0.009043 0.005637 0.000520 0.004120
Lipid Particles 0.002361 0.002363 0.000980 0.003469 0.004997 0.003166 0.000403 0.000504 0.004631 0.002864 0.000715 0.001686
Mitochondria 0.000884 0.002879 0.000260 0.003755 0.013220 0.005288 0.001016 0.002083 0.011506 0.004381 0.000608 0.002750
Mitotic Spindle 0.016306 0.003410 0.001448 0.016865 0.000635 0.004027 0.002097 0.013989 0.002811 0.003795 0.001746 0.015136
None 0.000498 0.000756 0.000966 0.001054 0.006389 0.000998 0.001041 0.002492 0.005571 0.000907 0.001001 0.001919
Nuclear Periphery 0.000300 0.000126 0.000079 0.000356 0.000073 0.000166 0.000082 0.000177 0.000105 0.000151 0.000081 0.000248
Nuclear Periphery Foci 0.002342 0.000796 0.002302 0.002648 0.000439 0.000459 0.000261 0.000423 0.000703 0.000586 0.001363 0.001310
Nucleolus 0.000115 0.000426 0.000093 0.000116 0.000310 0.000530 0.000107 0.000212 0.000283 0.000491 0.000100 0.000174
Nucleus 0.074123 0.052015 0.057150 0.076809 0.024759 0.044106 0.093920 0.039461 0.031614 0.047082 0.074059 0.054348
Peroxisomes 0.003998 0.006868 0.003139 0.003758 0.005867 0.010341 0.002046 0.001711 0.005607 0.009035 0.002637 0.002527
Vacuole 0.383881* 0.127520 0.061444 0.196430 0.021947 0.081569 0.082498 0.161834 0.072208 0.098857 0.071125 0.175624
Vacuole Periphery 0.002788 0.000997 0.000157 0.002095 0.001945 0.001544 0.000114 0.002823 0.002062 0.001339 0.000137 0.002533

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.67 -0.19 -0.20 -7.26 -0.02 4.77 5.46 5.61 2.34 0.42 5.27 2.14 3.12 -5.18 1.50
Bud Neck -3.77 -3.62 -0.14 5.60 7.39 2.69 9.96 11.99 10.83 2.47 3.98 10.00 12.64 12.23 5.59
Bud Site 1.37 -13.91 -4.26 -9.30 13.27 20.65* 22.47* 15.38* -7.19 -10.04 21.08 9.83 14.51 -11.18 6.63
Cell Periphery 1.84 0.12 -1.71 -7.72 -3.99 8.08 8.43 8.42 6.66 -0.35 8.22 8.23 8.06 -2.39 -2.68
Cytoplasm -13.05 -14.28 -4.80 14.35 17.57 -7.71 -22.53 -7.41 0.37 16.99 -11.73 -20.79 -4.51 9.17 20.84
Cytoplasmic Foci -15.51 2.20 5.29 25.71 7.67 -9.08 22.42 21.93 33.99 -1.43 -12.33 19.55 21.97 42.57 6.64
Eisosomes -0.92 1.79 -2.35 -1.60 -4.38 7.24 11.80 11.98 12.62 1.97 8.23 11.71 11.36 10.61 -2.62
Endoplasmic Reticulum 3.93 2.13 -0.90 -11.95 -7.27 7.62 7.91 7.45 -1.39 -3.86 8.11 7.03 5.61 -11.06 -5.83
Endosome -3.48 3.92 2.62 6.99 -2.41 -7.01 7.06 5.99 13.13 -2.31 -7.61 8.80 6.28 13.99 -3.43
Golgi 1.35 1.96 1.57 1.04 -1.93 0.76 13.30 7.45 5.82 -2.50 2.55 9.55 6.67 5.44 -3.00
Lipid Particles -0.94 2.82 -1.95 -1.42 -4.02 2.40 6.13 5.91 11.11 -4.42 2.66 5.87 4.50 4.99 -3.96
Mitochondria -2.53 1.40 -1.94 1.16 -2.49 4.50 7.86 7.42 4.46 -1.54 4.80 8.06 7.23 4.30 -3.19
Mitotic Spindle 0.95 1.34 -0.25 -3.00 -4.74 -3.44 -1.57 -7.24 -3.92 -5.81 -1.87 0.19 -6.56 -4.92 -7.67
None -1.83 -3.30 -3.40 -1.79 -0.21 4.21 4.24 3.39 -2.36 -2.58 4.23 4.19 3.61 -2.62 -2.62
Nuclear Periphery 5.86 6.71 -3.46 -11.41 -12.77 -1.36 -4.29 -15.24 -2.73 -14.22 -0.95 -0.62 -16.33 -5.85 -18.86
Nuclear Periphery Foci 3.89 -1.39 -0.38 -3.95 0.85 -0.17 2.05 -1.83 -0.70 -4.87 0.68 -6.36 -3.65 -3.81 1.69
Nucleolus -2.54 -0.01 -0.08 2.53 -0.09 -1.08 2.45 1.43 2.09 -1.17 -1.44 2.55 1.81 3.02 -1.25
Nucleus 2.35 0.86 -2.00 -11.46 -7.64 -9.07 -23.31 -15.59 -7.32 11.79 -6.59 -19.85 -17.08 -13.32 3.57
Peroxisomes -3.38 -0.45 0.34 4.95 1.58 -4.25 7.13 8.78 9.75 1.66 -4.47 6.19 7.72 10.83 2.87
Vacuole 15.11 17.66 5.27 -23.34 -31.93 -20.05 -22.52 -39.18 -27.18 -20.10 -2.87 -2.18 -28.73 -35.46 -36.73
Vacuole Periphery 0.62 1.69 0.78 0.36 -2.31 1.29 9.26 0.53 -0.16 -2.76 2.05 8.63 1.40 0.03 -3.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated unfolded protein response; regulates HAC1 mRNA translocation, splicing and translation with KIN2 during ER stress; direct phosphorylation of the substrate Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the plasma membrane; activation loop phosphorylation (T302) required for full kinase activity; orthologous to MARK/PAR-1, AMP-activated protein kinase (AMPK) family members
Localization
Cell Percentages cytoplasm (40%), ER (2%), mixed (45%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Kin1

Kin1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kin1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available