Standard name
Human Ortholog
Description Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.06 0.05
Bud 0 0 0 0 0.06 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0.07 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0.05 0.07 0.05 0.05
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0.06 – 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Endosome 0 0 0.09 0.05 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0.05 0.06 0.08 0 0.07 0.05
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.1 0.19 0.05 0 0.05 0.07 0 0 0
Mitochondria 0.47 0.52 0.48 0.63 0.62 0.68 0.66 0.63 0.75 – 0.75 0.67 0.52 0.23 0.25 0.22 0.16 0.16 0.27 0.31 0.32 0.28 0.09 0.08
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.39 0.34 0.19 0.17 0.14 0.21 0.26 0.32 0.24 – 0.26 0.36 0.16 0.24 0.29 0.62 0.52 0.5 0.09 0.16 0.06 0.06 0.05 0
Peroxisomes 0.15 0.17 0.22 0.14 0.22 0.08 0.11 0.05 0 – 0.06 0.07 0.37 0.54 0.48 0 0.08 0 0.14 0.09 0.13 0.17 0.35 0.37
SpindlePole 0.13 0.07 0.22 0.07 0.1 0 0.05 0 0 – 0 0 0.16 0.28 0.28 0.05 0.08 0.11 0.21 0.12 0.17 0.13 0.19 0.25
Vac/Vac Membrane 0 0 0.06 0.07 0.05 0.05 0 0.07 0 – 0 0 0 0 0 0.07 0.09 0.13 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 5 0 1 3 0 2 3 0 – 4 1 0 0 1 1 2 1 7 13 11 9 19 10
Bud 4 4 7 6 11 3 5 5 8 – 19 6 1 0 1 0 0 0 5 8 7 10 9 4
Bud Neck 0 5 1 5 1 3 2 0 0 – 0 0 1 0 1 0 0 0 13 13 11 10 14 8
Bud Site 4 3 1 1 0 2 6 1 2 – 1 9 1 1 0 0 0 0 – – – – – –
Cell Periphery 1 2 0 3 2 0 0 0 0 – 0 0 0 0 0 0 0 2 0 0 0 0 0 0
Cytoplasm 1 1 2 5 4 6 9 14 13 – 16 6 1 5 3 1 2 2 1 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 1 4 1 0 1 2 0 0 0 0
Endosome 3 7 16 7 7 5 6 4 0 – 2 2 3 7 8 0 3 2 8 19 17 4 22 10
Golgi 0 2 3 0 3 1 1 5 0 – 2 2 0 1 0 6 19 2 6 16 15 6 13 5
Mitochondria 65 114 81 96 116 150 204 212 174 – 264 173 64 37 47 13 16 6 50 96 73 41 28 15
Nucleus 2 4 0 1 0 3 3 3 3 – 3 1 2 0 1 0 0 0 0 2 0 0 0 0
Nuclear Periphery 3 4 0 1 0 3 4 2 1 – 1 1 0 0 0 0 0 1 0 1 0 0 0 0
Nucleolus 53 75 32 26 26 47 82 107 56 – 91 93 19 39 54 37 52 19 17 48 14 8 15 8
Peroxisomes 20 37 37 21 41 18 34 17 5 – 21 19 45 88 90 1 8 1 25 29 30 25 109 68
SpindlePole 18 16 38 11 19 8 15 14 6 – 12 5 19 46 53 3 8 4 40 36 38 18 57 47
Vac/Vac Membrane 4 4 10 10 9 12 7 22 5 – 2 8 2 3 2 4 9 5 3 12 4 3 2 1
Unique Cell Count 137 220 170 152 186 219 310 338 232 350 259 122 162 188 60 100 38 188 312 230 149 309 185
Labelled Cell Count 179 283 228 194 242 261 380 409 273 438 326 158 227 262 70 120 45 188 312 230 149 309 185


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 20.3 19.1 18.1 15.5 18.2 18.4 19.1 22.6 20.1 – 22.2 24.8 20.2 24.5 22.7 49.0 43.3 38.4 16.9 18.3 18.8
Std Deviation (1e-4) 11.4 11.1 10.1 9.0 8.2 8.5 8.3 11.5 10.0 – 12.2 12.5 9.7 13.8 10.3 30.0 23.1 18.8 8.1 9.7 9.4
Intensity Change (Log2) – – – -0.22 0.01 0.02 0.07 0.32 0.15 – 0.3 0.45 0.16 0.44 0.32 1.44 1.26 1.08 -0.1 0.01 0.05


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud -0.1 0.8 0 0 0 -0.3 – 0.6 -1.1 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 1.8 2.3 – 2.0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome -1.7 -2.2 -3.1 -3.7 -4.5 -4.8 – -5.2 -4.4 -2.4 -1.8 -1.9 0 -2.0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 5.0 0
Mitochondria 2.8 2.8 4.2 3.9 3.2 5.6 – 6.3 3.9 0.8 -4.7 -4.5 -3.5 -5.2 -3.6
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus -0.4 -1.2 0.6 1.9 3.1 1.3 – 1.8 3.8 -0.7 1.2 2.2 6.2 5.7 4.0
Peroxisomes -1.9 0.1 -3.8 -3.2 -5.8 -6.3 – -5.4 -4.3 2.8 6.1 5.2 -3.6 -2.9 -2.8
SpindlePole -3.8 -3.1 -5.7 -5.9 -6.4 -6.3 – -6.9 -6.9 -1.4 1.3 1.3 -3.0 -3.0 -1.6
Vacuole 0.3 -0.4 -0.2 -2.1 0.3 -1.9 – 0 -1.4 -1.8 -1.9 -2.5 0 1.0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.7075 17.8777 16.2619 14.5445 15.9877 17.4341 15.1657 18.1814 15.6584 15.8544 12.9313 15.9648 13.5806 16.7448 14.2533 14.5094 14.0091 14.7998
Actin 0.0068 0.0005 0.0124 0.0021 0.0138 0.0074 0.008 0.0005 0.0102 0.0004 0.0008 0.0021 0.0182 0.0078 0.0049 0.0218 0.0007 0.0012
Bud 0.0002 0.0002 0.0004 0.0001 0.0003 0 0.0003 0 0.0001 0 0.0001 0 0.0002 0.0002 0.0005 0.0001 0.0001 0.0003
Bud Neck 0.0021 0.0001 0.0003 0 0.0002 0 0.0004 0 0.0001 0 0.0001 0 0.0019 0.0001 0.0004 0.0001 0.0001 0.0001
Bud Periphery 0.0003 0.0004 0.0005 0.0001 0.0004 0 0.0006 0 0.0001 0.0001 0.0001 0 0.0004 0.0002 0.0007 0.0002 0.0003 0.0002
Bud Site 0.002 0.0002 0.0035 0.0007 0.0003 0.0001 0.0031 0 0.0003 0 0.0002 0 0.0007 0.001 0.0053 0.0003 0.0002 0.0007
Cell Periphery 0.0004 0.0005 0.0004 0.0001 0.0002 0 0.0004 0.0001 0.0001 0 0.0003 0.0001 0.0002 0.0003 0.0003 0.0001 0.0002 0.0001
Cytoplasm 0.0008 0 0.002 0.0012 0.0006 0.0001 0.001 0 0.0001 0 0.0013 0.0001 0.0022 0 0.0002 0 0 0.0003
Cytoplasmic Foci 0.0145 0.0029 0.0121 0.0178 0.0062 0.0039 0.0048 0.0022 0.0019 0 0.0176 0.0016 0.019 0.0028 0.0119 0.0031 0.003 0.0033
Eisosomes 0.0005 0.0001 0.0006 0.0002 0.0001 0.0002 0.0006 0.0001 0.0005 0.0001 0.0001 0.0001 0.0003 0.0002 0.0006 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0025 0 0.0005 0.0014 0.0013 0 0.0034 0 0.0004 0 0.0004 0 0.0023 0 0.0001 0.0001 0 0.0001
Endosome 0.0037 0.0014 0.0061 0.0025 0.031 0.0006 0.0053 0.0032 0.0042 0.0001 0.0213 0.0016 0.0095 0.0036 0.0027 0.0059 0.0138 0.0108
Golgi 0.0049 0.0021 0.0109 0.0013 0.008 0.002 0.003 0.0119 0.0037 0.0003 0.0395 0.0113 0.0097 0.0251 0.0063 0.0071 0.0247 0.0288
Lipid Particles 0.0546 0.023 0.0205 0.034 0.011 0.0099 0.0152 0.0115 0.0094 0.0011 0.0246 0.0117 0.024 0.0304 0.0102 0.0167 0.0222 0.0181
Mitochondria 0.8634 0.932 0.8804 0.9178 0.8742 0.9639 0.9203 0.943 0.9528 0.9959 0.8689 0.9616 0.8728 0.8903 0.9271 0.9213 0.8757 0.9262
None 0.002 0 0.002 0.0064 0.0006 0.0003 0.0011 0 0.0001 0 0.0002 0 0.0011 0 0.0001 0.0001 0 0
Nuclear Periphery 0.0017 0 0.0012 0.0006 0.0046 0 0.0049 0 0.0009 0 0.0008 0.0001 0.001 0.0002 0 0.0001 0.0001 0.0001
Nucleolus 0.0028 0.0045 0.0063 0.0005 0.0008 0.0004 0.0017 0.0004 0.0002 0 0.0003 0.0004 0.0002 0.0011 0.0053 0.0001 0.001 0.0002
Nucleus 0.0009 0.0002 0.003 0.0002 0.0007 0 0.0011 0 0.0001 0 0.0004 0.0001 0.0002 0.0002 0.0004 0.0001 0.0002 0.0002
Peroxisomes 0.0267 0.0135 0.0225 0.0059 0.0207 0.0101 0.0125 0.0168 0.0117 0.0011 0.0085 0.0046 0.0278 0.0206 0.0149 0.0199 0.0138 0.0025
Punctate Nuclear 0.0016 0 0.0021 0.001 0.001 0 0.0022 0 0.0002 0 0.0028 0 0.0029 0 0.0001 0.0001 0 0.0001
Vacuole 0.0012 0.0062 0.003 0.0014 0.0139 0.0002 0.005 0.0012 0.0005 0.0001 0.0037 0.0007 0.0014 0.0026 0.0022 0.001 0.005 0.0014
Vacuole Periphery 0.0064 0.0122 0.0093 0.0046 0.01 0.0009 0.0051 0.0089 0.0026 0.0006 0.008 0.0039 0.004 0.0132 0.0057 0.0019 0.0387 0.0048

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.3239 20.2458 26.1405 51.8851 30.8322 32.1422 59.0575 84.1408 99.7414 51.5825
Translational Efficiency 2.107 2.2281 1.7205 1.8056 1.8655 1.7331 1.4521 1.6427 1.4739 1.6975

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1504 1315 2302 1692 2315 1607 96 88 3819 2922 2398 1780

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1041.64 1843.53 3547.73 2769.43 1961.79 1797.80 3119.26 3296.01 1599.42 1818.38 3530.58 2795.46
Standard Deviation 407.42 713.51 923.48 980.68 738.60 762.54 1046.19 1057.47 773.42 741.22 932.49 991.21
Intensity Change Log 2 — 0.823614 1.768039 1.410732 — -0.125938 0.669033 0.748550 — 0.277854 1.150425 1.014001

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002098 0.011867 0.008107 0.019499 0.007824 0.011474 0.023515 0.026169 0.005569 0.011651 0.008723 0.019828
Bud Neck 0.025876 0.015702 0.003169 0.010889 0.009705 0.018742 0.017348 0.015072 0.016074 0.017374 0.003737 0.011096
Bud Site 0.056615 0.026464 0.002776 0.027018 0.019412 0.038139 0.014064 0.035141 0.034063 0.032885 0.003228 0.027420
Cell Periphery 0.001014 0.000355 0.000093 0.000517 0.000283 0.000564 0.000337 0.000488 0.000571 0.000470 0.000103 0.000515
Cytoplasm 0.019654 0.006027 0.000600 0.004535 0.005374 0.009031 0.001258 0.007059 0.010998 0.007679 0.000627 0.004660
Cytoplasmic Foci 0.530259* 0.307922* 0.038121 0.082766 0.198506* 0.284142* 0.178796 0.148970 0.329157* 0.294844* 0.043753 0.086039
Eisosomes 0.001477 0.002316 0.001632 0.001011 0.003029 0.003616 0.002013 0.002853 0.002418 0.003031 0.001648 0.001102
Endoplasmic Reticulum 0.000703 0.000444 0.000078 0.000333 0.000242 0.000411 0.000509 0.000317 0.000424 0.000426 0.000095 0.000332
Endosome 0.023541 0.005812 0.000858 0.005855 0.002467 0.006416 0.004980 0.004451 0.010766 0.006144 0.001023 0.005786
Golgi 0.013881 0.020299 0.011804 0.026122 0.011879 0.020809 0.025375 0.023235 0.012667 0.020579 0.012348 0.025980
Lipid Particles 0.009683 0.024742 0.012306 0.010480 0.019131 0.020088 0.009245 0.004853 0.015410 0.022182 0.012183 0.010202
Mitochondria 0.052897 0.264248* 0.854913* 0.678049* 0.487830* 0.280690* 0.501168* 0.589742* 0.316545* 0.273291* 0.840752* 0.673683*
Mitotic Spindle 0.014994 0.027650 0.007942 0.021689 0.010722 0.018541 0.093092 0.018231 0.012405 0.022640 0.011351 0.021518
None 0.004628 0.001338 0.002463 0.001873 0.002073 0.002168 0.002202 0.001787 0.003079 0.001794 0.002452 0.001868
Nuclear Periphery 0.000240 0.000521 0.001271 0.000888 0.000558 0.000543 0.001943 0.000897 0.000433 0.000533 0.001297 0.000889
Nuclear Periphery Foci 0.005399 0.001189 0.000432 0.000602 0.000936 0.001116 0.000853 0.000482 0.002694 0.001149 0.000449 0.000596
Nucleolus 0.018085 0.010352 0.002458 0.002617 0.007706 0.010042 0.003783 0.001464 0.011793 0.010181 0.002511 0.002560
Nucleus 0.011526 0.002808 0.000128 0.000512 0.002020 0.003262 0.000364 0.000288 0.005763 0.003057 0.000137 0.000501
Peroxisomes 0.185608* 0.253399* 0.040479 0.079686 0.201604* 0.253943* 0.084614 0.102666* 0.195305* 0.253698* 0.042246 0.080822
Vacuole 0.017895 0.011532 0.004558 0.011222 0.005868 0.011095 0.019506 0.006868 0.010604 0.011292 0.005156 0.011007
Vacuole Periphery 0.003927 0.005012 0.005811 0.013837 0.002830 0.005169 0.015037 0.008970 0.003262 0.005098 0.006181 0.013596

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.21 -6.62 -10.95 -4.04 -6.53 -2.89 -1.75 -2.31 -1.85 -0.22 -6.82 -3.25 -9.04 -4.83 -6.37
Bud Neck 5.71 14.34 8.87 4.54 -11.69 -7.98 -2.68 -1.84 1.17 0.55 -1.40 16.34 5.30 6.82 -11.21
Bud Site 8.54 17.81 8.11 -0.34 -12.34 -7.07 1.79 -1.27 0.14 -1.64 0.43 20.26 2.45 2.03 -12.25
Cell Periphery 5.85 8.23 3.69 -1.94 -5.14 -3.55 -0.37 -1.64 0.48 -0.91 1.55 8.62 0.56 -0.56 -5.24
Cytoplasm 9.05 13.23 10.09 2.78 -9.97 -4.92 10.38 -0.59 0.77 -2.13 4.40 16.65 8.49 5.32 -10.14
Cytoplasmic Foci 18.08 55.14 46.48 24.14 -10.50 -9.43 0.79 1.99 5.35 0.88 4.26 48.68 35.73 30.82 -9.70
Eisosomes -3.21 -0.82 2.46 6.54 5.91 -1.68 2.82 0.18 0.75 -0.81 -2.70 4.80 8.61 9.86 4.86
Endoplasmic Reticulum 2.03 8.42 4.69 1.69 -8.27 -5.11 -1.03 -0.99 1.26 0.72 -0.35 9.62 2.21 2.25 -7.58
Endosome 8.30 10.99 8.28 -0.14 -9.92 -5.33 -2.70 -2.39 1.81 0.44 4.79 11.59 5.06 0.46 -9.87
Golgi -3.02 1.37 -5.74 -2.38 -7.31 -5.28 -2.72 -2.00 -0.42 0.29 -5.98 0.26 -7.28 -2.66 -7.19
Lipid Particles -5.97 -1.86 -0.57 5.74 1.33 -0.44 5.09 8.00 7.47 2.40 -4.08 2.59 3.75 7.05 1.51
Mitochondria -19.98* -123.31* -64.19* -31.91* 18.01* 16.83* -0.33 -2.53 -7.71 -1.60 4.81 -63.80* -33.34* -37.25* 17.10*
Mitotic Spindle -4.01 3.58 -2.55 1.83 -6.61 -4.22 -3.96 -1.47 0.06 3.50 -5.95 0.75 -4.51 0.40 -4.70
None 3.83 2.56 3.24 -3.68 4.93 -0.27 -0.29 1.14 0.97 0.92 3.31 1.83 3.48 -0.31 5.04
Nuclear Periphery -5.93 -4.63 -6.42 -3.48 1.57 0.07 -3.07 -0.86 -1.00 1.95 -0.81 -3.58 -3.08 -3.40 1.75
Nuclear Periphery Foci 5.03 5.98 5.79 4.03 -1.51 -1.08 0.46 1.89 2.82 1.55 4.44 6.45 6.10 5.25 -1.37
Nucleolus 4.18 10.58 10.36 6.28 -0.42 -2.08 4.08 8.43 9.32 3.11 1.64 12.28 11.82 9.69 -0.16
Nucleus 7.03 10.53 10.05 4.70 -4.37 -1.95 4.20 4.38 5.89 0.71 4.23 11.40 10.31 6.96 -4.35
Peroxisomes -6.89 22.67 14.61 19.70 -8.59 -5.93 7.81 5.28 7.83 -0.78 -8.86 33.34 20.36 26.66 -8.61
Vacuole 3.01 7.50 3.30 0.18 -6.68 -5.43 -2.34 -0.72 2.50 2.10 -0.75 6.35 -0.48 0.19 -5.98
Vacuole Periphery -1.27 -2.63 -7.58 -6.46 -6.20 -2.99 -2.34 -2.49 -1.49 1.05 -3.23 -5.11 -8.84 -6.81 -5.91
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
Localization
Cell Percentages mitochondrion (51%)
Cell Cycle Regulation No
Subcompartmental Group mito-3

Hsp78

Hsp78


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hsp78-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available