Standard name
Human Ortholog
Description Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.05 0.09 0 0.05 0 0.06
Bud 0.06 0.05 0.12 0 0.12 0.1 0.05 0.05 0.08 0.13 0.11 0.1 0.08 0.05 0 0.08 0.1 0.08 0 0.06 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 0.06 0.07 0.08 0.25 0.26 0.25 0.22 0.27 0.2 0.25 0.13 0.21 0.11 0.12 0.16 0.14 0.09 0.09 0 0 0 0.23 0.47 0.43
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.1 0.14 0 0 0 0 0 0 0 0 0 0 0.18 0.26 0.26 0.22 0.18 0.12 0.17 0.19 0.17 0.12 0.06 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.14 0.15 0.06 0.06 0 0 0 0
Mitochondria 0.77 0.64 0.87 0.8 0.68 0.7 0.77 0.69 0.8 0.74 0.84 0.74 0.52 0.43 0.43 0.09 0.15 0.14 0.45 0.36 0.51 0.36 0.26 0.22
Nucleus 0 0 0 0 0.05 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.09 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.09 0 0 0 0 0 0
Peroxisomes 0.07 0 0 0 0 0 0 0 0 0 0 0 0.11 0.19 0.13 0.28 0.2 0.17 0.09 0.05 0.07 0 0 0
SpindlePole 0.05 0 0 0 0 0 0 0.1 0 0 0.06 0.05 0 0.06 0 0.22 0.2 0.19 0.05 0 0.05 0.06 0 0
Vac/Vac Membrane 0.06 0.13 0 0.06 0 0 0 0 0 0 0 0 0.11 0.12 0.12 0.11 0.13 0.06 0 0.09 0 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 2 1 0 0 1 0 0 0 0 0 0 9 4 1 8 8 26 8 19 1 10 5 13
Bud 10 9 9 2 11 15 7 13 12 18 16 13 22 14 9 23 26 18 4 12 2 5 4 6
Bud Neck 0 0 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 1 1 4 1 3 3 10
Bud Site 1 3 0 3 0 2 3 6 6 5 3 3 2 2 1 10 8 10 – – – – – –
Cell Periphery 1 8 0 2 0 1 1 1 2 0 2 2 7 7 2 10 8 12 0 0 0 1 2 2
Cytoplasm 10 13 6 16 24 37 32 73 29 34 19 28 32 34 46 40 24 19 1 4 0 48 110 101
Endoplasmic Reticulum 2 7 0 1 1 2 3 1 0 1 0 0 1 4 8 5 10 4 0 2 0 1 5 3
Endosome 17 26 1 0 1 1 0 3 0 0 0 0 51 77 77 63 46 26 28 43 13 25 13 10
Golgi 1 6 0 0 0 0 0 0 0 0 0 0 7 8 10 15 37 33 9 14 1 4 0 1
Mitochondria 126 121 65 51 63 105 113 188 118 102 121 99 152 125 128 27 39 31 75 81 40 78 61 51
Nucleus 2 0 1 0 5 0 3 4 8 3 1 5 1 0 0 4 8 7 0 1 0 0 1 0
Nuclear Periphery 0 0 0 1 1 2 3 4 1 0 1 3 1 0 1 3 2 2 1 0 1 1 0 0
Nucleolus 14 11 4 1 3 2 2 5 3 2 0 0 11 13 5 18 5 19 2 0 0 0 0 0
Peroxisomes 12 6 2 0 1 2 1 6 1 1 0 2 32 55 37 80 51 38 15 10 5 7 0 0
SpindlePole 9 5 2 2 4 6 4 26 3 6 9 7 8 19 10 65 53 42 9 6 3 12 9 7
Vac/Vac Membrane 10 25 0 4 1 5 2 11 1 1 0 3 32 34 35 33 33 14 3 19 1 6 7 14
Unique Cell Count 164 190 75 64 93 151 147 271 148 138 144 133 290 294 295 289 260 222 169 226 80 216 237 235
Labelled Cell Count 217 242 91 83 115 181 175 342 185 174 172 165 368 396 370 404 358 302 169 226 80 216 237 235


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 6.3 4.4 4.4 4.6 4.4 3.4 4.4 4.0 3.8 3.9 3.9 6.3 6.3 6.0 7.1 8.3 8.5 5.0 5.1 5.9
Std Deviation (1e-4) 0.9 1.1 0.9 1.0 1.3 1.3 1.0 1.7 1.3 1.5 1.5 1.9 1.2 1.4 1.5 1.6 1.6 1.7 1.3 1.9 1.8
Intensity Change (Log2) – – – -0.0 0.05 -0.01 -0.39 -0.02 -0.15 -0.21 -0.18 -0.18 0.5 0.51 0.44 0.68 0.9 0.93 0.17 0.19 0.42


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.7
Bud 0 0 0 0 0 0 0 0 0 -1.2 0 0 -1.1 -0.5 -1.0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.7 3.0 3.0 2.6 3.5 2.2 3.0 1.1 2.4 0.8 0.9 1.7 1.4 0.3 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 3.6 4.7 4.7 4.1 3.6 2.7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 3.5 3.5
Mitochondria 0 0 0 0 0 0 0 0 0 -5.4 -6.8 -6.7 -13.7 -11.8 -11.6
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.9
Peroxisomes 0 0 0 0 0 0 0 0 0 2.2 3.4 2.5 4.6 3.5 3.2
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 3.9 3.6 3.4
Vacuole 0 0 0 0 0 0 0 0 0 3.0 3.1 3.1 3.1 3.2 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9028 3.6428 3.7706 3.4183 3.7035 3.5045 2.7347 3.2349 3.1038 3.5237 2.0903 2.69 4.4837 4.3441 4.0577 4.5461 4.4154 4.0261
Actin 0.0661 0.0732 0.054 0.0324 0.1089 0.0449 0.0865 0.0664 0.0662 0.0349 0.0191 0.0383 0.0944 0.0864 0.0539 0.1066 0.0871 0.0667
Bud 0.0017 0.0033 0.0295 0.0026 0.0205 0.0016 0.0095 0.005 0.0252 0.0432 0.0173 0.0017 0.0019 0.0185 0.0227 0.0259 0.0121 0.0059
Bud Neck 0.0213 0.0046 0.0061 0.0006 0.001 0.0092 0.0023 0.0015 0.0015 0.0009 0.0002 0.0014 0.0033 0.001 0.0012 0.0097 0.001 0.0039
Bud Periphery 0.0037 0.006 0.0549 0.0046 0.1248 0.0033 0.0175 0.0085 0.0789 0.1781 0.1234 0.0048 0.0027 0.0278 0.0672 0.0932 0.0495 0.0188
Bud Site 0.013 0.0571 0.0687 0.0039 0.0049 0.0031 0.0243 0.0675 0.0685 0.0636 0.0012 0.002 0.0241 0.0265 0.0411 0.0128 0.0093 0.0084
Cell Periphery 0.0021 0.0039 0.0114 0.0004 0.0016 0.0005 0.0014 0.0021 0.0017 0.0035 0.0009 0.0006 0.0021 0.0009 0.0037 0.002 0.0024 0.0017
Cytoplasm 0.0448 0.0124 0.0322 0.001 0.0069 0.0027 0.0318 0.0121 0.0104 0.0026 0.0005 0.0028 0.0225 0.0081 0.0113 0.0035 0.0379 0.0087
Cytoplasmic Foci 0.1522 0.1325 0.1104 0.0383 0.0569 0.093 0.1972 0.127 0.1391 0.0787 0.0506 0.1305 0.1772 0.1268 0.1078 0.1128 0.1086 0.1414
Eisosomes 0.0015 0.0025 0.0008 0.0005 0.0008 0.0004 0.0011 0.0017 0.0009 0.0007 0.0007 0.0004 0.0012 0.0007 0.0011 0.0005 0.001 0.0007
Endoplasmic Reticulum 0.0245 0.0007 0.0079 0.0002 0.0017 0.0005 0.005 0.0023 0.0012 0.0005 0.0003 0.0017 0.0095 0.0026 0.0032 0.0004 0.0042 0.0017
Endosome 0.1312 0.1299 0.139 0.0419 0.1278 0.1186 0.1556 0.1782 0.0874 0.0553 0.0434 0.1649 0.1733 0.1265 0.1251 0.1173 0.0895 0.1276
Golgi 0.0863 0.1061 0.071 0.0762 0.0321 0.1252 0.0551 0.0451 0.0454 0.0525 0.0576 0.1077 0.0896 0.1098 0.0817 0.122 0.1125 0.1425
Lipid Particles 0.0833 0.0801 0.0223 0.0359 0.0404 0.0767 0.0537 0.0312 0.0115 0.0479 0.0957 0.0578 0.0648 0.0517 0.0411 0.0175 0.0105 0.0607
Mitochondria 0.1359 0.2306 0.2536 0.6726 0.3489 0.4239 0.1744 0.2696 0.313 0.3045 0.4064 0.3447 0.2092 0.2903 0.2916 0.2547 0.3093 0.2445
None 0.0088 0.0132 0.0089 0.0005 0.001 0.0006 0.0188 0.0457 0.0102 0.0057 0.0017 0.0008 0.0183 0.0285 0.0145 0.0015 0.0378 0.0009
Nuclear Periphery 0.0351 0.0005 0.0175 0.0001 0.0009 0.0002 0.016 0.0011 0.0005 0.0003 0.0001 0.0004 0.0054 0.0011 0.0011 0.0002 0.0014 0.0003
Nucleolus 0.0014 0.0023 0.0014 0.0004 0.0006 0.0004 0.0242 0.0012 0.0016 0.002 0.0005 0.0004 0.0007 0.0006 0.0009 0.0004 0.0004 0.0003
Nucleus 0.0083 0.0007 0.0081 0.0003 0.0006 0.0003 0.0327 0.0008 0.0012 0.0009 0.0002 0.0003 0.0015 0.0007 0.0007 0.0003 0.0004 0.0003
Peroxisomes 0.1528 0.1168 0.0726 0.0823 0.1079 0.0884 0.0476 0.1054 0.1144 0.1147 0.1757 0.1276 0.0764 0.0836 0.1136 0.1131 0.1173 0.1576
Punctate Nuclear 0.0136 0.0007 0.0012 0.0002 0.0005 0.0005 0.0272 0.0009 0.0033 0.0012 0.002 0.0007 0.0106 0.0006 0.0029 0.0005 0.001 0.0012
Vacuole 0.0073 0.0191 0.0232 0.0026 0.0075 0.0034 0.0129 0.0203 0.0144 0.0057 0.0013 0.0063 0.0082 0.0051 0.0104 0.0033 0.0045 0.0035
Vacuole Periphery 0.0052 0.0036 0.0052 0.0024 0.0039 0.0029 0.0051 0.0062 0.0034 0.0027 0.0014 0.0043 0.003 0.0022 0.0032 0.0019 0.0024 0.0027

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.6782 15.5224 10.4712 10.7782 13.8149 17.3544 17.8348 20.4634 12.9438 21.1487
Translational Efficiency 0.8081 1.4157 1.069 0.9972 1.309 1.0578 1.1149 0.9164 1.0577 1.1414

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2066 1354 1852 1685 1836 847 233 186 3902 2201 2085 1871

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 779.62 694.67 991.45 1051.44 775.84 796.08 1200.89 1132.78 777.84 733.70 1014.86 1059.53
Standard Deviation 96.14 104.10 123.63 136.89 100.53 106.30 137.61 137.73 98.25 115.97 141.59 139.12
Intensity Change Log 2 — -0.166443 0.346769 0.431524 — 0.037154 0.630273 0.546037 — -0.061303 0.495130 0.489777

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003320 0.005229 0.003466 0.029714 0.001556 0.002660 0.019820 0.023337 0.002490 0.004240 0.005294 0.029080
Bud Neck 0.012208 0.019320 0.017474 0.011048 0.025630 0.009011 0.021310 0.012355 0.018523 0.015353 0.017903 0.011178
Bud Site 0.062632 0.074534 0.118430* 0.377928* 0.031879 0.044939 0.281897* 0.275007* 0.048162 0.063145 0.136698* 0.367697*
Cell Periphery 0.001213 0.001408 0.000277 0.000684 0.000975 0.000401 0.000417 0.000250 0.001101 0.001020 0.000293 0.000641
Cytoplasm 0.012655 0.015590 0.037176 0.108173* 0.015337 0.013837 0.038358 0.068376 0.013917 0.014916 0.037308 0.104217*
Cytoplasmic Foci 0.054735 0.072786 0.092968 0.055920 0.077374 0.072439 0.102998 0.131355 0.065387 0.072653 0.094089 0.063419
Eisosomes 0.000110 0.000156 0.000071 0.000105 0.000134 0.000094 0.000106 0.000071 0.000121 0.000133 0.000075 0.000101
Endoplasmic Reticulum 0.000518 0.000720 0.000947 0.000685 0.000840 0.000355 0.001760 0.000825 0.000669 0.000580 0.001038 0.000699
Endosome 0.144242 0.139313 0.168549 0.033624 0.152962 0.128946 0.093662 0.093085 0.148345 0.135323 0.160180 0.039535
Golgi 0.097359 0.122379* 0.070509 0.055469 0.113286* 0.171045* 0.058759 0.070645 0.104853 0.141107* 0.069196 0.056978
Lipid Particles 0.003885 0.005766 0.001841 0.000362 0.015565 0.002273 0.001626 0.001133 0.009381 0.004422 0.001817 0.000439
Mitochondria 0.484256* 0.392751* 0.127247* 0.086963 0.419502* 0.424178* 0.014081 0.018151 0.453788* 0.404845* 0.114601* 0.080122
Mitotic Spindle 0.016496 0.018331 0.214321* 0.140142* 0.026332 0.032814 0.132466* 0.166382* 0.021124 0.023905 0.205174* 0.142751*
None 0.000809 0.001032 0.000508 0.000280 0.003686 0.000339 0.000138 0.000136 0.002163 0.000765 0.000466 0.000266
Nuclear Periphery 0.000086 0.000051 0.000434 0.000065 0.000273 0.000066 0.000276 0.000118 0.000174 0.000056 0.000417 0.000070
Nuclear Periphery Foci 0.000339 0.000765 0.001292 0.000173 0.001321 0.000678 0.001034 0.000342 0.000801 0.000731 0.001263 0.000190
Nucleolus 0.000415 0.001379 0.001642 0.000091 0.006108 0.001058 0.000621 0.000210 0.003094 0.001255 0.001528 0.000103
Nucleus 0.000572 0.001336 0.002308 0.000743 0.006562 0.000636 0.004152 0.000760 0.003390 0.001067 0.002514 0.000745
Peroxisomes 0.073490 0.104145* 0.052429 0.064820 0.064485 0.067993 0.152803* 0.082367 0.069253 0.090233 0.063646 0.066564
Vacuole 0.017801 0.014122 0.070565 0.025966 0.022321 0.014715 0.064413 0.050722 0.019928 0.014350 0.069877 0.028427
Vacuole Periphery 0.012859 0.008887 0.017546 0.007044 0.013872 0.011522 0.009303 0.004375 0.013336 0.009901 0.016625 0.006778

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.44 -0.29 -12.82 -11.42 -12.82 -1.42 -4.31 -4.20 -3.95 -0.61 -3.13 -4.64 -13.95 -12.64 -12.09
Bud Neck -3.83 -4.57 0.83 4.68 6.51 7.34 1.25 3.95 -2.23 2.72 2.09 0.08 5.83 3.11 7.10
Bud Site -2.21 -10.72 -38.65* -35.14* -30.30* -2.84 -13.31 -11.45 -10.67 0.19 -4.07 -18.56 -43.45 -39.41* -27.71*
Cell Periphery -1.09 7.09 3.94 5.74 -7.62 4.95 4.15 6.26 2.85 1.72 0.70 9.18 4.95 4.54 -7.09
Cytoplasm -1.69 -10.01 -24.50 -23.55 -16.65 0.75 -4.26 -5.92 -6.07 -2.40 -0.62 -10.61 -25.06 -24.59 -16.65
Cytoplasmic Foci -5.31 -11.39 -0.18 4.82 10.45 1.34 -2.83 -4.39 -4.85 -2.08 -2.61 -9.14 1.11 3.22 8.86
Eisosomes -7.02 9.11 1.39 8.11 -7.54 3.31 1.87 4.36 2.06 2.64 -1.62 7.63 3.30 6.32 -6.21
Endoplasmic Reticulum -1.88 -4.32 -1.88 0.08 2.11 3.96 -2.96 -0.22 -1.47 2.00 1.06 -3.92 -0.59 -1.30 2.80
Endosome 0.78 -3.73 24.61 21.34 30.12* 3.24 6.63 5.93 3.63 0.26 2.68 -1.98 30.75 24.00 28.37*
Golgi -4.65 7.20 10.79 13.79 4.59 -7.80 8.09 4.91 9.42 -0.80 -8.26 11.51 14.56 19.54 4.00
Lipid Particles -1.94 3.28 6.90 6.27 5.48 9.13 9.53 9.82 1.03 0.90 5.58 9.87 12.48 6.88 5.61
Mitochondria 7.39 38.02* 43.95* 29.70* 6.30 -0.40 46.01* 41.84* 31.24* -0.55 5.15 46.57* 53.87* 38.90* 5.96
Mitotic Spindle -0.96 -32.20* -22.30 -21.54 9.19 -1.82 -7.75 -7.12 -6.74 -1.37 -1.50 -32.29 -22.67 -21.69 8.21
None -1.03 1.85 3.64 4.11 3.08 4.91 5.16 5.20 3.66 0.56 3.99 5.04 5.73 4.37 3.09
Nuclear Periphery 1.53 -6.54 0.39 -2.57 7.17 3.75 -0.54 1.11 -1.75 1.14 4.22 -4.93 3.18 -2.09 7.20
Nuclear Periphery Foci -2.35 -4.67 2.10 3.02 5.15 0.99 0.06 1.54 0.06 2.52 0.26 -2.39 2.68 2.01 5.45
Nucleolus -2.77 -4.78 3.89 3.74 6.04 4.28 5.45 6.24 1.13 2.37 3.24 2.67 6.72 3.30 6.27
Nucleus -2.24 -6.28 -3.11 0.13 3.63 6.28 -0.12 4.08 -1.66 2.26 4.75 0.40 4.28 -0.91 4.28
Peroxisomes -5.19 5.20 2.33 7.19 -2.80 -0.63 -6.00 -1.30 -0.91 4.07 -5.02 1.94 1.31 5.66 -0.48
Vacuole 2.71 -19.31 -6.55 -8.31 12.26 3.81 -5.75 -4.97 -5.69 0.41 4.84 -19.55 -7.39 -9.92 11.19
Vacuole Periphery 4.00 -3.74 5.28 1.91 8.33 1.79 2.20 6.20 4.48 1.94 4.36 -2.98 7.02 3.49 8.47
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
Localization
Cell Percentages mitochondrion (88%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mfb1

Mfb1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mfb1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available