Standard name
Human Ortholog
Description Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and mitochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.48 0.61 0.34 0.33 0.41 0.26 0.19 0.08 0.14 0.08 0.08 0.08 0.68 0.51 0.48 0.39 0.37 0.32 0.41 0.35 0.38 0.3 0.37 0.31
Bud 0.13 0.17 0.19 0.24 0.34 0.24 0.22 0.22 0.17 0.18 0.21 0.15 0.17 0.16 0.17 0.11 0.13 0.14 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.14 0.08 0.12 0.05 0.08
Bud Site 0.07 0.07 0.2 0.21 0.13 0.12 0.09 0.07 0.11 0.12 0.07 0.1 0.14 0.06 0.11 0 0 0.08 – – – – – –
Cell Periphery 0.14 0.16 0.06 0.09 0.08 0.1 0.09 0.05 0.08 0.05 0.05 0.09 0.13 0.27 0.21 0.15 0.1 0.11 0.28 0.19 0.17 0.34 0.47 0.46
Cytoplasm 0.15 0.11 0.18 0.15 0.13 0.18 0.16 0.19 0.14 0.11 0.09 0.12 0 0.15 0.19 0.15 0.13 0.17 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.06 0.07 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.09 0 0 0 0 0 0 0
Mitochondria 0.06 0.23 0.18 0.37 0.27 0.4 0.45 0.5 0.67 0.71 0.76 0.74 0.06 0 0.11 0.05 0 0.07 0.05 0.11 0.13 0.1 0 0.05
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.22 0.1 0.11 0.24 0.21 0.15 0.15 0.1 0.1 0.14 0.09 0.09 0.25 0.17 0.15 0.12 0.11 0.17 0 0 0.09 0 0 0
SpindlePole 0.23 0.06 0.28 0.14 0.16 0.15 0.16 0.21 0.08 0.12 0.09 0.1 0.14 0.16 0.09 0.28 0.39 0.27 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 162 78 148 117 185 148 128 56 61 51 28 32 129 104 112 85 114 94 172 61 215 52 87 93
Bud 46 21 84 85 153 137 151 149 77 120 74 59 33 32 40 24 39 40 10 2 10 2 1 4
Bud Neck 0 1 19 5 4 3 5 5 0 0 1 0 1 0 1 0 12 0 32 24 47 20 10 25
Bud Site 24 9 89 74 60 68 63 48 50 80 26 37 26 13 27 9 13 24 – – – – – –
Cell Periphery 48 20 27 31 38 55 60 31 37 34 19 35 25 55 49 32 32 32 116 33 96 59 110 139
Cytoplasm 50 14 80 55 57 104 112 125 64 71 33 47 6 30 44 32 39 49 3 4 8 2 1 4
Endoplasmic Reticulum 8 11 7 5 10 8 15 5 11 7 5 9 3 4 4 11 12 17 29 6 13 5 4 8
Endosome 7 0 0 0 2 4 1 7 0 0 0 0 2 4 2 5 5 2 9 4 25 2 2 5
Golgi 5 0 0 1 1 0 0 0 0 0 0 0 1 0 0 15 29 11 1 0 4 0 0 2
Mitochondria 22 29 80 132 123 230 309 334 303 474 274 284 11 3 26 11 13 20 19 18 74 16 7 13
Nucleus 4 2 2 2 5 5 4 13 3 5 6 1 3 0 0 5 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 1 0 0 1 0 0 0
Nucleolus 1 0 1 1 2 2 1 2 0 1 1 0 0 0 0 0 1 0 0 0 0 0 0 0
Peroxisomes 76 13 48 85 95 85 101 64 44 94 34 35 48 35 36 27 33 49 13 3 48 2 2 3
SpindlePole 78 7 121 51 72 86 108 137 34 79 31 37 27 33 22 62 118 78 1 0 4 1 0 0
Vac/Vac Membrane 1 0 0 0 1 0 0 3 1 1 1 2 0 0 0 6 7 4 8 11 11 2 1 2
Unique Cell Count 341 127 440 356 454 573 682 665 450 663 360 383 189 202 235 220 306 294 421 177 568 173 234 306
Labelled Cell Count 532 205 706 644 808 935 1058 979 686 1017 533 580 315 313 363 324 467 421 421 177 568 173 234 306


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.6 6.0 4.8 4.8 5.1 4.6 4.3 4.3 3.8 3.7 3.6 3.5 6.0 6.2 5.4 9.1 9.7 9.7 6.4 6.8 7.1
Std Deviation (1e-4) 1.2 1.1 0.9 1.2 1.3 1.1 1.1 1.2 1.1 0.9 0.9 1.0 1.0 1.1 1.0 1.3 1.5 1.8 1.3 1.5 1.4
Intensity Change (Log2) – – – -0.02 0.08 -0.07 -0.18 -0.17 -0.35 -0.4 -0.41 -0.45 0.3 0.35 0.14 0.9 1.0 0.99 0.39 0.48 0.54

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 2.2 0 0 0 0 0 0 0 8.0 4.3 3.6 1.3 1.0 -0.5
Bud 0 4.9 0 0 0 0 0 0 0 -0.5 -1.0 -0.7 -2.7 -2.3 -1.9
Bud Neck 0 -3.2 0 0 0 0 0 0 0 -2.5 -3.0 -2.8 -3.1 -0.3 -3.6
Bud Site 0 -2.8 0 0 0 0 0 0 0 -1.9 -4.4 -2.9 -5.5 -6.2 -4.4
Cell Periphery 0 1.3 0 0 0 0 0 0 0 3.0 7.4 5.8 3.6 2.2 2.3
Cytoplasm -1.0 -2.3 0 -0.8 0.3 -1.6 -3.5 -3.6 -2.3 -5.0 -1.0 0.2 -1.2 -2.0 -0.5
Endoplasmic Reticulum 0 0.7 0 0 0 0 0 0 0 0 0 0 2.5 2.0 3.1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 5.5 6.6 0
Mitochondria 0 3.2 0 0 0 0 0 0 0 -4.0 -5.9 -2.4 -4.6 -5.7 -4.4
Nucleus 0 0 0 0 2.1 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 4.1 0 0 0 0 0 0 0 4.6 2.3 1.7 0.5 -0.1 2.3
SpindlePole 0 -4.2 0 0 0 0 0 0 0 -3.6 -3.1 -5.5 0.2 3.2 -0.3
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4435 5.8351 5.404 5.1995 5.2607 5.998 1.3998 2.7498 2.2529 2.59 2.0448 2.6983 6.7075 8.2146 7.3946 7.9048 7.3886 7.8054
Actin 0.2664 0.2029 0.2353 0.2706 0.2592 0.3227 0.318 0.3403 0.272 0.3175 0.4077 0.4183 0.2087 0.1732 0.2648 0.3538 0.4279 0.3397
Bud 0.0036 0.0069 0.0058 0.0033 0.013 0.0067 0.0065 0.0056 0.0055 0.0058 0.0066 0.0045 0.0031 0.0039 0.004 0.0028 0.004 0.0047
Bud Neck 0.0386 0.0184 0.1048 0.1833 0.1287 0.1249 0.0305 0.0149 0.0583 0.067 0.0295 0.0623 0.0352 0.0192 0.0829 0.1319 0.0818 0.1277
Bud Periphery 0.0223 0.0136 0.0243 0.0171 0.0763 0.042 0.0244 0.0131 0.0272 0.0606 0.0322 0.0303 0.0162 0.0105 0.0215 0.0128 0.0265 0.0364
Bud Site 0.194 0.4791 0.2706 0.106 0.0348 0.0436 0.1477 0.3715 0.1839 0.0282 0.0442 0.0172 0.2191 0.5365 0.2653 0.0926 0.0332 0.0269
Cell Periphery 0.1667 0.105 0.1608 0.2128 0.2052 0.2225 0.2168 0.0753 0.1992 0.1737 0.081 0.164 0.3058 0.1093 0.1984 0.2196 0.2586 0.2574
Cytoplasm 0.0432 0.0517 0.0396 0.0393 0.0256 0.0413 0.038 0.0159 0.034 0.0277 0.0552 0.0253 0.0356 0.0435 0.0302 0.0305 0.0418 0.0225
Cytoplasmic Foci 0.0246 0.0272 0.0301 0.0143 0.0415 0.0341 0.019 0.0225 0.0169 0.0143 0.0458 0.0297 0.0079 0.0284 0.0126 0.0162 0.0089 0.0208
Eisosomes 0.0535 0.0161 0.0343 0.0446 0.0346 0.0495 0.0936 0.0599 0.0764 0.1366 0.0685 0.0934 0.1177 0.0516 0.0796 0.0581 0.0795 0.1173
Endoplasmic Reticulum 0.0108 0.0009 0.0013 0.0025 0.0007 0.0039 0.006 0.0038 0.0043 0.0072 0.0058 0.0032 0.0018 0.0004 0.0017 0.0032 0.0017 0.0014
Endosome 0.0206 0.0049 0.0022 0.008 0.0042 0.0064 0.0115 0.0019 0.0059 0.0029 0.0092 0.0093 0.0006 0.0003 0.0012 0.0008 0.0018 0.0009
Golgi 0.0199 0.0086 0.0062 0.0165 0.0196 0.0126 0.0157 0.0074 0.0123 0.0128 0.0192 0.0176 0.0029 0.0017 0.0038 0.0071 0.0111 0.0055
Lipid Particles 0.0251 0.0054 0.0134 0.0328 0.0102 0.0082 0.0145 0.0075 0.0036 0.0164 0.0128 0.0238 0.006 0.0014 0.0038 0.0073 0.0091 0.0031
Mitochondria 0.0209 0.0044 0.0381 0.0088 0.12 0.0285 0.0265 0.0199 0.0423 0.0785 0.1115 0.0537 0.0153 0.0026 0.0085 0.0242 0.0044 0.0126
None 0.0048 0.011 0.001 0.0197 0.0012 0.0013 0.0034 0.0017 0.0026 0.0032 0.0039 0.0033 0.002 0.0009 0.0011 0.0016 0.0011 0.0016
Nuclear Periphery 0.0292 0.0002 0.0002 0.0004 0.0001 0.0044 0.0005 0.0003 0.0027 0.0004 0.004 0.0041 0.0002 0.0001 0.0001 0.0002 0.0002 0.0001
Nucleolus 0.0012 0.0007 0.0006 0.0006 0.0004 0.0007 0.001 0.0004 0.0007 0.0008 0.0011 0.0005 0.0003 0.0004 0.0004 0.0005 0.0006 0.0004
Nucleus 0.006 0.0004 0.0004 0.0004 0.0003 0.0013 0.0008 0.0003 0.0009 0.0004 0.0017 0.0009 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003
Peroxisomes 0.0334 0.0404 0.0278 0.0159 0.0218 0.0395 0.0196 0.0364 0.0472 0.0424 0.0532 0.0348 0.0192 0.0146 0.0179 0.0346 0.0048 0.0185
Punctate Nuclear 0.0045 0.0005 0.0003 0.0005 0.0003 0.0004 0.0005 0.0003 0.0003 0.0003 0.0005 0.0012 0.0002 0.0002 0.0002 0.0003 0.0002 0.0001
Vacuole 0.0071 0.0017 0.0026 0.002 0.0017 0.004 0.005 0.001 0.0034 0.0028 0.0034 0.0021 0.0019 0.0011 0.0015 0.0014 0.0023 0.0017
Vacuole Periphery 0.0036 0.0001 0.0003 0.0005 0.0005 0.0016 0.0005 0.0001 0.0007 0.0006 0.0031 0.0005 0.0001 0.0001 0.0001 0.0001 0.0002 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 77.0657 99.2715 93.2778 81.0947 67.9137 69.6684 120.7806 119.5336 96.1816 89.3559
Translational Efficiency 0.2533 0.2636 0.2507 0.2314 0.2092 0.2808 0.2214 0.2008 0.2199 0.2231

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1637 586 1227 816 1071 2058 1033 750 2708 2644 2260 1566

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 582.52 823.22 1080.11 1026.14 714.97 792.23 983.62 1147.22 634.90 799.10 1036.01 1084.13
Standard Deviation 78.29 106.38 141.23 132.40 86.92 111.80 123.79 149.42 104.34 111.37 141.93 153.25
Intensity Change Log 2 — 0.498970 0.890799 0.816848 — 0.148037 0.460218 0.682187 — 0.316213 0.669531 0.744204

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.069587 0.337119 0.704684 0.525275 0.259262 0.365898 0.532392 0.460689 0.144603 0.359520 0.625933 0.494343
Bud Neck 0.150150 0.074210 0.012389 0.025201 0.096862 0.078237 0.028445 0.040297 0.129075 0.077344 0.019727 0.032431
Bud Site 0.081932 0.196011 0.112825 0.151876 0.197270 0.120063 0.116096 0.042994 0.127548 0.136896 0.114320 0.099730
Cell Periphery 0.025028 0.081511 0.046463 0.187798 0.094033 0.069392 0.196158 0.136055 0.052319 0.072078 0.114885 0.163017
Cytoplasm 0.137019 0.068987 0.017749 0.009614 0.059087 0.070499 0.012772 0.015578 0.106197 0.070164 0.015474 0.012470
Cytoplasmic Foci 0.273145 0.076840 0.010704 0.002660 0.145302 0.083054 0.009115 0.043178 0.222584 0.081677 0.009978 0.022065
Eisosomes 0.024055 0.021975 0.044572 0.069914 0.032912 0.053136 0.089922 0.043593 0.027558 0.046230 0.065300 0.057308
Endoplasmic Reticulum 0.003459 0.001574 0.020183 0.003815 0.002472 0.001650 0.003172 0.000295 0.003069 0.001633 0.012407 0.002129
Endosome 0.010701 0.012356 0.001700 0.004469 0.008158 0.008827 0.000494 0.023445 0.009696 0.009609 0.001149 0.013557
Golgi 0.018177 0.030856 0.003123 0.003317 0.019017 0.019305 0.001294 0.033966 0.018509 0.021865 0.002287 0.017996
Lipid Particles 0.024395 0.008745 0.006173 0.001380 0.007522 0.008167 0.001247 0.062097 0.017722 0.008295 0.003921 0.030459
Mitochondria 0.033114 0.009320 0.000268 0.003322 0.013913 0.017050 0.000864 0.008712 0.025520 0.015337 0.000541 0.005903
Mitotic Spindle 0.000314 0.000931 0.000213 0.001474 0.000316 0.000641 0.000151 0.000245 0.000315 0.000705 0.000185 0.000885
None 0.005907 0.000196 0.000059 0.000060 0.000707 0.000426 0.000169 0.000186 0.003851 0.000375 0.000109 0.000121
Nuclear Periphery 0.000082 0.000014 0.000024 0.000192 0.000019 0.000015 0.000016 0.000006 0.000058 0.000015 0.000021 0.000103
Nuclear Periphery Foci 0.000217 0.000222 0.000444 0.000347 0.000181 0.000092 0.000149 0.000033 0.000203 0.000121 0.000309 0.000196
Nucleolus 0.000464 0.000024 0.000006 0.000071 0.000040 0.000040 0.000004 0.000018 0.000296 0.000037 0.000005 0.000046
Nucleus 0.017103 0.001248 0.002758 0.000458 0.001339 0.001773 0.001016 0.000490 0.010868 0.001657 0.001961 0.000473
Peroxisomes 0.120166 0.074886 0.008127 0.003146 0.059627 0.099479 0.004189 0.087218 0.096223 0.094028 0.006327 0.043410
Vacuole 0.003935 0.002627 0.007504 0.004027 0.001596 0.001490 0.002312 0.000755 0.003010 0.001742 0.005131 0.002460
Vacuole Periphery 0.001051 0.000349 0.000034 0.001585 0.000364 0.000766 0.000023 0.000150 0.000779 0.000673 0.000029 0.000898

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -19.40 -68.22 -35.81 -10.48 11.98 -9.40 -19.91 -12.72 -6.32 4.27 -27.66 -58.25 -34.82 -12.30 11.56
Bud Neck 9.32 23.54 20.81 8.26 -6.97 3.19 12.94 9.45 8.05 -2.95 10.54 26.28 21.77 13.38 -5.92
Bud Site -10.62 -4.97 -8.53 3.54 -4.40 9.19 8.74 18.36 13.40 10.50 -1.71 2.40 4.66 6.22 2.51
Cell Periphery -7.88 -6.27 -19.32 -9.89 -16.26 4.21 -11.54 -4.07 -6.92 5.15 -5.27 -13.44 -16.86 -13.37 -6.56
Cytoplasm 9.48 23.61 25.73 10.65 3.79 -2.54 11.91 10.60 16.76 -1.23 8.88 26.06 26.84 21.61 1.92
Cytoplasmic Foci 18.72 32.67 34.07 10.71 5.39 7.17 17.28 11.54 6.79 -7.42 20.90 36.07 32.41 14.67 -5.05
Eisosomes 0.71 -6.33 -10.73 -10.41 -5.26 -6.03 -12.51 -2.72 2.45 9.32 -7.94 -13.75 -10.24 -3.45 2.27
Endoplasmic Reticulum 2.49 -8.24 -0.37 -2.93 8.03 1.42 -1.06 4.66 3.85 5.91 2.64 -8.01 1.54 -1.07 9.02
Endosome -0.92 10.03 4.34 4.03 -2.37 -0.53 7.89 -5.11 -4.94 -8.09 0.08 12.90 -2.38 -2.36 -8.23
Golgi -3.41 11.85 9.53 7.47 -0.17 -0.13 9.64 -3.72 -3.87 -9.07 -2.12 15.43 0.24 1.75 -8.40
Lipid Particles 5.67 8.92 12.59 3.38 4.11 -0.52 6.68 -9.14 -9.04 -10.30 6.80 10.85 -4.01 -7.25 -8.83
Mitochondria 8.37 15.74 13.06 2.81 -3.31 -1.62 8.82 2.35 3.91 -4.55 5.71 17.78 11.66 6.50 -5.60
Mitotic Spindle -1.04 1.58 -1.84 -0.62 -1.99 -1.63 5.99 0.78 1.82 -1.09 -1.91 3.52 -1.72 -0.45 -2.10
None 5.20 5.32 5.32 3.43 -0.01 2.01 4.18 3.88 3.31 -0.37 5.20 5.60 5.58 5.05 -0.46
Nuclear Periphery 4.19 3.41 -0.65 -1.06 -0.99 1.57 1.25 6.26 4.97 9.28 4.30 3.58 -0.51 -1.01 -0.93
Nuclear Periphery Foci -0.13 -3.12 -0.53 -0.45 0.49 4.11 0.95 7.47 5.65 4.39 2.79 -2.55 0.06 -0.58 0.97
Nucleolus 4.88 5.08 3.85 -0.95 -1.32 -0.23 6.92 3.76 2.74 -5.76 4.70 5.32 4.16 -0.30 -1.58
Nucleus 8.77 7.80 9.47 2.07 5.31 -2.01 1.33 4.16 5.33 2.04 8.45 7.96 9.65 6.34 5.65
Peroxisomes 6.03 24.26 25.49 11.88 4.02 -7.60 15.20 -3.93 1.72 -13.68 0.47 28.21 11.96 11.23 -11.73
Vacuole 1.45 -3.61 -0.12 -1.13 2.92 0.27 -1.43 2.16 3.06 3.56 3.71 -3.65 0.96 -1.35 3.83
Vacuole Periphery 2.58 3.87 -0.73 -1.79 -2.25 -1.70 4.44 2.44 2.71 -2.81 0.44 4.64 -0.30 -0.56 -2.41
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and mitochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
Localization
Cell Percentages peroxisome (18%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Num1

Num1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Num1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available