Standard name
Human Ortholog
Description Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.22 0.26 0.17 0.16 0.1 0.07 0.05 0.07 0.07 0.07 0.08 0.1 0.15 0.11 0.14 0.32 0.31 0.32 0 0.06 0.12 0.07 0.08 0.08
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0.13 0 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0.07 0.1 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0.19 0.29 0.15 0.11 0.1 0.13 0.09 0.06 0.09 0.09 0.08 0.07 0.26 0.27 0.2 0 0 0 0 0.06 0 0 0.06 0.08
Endosome 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0.05 0.09 0 0.05 0.08 0.05
Golgi 0.68 0.44 0.73 0.69 0.45 0.23 0.11 0.15 0.17 0.17 0.14 0.22 0.61 0.68 0.8 0.69 0.75 0.7 0.8 0.58 0.79 0.74 0.69 0.71
Mitochondria 0.44 0.39 0.57 0.53 0.61 0.81 0.84 0.78 0.86 0.86 0.88 0.8 0.29 0.05 0.15 0.15 0.14 0.15 0 0.05 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0.05 0.09 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.05 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0.06 0.07 0.07 0 0 0.07 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 50 71 78 67 51 58 43 62 43 61 60 82 18 17 24 67 59 67 9 21 56 8 21 27
Bud 3 6 7 6 20 21 19 21 18 22 29 31 1 0 1 3 3 6 0 2 0 0 2 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 1 2 2 3 0 2 4 7 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 4 2 4 12 5 6 4 11 5 9 0 0 2 4 3 1 0 0 0 0 0 0
Cytoplasm 13 37 15 27 31 28 32 23 15 7 7 10 3 5 7 14 18 16 1 13 0 0 0 0
Endoplasmic Reticulum 43 81 67 46 56 105 75 57 57 74 62 58 31 41 33 8 7 8 10 20 15 5 17 27
Endosome 9 1 12 8 41 15 18 38 11 16 12 25 4 7 2 13 8 8 14 29 18 6 21 17
Golgi 156 121 329 288 243 177 91 140 103 143 105 182 72 103 134 143 141 148 219 190 383 95 191 234
Mitochondria 101 108 257 220 329 631 690 717 535 707 657 665 34 8 26 31 27 32 9 17 4 5 11 12
Nucleus 1 0 0 0 1 1 3 2 1 2 0 0 0 0 1 1 2 2 0 1 0 0 0 0
Nuclear Periphery 0 0 1 0 1 5 15 5 7 16 6 15 1 0 0 0 0 0 0 1 0 1 1 0
Nucleolus 0 0 3 0 4 9 43 86 20 29 19 39 0 2 0 1 0 3 0 0 0 0 0 0
Peroxisomes 0 0 0 0 3 2 1 4 1 3 2 9 0 1 0 0 0 1 0 1 1 2 3 1
SpindlePole 0 0 0 0 2 0 1 1 2 5 4 5 0 1 0 1 1 5 0 0 0 0 0 0
Vac/Vac Membrane 9 15 3 5 24 22 19 25 12 13 10 20 8 7 10 14 13 7 8 24 1 1 6 4
Unique Cell Count 230 275 450 417 536 779 824 921 619 823 746 834 119 151 168 208 189 210 276 326 484 129 279 330
Labelled Cell Count 386 440 776 669 811 1088 1057 1190 829 1111 982 1157 172 192 240 300 282 304 276 326 484 129 279 330


Early Golgi, Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.4 11.0 12.1 11.5 10.6 9.4 9.3 9.8 9.8 9.8 10.0 10.2 11.9 11.9 12.6 14.8 14.4 14.2 11.1 11.3 12.0
Std Deviation (1e-4) 1.8 1.9 1.5 1.9 1.7 1.5 1.7 1.8 1.7 1.6 1.8 2.0 1.7 1.8 1.7 2.9 3.1 2.7 1.7 1.7 1.6
Intensity Change (Log2) – – – -0.07 -0.19 -0.36 -0.37 -0.3 -0.31 -0.3 -0.27 -0.24 -0.02 -0.02 0.06 0.29 0.25 0.23 -0.12 -0.09 -0.01

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.5 -3.6 -5.3 -7.0 -6.1 -5.3 -5.4 -4.9 -3.9 -0.6 -1.8 -0.9 4.3 3.9 4.2
Bud -0.1 2.1 1.3 0.9 0.9 1.4 1.3 2.3 2.2 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 1.0 0 0 0 0.7 0 0 0 0 0 0 0 0
Cytoplasm 2.2 1.8 0.2 0.5 -0.9 -0.9 -3.2 -3.0 -2.6 0 0 0.5 2.0 3.2 2.4
Endoplasmic Reticulum -1.7 -2.1 -0.7 -3.1 -5.3 -2.9 -3.2 -3.6 -4.6 2.9 3.4 1.4 -4.1 -4.0 -4.2
Endosome -0.7 3.5 -0.9 -0.5 1.4 -1.0 -0.8 -1.3 0.3 0 0 0 2.2 1.0 0.8
Golgi -1.3 -8.8 -17.3 -22.5 -21.2 -18.6 -19.7 -20.6 -17.9 -2.7 -1.2 1.7 -1.2 0.4 -0.7
Mitochondria -1.3 1.4 9.0 10.4 8.0 10.8 11.5 12.2 8.6 -5.5 -11.1 -9.2 -10.1 -9.9 -10.1
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 2.4 0 0 2.6 0 2.4 0 0 0 0 0 0
Nucleolus 0 0 0 4.2 6.1 2.9 3.1 2.3 3.9 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 3.7 2.6 2.1 2.5 1.7 1.4 0 2.2 0 0 0 4.6 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.8324 7.5643 7.7682 6.3519 6.535 7.222 9.6036 10.4856 10.0989 9.5688 8.5705 10.0539 7.843 8.9443 8.2282 6.9489 8.7131 8.3607
Actin 0.0528 0.0255 0.0182 0.0104 0.0017 0.0037 0.037 0.0184 0.011 0.0518 0.0079 0.0087 0.1199 0.0979 0.0446 0.0248 0.001 0.0569
Bud 0.0005 0.0004 0.0002 0.0005 0.0001 0.0001 0.0003 0.0005 0.0002 0.0001 0.0001 0.0001 0.0008 0.0017 0.0007 0.0268 0.0001 0.0007
Bud Neck 0.0007 0.0005 0.0004 0.0003 0.0001 0.0003 0.0005 0.0003 0.0003 0.0002 0.0002 0.0002 0.0014 0.0015 0.001 0.0008 0.0001 0.0007
Bud Periphery 0.0006 0.0002 0.0001 0.0005 0.0001 0.0001 0.0004 0.0002 0.0002 0.0001 0.0002 0.0001 0.0008 0.0017 0.0006 0.0863 0.0001 0.0009
Bud Site 0.0015 0.0051 0.0004 0.0008 0.0001 0.0001 0.0011 0.0024 0.0003 0.0007 0.0005 0.0001 0.0038 0.024 0.0299 0.0017 0.0001 0.0007
Cell Periphery 0.0003 0.0001 0.0001 0.0001 0 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0 0.0003 0.0004 0.0002 0.0006 0 0.0001
Cytoplasm 0.011 0.0057 0.011 0.0035 0.0016 0.002 0.0041 0.0089 0.0029 0.0025 0.0025 0.0015 0.0063 0.0044 0.0042 0.0083 0.0023 0.0013
Cytoplasmic Foci 0.0583 0.0772 0.0619 0.0506 0.0394 0.0304 0.0596 0.0654 0.0445 0.068 0.0533 0.0378 0.0709 0.0697 0.0415 0.0273 0.0838 0.0291
Eisosomes 0.0003 0 0.0001 0.0001 0 0 0.0002 0 0.0001 0.0001 0.0004 0 0.0006 0.0003 0.0001 0 0 0.0002
Endoplasmic Reticulum 0.0081 0.0025 0.0048 0.0013 0.0126 0.0051 0.0095 0.0021 0.0038 0.0023 0.0022 0.0016 0.0049 0.0022 0.0015 0.0059 0.0014 0.0028
Endosome 0.219 0.2318 0.1869 0.1918 0.2413 0.1544 0.1874 0.1689 0.1627 0.2556 0.1958 0.1244 0.198 0.1916 0.1595 0.3265 0.254 0.141
Golgi 0.5704 0.6216 0.6922 0.6488 0.6588 0.7627 0.6175 0.7129 0.729 0.5785 0.6701 0.7958 0.5003 0.5374 0.6674 0.4375 0.6306 0.7253
Lipid Particles 0.0211 0.0068 0.0039 0.0013 0.0015 0.0092 0.0214 0.0037 0.0039 0.0204 0.027 0.0032 0.0221 0.0077 0.0023 0.0026 0.0039 0.0053
Mitochondria 0.0309 0.0081 0.0122 0.0847 0.0216 0.0206 0.0343 0.0128 0.0341 0.0081 0.0236 0.0228 0.0233 0.0419 0.0137 0.0176 0.0178 0.0281
None 0.0036 0.0001 0.0023 0.0003 0.0001 0.0003 0.0024 0 0.0001 0.0003 0.0004 0.0001 0.0086 0.0024 0.0282 0.0006 0 0.0002
Nuclear Periphery 0.0029 0.0002 0.0004 0.0002 0.012 0.0051 0.0072 0.0001 0.0002 0.0002 0.0018 0.0001 0.0076 0.0002 0.0002 0.0019 0.0002 0.0008
Nucleolus 0.0002 0 0 0 0 0 0.0002 0 0 0 0.0001 0 0.0006 0.0004 0 0.0001 0 0
Nucleus 0.0006 0.0001 0.0001 0.0001 0.0003 0.0003 0.0008 0 0 0 0.0002 0 0.0008 0.0002 0.0001 0.0005 0 0.0002
Peroxisomes 0.0077 0.0113 0.0017 0.0012 0.0004 0.0009 0.0074 0.0015 0.0038 0.0073 0.0077 0.0015 0.0165 0.0089 0.0012 0.0007 0.0014 0.002
Punctate Nuclear 0.0038 0.0001 0.0004 0.0001 0.0001 0.0005 0.0032 0.0001 0.0001 0.0004 0.0027 0.0001 0.0074 0.0003 0.0001 0.0001 0.0001 0.0003
Vacuole 0.003 0.0012 0.0011 0.0013 0.003 0.0013 0.0024 0.0006 0.001 0.001 0.0013 0.0005 0.0023 0.0031 0.0013 0.0203 0.0009 0.0011
Vacuole Periphery 0.0027 0.0014 0.0015 0.002 0.0054 0.0025 0.0028 0.001 0.0019 0.0021 0.0021 0.0013 0.0029 0.0021 0.0016 0.0091 0.002 0.0022

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.7356 37.4636 24.5075 33.9602 43.2544 40.783 33.1444 31.6211 30.7292 46.5841
Translational Efficiency 1.3911 1.0604 1.3204 0.9777 0.9869 1.1595 1.1295 0.932 1.0075 0.9536

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1743 1320 717 1196 1486 1147 1704 1965 3229 2467 2421 3161

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1027.60 1179.27 1430.66 1589.21 974.21 1112.87 1266.49 1537.07 1003.03 1148.40 1315.11 1556.80
Standard Deviation 169.43 194.93 204.07 289.46 199.63 162.16 238.79 222.40 185.86 183.45 241.01 251.18
Intensity Change Log 2 — 0.198615 0.477402 0.629031 — 0.191980 0.378531 0.657878 — 0.195390 0.430131 0.643142

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.004606 0.005476 0.007389 0.027806 0.003443 0.005566 0.005684 0.006443 0.004071 0.005518 0.006189 0.014526
Bud Neck 0.000092 0.000134 0.000634 0.003483 0.000264 0.000134 0.000227 0.000227 0.000171 0.000134 0.000347 0.001459
Bud Site 0.001184 0.002041 0.003745 0.035078 0.002080 0.001590 0.002201 0.003714 0.001596 0.001832 0.002658 0.015581
Cell Periphery 0.000204 0.000217 0.000331 0.002708 0.000279 0.000273 0.000436 0.000452 0.000239 0.000243 0.000405 0.001306
Cytoplasm 0.000425 0.000609 0.000497 0.009376 0.001378 0.000756 0.000489 0.000833 0.000864 0.000677 0.000492 0.004065
Cytoplasmic Foci 0.163138 0.169522 0.071468 0.081934 0.178188 0.176048 0.074582 0.115459 0.170064 0.172557 0.073660 0.102775
Eisosomes 0.000108 0.000104 0.000097 0.000366 0.000090 0.000101 0.000179 0.000192 0.000100 0.000102 0.000155 0.000258
Endoplasmic Reticulum 0.005336 0.009673 0.017638 0.023571 0.011963 0.008533 0.017544 0.008896 0.008386 0.009143 0.017572 0.014448
Endosome 0.140395 0.126212 0.109337 0.114731 0.159059 0.149908 0.109259 0.164326 0.148984 0.137229 0.109282 0.145561
Golgi 0.655911 0.662557 0.733123 0.597718 0.594424 0.631505 0.729650 0.641151 0.627614 0.648120 0.730679 0.624718
Lipid Particles 0.010174 0.009239 0.018395 0.057874 0.018468 0.007080 0.035762 0.023376 0.013991 0.008235 0.030619 0.036429
Mitochondria 0.006741 0.002744 0.000493 0.002176 0.007230 0.003190 0.000686 0.000865 0.006966 0.002951 0.000629 0.001361
Mitotic Spindle 0.000113 0.000509 0.001877 0.004439 0.000374 0.000698 0.000440 0.001300 0.000233 0.000597 0.000866 0.002488
None 0.000039 0.000047 0.000024 0.001265 0.000164 0.000022 0.000042 0.000027 0.000096 0.000035 0.000037 0.000495
Nuclear Periphery 0.000033 0.000076 0.000364 0.000160 0.000078 0.000173 0.000108 0.000162 0.000054 0.000121 0.000184 0.000161
Nuclear Periphery Foci 0.000239 0.000538 0.002379 0.002195 0.001690 0.000763 0.001452 0.002150 0.000907 0.000642 0.001727 0.002167
Nucleolus 0.000003 0.000010 0.000025 0.000033 0.000107 0.000005 0.000002 0.000003 0.000051 0.000008 0.000009 0.000014
Nucleus 0.000014 0.000026 0.000039 0.000593 0.000399 0.000026 0.000014 0.000015 0.000191 0.000026 0.000021 0.000234
Peroxisomes 0.000598 0.000377 0.000332 0.000946 0.000753 0.000504 0.000440 0.000576 0.000670 0.000436 0.000408 0.000716
Vacuole 0.003253 0.004296 0.021777 0.025542 0.007940 0.005330 0.012580 0.021994 0.005410 0.004776 0.015304 0.023337
Vacuole Periphery 0.007394 0.005591 0.010037 0.008005 0.011628 0.007795 0.008222 0.007837 0.009342 0.006616 0.008760 0.007900

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.04 -2.14 -7.97 -7.58 -6.55 -1.97 -2.06 -2.66 -0.70 -0.59 -2.15 -2.59 -8.01 -6.65 -5.79
Bud Neck -1.16 -3.97 -9.83 -9.69 -7.94 2.10 0.51 0.39 -2.12 -0.11 1.06 -3.26 -9.39 -9.69 -7.98
Bud Site -1.58 -4.42 -11.65 -11.25 -10.69 1.59 -0.40 -2.89 -3.80 -2.59 -0.74 -3.75 -11.80 -11.39 -10.82
Cell Periphery -0.26 -2.77 -8.42 -8.33 -7.99 0.09 -3.39 -2.70 -2.06 -0.20 -0.10 -4.81 -8.82 -8.52 -7.40
Cytoplasm -1.57 -1.19 -6.44 -6.31 -6.39 1.52 2.64 1.49 -0.35 -3.08 0.92 2.31 -5.87 -6.24 -6.66
Cytoplasmic Foci -1.58 24.69 21.89 20.80 -2.84 0.45 27.67 15.33 14.57 -13.35 -0.81 38.16 24.42 23.46 -12.17
Eisosomes 0.44 1.08 -4.53 -4.60 -4.72 -0.82 -3.28 -2.34 -2.07 -0.25 -0.29 -2.85 -4.56 -4.47 -2.63
Endoplasmic Reticulum -3.01 -5.29 -8.10 -5.72 -1.89 1.99 -2.88 1.90 -0.26 4.87 -0.68 -6.46 -4.84 -4.01 2.03
Endosome 3.41 6.19 6.50 3.00 -0.84 1.78 10.96 -1.07 -3.00 -13.17 3.59 12.41 1.13 -2.43 -11.16
Golgi -0.95 -8.16 7.01 7.40 12.23 -4.46 -17.48 -5.79 -1.12 11.97 -3.79 -18.13 1.07 4.40 17.23
Lipid Particles 0.56 -3.36 -12.10 -12.40 -9.13 5.15 -5.97 -1.98 -7.89 4.39 4.22 -8.28 -10.73 -14.29 -2.37
Mitochondria 3.65 6.55 4.37 0.75 -4.10 3.35 6.71 6.36 3.00 -0.58 4.95 9.24 7.81 3.12 -2.96
Mitotic Spindle -1.39 -2.16 -5.25 -4.56 -2.30 -1.56 -0.29 -3.48 -1.92 -2.22 -2.02 -2.04 -6.38 -4.89 -3.50
None -0.38 1.54 -2.00 -1.98 -2.02 3.13 2.67 2.98 -0.82 1.60 2.49 2.72 -1.72 -1.98 -1.98
Nuclear Periphery -1.24 -3.26 -9.06 -2.47 1.92 -1.10 -1.31 -1.81 0.11 -1.23 -1.52 -3.98 -3.89 -0.86 0.48
Nuclear Periphery Foci -1.84 -4.62 -7.94 -5.86 0.20 1.33 0.35 -0.73 -3.42 -1.98 0.79 -2.32 -3.70 -6.02 -1.68
Nucleolus -0.83 -0.99 -5.42 -2.70 -0.47 1.85 1.91 1.90 0.78 -1.66 1.68 1.59 1.37 -1.61 -0.95
Nucleus -0.89 -1.14 -3.41 -3.35 -3.28 1.17 1.20 1.20 0.89 -0.72 1.12 1.15 -0.70 -3.26 -3.31
Peroxisomes 1.19 1.37 -1.70 -3.72 -3.81 1.69 1.93 0.88 -0.40 -0.72 1.93 1.99 -0.29 -2.23 -2.27
Vacuole -1.61 -9.49 -12.51 -11.58 -2.14 2.63 -4.22 -9.21 -10.79 -5.82 1.09 -10.86 -15.93 -15.98 -6.31
Vacuole Periphery 2.57 -2.24 -0.88 -3.38 1.64 3.02 3.18 3.61 -0.05 0.55 3.90 0.80 2.22 -2.20 1.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
Localization
Cell Percentages Golgi (52%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sly1

Sly1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sly1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available