Standard name
Human Ortholog
Description mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.07 0.06 0.06 0.07 0.08 0.06 0.06 0.05 – 0 0.05 0.12 0.21 0.2 0.2 0.16 0.14 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0.07 0.06 0 0 0 0 0 0
Endosome 0.33 0.16 0.08 0 0.11 0 0 0 0 – 0 0 0.2 0.25 0.07 0.27 0.28 0.32 0.18 0.21 0.2 0.15 0.21 0.22
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0.29 0.67 0.75 0.62 0.83 0.8 0.87 0.89 – 0.89 0.9 0.42 0.24 0.45 0.1 0.13 0.12 0.05 0.08 0.09 0.11 0.09 0.09
Nucleus 0 0 0 0 0 0.08 0.05 0.06 0 – 0.06 0 0 0 0 0.05 0.07 0.07 0 0 0 0 0 0
Nuclear Periphery 0.57 0.34 0.28 0.25 0.23 0.15 0.23 0.1 0.18 – 0.17 0.19 0.34 0.29 0.22 0.23 0.22 0.3 0.66 0.48 0.51 0.47 0.46 0.48
Nucleolus 0.09 0 0 0 0 0 0.06 0.05 0.05 – 0.07 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0.11 0.1 0 0.05 0.05 0.07 0.07 0.05
Vac/Vac Membrane 0.43 0.41 0.12 0.13 0.14 0.08 0.06 0 0 – 0 0 0.19 0.17 0.21 0.34 0.29 0.24 0 0 0 0.06 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 1 3 5 2 1 6 6
Bud 0 2 2 2 7 7 5 6 14 – 15 16 1 1 5 1 5 1 0 2 2 3 4 8
Bud Neck 0 0 1 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 1 0 1 2 4
Bud Site 0 0 0 1 3 2 10 8 12 – 7 12 0 1 3 0 0 1 – – – – – –
Cell Periphery 2 0 0 0 0 0 1 0 1 – 0 0 0 0 0 5 2 2 0 0 0 0 0 0
Cytoplasm 7 25 19 18 26 29 32 29 31 – 18 21 42 84 94 252 157 127 1 9 0 3 5 4
Endoplasmic Reticulum 4 3 7 4 1 0 2 1 2 – 2 4 0 6 3 83 70 53 0 0 4 2 4 2
Endosome 106 53 25 3 39 11 7 8 3 – 3 1 72 99 32 343 281 293 76 85 81 56 110 123
Golgi 1 2 0 0 0 0 0 0 0 – 0 0 0 0 1 2 3 1 5 6 2 3 5 5
Mitochondria 20 97 207 240 223 293 397 403 520 – 377 401 152 96 219 121 132 110 19 35 35 39 48 52
Nucleus 8 15 8 13 11 29 25 28 25 – 26 16 8 14 12 67 72 62 1 10 2 11 4 3
Nuclear Periphery 181 115 85 80 83 54 117 48 107 – 72 83 122 117 105 292 219 277 274 198 204 174 237 275
Nucleolus 28 11 9 8 11 12 29 24 30 – 30 25 19 9 13 41 37 41 2 15 7 13 11 7
Peroxisomes 3 5 0 0 9 2 1 0 3 – 0 2 1 4 9 10 10 9 5 5 11 5 16 25
SpindlePole 7 6 11 5 7 9 18 15 17 – 8 12 5 14 12 103 108 96 14 18 19 24 35 26
Vac/Vac Membrane 136 139 38 41 50 28 31 14 21 – 17 16 70 70 103 432 290 222 3 14 15 20 15 13
Unique Cell Count 319 338 309 318 358 351 498 463 582 422 447 364 404 482 1265 1006 924 417 416 403 368 518 572
Labelled Cell Count 503 473 412 415 470 476 675 584 786 575 609 493 515 611 1752 1387 1297 417 416 403 368 518 572


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 5.5 4.3 4.2 4.5 3.9 3.9 3.8 3.4 – 3.5 3.3 5.0 5.1 4.5 6.8 6.8 6.7 5.4 5.2 5.7
Std Deviation (1e-4) 1.0 1.2 0.9 1.3 1.5 1.4 1.4 1.4 1.0 – 1.3 1.1 1.1 1.3 1.2 1.7 1.7 1.7 1.5 1.4 1.4
Intensity Change (Log2) – – – -0.05 0.07 -0.14 -0.16 -0.18 -0.36 – -0.31 -0.38 0.21 0.24 0.06 0.65 0.65 0.64 0.32 0.27 0.41


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm -0.3 0.6 1.0 0.2 0.1 -0.5 – -1.1 -0.9 2.4 5.5 5.2 5.7 4.3 3.6
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 -0.8 0 2.9 3.1 2.5
Endosome 0 0 0 0 0 0 – 0 0 4.3 5.7 0 7.1 7.2 8.2
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 -6.5 -11.6 0 -22.3 -18.9 -19.2
Nucleus 1.0 0.4 3.2 1.7 2.2 1.3 – 2.3 0.8 -0.3 0.7 -0.1 2.0 2.9 2.7
Nuclear Periphery 0 0 0 0 0 0 – 0 0 1.7 0.4 0 -1.6 -2.1 0.8
Nucleolus 0 0 0 0 0 0 – 0 0 1.5 -0.6 0 0.3 0.6 1.2
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 -1.9 -0.1 0 2.8 3.8 3.7
Vacuole 0.2 0.6 -1.8 -3.0 -5.0 -5.0 – -4.2 -4.6 2.4 1.9 3.3 7.5 5.9 4.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4405 5.1132 4.6584 4.3586 4.3243 4.8546 3.4472 3.4185 3.3287 3.1909 3.5757 3.24 3.9742 3.8744 3.6676 3.7235 3.7999 4.0462
Actin 0.0205 0.0014 0.0074 0.0229 0.0019 0.0027 0.0147 0.0027 0.0172 0.0252 0.0029 0.0014 0.03 0.0049 0.025 0.0079 0.001 0.0077
Bud 0.0004 0.0001 0.0003 0.0005 0.0001 0.0001 0.0003 0.0003 0.0003 0.0005 0.0002 0.0001 0.0006 0.0008 0.0003 0.0002 0 0
Bud Neck 0.0041 0.002 0.0016 0.0126 0.0018 0.0026 0.0018 0.0004 0.0004 0.0245 0.0008 0.0007 0.0022 0.0009 0.0002 0.0016 0.0002 0.0004
Bud Periphery 0.0014 0.0004 0.0012 0.002 0.0005 0.0004 0.001 0.0008 0.0006 0.0016 0.001 0.0003 0.0014 0.0015 0.0009 0.0006 0.0001 0.0002
Bud Site 0.0012 0.0049 0.0017 0.0018 0.0006 0.0004 0.0016 0.0018 0.0023 0.0012 0.0006 0.0002 0.0026 0.0059 0.001 0.0005 0.0001 0.0001
Cell Periphery 0.0004 0.0002 0.0003 0.0003 0.0005 0.0002 0.0003 0.0001 0.0002 0.0005 0.0003 0.0001 0.0004 0.0004 0.0002 0.0002 0.0001 0
Cytoplasm 0.0095 0.0088 0.0017 0.004 0.0024 0.0028 0.0065 0.0021 0.0038 0.002 0.0093 0.0024 0.0027 0.0075 0.0018 0.0056 0.0028 0.0025
Cytoplasmic Foci 0.0033 0.0028 0.0028 0.0055 0.0042 0.0019 0.0115 0.0018 0.0142 0.0064 0.0094 0.0024 0.0088 0.0047 0.0094 0.0105 0.0022 0.0052
Eisosomes 0.0004 0.0001 0.0003 0.0004 0.0003 0.0001 0.0004 0.0002 0.0002 0.0007 0.0003 0.0001 0.0004 0.0004 0.0009 0.0003 0 0.0001
Endoplasmic Reticulum 0.0099 0.0155 0.0077 0.007 0.0089 0.0058 0.0168 0.0091 0.007 0.009 0.0067 0.0056 0.0084 0.0231 0.0054 0.0116 0.0037 0.0107
Endosome 0.0191 0.0154 0.0131 0.0112 0.0113 0.0111 0.0312 0.0077 0.0148 0.0317 0.0508 0.0178 0.035 0.0177 0.0084 0.029 0.0131 0.0099
Golgi 0.0059 0.0021 0.0037 0.0051 0.0029 0.0022 0.0129 0.0019 0.0098 0.0224 0.0081 0.0025 0.0137 0.0022 0.0069 0.0045 0.0029 0.0028
Lipid Particles 0.0419 0.0266 0.0326 0.0377 0.068 0.0247 0.092 0.026 0.0568 0.0874 0.0612 0.014 0.0643 0.0624 0.052 0.0643 0.073 0.0457
Mitochondria 0.006 0.0015 0.0081 0.0061 0.0049 0.0019 0.0073 0.0107 0.0048 0.0434 0.027 0.0078 0.0151 0.0043 0.0164 0.0032 0.002 0.0013
None 0.0066 0.0055 0.0023 0.0043 0.003 0.0052 0.0044 0.0021 0.0068 0.0045 0.0519 0.0007 0.0034 0.0115 0.0135 0.03 0.0014 0.0072
Nuclear Periphery 0.7002 0.68 0.7282 0.6446 0.6674 0.7602 0.6777 0.7836 0.7121 0.6144 0.6226 0.8337 0.7331 0.6813 0.7465 0.7258 0.8059 0.8029
Nucleolus 0.01 0.0207 0.0204 0.0226 0.0119 0.0253 0.0061 0.0093 0.0106 0.0035 0.0205 0.0125 0.002 0.0218 0.0047 0.0075 0.0032 0.0064
Nucleus 0.051 0.1214 0.0523 0.0813 0.1382 0.0773 0.0365 0.0484 0.0379 0.0328 0.0618 0.052 0.0082 0.0658 0.0354 0.0157 0.0418 0.0244
Peroxisomes 0.0021 0.0009 0.0022 0.0037 0.0021 0.0011 0.0094 0.0022 0.0048 0.0059 0.0045 0.001 0.0327 0.0013 0.0117 0.0058 0.0008 0.0077
Punctate Nuclear 0.0895 0.0706 0.0943 0.1096 0.0535 0.0625 0.0505 0.0688 0.0756 0.0625 0.035 0.0328 0.0199 0.0584 0.0376 0.06 0.0246 0.0531
Vacuole 0.0056 0.0053 0.003 0.0026 0.0046 0.003 0.0034 0.0022 0.002 0.0039 0.0043 0.0025 0.0031 0.0066 0.0019 0.0035 0.0022 0.0017
Vacuole Periphery 0.0111 0.0137 0.0147 0.0143 0.0108 0.0083 0.0137 0.0176 0.0178 0.016 0.0207 0.0094 0.0119 0.0164 0.02 0.0116 0.0191 0.0099

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.0058 11.6163 10.4937 19.6181 11.9035 12.705 14.4262 16.3715 14.9326 18.2475
Translational Efficiency 0.4539 0.4151 0.6056 0.3297 0.4857 0.4794 0.422 0.3205 0.4431 0.3432

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
410 1692 216 1522 1814 1960 201 1514 2224 3652 417 3036

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 683.32 799.98 1112.40 915.19 723.49 761.52 1013.52 855.27 716.08 779.34 1064.74 885.31
Standard Deviation 70.08 110.59 133.70 117.32 94.42 98.44 105.45 137.64 91.76 106.00 130.61 131.32
Intensity Change Log 2 — 0.227403 0.703042 0.421510 — 0.073909 0.486330 0.241407 — 0.150505 0.595660 0.331697

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000218 0.000120 0.000952 0.000150 0.000090 0.000187 0.000746 0.000596 0.000113 0.000156 0.000852 0.000372
Bud Neck 0.000196 0.000413 0.002541 0.001892 0.000322 0.000479 0.001269 0.001798 0.000299 0.000448 0.001928 0.001845
Bud Site 0.000456 0.000583 0.000614 0.001640 0.000111 0.000389 0.000232 0.002728 0.000175 0.000479 0.000430 0.002183
Cell Periphery 0.000114 0.000038 0.000038 0.000024 0.000035 0.000036 0.000034 0.000039 0.000049 0.000037 0.000036 0.000032
Cytoplasm 0.011905 0.011275 0.000573 0.007351 0.011610 0.008444 0.001368 0.014656 0.011664 0.009756 0.000956 0.010994
Cytoplasmic Foci 0.012479 0.007076 0.000340 0.001389 0.005611 0.006736 0.000388 0.003433 0.006877 0.006894 0.000363 0.002408
Eisosomes 0.000027 0.000013 0.000015 0.000005 0.000016 0.000016 0.000020 0.000010 0.000018 0.000015 0.000017 0.000008
Endoplasmic Reticulum 0.005293 0.005438 0.010558 0.005294 0.004520 0.004747 0.012248 0.004857 0.004662 0.005067 0.011373 0.005076
Endosome 0.003416 0.006530 0.001087 0.003971 0.003747 0.007149 0.001567 0.006052 0.003686 0.006862 0.001318 0.005009
Golgi 0.001330 0.002237 0.000163 0.001792 0.001066 0.003207 0.000112 0.002629 0.001115 0.002757 0.000139 0.002209
Lipid Particles 0.324688* 0.087327 0.001715 0.002625 0.082334 0.089091 0.002819 0.004035 0.127012* 0.088273 0.002247 0.003328
Mitochondria 0.009189 0.007359 0.001310 0.002785 0.007078 0.010412 0.001529 0.005909 0.007467 0.008997 0.001415 0.004343
Mitotic Spindle 0.006936 0.041415 0.131670* 0.330379* 0.022207 0.056066 0.060750 0.256020* 0.019392 0.049278 0.097485 0.293298*
None 0.006115 0.003510 0.000264 0.000564 0.003763 0.003510 0.000470 0.001666 0.004196 0.003510 0.000363 0.001114
Nuclear Periphery 0.055183 0.071272 0.219778* 0.167447* 0.105898* 0.094584 0.183236* 0.151320* 0.096548 0.083783 0.202164* 0.159405*
Nuclear Periphery Foci 0.529816* 0.720702* 0.530442* 0.437072* 0.695258* 0.660264* 0.628084* 0.487130* 0.664758* 0.688265* 0.577507* 0.462035*
Nucleolus 0.016939 0.012187 0.038904 0.005978 0.025896 0.025293 0.037770 0.012721 0.024245 0.019221 0.038358 0.009341
Nucleus 0.011862 0.017504 0.055442 0.018052 0.027610 0.023793 0.064004 0.032427 0.024707 0.020880 0.059569 0.025221
Peroxisomes 0.003084 0.000892 0.000706 0.000124 0.000589 0.001106 0.000614 0.000435 0.001049 0.001007 0.000662 0.000279
Vacuole 0.000306 0.002529 0.001980 0.008913 0.001415 0.002472 0.002419 0.008062 0.001211 0.002498 0.002192 0.008488
Vacuole Periphery 0.000447 0.001580 0.000908 0.002553 0.000824 0.002019 0.000322 0.003477 0.000755 0.001815 0.000626 0.003014

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.83 -4.71 -0.20 -3.89 5.69 -1.36 -6.27 -2.68 -2.09 0.81 -0.93 -8.67 -3.09 -2.59 3.87
Bud Neck -1.88 -4.58 -8.86 -8.08 0.64 -1.79 -4.39 -8.04 -7.40 -2.79 -2.01 -5.61 -11.76 -10.95 -0.55
Bud Site -0.15 -1.01 -2.86 -2.56 -1.23 -2.19 -2.63 -3.48 -3.21 -3.32 -1.33 -1.48 -4.76 -4.13 -3.03
Cell Periphery 2.03 1.67 2.28 1.70 1.91 -0.32 -0.35 -1.51 -1.19 -0.89 1.62 0.64 1.79 0.37 1.24
Cytoplasm 0.11 3.71 -0.40 -0.80 -8.35 1.66 7.61 -4.20 -5.59 -9.77 1.12 8.87 -3.32 -4.74 -12.80
Cytoplasmic Foci 2.13 4.55 4.15 6.10 -3.52 -1.29 7.71 2.76 4.31 -5.51 0.20 8.80 5.78 7.52 -6.53
Eisosomes 3.26 2.12 4.37 4.62 3.84 -0.72 -1.37 2.00 2.64 2.09 2.44 -0.34 5.96 5.04 3.84
Endoplasmic Reticulum -0.25 -4.55 -1.03 -0.85 3.62 -0.34 -6.10 -2.26 -1.68 5.16 -0.86 -7.95 -2.53 -1.65 6.17
Endosome -3.30 3.97 -0.95 2.60 -5.29 -3.77 3.12 -3.12 0.92 -5.61 -4.73 4.86 -2.67 2.46 -7.67
Golgi -2.02 6.42 -0.20 0.84 -1.88 -3.44 5.11 -1.96 1.02 -3.65 -4.12 6.25 -1.60 1.36 -3.78
Lipid Particles 14.81 20.96 20.90 20.43 -1.69 -1.14 21.17 20.87 21.52 -1.88 7.14 27.08 26.84 29.70 -2.58
Mitochondria 0.77 3.37 2.54 3.90 -2.55 -3.27 8.25 1.15 3.60 -3.78 -1.71 8.75 3.39 5.39 -4.56
Mitotic Spindle -9.78 -8.44 -34.64* -30.10* -10.55 -8.82 -3.58 -27.12* -22.06* -14.09 -10.71 -8.31 -42.42 -36.70* -16.47
None 1.71 3.89 3.49 4.73 -4.81 -0.27 7.96 3.03 2.76 -4.55 0.84 8.81 5.78 5.23 -5.91
Nuclear Periphery -3.27 -11.27 -16.70 -16.15 3.29 2.41 -5.70 -6.50 -8.85 2.63 3.35 -10.35 -12.56 -17.42 4.23
Nuclear Periphery Foci -10.63 0.52 6.82 27.74* 5.46 3.79 3.78 20.99* 17.48 7.56 -2.50 6.47 25.55 31.51* 9.01
Nucleolus 1.38 -2.96 2.53 2.72 4.90 -0.29 -2.08 4.25 4.63 3.85 2.15 -3.11 6.58 5.61 6.19
Nucleus -1.77 -5.36 -5.05 -3.89 3.34 1.02 -4.24 -4.26 -5.10 2.59 1.53 -5.95 -4.49 -6.28 4.11
Peroxisomes 3.12 3.26 4.19 5.64 5.45 -3.52 -0.06 1.50 4.11 1.12 0.28 2.36 5.31 6.69 4.38
Vacuole -3.54 -4.12 -8.08 -6.03 -5.90 -1.92 -1.26 -7.27 -6.53 -5.67 -2.86 -2.59 -10.34 -8.90 -8.19
Vacuole Periphery -3.04 -1.27 -4.00 -1.35 -2.39 -2.58 3.02 -3.18 -1.42 -3.92 -3.39 0.44 -4.51 -1.90 -4.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
Localization
Cell Percentages nuclear periphery (69%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sac3

Sac3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sac3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available