Standard name
Human Ortholog
Description Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.07 0.14 0 0 0 0 0 0 0 0 0 0 0.11 0.07 0.07 0.17 0.15 0 0.08 0.11 0.07 0.05 0.05 0
Bud 0 0 0 0 0.07 0.1 0.11 0.07 0.09 0.08 0.09 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0.06 0 0 0 0 0 0.06 0.05 0 0.06 0.06 0.16 0.08 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.05 0 0.08 0.1 0.09 0.06 0 0.07 0 0 0.06 0 0.05 0.06 0.09 0 0.07 0 0.15 0.12 0.11 0.12 0.09 0.08
Golgi 0.26 0.33 0.26 0.08 0.08 0 0 0 0 0 0 0 0.78 0.74 0.68 0.68 0.68 0.68 0.59 0.59 0.57 0.64 0.7 0.72
Mitochondria 0.85 0.79 0.68 0.7 0.71 0.8 0.76 0.73 0.78 0.75 0.77 0.8 0.35 0.11 0.22 0.06 0.08 0.1 0 0.06 0 0 0 0.05
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.14 0.14 0.11 0.09 0.07 0.08 0.11 0.14 0.1 0.12 0.14 0.14 0.06 0.06 0.06 0.05 0.11 0.11 0 0 0 0 0 0
Peroxisomes 0 0 0.1 0.15 0.09 0.14 0.14 0.1 0.08 0.1 0.11 0 0 0 0 0 0 0 0.07 0 0.11 0 0 0
SpindlePole 0 0 0 0.05 0 0.05 0.05 0.07 0.07 0.07 0.08 0.05 0 0.05 0.06 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0.07 0 0 0 0 0 0 0 0 0 0 0 0.09 0.08 0.07 0.09 0.11 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 15 15 7 6 7 8 7 11 12 2 0 8 25 21 17 35 23 5 20 13 20 9 9 11
Bud 2 1 4 5 12 29 42 29 33 28 22 15 2 2 4 2 3 2 1 0 1 1 2 2
Bud Neck 0 0 0 0 0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0
Bud Site 1 0 0 1 3 4 11 14 11 18 9 10 0 0 0 0 1 0 – – – – – –
Cell Periphery 0 0 4 1 0 3 3 0 1 2 0 0 1 0 2 0 1 0 0 0 0 0 0 0
Cytoplasm 4 1 7 12 10 10 16 17 9 16 14 12 4 17 13 32 12 11 0 0 2 2 2 3
Endoplasmic Reticulum 2 3 1 0 0 1 1 2 3 0 0 1 4 0 1 4 4 1 0 0 1 0 1 2
Endosome 11 3 19 23 17 17 12 29 15 11 14 4 12 18 22 4 11 5 39 14 31 24 18 23
Golgi 58 35 62 18 14 5 1 2 7 2 1 3 175 213 158 137 101 82 152 73 158 127 140 194
Mitochondria 192 85 160 155 127 238 279 322 283 269 183 207 78 33 51 13 12 12 10 7 11 7 8 12
Nucleus 0 2 0 0 1 3 2 3 1 3 0 2 0 0 0 2 0 0 0 0 1 2 1 0
Nuclear Periphery 0 1 2 0 0 0 3 0 3 2 2 2 1 0 0 0 1 0 0 0 0 0 0 1
Nucleolus 31 15 26 19 13 25 39 60 37 45 34 37 14 16 13 10 16 13 1 2 2 0 0 0
Peroxisomes 1 1 23 33 17 41 50 44 28 36 26 10 4 1 3 2 0 0 17 2 31 8 5 9
SpindlePole 1 0 7 11 5 14 19 29 25 25 19 13 6 15 15 5 3 3 4 2 8 2 1 0
Vac/Vac Membrane 16 7 8 2 5 1 11 11 6 5 3 5 10 25 19 15 14 13 4 4 4 8 5 5
Unique Cell Count 226 107 236 220 180 297 366 439 362 361 239 258 223 289 233 202 149 120 256 125 279 199 200 271
Labelled Cell Count 334 169 330 286 231 399 496 573 474 465 327 330 336 362 318 261 202 147 256 125 279 199 200 271


Late Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.3 15.0 13.0 11.8 11.0 9.1 8.4 8.2 7.9 7.6 7.1 7.0 14.8 14.7 13.6 18.4 16.4 16.9 15.6 15.7 17.1
Std Deviation (1e-4) 2.4 3.0 2.3 2.1 2.2 1.9 2.0 1.7 1.6 1.7 1.9 1.6 2.5 2.8 2.5 5.4 4.1 3.9 3.4 3.1 3.5
Intensity Change (Log2) – – – -0.14 -0.24 -0.52 -0.63 -0.67 -0.72 -0.78 -0.87 -0.89 0.19 0.18 0.06 0.5 0.33 0.38 0.26 0.27 0.4


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.2 0.5 -0.2 -0.8 -0.4 0.2 0 0 0.1 3.5 2.2 2.1 5.1 4.4 0
Bud 0 2.6 3.8 4.4 2.8 3.7 3.2 3.6 2.4 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 3.5 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.3 1.3 0.3 0.9 0.6 -0.4 0.9 1.5 1.0 -0.8 1.6 1.4 4.7 2.2 2.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.9 0.5 -1.1 -2.6 -0.7 -2.0 -2.7 -0.9 -3.4 -1.1 -0.8 0.5 -2.8 -0.2 -1.4
Golgi -5.1 -4.8 -8.5 -10.2 -10.9 -9.1 -9.9 -8.3 -8.2 11.2 10.8 9.0 8.7 8.0 7.6
Mitochondria 0.6 0.6 3.3 2.3 1.5 2.8 1.8 2.1 3.2 -7.0 -13.3 -10.0 -13.1 -11.5 -10.3
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -0.9 -1.3 -1.0 -0.1 1.0 -0.3 0.5 1.1 1.1 -1.8 -2.3 -2.1 -2.3 -0.1 -0.1
Peroxisomes 1.7 -0.1 1.4 1.4 0.1 -0.9 0.1 0.4 -2.6 -3.6 -5.1 -4.0 -3.9 -3.9 -3.5
SpindlePole 1.1 -0.1 1.0 1.3 2.0 2.1 2.1 2.4 1.2 -0.2 1.3 1.8 -0.3 0 0
Vacuole 0 -0.4 0 -0.3 -0.7 -1.4 -1.6 -1.5 -1.0 0.6 2.5 2.2 1.9 2.5 2.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.6659 10.4907 9.5248 9.0659 8.8749 10.1115 8.8819 11.8431 11.1741 10.8112 11.6822 10.9095 9.1757 11.5133 9.6588 9.1718 9.912 10.6174
Actin 0.0675 0.0253 0.064 0.0072 0.0279 0.0461 0.0372 0.022 0.0272 0.0794 0.0002 0.0378 0.0523 0.0274 0.0257 0.0018 0.0123 0.0174
Bud 0.0005 0.0002 0.0006 0.0004 0.0002 0.0003 0.0007 0.0012 0.0007 0.007 0 0.0002 0.0003 0.0004 0.0003 0.0001 0 0.0004
Bud Neck 0.0009 0.0004 0.0022 0.0003 0.0003 0.0004 0.0009 0.0008 0.0011 0.0019 0.0001 0.0008 0.0006 0.0005 0.0005 0.0003 0.0002 0.0004
Bud Periphery 0.0006 0.0001 0.0007 0.0006 0.0002 0.0003 0.001 0.001 0.0008 0.0066 0 0.0001 0.0003 0.0003 0.0003 0.0001 0 0.0004
Bud Site 0.0011 0.0005 0.0027 0.0005 0.0006 0.0003 0.0015 0.0076 0.0019 0.0126 0 0.0002 0.0006 0.0012 0.0008 0.0001 0.0001 0.0004
Cell Periphery 0.0002 0 0.0002 0.0001 0.0001 0.0001 0.0002 0.0004 0.0003 0.0003 0 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001
Cytoplasm 0.0044 0.001 0.0025 0.0006 0.0011 0.0005 0.0025 0.0019 0.0037 0.0024 0.0004 0.0008 0.003 0.0008 0.0008 0.0007 0.0004 0.0013
Cytoplasmic Foci 0.0742 0.0811 0.0627 0.0457 0.062 0.0391 0.0864 0.0704 0.0653 0.0787 0.0366 0.0514 0.0865 0.075 0.0765 0.0521 0.0627 0.0552
Eisosomes 0.0003 0 0.0004 0.0001 0.0001 0.0001 0.0004 0.0001 0.0001 0.0003 0 0.0001 0.0002 0.0001 0.0001 0 0 0.0001
Endoplasmic Reticulum 0.0023 0.0002 0.0007 0.0004 0.0008 0.0003 0.0032 0.0004 0.001 0.0006 0.0002 0.0003 0.0021 0.0002 0.0004 0.0004 0.0002 0.0006
Endosome 0.1575 0.138 0.1405 0.269 0.159 0.1 0.174 0.197 0.1766 0.3213 0.2518 0.1418 0.151 0.1506 0.1447 0.2377 0.1238 0.123
Golgi 0.5623 0.7161 0.6016 0.5573 0.6251 0.7117 0.5157 0.6205 0.5866 0.3791 0.683 0.7332 0.5737 0.6796 0.6763 0.6326 0.6579 0.7089
Lipid Particles 0.0299 0.0046 0.0172 0.0186 0.0403 0.0191 0.0468 0.0281 0.0303 0.0577 0.0172 0.0108 0.0196 0.0173 0.0184 0.0498 0.1163 0.0229
Mitochondria 0.0542 0.0085 0.0497 0.0445 0.0461 0.0459 0.0933 0.022 0.0548 0.0147 0.0025 0.0104 0.036 0.028 0.023 0.0104 0.005 0.0357
None 0.0029 0 0.0036 0 0.0006 0.0001 0.0013 0.0001 0.0006 0.0002 0 0 0.0075 0 0.0004 0 0.0001 0.0001
Nuclear Periphery 0.0049 0 0.0012 0.0002 0.0007 0.01 0.0054 0.0003 0.0052 0.0008 0.0001 0.0002 0.0255 0.0001 0.0002 0.0002 0.0001 0.0036
Nucleolus 0.0002 0 0.0009 0.0001 0.0002 0 0.0016 0.0054 0.0008 0.0002 0 0 0.0005 0.0002 0.0001 0.0001 0.0001 0.0002
Nucleus 0.003 0 0.0012 0.0001 0.0002 0.0002 0.0016 0.0006 0.0055 0.0003 0 0.0001 0.0043 0.0001 0.0001 0.0001 0 0.003
Peroxisomes 0.0223 0.0221 0.0378 0.0431 0.0284 0.0232 0.0153 0.01 0.0211 0.0192 0.0018 0.0035 0.0199 0.0119 0.0274 0.004 0.0187 0.0226
Punctate Nuclear 0.006 0.0001 0.0061 0.0001 0.0016 0.0002 0.0028 0.0002 0.0024 0.001 0 0.0002 0.0089 0.0002 0.0015 0.0001 0.0004 0.0008
Vacuole 0.0021 0.0008 0.0017 0.0067 0.002 0.0006 0.004 0.0067 0.0086 0.0078 0.0023 0.0033 0.003 0.0023 0.001 0.0032 0.0005 0.0012
Vacuole Periphery 0.0026 0.0008 0.0019 0.0045 0.0024 0.0014 0.0044 0.0036 0.0054 0.008 0.0035 0.0047 0.0037 0.0037 0.0016 0.0061 0.0011 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.9234 29.5274 23.6872 33.7655 27.7789 27.6591 29.25 33.4929 28.712 29.4262
Translational Efficiency 2.2022 2.2351 2.4907 1.4944 2.0508 2.5659 2.0449 1.6288 1.8471 1.8707

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
142 223 1671 563 1922 1930 388 1268 2064 2153 2059 1831

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1350.52 1337.19 1445.05 1575.52 1201.55 1269.57 1567.50 1532.57 1211.80 1276.57 1468.12 1545.78
Standard Deviation 202.60 226.07 201.94 238.95 191.74 191.93 180.52 250.15 196.17 196.83 203.79 247.55
Intensity Change Log 2 — -0.014311 0.097604 0.222313 — 0.079443 0.383569 0.351056 — 0.030590 0.239317 0.284360

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.012684 0.012173 0.034821 0.039182 0.008073 0.011963 0.019229 0.024586 0.008390 0.011985 0.031883 0.029074
Bud Neck 0.002035 0.001583 0.002582 0.003481 0.000922 0.001048 0.006790 0.002627 0.000999 0.001104 0.003375 0.002889
Bud Site 0.007063 0.004348 0.004342 0.044697 0.003017 0.003566 0.011954 0.038726 0.003296 0.003647 0.005777 0.040562
Cell Periphery 0.000489 0.000192 0.000169 0.000566 0.000159 0.000206 0.000184 0.000387 0.000182 0.000205 0.000172 0.000442
Cytoplasm 0.000915 0.002093 0.001216 0.008024 0.001143 0.002267 0.001237 0.012322 0.001128 0.002249 0.001220 0.011001
Cytoplasmic Foci 0.141160 0.156907 0.159751 0.079284 0.196016* 0.158851 0.209124* 0.122568 0.192242* 0.158650 0.169055 0.109259
Eisosomes 0.000226 0.000134 0.000192 0.000159 0.000105 0.000134 0.000081 0.000100 0.000113 0.000134 0.000171 0.000118
Endoplasmic Reticulum 0.002897 0.001300 0.001306 0.002071 0.000937 0.000955 0.001095 0.001086 0.001072 0.000991 0.001267 0.001389
Endosome 0.139828 0.149463 0.103530 0.117463 0.105867 0.123727 0.168325 0.131826 0.108203 0.126393 0.115740 0.127409
Golgi 0.573218* 0.528837* 0.525201* 0.598671* 0.458946* 0.501170* 0.421667* 0.551546* 0.466808* 0.504035* 0.505691* 0.566036*
Lipid Particles 0.004569 0.027162 0.065699 0.010200 0.020250 0.017800 0.022971 0.005960 0.019172 0.018770 0.057647 0.007264
Mitochondria 0.070476 0.064787 0.048553 0.008722 0.166584* 0.130221* 0.012407 0.015526 0.159972* 0.123443* 0.041741 0.013434
Mitotic Spindle 0.005919 0.005484 0.009048 0.015116 0.005809 0.005550 0.050184 0.022676 0.005816 0.005544 0.016799 0.020352
None 0.000109 0.000122 0.000157 0.000100 0.000203 0.000164 0.000072 0.000095 0.000196 0.000160 0.000141 0.000096
Nuclear Periphery 0.000211 0.000357 0.001341 0.000295 0.000400 0.000347 0.001185 0.000159 0.000387 0.000348 0.001312 0.000201
Nuclear Periphery Foci 0.000652 0.000801 0.001564 0.001656 0.001007 0.001260 0.004991 0.000880 0.000983 0.001213 0.002210 0.001119
Nucleolus 0.000028 0.000047 0.000083 0.000038 0.000065 0.000139 0.000225 0.000054 0.000063 0.000130 0.000109 0.000049
Nucleus 0.000038 0.000050 0.000050 0.000075 0.000062 0.000135 0.000103 0.000070 0.000060 0.000126 0.000060 0.000072
Peroxisomes 0.006880 0.014969 0.007141 0.008994 0.005280 0.007850 0.010183 0.011387 0.005390 0.008587 0.007714 0.010652
Vacuole 0.017826 0.015134 0.018390 0.043532 0.011463 0.016190 0.043927 0.042095 0.011900 0.016080 0.023203 0.042537
Vacuole Periphery 0.012774 0.014056 0.014864 0.017673 0.013692 0.016454 0.014065 0.015323 0.013628 0.016206 0.014714 0.016046

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.09 -4.04 -3.69 -4.73 -0.74 -2.84 -2.68 -6.02 -4.48 -1.09 -2.74 -10.15 -8.03 -6.53 0.89
Bud Neck 0.78 -1.07 -2.57 -3.92 -2.16 -0.85 -5.86 -6.59 -5.96 3.84 -0.73 -8.15 -8.38 -7.71 0.82
Bud Site 0.97 1.01 -7.29 -8.71 -8.83 -1.15 -4.62 -13.59 -13.44 -8.45 -0.74 -3.90 -16.13 -16.09 -14.91
Cell Periphery 1.12 1.20 -0.31 -7.46 -8.45 -3.37 -1.62 -8.77 -6.79 -7.29 -1.03 0.45 -8.79 -9.78 -11.65
Cytoplasm -2.02 -1.36 -5.41 -4.32 -5.22 -1.81 -0.77 -8.98 -7.34 -8.91 -1.99 -0.74 -10.36 -8.09 -10.25
Cytoplasmic Foci -1.16 -1.71 5.54 8.03 15.34 7.81 -1.48 13.75 7.05 9.42 7.44 5.03 18.12 11.48 13.63
Eisosomes 0.81 0.30 0.59 -0.86 1.32 -4.11 3.21 0.80 4.02 -2.03 -2.03 -5.46 -0.33 1.62 5.01
Endoplasmic Reticulum 1.07 1.10 0.56 -1.37 -1.73 -0.21 -1.13 -0.97 -0.74 0.06 0.53 -1.04 -1.63 -2.15 -0.53
Endosome -0.63 3.01 1.82 2.96 -2.37 -4.57 -8.70 -5.94 -1.73 4.95 -4.78 -1.99 -4.92 -0.13 -2.86
Golgi 1.51 1.99 -0.65 -2.82 -4.59 -5.06 2.56 -8.36 -4.14 -7.50 -4.63 -4.58 -10.18 -5.98 -5.75
Lipid Particles -3.92 -16.76 -3.00 2.79 14.14 1.16 -0.83 8.53 7.09 5.23 0.21 -11.90 7.38 6.90 16.70
Mitochondria 0.32 1.57 4.52 5.00 10.94 4.66 24.13 24.42 21.29 -1.00 4.98 19.01 25.37 22.43 9.49
Mitotic Spindle 0.15 -1.20 -2.99 -3.82 -2.63 0.24 -6.17 -7.84 -7.77 3.57 0.27 -6.28 -8.54 -8.49 -1.95
None -0.74 -2.84 0.47 1.41 4.15 3.28 11.54 9.51 6.81 -2.52 3.34 4.29 9.95 7.27 4.08
Nuclear Periphery -1.55 -5.41 -1.01 0.45 4.80 0.48 -3.85 2.74 2.65 5.41 0.38 -5.04 2.16 2.13 6.51
Nuclear Periphery Foci -0.47 -2.78 -1.82 -1.65 -0.35 -0.47 -2.55 0.22 0.69 2.64 -0.47 -2.80 -0.61 0.04 2.58
Nucleolus -1.11 -2.40 -1.29 0.22 1.75 -1.45 -1.63 0.05 1.48 1.64 -1.46 -1.67 0.28 1.60 1.94
Nucleus -0.86 -1.44 -2.98 -1.95 -2.28 -1.02 -1.45 -1.48 0.21 -0.33 -1.02 -0.11 -1.75 0.27 -1.73
Peroxisomes -1.68 -0.12 -0.78 1.31 -1.06 -2.65 -3.26 -5.14 -2.66 -0.66 -3.21 -2.92 -5.15 -1.69 -2.72
Vacuole 0.55 -0.17 -4.85 -6.23 -6.41 -3.65 -8.23 -12.54 -10.32 -0.03 -3.37 -8.21 -14.44 -12.12 -8.75
Vacuole Periphery -0.33 -0.82 -1.62 -1.01 -1.42 -2.61 -0.24 -1.47 0.93 -0.77 -2.51 -1.15 -2.31 0.16 -1.21
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Ent5

Ent5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ent5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available