Standard name
Human Ortholog
Description Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Env10p/Snd2p and Pho88p/Snd3p; can compensate for loss of SRP; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.93 0.97 0.96 0.98 0.97 0.93 0.92 0.92 0.85 – 0.69 0.79 0.99 1.0 0.99 0.9 0.89 0.86 0.87 0.93 0.88 0.75 0.78 0.82
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0 0.07 0 0 0 0.07 0.08 0.06
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 0 0.05 0 0.17 0.13 0.09 0.32 – 0.48 0.29 0 0 0 0 0 0 0 0 0 0.07 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0.08 0.13 0 0 0 0.05 0.05 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 1 2 0 1 0 0 1 0 – 0 0 0 0 0 2 0 0 1 0 0 1 4 1
Bud 0 0 3 0 0 0 1 3 5 – 4 6 2 3 0 0 0 0 0 0 1 0 6 2
Bud Neck 0 0 0 0 0 0 0 2 0 – 0 2 0 0 0 0 0 0 0 1 2 1 4 1
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 5 9 5 9 4 4 8 0 – 2 9 2 14 5 3 6 7 0 0 0 0 1 1
Cytoplasm 145 172 276 167 293 209 303 274 160 – 118 208 228 420 416 162 157 156 139 176 258 122 378 351
Endoplasmic Reticulum 2 7 5 1 1 0 2 0 1 – 1 2 0 0 1 10 5 12 4 1 5 11 38 25
Endosome 1 0 0 0 0 1 1 0 0 – 1 0 0 1 2 2 2 1 3 1 0 0 1 1
Golgi 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 1 0 0 1 0 2 1
Mitochondria 10 1 0 9 6 39 43 26 60 – 82 77 10 4 6 5 3 8 2 2 12 11 17 11
Nucleus 2 0 3 1 1 1 3 6 0 – 7 3 0 0 1 4 4 3 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 1 – 0 2 0 0 0 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 3 0 3 2 3 0 3 4 0 – 1 0 0 1 2 14 15 23 2 3 5 8 25 23
Unique Cell Count 156 178 287 170 301 225 331 299 189 172 264 230 422 422 181 177 182 161 189 294 163 486 430
Labelled Cell Count 166 186 301 185 314 254 360 326 228 216 310 242 443 433 202 192 211 161 189 294 163 486 430


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 7.6 6.9 6.0 6.7 4.8 5.2 5.5 4.4 – 4.1 4.7 6.8 6.8 6.8 9.4 9.4 9.5 6.6 6.6 7.0
Std Deviation (1e-4) 0.9 1.1 1.2 0.9 1.7 1.1 1.4 1.5 1.3 – 1.1 1.2 1.2 1.0 1.4 1.4 1.6 1.5 1.5 1.3 1.5
Intensity Change (Log2) – – – -0.21 -0.05 -0.52 -0.42 -0.33 -0.65 – -0.77 -0.55 -0.02 -0.03 -0.02 0.44 0.44 0.47 -0.07 -0.06 0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery -0.1 -0.1 0 -1.7 -0.3 0 – 0 0 0 0.1 -1.8 0 0.2 0.4
Cytoplasm 1.2 0.8 -1.6 -2.4 -2.3 -4.4 – -8.2 -6.2 2.1 3.3 2.1 -2.9 -3.1 -4.1
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 2.3 0 2.7
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 6.3 5.1 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 3.8 4.0 5.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.1812 4.4647 3.5351 3.4841 2.0809 3.6031 2.4584 3.0657 2.9142 2.3862 2.6228 2.8981 2.1851 2.8923 2.6754 2.8573 1.8461 2.5189
Actin 0.0137 0.0003 0.0138 0.0097 0.0002 0.0036 0.0205 0.001 0.0241 0.0174 0.0004 0.0033 0.0466 0.011 0.0164 0.0311 0.0054 0.0066
Bud 0.0001 0.0006 0.0014 0.0009 0.0005 0.0005 0.0015 0.0025 0.0168 0.0019 0.0006 0.0018 0.0053 0.0139 0.0123 0.0153 0.0075 0.0077
Bud Neck 0.0003 0.0001 0.0032 0.0018 0.0004 0.0014 0.0014 0.0007 0.0018 0.0025 0.0083 0.0018 0.0027 0.0005 0.0031 0.0019 0.0012 0.0015
Bud Periphery 0.0002 0.0009 0.0014 0.0008 0.0005 0.0008 0.0015 0.0016 0.0134 0.0021 0.0003 0.0018 0.007 0.0092 0.0123 0.0147 0.0047 0.0122
Bud Site 0.0009 0.0018 0.0177 0.0035 0.0003 0.0003 0.0115 0.0123 0.0135 0.0056 0.001 0.0009 0.0077 0.0117 0.0134 0.0035 0.0058 0.0012
Cell Periphery 0.0008 0.0007 0.0009 0.0004 0.0014 0.0003 0.0004 0.0004 0.0021 0.0029 0.0001 0.0002 0.0007 0.0008 0.0005 0.0006 0.0002 0.0004
Cytoplasm 0.5457 0.7225 0.6179 0.793 0.5957 0.73 0.6756 0.8789 0.8024 0.711 0.8531 0.8625 0.661 0.8394 0.6954 0.5671 0.7451 0.7937
Cytoplasmic Foci 0.0164 0.014 0.019 0.0621 0.0189 0.0298 0.0258 0.0259 0.0312 0.0526 0.0407 0.0435 0.04 0.0281 0.0293 0.0529 0.0447 0.0421
Eisosomes 0.0007 0.0001 0.0003 0 0.0005 0.0001 0.0002 0 0.0001 0.0004 0 0 0.0004 0 0.0002 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.0147 0.0066 0.0062 0.0043 0.004 0.0176 0.0128 0.0038 0.0049 0.0037 0.0028 0.0053 0.0099 0.0025 0.0027 0.0033 0.0026 0.0027
Endosome 0.037 0.0133 0.0216 0.023 0.0081 0.032 0.082 0.019 0.0293 0.0841 0.0697 0.0345 0.0325 0.0158 0.0227 0.0458 0.0403 0.0305
Golgi 0.0042 0.001 0.0039 0.0016 0.0005 0.0105 0.015 0.0027 0.0064 0.0196 0.009 0.006 0.0081 0.0016 0.004 0.0158 0.0142 0.0024
Lipid Particles 0.016 0.0005 0.002 0.0007 0.0057 0.0019 0.0101 0.0003 0.002 0.0122 0.0011 0.0004 0.0107 0.0002 0.002 0.0112 0.0216 0.0008
Mitochondria 0.0028 0.0008 0.0026 0.0041 0.0338 0.0349 0.0187 0.0015 0.0066 0.0497 0.0008 0.0101 0.0049 0.0014 0.009 0.0047 0.0259 0.0034
None 0.2659 0.2266 0.258 0.0232 0.2429 0.1269 0.0659 0.0402 0.0269 0.0059 0.0044 0.0154 0.1263 0.0565 0.0659 0.1623 0.0612 0.0702
Nuclear Periphery 0.0348 0.001 0.0026 0.0053 0.001 0.0015 0.0192 0.0007 0.0021 0.0009 0.0004 0.0025 0.0041 0.0009 0.0053 0.0025 0.0016 0.0028
Nucleolus 0.002 0.0001 0.0011 0.0074 0.0604 0.0001 0.0031 0.0001 0.0003 0.0006 0.0003 0.0002 0.0006 0.0001 0.0012 0.0007 0.0003 0.0039
Nucleus 0.0223 0.001 0.0029 0.0391 0.0092 0.0009 0.0079 0.0016 0.0017 0.0012 0.0007 0.0033 0.0076 0.0015 0.0917 0.004 0.0019 0.0109
Peroxisomes 0.0046 0.0001 0.0024 0.0017 0.0017 0.0006 0.0035 0.0004 0.0032 0.0106 0.001 0.0015 0.0094 0.0005 0.003 0.0497 0.007 0.0013
Punctate Nuclear 0.0115 0.0003 0.0129 0.0025 0.0005 0.0008 0.0054 0.0008 0.003 0.0005 0.0004 0.0006 0.0058 0.0004 0.0044 0.0048 0.0019 0.0015
Vacuole 0.0038 0.0064 0.0071 0.0124 0.0068 0.004 0.0136 0.005 0.0069 0.012 0.0041 0.0034 0.0073 0.0036 0.0044 0.0066 0.0053 0.0032
Vacuole Periphery 0.0015 0.0008 0.0009 0.0024 0.0069 0.0014 0.0043 0.0006 0.0011 0.0026 0.0009 0.001 0.0015 0.0005 0.001 0.0015 0.0015 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 37.4923 25.4645 25.5649 34.3986 38.834 39.3556 37.0115 36.6718 35.4835 42.7385
Translational Efficiency 0.7572 0.7703 0.7671 0.5038 0.5074 0.7792 0.6066 0.6194 0.6425 0.6265

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2294 1415 295 1822 1489 1393 134 67 3783 2808 429 1889

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 827.83 858.75 1240.88 1002.64 808.14 812.15 1059.63 976.83 820.08 835.63 1184.27 1001.72
Standard Deviation 97.52 126.13 162.62 131.86 103.39 113.37 123.86 134.58 100.34 122.21 173.30 132.04
Intensity Change Log 2 — 0.052904 0.583957 0.276397 — 0.007141 0.390883 0.273502 — 0.030479 0.491807 0.274968

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000081 0.000212 0.000838 0.000545 0.000159 0.000400 0.000208 0.000243 0.000112 0.000305 0.000641 0.000535
Bud Neck 0.004795 0.005766 0.003004 0.003051 0.004572 0.009770 0.010275 0.004264 0.004708 0.007752 0.005275 0.003094
Bud Site 0.011982 0.018503 0.011186 0.030973 0.018553 0.022234 0.010686 0.044703 0.014568 0.020354 0.011030 0.031460
Cell Periphery 0.000132 0.000076 0.000219 0.000050 0.000123 0.000134 0.000107 0.000152 0.000128 0.000105 0.000184 0.000054
Cytoplasm 0.689227* 0.673723* 0.633192* 0.790863* 0.670620* 0.554416* 0.513722* 0.669796* 0.681903* 0.614537* 0.595875* 0.786569*
Cytoplasmic Foci 0.148207 0.168081 0.044261 0.029328 0.201860* 0.215322* 0.048890 0.118375 0.169325 0.191517* 0.045707 0.032486
Eisosomes 0.000041 0.000029 0.000025 0.000009 0.000041 0.000073 0.000053 0.000023 0.000041 0.000051 0.000034 0.000009
Endoplasmic Reticulum 0.001759 0.000530 0.002926 0.000216 0.001298 0.000534 0.001502 0.000283 0.001577 0.000532 0.002482 0.000218
Endosome 0.011213 0.015351 0.005379 0.003348 0.013017 0.027147 0.009999 0.006818 0.011923 0.021203 0.006822 0.003471
Golgi 0.007440 0.005066 0.000477 0.002154 0.008068 0.008184 0.000153 0.000516 0.007687 0.006612 0.000375 0.002096
Lipid Particles 0.001856 0.001163 0.002331 0.000272 0.001579 0.003319 0.002061 0.000546 0.001747 0.002233 0.002247 0.000282
Mitochondria 0.002232 0.003378 0.000228 0.001968 0.002512 0.004286 0.000061 0.000061 0.002342 0.003828 0.000176 0.001900
Mitotic Spindle 0.000784 0.006684 0.019901 0.024307 0.001323 0.003867 0.003676 0.004223 0.000996 0.005286 0.014833 0.023595
None 0.003504 0.000826 0.004581 0.001761 0.001869 0.000789 0.000795 0.001938 0.002861 0.000807 0.003398 0.001767
Nuclear Periphery 0.000070 0.000107 0.000894 0.000121 0.000046 0.000152 0.000772 0.000100 0.000060 0.000129 0.000856 0.000120
Nuclear Periphery Foci 0.000215 0.000279 0.006979 0.000685 0.000284 0.000322 0.004594 0.002840 0.000242 0.000300 0.006234 0.000761
Nucleolus 0.000372 0.000377 0.000152 0.000126 0.000216 0.000368 0.000178 0.000083 0.000310 0.000373 0.000160 0.000125
Nucleus 0.019561 0.019424 0.135138* 0.030473 0.015237 0.026184 0.057850 0.012812 0.017859 0.022778 0.110997 0.029847
Peroxisomes 0.000932 0.002280 0.000360 0.000784 0.001254 0.004616 0.000314 0.001538 0.001059 0.003439 0.000346 0.000811
Vacuole 0.091034 0.074863 0.127659 0.077189 0.053327 0.114867 0.333821* 0.130377 0.076192 0.094708 0.192054 0.079075
Vacuole Periphery 0.004564 0.003281 0.000268 0.001778 0.004042 0.003017 0.000282 0.000307 0.004359 0.003150 0.000272 0.001726

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.25 -8.87 -3.70 -1.96 5.11 -3.08 -3.44 -1.89 0.55 -0.41 -4.77 -8.99 -3.40 -0.80 4.14
Bud Neck -1.46 0.74 5.72 4.96 4.09 -6.42 -0.26 0.99 4.06 0.60 -5.90 -0.09 5.80 9.10 1.95
Bud Site -4.41 -0.82 -3.67 -0.11 -2.93 -2.02 3.62 -1.50 -1.18 -2.28 -5.08 2.49 -2.62 0.52 -3.84
Cell Periphery 6.31 -5.96 13.57 4.76 9.90 -0.74 0.14 -0.28 0.12 -0.33 2.35 -5.63 14.60 6.82 10.60
Cytoplasm 2.25 10.27 -4.13 -5.57 -11.96 12.12 9.03 2.61 -0.57 -2.92 10.88 13.39 -4.80 -13.32 -15.09
Cytoplasmic Foci -3.51 24.66 35.13 29.26 2.95 -1.93 27.49 6.82 7.62 -3.72 -5.01 36.02 45.74 43.03 2.71
Eisosomes 3.61 1.95 12.56 8.03 8.37 -7.21 -2.98 2.90 8.03 4.57 -3.45 -0.09 17.25 17.27 11.73
Endoplasmic Reticulum 4.97 -2.42 6.65 4.28 5.11 3.21 -1.76 3.98 2.47 6.79 5.95 -2.83 8.13 6.78 6.22
Endosome -3.44 6.54 15.45 12.33 6.31 -8.46 4.76 5.28 11.90 1.30 -9.17 8.18 18.13 20.57 7.91
Golgi 3.90 23.15 14.27 6.05 -1.52 -0.04 21.09 19.66 9.56 -2.28 2.17 31.07 16.68 9.44 -1.81
Lipid Particles 3.03 -4.86 10.37 3.74 10.24 -2.47 -1.31 4.63 3.82 4.67 -1.32 -5.04 12.29 4.98 11.55
Mitochondria -1.36 5.59 2.46 2.91 -1.53 -1.60 4.10 4.11 4.63 0.22 -2.19 6.72 2.89 4.15 -1.69
Mitotic Spindle -3.67 -3.67 -6.62 -3.06 0.91 -2.23 -1.09 -1.74 -0.85 0.12 -4.36 -3.73 -6.61 -4.01 0.37
None 5.20 0.36 3.73 -5.02 2.76 1.79 1.56 0.47 -0.67 -0.53 5.23 0.62 3.31 -5.06 2.21
Nuclear Periphery -1.77 -12.58 -11.03 -4.56 11.09 -2.59 -7.06 -3.61 -1.32 5.27 -3.02 -14.37 -12.76 -3.75 12.34
Nuclear Periphery Foci -1.89 -12.30 -9.32 -7.99 11.41 -0.79 -7.31 -3.35 -3.31 1.16 -1.94 -14.14 -9.29 -8.10 12.75
Nucleolus -0.10 3.35 4.10 1.62 2.17 -2.72 2.31 4.68 5.32 3.45 -0.93 3.84 4.58 3.04 1.75
Nucleus -0.22 -13.24 -15.20 -13.23 10.64 -5.31 -8.10 -0.17 3.28 7.48 -4.22 -14.52 -16.61 -11.32 10.87
Peroxisomes -6.14 11.28 2.95 6.92 -1.04 -6.52 13.40 0.27 4.81 -1.55 -8.50 17.02 3.83 9.43 -1.44
Vacuole 2.84 -9.37 -12.11 -14.34 4.01 -12.86 -14.53 -5.63 -3.83 3.50 -6.40 -15.81 -16.59 -11.93 8.39
Vacuole Periphery 3.36 17.76 11.61 6.17 -2.41 2.23 9.29 9.12 11.50 -0.63 4.26 18.75 11.81 7.99 -2.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Env10p/Snd2p and Pho88p/Snd3p; can compensate for loss of SRP; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Snd1

Snd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Snd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available