Standard name
Human Ortholog
Description Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.13 0.14 0 0.06 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.1 0.05 0.09 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.71 0.81 0.73 0.93 0.84 0.84 0.83 0.78 0.73 0.77 0.77 0.72 0.75 0.71 0.75 0.81 0.78 0.75 0.56 0.69 0.57 0.49 0.4 0.33
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.25 0.18 0.24 0 0.09 0.1 0.12 0.15 0.23 0.16 0.17 0.23 0.17 0.16 0.09 0.15 0.12 0.12 0.32 0.25 0.35 0.24 0.28 0.33
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0 0 0 0.06 0.06 0.05 0.07 0.05 0.06 0 0.06 0 0 0 0 0.08 0.09 0.06 0 0.05 0.16 0.21 0.23
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 0 1 0 1 1 5 7 6 3 1 1 0 0 0 0 0 12 5 4 6 8 3
Bud Neck 0 0 0 0 1 0 0 0 1 2 0 2 0 0 0 0 0 0 0 0 1 3 0 0
Bud Site 0 0 0 2 0 3 0 0 9 10 6 23 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 11 9 21 17 20 21 19 29 16 15 14 12 36 61 59 8 12 12 0 1 2 3 6 3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 3 0 0 0 0 0 1
Endosome 3 2 2 1 3 2 7 2 1 1 3 6 2 2 8 1 1 1 4 2 5 7 9 9
Golgi 3 0 1 0 1 1 0 1 0 0 0 0 0 0 0 0 1 0 1 0 1 2 3 0
Mitochondria 4 5 1 2 10 14 14 6 79 42 63 50 2 1 1 5 0 0 0 0 1 3 5 8
Nucleus 293 409 451 456 452 586 741 604 591 608 519 547 264 331 310 158 153 114 260 401 411 167 209 141
Nuclear Periphery 0 3 5 0 5 8 14 1 4 4 6 6 1 7 1 0 1 1 1 0 2 1 2 8
Nucleolus 105 89 151 14 48 69 112 113 188 124 116 174 58 75 38 30 23 19 150 141 253 82 145 145
Peroxisomes 1 0 0 0 0 0 0 0 0 0 0 0 0 3 6 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 2 0 1 2 0 4 0 0 0 0 1 4 6 0 0 0 4 2 3 5 8 6
Vac/Vac Membrane 27 19 19 8 33 41 46 55 42 45 30 42 6 14 16 7 16 13 27 18 34 54 110 99
Unique Cell Count 412 505 618 490 540 698 896 778 810 794 670 757 351 463 414 195 196 152 464 578 725 342 518 436
Labelled Cell Count 448 537 653 502 574 748 954 820 938 857 760 863 372 498 445 211 208 163 464 578 725 342 518 436


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.6 12.5 14.2 12.6 10.3 10.7 10.8 10.8 9.2 10.3 9.4 9.6 13.7 13.7 13.0 13.5 17.0 17.4 14.3 14.8 15.5
Std Deviation (1e-4) 4.5 2.7 3.7 2.7 2.6 3.1 2.5 2.8 2.5 2.6 2.4 2.4 4.3 4.4 4.1 3.7 4.5 6.0 3.7 3.8 4.6
Intensity Change (Log2) – – – -0.18 -0.46 -0.41 -0.4 -0.39 -0.62 -0.46 -0.6 -0.57 -0.05 -0.06 -0.12 -0.07 0.26 0.29 0.01 0.06 0.13


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 4.4 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 0.3 -0.4 -1.5 0.3 -1.7 -1.8 -1.4 -2.2 4.4 6.0 6.4 0.5 1.7 2.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.0 3.1 2.7 0 7.8 5.6 7.6 6.3 0 0 0 0 0 0
Nucleus 8.6 4.4 4.9 4.5 2.0 0 1.5 1.9 -0.3 0.8 -0.5 0.7 2.3 1.4 0.5
Nuclear Periphery 0 0 0.6 1.3 0 0 0 0.2 0 0 1.1 0 0 0 0
Nucleolus -10.0 -7.0 -7.1 -6.0 -4.7 -0.5 -4.2 -3.1 -0.6 -2.9 -3.3 -6.2 -2.6 -3.8 -3.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.5 2.5 2.4 1.9 3.3 2.0 2.3 1.3 2.2 -1.3 0 0.7 0.4 3.1 3.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.7596 13.2976 11.9433 11.6662 10.5069 12.4371 16.5691 16.8607 16.4234 15.0038 15.4689 16.6731 15.1085 15.7 14.3071 14.1609 14.3251 13.9902
Actin 0.0181 0 0.0007 0 0.0001 0 0.0055 0 0.0042 0.0025 0.0387 0 0.0032 0 0.0074 0 0 0
Bud 0.0003 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0002 0.0005 0.0003 0.0021 0.0001 0.0003 0.0001 0.0001 0 0.0001 0.0001
Bud Neck 0.0009 0.0006 0.0007 0.0004 0.0008 0.0019 0.0003 0.0005 0.0004 0.0005 0.0007 0.001 0.0004 0.0002 0.0004 0.0003 0.0003 0.0016
Bud Periphery 0.0006 0.0003 0.0002 0.0002 0.0004 0.0005 0.0002 0.0002 0.0009 0.0003 0.0043 0.0002 0.0004 0.0001 0.0002 0.0001 0.0001 0.0002
Bud Site 0.0013 0.0002 0.0009 0.0003 0.0003 0.0002 0.0005 0.0004 0.0004 0.0005 0.0069 0.0001 0.0021 0.0001 0.0005 0.0001 0.0001 0.0001
Cell Periphery 0.0004 0.0003 0.0002 0.0002 0.0004 0.0011 0.0002 0.0001 0.0004 0.0001 0.0003 0.0001 0.0002 0.0001 0.0002 0.0001 0 0.0001
Cytoplasm 0.0014 0.0001 0.0003 0.0001 0.0001 0 0.0069 0.001 0.0008 0.0068 0.0181 0.0001 0.0002 0 0.0009 0 0 0.0001
Cytoplasmic Foci 0.008 0 0.0096 0 0.0002 0 0.0046 0.0001 0.0025 0.0016 0.005 0.0001 0.0005 0 0.0054 0 0 0.0001
Eisosomes 0.0002 0 0.0001 0 0 0 0.0001 0 0 0 0.0003 0 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0007 0 0.0001 0 0.0001 0 0.0016 0.0001 0.0004 0.0084 0.005 0 0.0001 0 0.0006 0 0 0
Endosome 0.0092 0.0001 0.0023 0 0.0002 0.0001 0.0098 0.0002 0.0013 0.0077 0.007 0.0001 0.0012 0 0.0008 0 0 0
Golgi 0.0043 0 0.0012 0 0 0 0.0031 0 0.0007 0.0007 0.0016 0 0.0007 0 0.0005 0 0 0
Lipid Particles 0.0253 0 0.0074 0.0001 0.0002 0.0001 0.0021 0 0.0012 0.0007 0.0021 0 0.0008 0 0.002 0 0 0
Mitochondria 0.0143 0.0004 0.011 0.0003 0.0006 0.0003 0.001 0.0003 0.0047 0.0021 0.0018 0.0002 0.0009 0.0002 0.0005 0.0001 0.0004 0.0001
None 0.0025 0 0.0002 0 0.0001 0 0.0013 0 0.0003 0.0009 0.0217 0 0.0002 0 0.0009 0 0 0
Nuclear Periphery 0.0035 0.0092 0.0012 0.001 0.0036 0.0003 0.0037 0.0081 0.0058 0.0082 0.0095 0.0004 0.001 0.0007 0.0056 0.0014 0.0008 0.0021
Nucleolus 0.2912 0.2654 0.4097 0.4276 0.3768 0.4108 0.2945 0.2704 0.3264 0.2577 0.1989 0.3089 0.2997 0.2654 0.2587 0.2526 0.2186 0.3503
Nucleus 0.5987 0.7199 0.5437 0.5681 0.602 0.5763 0.6582 0.7149 0.6364 0.694 0.6604 0.6865 0.6852 0.7322 0.7068 0.7446 0.7786 0.6407
Peroxisomes 0.0114 0 0.0072 0 0 0 0.0012 0 0.0017 0.0001 0.0022 0 0.0005 0 0.0002 0 0 0
Punctate Nuclear 0.0033 0.0004 0.0017 0.0006 0.0112 0.0003 0.004 0.0013 0.0015 0.005 0.0115 0.0015 0.0014 0.0002 0.0064 0.0003 0.0006 0.003
Vacuole 0.003 0.0018 0.0011 0.0007 0.0021 0.0046 0.0009 0.0014 0.0053 0.0011 0.0013 0.0004 0.0006 0.0004 0.001 0.0003 0.0002 0.0009
Vacuole Periphery 0.0015 0.0012 0.0004 0.0003 0.0007 0.0034 0.0005 0.0007 0.0042 0.0008 0.0006 0.0001 0.0005 0.0002 0.0006 0.0001 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.6256 22.5642 23.9194 31.8559 37.4016 14.4156 24.1726 28.9635 28.1323 31.1205
Translational Efficiency 3.1819 2.0936 1.697 1.2724 1.1818 2.77 1.9183 1.0904 1.3254 1.3739

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1185 1227 2687 1739 2536 1834 2954 1180 3721 3061 5641 2919

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1126.04 1183.61 1400.41 1546.91 1179.40 1374.40 1568.21 1477.24 1162.41 1297.92 1488.28 1518.75
Standard Deviation 236.62 288.86 236.40 278.54 221.13 245.77 277.78 287.13 227.54 279.96 272.12 284.11
Intensity Change Log 2 — 0.071936 0.314591 0.458131 — 0.220749 0.411066 0.324851 — 0.149980 0.364750 0.391488

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000450 0.000523 0.000376 0.000702 0.000318 0.000437 0.000451 0.000948 0.000360 0.000472 0.000415 0.000802
Bud Neck 0.004559 0.007083 0.011874 0.044730 0.007561 0.010442 0.021684 0.052894 0.006605 0.009096 0.017011 0.048030
Bud Site 0.000558 0.001076 0.000740 0.003140 0.000512 0.001007 0.001176 0.005653 0.000526 0.001035 0.000968 0.004156
Cell Periphery 0.000077 0.000099 0.000018 0.000074 0.000077 0.000065 0.000056 0.000134 0.000077 0.000078 0.000038 0.000098
Cytoplasm 0.000751 0.004944 0.000117 0.002058 0.000627 0.000589 0.000287 0.001890 0.000667 0.002335 0.000206 0.001990
Cytoplasmic Foci 0.000140 0.000477 0.000152 0.000580 0.000033 0.000232 0.000035 0.001301 0.000067 0.000330 0.000091 0.000872
Eisosomes 0.000059 0.000062 0.000058 0.000049 0.000068 0.000073 0.000075 0.000057 0.000065 0.000068 0.000067 0.000052
Endoplasmic Reticulum 0.001658 0.001107 0.000528 0.000840 0.001630 0.001561 0.000649 0.001238 0.001639 0.001379 0.000592 0.001001
Endosome 0.000421 0.000360 0.000230 0.001250 0.000179 0.000308 0.000132 0.002316 0.000256 0.000329 0.000179 0.001681
Golgi 0.000217 0.000307 0.000163 0.001455 0.000080 0.000287 0.000093 0.005089 0.000123 0.000295 0.000126 0.002924
Lipid Particles 0.000067 0.000215 0.000017 0.000192 0.000036 0.000170 0.000017 0.000336 0.000046 0.000188 0.000017 0.000250
Mitochondria 0.000691 0.000796 0.000750 0.003059 0.000558 0.001854 0.001314 0.004254 0.000600 0.001430 0.001046 0.003542
Mitotic Spindle 0.000490 0.000905 0.000786 0.014574 0.000424 0.003129 0.000816 0.015479 0.000445 0.002238 0.000801 0.014940
None 0.001675 0.004489 0.000426 0.001514 0.001250 0.001897 0.000537 0.001739 0.001386 0.002936 0.000484 0.001605
Nuclear Periphery 0.000412 0.000095 0.000169 0.001790 0.000145 0.000482 0.000417 0.002348 0.000230 0.000327 0.000299 0.002016
Nuclear Periphery Foci 0.001239 0.000574 0.000108 0.000568 0.000160 0.000833 0.000128 0.001596 0.000504 0.000729 0.000119 0.000984
Nucleolus 0.289106* 0.286212* 0.364068* 0.243854* 0.197257 0.299972* 0.271003* 0.270768* 0.226507* 0.294456* 0.315333* 0.254734*
Nucleus 0.694877* 0.687473* 0.617360* 0.671832* 0.787804* 0.672782* 0.698796* 0.621702* 0.758210* 0.678671* 0.660005* 0.651567*
Peroxisomes 0.001342 0.001751 0.001505 0.001009 0.000498 0.001286 0.000810 0.001221 0.000767 0.001472 0.001141 0.001095
Vacuole 0.000735 0.000813 0.000234 0.003198 0.000370 0.001218 0.000708 0.004717 0.000486 0.001055 0.000482 0.003812
Vacuole Periphery 0.000475 0.000639 0.000322 0.003531 0.000414 0.001375 0.000814 0.004320 0.000434 0.001080 0.000580 0.003850

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.19 0.75 -9.98 -7.90 -12.53 -6.03 -10.32 -10.39 -8.49 -7.72 -6.24 -6.20 -16.47 -12.42 -13.26
Bud Neck -4.30 -13.12 -26.92 -25.55 -21.97 -4.56 -19.89 -22.05 -20.56 -14.76 -5.58 -22.94 -34.33 -32.11 -25.10
Bud Site -3.09 -1.63 -12.09 -8.77 -8.92 -3.74 -6.73 -7.12 -6.50 -5.97 -4.95 -5.42 -11.51 -9.86 -9.38
Cell Periphery -0.79 2.48 -0.01 1.24 -10.28 0.60 0.84 -2.95 -4.29 -4.40 -0.15 2.47 -1.80 -2.18 -6.97
Cytoplasm -3.38 2.22 -3.71 1.99 -6.00 -0.04 0.80 -4.45 -4.93 -5.54 -3.25 1.94 -5.72 -0.25 -7.98
Cytoplasmic Foci -1.30 -0.03 -2.04 0.46 -1.51 -1.84 -1.14 -3.36 -2.40 -3.28 -2.17 -0.54 -4.25 -1.47 -3.74
Eisosomes -0.48 0.22 2.69 4.80 5.46 -1.11 -1.35 4.01 4.35 5.40 -0.96 -0.10 6.12 7.04 8.30
Endoplasmic Reticulum 3.64 7.02 4.42 0.96 -6.34 0.41 11.74 1.67 1.05 -5.55 2.55 13.48 5.48 2.21 -8.37
Endosome 0.31 0.97 -1.45 -1.61 -2.28 -1.75 0.44 -3.98 -3.63 -4.09 -0.74 0.76 -4.51 -4.00 -4.75
Golgi -0.67 0.68 -1.86 -1.56 -2.01 -1.68 -2.07 -2.94 -2.73 -2.91 -1.90 -0.46 -3.54 -3.15 -3.51
Lipid Particles -0.76 1.93 -1.34 0.37 -2.44 -1.39 0.55 -2.46 -0.79 -2.69 -1.49 1.29 -2.91 -0.08 -3.61
Mitochondria -1.24 -2.25 -14.17 -14.18 -13.75 -2.90 -5.11 -11.05 -4.78 -7.84 -3.05 -5.51 -17.29 -7.72 -13.46
Mitotic Spindle -0.45 -1.34 -6.77 -6.21 -6.53 -3.29 -1.81 -7.11 -5.76 -6.87 -3.07 -2.32 -9.82 -8.13 -9.46
None -2.57 4.78 -2.12 2.01 -9.44 -1.20 2.46 -3.44 -0.97 -7.29 -2.84 4.42 -4.18 1.11 -11.76
Nuclear Periphery 1.10 0.75 -2.72 -4.16 -3.90 -2.99 -2.54 -6.66 -5.35 -5.40 -0.92 -0.91 -6.16 -5.95 -5.96
Nuclear Periphery Foci 1.04 1.89 1.45 1.19 -2.86 -2.27 0.30 -4.01 -1.34 -4.02 -0.87 1.91 -1.23 -0.24 -4.77
Nucleolus 0.32 -7.95 7.23 6.77 17.47 -13.34* -10.53 -5.89 4.83 1.91 -10.76 -15.97 -0.73 9.05 13.28
Nucleus 0.72 8.54 1.56 0.77 -7.34 15.02 13.80 17.78 5.33 7.88 12.73 18.68 15.74 3.42 0.52
Peroxisomes -2.23 -1.50 1.71 4.56 4.03 -7.16 -7.46 -9.27 -1.01 -5.27 -7.63 -6.57 -6.28 2.34 -0.25
Vacuole -0.33 2.07 -3.98 -4.03 -5.14 -2.91 -1.92 -6.39 -5.23 -5.82 -2.90 -0.46 -7.69 -6.30 -7.58
Vacuole Periphery -1.41 1.66 -3.28 -3.04 -3.63 -3.18 -2.80 -5.43 -3.22 -4.58 -3.44 -1.73 -5.84 -3.82 -5.42
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (67%), nucleolus (9%), mixed (23%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Rrp45

Rrp45


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rrp45-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available