Standard name
Human Ortholog
Description Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.14 0.16 0.08 0.05 0 0 0 – 0 0 0 0 0.17 0.12 0.06 0.2 0.26 0.24 0.09 0.08 0.07 0.08 0.08 0.07
Bud 0.08 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0.07 0.05 0 0.06
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.58 0.46 0.37 0.46 0.19 0.16 0.11 – 0.11 0.12 0.12 0.12 0.58 0.55 0.47 0.2 0.27 0.19 0.65 0.61 0.66 0.73 0.7 0.7
Cytoplasm 0.47 0.7 0.83 0.85 0.92 0.87 0.9 – 0.8 0.77 0.63 0.78 0.63 0.73 0.8 0.6 0.57 0.61 0.08 0.1 0.06 0 0.06 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0.06 0 0 0 0 0.11 0 0.05 0.06 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.09 0.16 – 0.26 0.21 0.33 0.17 0 0 0 0.07 0 0 0 0 0.05 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 25 52 24 13 14 4 4 – 6 11 9 10 33 25 14 111 88 87 20 31 22 12 17 15
Bud 15 6 6 0 1 0 8 – 6 7 11 4 8 1 3 11 8 13 1 1 2 0 2 1
Bud Neck 1 1 14 2 8 2 1 – 2 3 1 4 0 1 1 6 5 7 12 27 22 7 9 13
Bud Site 0 2 0 1 0 0 1 – 0 0 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 106 150 105 127 62 56 52 – 43 39 35 34 114 116 118 116 90 68 144 227 222 114 159 150
Cytoplasm 86 227 239 234 293 306 436 – 316 253 186 223 124 154 202 343 189 220 17 36 20 6 14 8
Endoplasmic Reticulum 5 10 1 0 0 3 0 – 4 3 17 5 2 2 4 64 12 17 13 16 9 4 6 5
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 4 2 0 1 3 3 1 1 4
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 1 1 3 0 0 1 1 2 0 1 1
Mitochondria 3 3 1 4 5 32 76 – 104 69 98 49 1 3 1 38 10 15 2 7 15 4 7 5
Nucleus 0 0 0 1 0 0 2 – 1 3 0 2 0 0 3 1 2 3 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 1 1 0 0 0 1 0 0 1 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 4 2 0 0 0 0 0 0 0 0 0
SpindlePole 4 5 2 4 4 1 5 – 3 2 2 5 1 5 0 28 12 23 0 0 1 0 0 0
Vac/Vac Membrane 0 1 0 1 2 0 1 – 0 0 0 0 0 0 2 9 1 0 6 11 6 1 3 3
Unique Cell Count 184 324 287 276 320 350 487 397 330 296 286 197 212 251 567 333 360 224 370 336 156 228 216
Labelled Cell Count 245 457 392 387 389 404 586 485 391 361 337 283 312 352 734 419 454 224 370 336 156 228 216


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.6 6.2 5.9 5.6 5.6 4.6 4.6 – 4.2 4.0 3.8 4.4 5.6 5.9 5.9 7.1 7.3 6.7 5.2 5.2 5.3
Std Deviation (1e-4) 0.6 0.9 1.0 1.3 1.1 1.1 0.8 – 1.1 0.8 0.7 0.9 1.2 1.7 2.4 1.1 1.3 1.0 1.6 1.7 1.2
Intensity Change (Log2) – – – -0.09 -0.09 -0.37 -0.36 – -0.5 -0.55 -0.64 -0.43 -0.09 -0.01 0.0 0.27 0.3 0.18 -0.18 -0.2 -0.16


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.7 -2.0 0 0 – 0 0 0 0 2.8 1.3 -1.3 4.2 5.8 5.3
Bud 0 0 0 0 – 0 0 0 0 1.3 0 0 -0.1 0.3 1.1
Bud Neck -3.0 -1.6 0 0 – 0 0 0 0 -3.1 -2.8 -3.1 -3.5 -2.4 -2.1
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2.3 -4.7 0 0 – 0 0 0 0 4.6 4.0 2.4 -5.1 -2.6 -5.1
Cytoplasm 0.5 3.1 1.5 2.5 – -1.2 -2.0 -5.6 -1.6 -5.1 -2.9 -0.8 -6.7 -7.1 -6.2
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 5.7 2.8 3.4
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 4.2 2.5 3.1
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 3.2 2.4 3.7
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.1507 1.5151 1.3279 1.0762 0.5786 1.5169 1.9043 2.3549 2.1651 2.1101 2.0043 2.24 1.4238 1.8165 1.6756 1.4541 1.7896 1.6532
Actin 0.009 0.0233 0.0221 0.0373 0.0534 0.0182 0.0115 0.01 0.0122 0.0127 0.0328 0.0087 0.0133 0.0057 0.0034 0.011 0.0533 0.0041
Bud 0.0007 0.0021 0.002 0.0054 0.0047 0.0027 0.0003 0.0004 0.0024 0.0027 0.0007 0.001 0.0002 0.0016 0.0011 0.0007 0.0002 0.0009
Bud Neck 0.0069 0.0058 0.0167 0.0095 0.0103 0.0299 0.0099 0.0048 0.017 0.0328 0.0513 0.0377 0.0074 0.0056 0.0062 0.0096 0.0216 0.0381
Bud Periphery 0.0071 0.0066 0.0099 0.0264 0.0306 0.0143 0.0027 0.0028 0.0132 0.0155 0.0062 0.0114 0.0013 0.0064 0.0045 0.0135 0.0035 0.01
Bud Site 0.027 0.1526 0.0631 0.0116 0.0136 0.0076 0.0267 0.1115 0.0877 0.0278 0.0102 0.0099 0.0085 0.1122 0.0286 0.0081 0.0016 0.0018
Cell Periphery 0.2411 0.1303 0.1653 0.1605 0.1259 0.1895 0.4095 0.3857 0.3385 0.3758 0.2222 0.4263 0.2572 0.1964 0.2224 0.2858 0.24 0.28
Cytoplasm 0.4712 0.5104 0.5432 0.5589 0.4276 0.5505 0.4389 0.4237 0.4462 0.4866 0.5764 0.4568 0.5526 0.5368 0.5933 0.4545 0.5412 0.5919
Cytoplasmic Foci 0.0105 0.0055 0.0043 0.0035 0.0154 0.0104 0.0085 0.001 0.0026 0.0048 0.008 0.0029 0.0033 0.0033 0.0038 0.0042 0.0037 0.0024
Eisosomes 0.0084 0.007 0.0064 0.005 0.0211 0.0045 0.0121 0.0044 0.0075 0.0014 0.0014 0.0019 0.0056 0.0041 0.0037 0.0013 0.0048 0.0019
Endoplasmic Reticulum 0.0134 0.0061 0.0078 0.017 0.0417 0.0082 0.0065 0.0036 0.0054 0.0067 0.0145 0.0058 0.0121 0.0053 0.0058 0.0171 0.0055 0.0074
Endosome 0.0024 0.0008 0.0007 0.0008 0.0078 0.0017 0.0018 0.0001 0.0004 0.0012 0.0019 0.0004 0.0009 0.0002 0.0003 0.0013 0.0002 0.0003
Golgi 0.0018 0.002 0.001 0.0021 0.0056 0.0014 0.0011 0.0003 0.0009 0.001 0.0013 0.0006 0.0015 0.0005 0.0005 0.0013 0.0005 0.0004
Lipid Particles 0.007 0.0013 0.0013 0.0026 0.0093 0.007 0.0044 0.0007 0.0015 0.0031 0.0041 0.0032 0.0044 0.0013 0.0019 0.0027 0.0022 0.0015
Mitochondria 0.0007 0.0007 0.0005 0.0004 0.002 0.0006 0.0002 0.0001 0.0002 0.0002 0.0004 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001
None 0.1755 0.1403 0.1484 0.1532 0.2122 0.1436 0.0513 0.0442 0.0567 0.0176 0.0584 0.0288 0.1262 0.1164 0.1186 0.1832 0.1176 0.0548
Nuclear Periphery 0.0013 0.0004 0.0005 0.0005 0.0019 0.0005 0.0037 0.0002 0.0003 0.0005 0.0006 0.0002 0.0006 0.0003 0.0003 0.0005 0.0001 0.0002
Nucleolus 0.0016 0.0006 0.0007 0.0005 0.0017 0.0007 0.0003 0.0005 0.001 0.0012 0.0004 0.0004 0.0002 0.0004 0.0004 0.0002 0.0001 0.0002
Nucleus 0.004 0.001 0.0015 0.0009 0.0025 0.0015 0.0013 0.0011 0.0023 0.0016 0.0011 0.0006 0.0003 0.0006 0.0004 0.0005 0.0002 0.0005
Peroxisomes 0.0008 0.0003 0.0002 0.0002 0.0011 0.0007 0.0045 0.0001 0.0001 0.0002 0.0006 0.0001 0.0002 0.0001 0.0001 0.0001 0.0007 0
Punctate Nuclear 0.0026 0.0005 0.0007 0.0004 0.0024 0.0013 0.0009 0.0031 0.0007 0.0009 0.0007 0.0003 0.0004 0.0003 0.0004 0.0004 0.0001 0.0002
Vacuole 0.0068 0.0022 0.0036 0.0032 0.009 0.0051 0.0039 0.002 0.003 0.0056 0.0066 0.0028 0.0036 0.0024 0.0041 0.0038 0.0028 0.0032
Vacuole Periphery 0.0002 0.0001 0.0001 0.0001 0.0004 0.0001 0.0001 0 0.0001 0.0001 0.0001 0 0.0001 0 0.0001 0.0001 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 27.1136 28.2424 30.028 33.3826 35.1539 22.1501 38.2521 36.1014 31.8332 37.5289
Translational Efficiency 1.1587 1.0549 0.8727 0.6464 0.6998 1.182 0.7857 0.7459 0.8448 0.7963

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
74 162 100 1772 1130 1488 1800 234 1204 1650 1900 2006

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 684.05 749.57 1162.52 982.58 682.81 717.91 962.43 1206.23 682.89 721.02 972.96 1008.67
Standard Deviation 77.03 109.00 135.25 114.54 90.88 116.24 125.63 184.15 90.09 115.94 133.84 143.87
Intensity Change Log 2 — 0.131961 0.765082 0.522473 — 0.072319 0.495197 0.820949 — 0.102475 0.636563 0.679281

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005524 0.022684 0.035506 0.085767 0.006484 0.016650 0.024757 0.039080 0.006425 0.017242 0.025323 0.080321
Bud Neck 0.093828 0.075306 0.023934 0.051408 0.064366 0.071385 0.047692 0.114500 0.066177 0.071770 0.046442 0.058768
Bud Site 0.026130 0.049425 0.101609* 0.146087* 0.024228 0.034055 0.072675 0.107237* 0.024345 0.035564 0.074198 0.141555*
Cell Periphery 0.138020* 0.052443 0.050185 0.231151* 0.034787 0.027602 0.075144 0.053467 0.041132 0.030041 0.073831 0.210424*
Cytoplasm 0.479136* 0.428289* 0.142650* 0.238695* 0.544120* 0.488258* 0.372071* 0.413611* 0.540126* 0.482370* 0.359996* 0.259099*
Cytoplasmic Foci 0.037395 0.113430 0.074734 0.004496 0.077586 0.106994 0.025365 0.006882 0.075116 0.107626 0.027963 0.004774
Eisosomes 0.075468 0.046896 0.010931 0.097740 0.045406 0.055843 0.045729 0.040368 0.047253 0.054964 0.043898 0.091048
Endoplasmic Reticulum 0.014513 0.020816 0.118564* 0.017103 0.014452 0.007289 0.025290 0.001388 0.014456 0.008617 0.030199 0.015270
Endosome 0.005864 0.012730 0.009914 0.001136 0.007503 0.012030 0.001893 0.001210 0.007402 0.012099 0.002316 0.001145
Golgi 0.014391 0.021574 0.003068 0.000857 0.016656 0.021074 0.000934 0.000863 0.016517 0.021123 0.001046 0.000857
Lipid Particles 0.016358 0.020900 0.017059 0.002715 0.020371 0.024955 0.005187 0.002068 0.020124 0.024557 0.005812 0.002639
Mitochondria 0.010385 0.008150 0.000241 0.001450 0.009109 0.009096 0.000407 0.001493 0.009187 0.009003 0.000398 0.001455
Mitotic Spindle 0.000126 0.000521 0.000225 0.001105 0.000079 0.000480 0.001043 0.000351 0.000082 0.000484 0.001000 0.001017
None 0.000474 0.000328 0.000103 0.000412 0.002426 0.002319 0.000910 0.001355 0.002306 0.002124 0.000867 0.000522
Nuclear Periphery 0.000168 0.000156 0.000777 0.000126 0.000263 0.000182 0.000324 0.000067 0.000257 0.000180 0.000348 0.000119
Nuclear Periphery Foci 0.000486 0.000839 0.014500 0.000692 0.000405 0.000462 0.001992 0.000152 0.000410 0.000499 0.002651 0.000629
Nucleolus 0.000086 0.000160 0.000128 0.000068 0.000273 0.000399 0.000079 0.000111 0.000261 0.000376 0.000082 0.000073
Nucleus 0.038872 0.069229 0.111988 0.044948 0.093635 0.066857 0.184391* 0.140977* 0.090269 0.067090 0.180580* 0.056150
Peroxisomes 0.017194 0.022049 0.001196 0.001141 0.011443 0.015928 0.000972 0.001550 0.011797 0.016529 0.000984 0.001189
Vacuole 0.024827 0.033453 0.282528* 0.072607 0.025584 0.037022 0.113066 0.073209 0.025538 0.036671 0.121985 0.072677
Vacuole Periphery 0.000756 0.000622 0.000161 0.000296 0.000825 0.001117 0.000077 0.000060 0.000821 0.001068 0.000081 0.000268

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.15 -4.09 -21.01 -12.52 -7.08 -6.97 -9.81 -4.70 -3.18 -2.11 -7.86 -10.45 -23.51 -18.78 -15.84
Bud Neck 0.87 3.65 2.29 2.21 -5.77 -1.48 4.72 -4.88 -4.22 -7.05 -1.20 5.54 2.07 3.74 -4.85
Bud Site -2.31 -5.64 -14.93 -11.07 -4.00 -3.94 -14.22 -7.39 -6.47 -3.04 -4.60 -15.07 -26.25 -22.99 -13.51
Cell Periphery 3.44 3.75 -3.64 -18.03 -21.83 2.46 -9.41 -2.05 -2.96 2.02 3.41 -7.08 -28.79 -33.16* -24.06
Cytoplasm 1.59 11.09 8.71 10.56 -6.59 6.38 21.79 7.71 4.40 -3.43 6.85 23.22 35.15 29.58 11.80
Cytoplasmic Foci -5.49 -2.86 4.27 9.35 7.07 -5.80 14.01 18.26 23.67 8.24 -6.74 13.17 21.26 27.96 15.25
Eisosomes 2.02 5.14 -1.57 -6.76 -24.61 -2.99 1.09 0.94 2.56 0.44 -2.28 2.36 -11.98 -9.50 -15.40
Endoplasmic Reticulum -0.66 -6.20 -0.32 0.89 7.19 3.70 -4.90 7.14 7.26 16.29 3.04 -6.66 -0.52 -5.75 8.03
Endosome -1.89 -2.16 2.95 3.52 8.03 -3.90 7.28 6.08 8.96 1.16 -4.21 6.91 8.84 11.68 4.06
Golgi -1.72 3.81 4.54 7.19 3.18 -2.95 15.32 13.98 17.14 0.04 -3.25 15.79 15.81 19.80 0.94
Lipid Particles -0.94 -0.11 3.36 5.77 8.98 -1.94 8.76 9.42 11.33 3.14 -2.02 8.68 10.96 13.49 7.69
Mitochondria 0.40 2.50 2.20 1.66 -4.17 0.01 6.75 5.84 7.55 -5.05 0.12 7.12 6.15 7.53 -4.15
Mitotic Spindle -0.96 -2.46 -2.73 -1.12 -2.44 -2.05 -2.93 -0.93 0.40 1.89 -2.22 -2.95 -2.94 -1.49 0.38
None 0.85 2.33 0.40 -0.83 -4.36 0.07 2.31 1.52 1.35 -1.10 0.17 2.33 2.95 2.65 3.16
Nuclear Periphery 0.24 -5.13 0.96 1.33 5.70 1.14 -1.62 2.97 4.66 21.07 1.17 -2.17 2.16 2.53 17.87
Nuclear Periphery Foci -2.50 -8.17 -2.67 0.67 8.02 -1.35 -11.08 5.70 6.07 12.46 -2.14 -12.92 -4.69 -2.84 11.17
Nucleolus -2.84 -2.19 0.61 2.50 1.87 -1.76 6.87 5.89 3.86 -1.06 -1.76 6.74 5.58 4.26 0.75
Nucleus -2.38 -5.30 -0.79 2.53 6.27 5.50 -15.53 -4.31 -7.00 4.17 4.99 -16.13 7.48 2.89 26.20
Peroxisomes -0.89 4.29 4.29 5.36 0.10 -4.04 14.22 11.24 14.71 -1.11 -4.25 14.84 14.52 17.83 -1.38
Vacuole -1.10 -13.30 -8.30 -7.53 11.03 -5.10 -25.89 -7.82 -6.00 7.49 -5.19 -27.89 -17.66 -13.19 13.21
Vacuole Periphery 0.45 2.10 1.48 1.98 -1.02 -1.28 8.32 8.68 5.05 0.92 -1.19 8.58 3.88 3.61 -1.59
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
Localization
Cell Percentages cell periphery (28%), cytoplasm (2%), mixed (44%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mss4

Mss4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mss4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available