Standard name
Human Ortholog
Description Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 0.25 0.07 0.35 0.17 0.24 0.22 0.23 – 0.25 0.32 0.28 0.18 0.19 0.17 0.13 0.17 0.12 0 0 0 0 0 0
Endoplasmic Reticulum – 0 0 0 0.05 0.1 0.1 0.08 – 0.16 0.12 0.11 0.05 0.05 0 0 0 0 0.07 0 0 0 0 0
Endosome – 0 0.13 0.19 0 0 0 0 – 0 0 0 0.05 0.1 0.11 0.08 0.13 0.1 0.14 0.18 0.18 0.13 0.16 0.15
Golgi – 0 0 0 0.11 0 0 0 – 0 0 0 0 0 0 0 0.05 0.06 0.07 0 0 0 0 0
Mitochondria – 0.06 0.25 0.15 0.22 0.32 0.43 0.41 – 0.28 0.38 0.4 0 0 0 0 0 0 0 0 0.06 0.05 0 0
Nucleus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0.05 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 0.7 0.71 0.56 0.59 0.43 0.47 0.39 – 0.42 0.34 0.35 0.79 0.75 0.76 0.85 0.81 0.85 0.52 0.68 0.66 0.73 0.71 0.72
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 2 2 – 6 0 6 2 5 1 0 0 0 0 0 1 1 1 2
Bud – 0 0 0 0 3 2 6 – 1 1 1 0 0 1 0 1 0 0 4 1 2 4 4
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 1 3 4 – 9 5 12 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 57 18 49 43 64 74 90 – 102 97 122 69 89 78 26 40 19 1 3 4 5 3 2
Endoplasmic Reticulum – 8 2 1 12 28 33 31 – 67 36 46 19 22 19 4 9 2 2 3 0 5 2 3
Endosome – 8 32 27 8 2 2 8 – 7 0 4 19 49 51 15 31 15 5 45 49 45 69 60
Golgi – 3 1 3 28 10 5 7 – 14 8 13 7 13 12 5 12 9 2 4 5 4 4 5
Mitochondria – 13 64 21 57 87 143 161 – 114 117 174 0 1 1 6 8 0 1 10 16 17 14 13
Nucleus – 6 2 0 0 2 3 1 – 2 1 0 3 3 4 3 0 2 0 2 0 3 3 4
Nuclear Periphery – 2 8 0 4 14 9 6 – 13 7 12 3 2 4 3 1 2 0 1 8 8 11 10
Nucleolus – 1 2 0 0 1 1 2 – 0 0 2 0 0 1 0 2 1 0 0 0 0 1 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 1 2 0 0 1 0 0 – 0 0 0 1 2 2 0 0 0 0 3 0 1 4 1
Vac/Vac Membrane – 161 179 78 152 117 158 152 – 170 105 153 299 363 343 164 186 134 20 170 177 260 299 285
Unique Cell Count 231 251 140 257 269 335 390 408 305 434 377 481 453 193 231 157 40 252 269 359 423 396
Labelled Cell Count 260 310 179 304 330 435 470 505 377 545 422 549 517 226 290 184 40 252 269 359 423 396


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 7.3 6.2 7.7 8.2 8.1 7.9 8.3 – 9.1 8.9 9.2 8.9 8.7 9.0 10.1 9.9 10.9 8.8 9.2 9.6
Std Deviation (1e-4) – 1.8 1.6 2.5 1.9 1.8 2.1 2.0 – 2.0 2.0 2.0 2.3 2.3 2.3 2.3 2.5 2.6 2.1 2.4 2.6
Intensity Change (Log2) – – – 0.33 0.41 0.39 0.36 0.43 – 0.56 0.53 0.58 0.54 0.5 0.54 0.71 0.68 0.83 0.52 0.58 0.64


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 7.0 3.3 5.2 4.9 5.3 – 5.8 7.1 6.5 4.0 4.1 3.7 2.2 3.4 1.7
Endoplasmic Reticulum 0 2.7 4.7 4.6 4.0 – 6.4 5.1 4.8 2.9 2.7 2.5 0 2.3 0
Endosome 1.7 -4.0 -5.5 -6.2 -5.5 – -5.8 -6.4 -6.7 -3.5 -1.0 -0.6 -1.7 0.2 -1.0
Golgi 0 5.1 2.6 0 0 – 2.5 0 2.3 0 0 0 0 3.2 0
Mitochondria -2.4 -0.9 1.7 4.3 4.1 – 0.7 3.2 3.9 -10.3 -11.4 -11.1 -6.4 -6.8 -6.9
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 -1.2 1.1 -0.4 -1.4 – 0 -0.6 -0.3 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole -3.1 -2.9 -6.4 -5.9 -8.0 – -7.4 -8.7 -9.1 2.3 1.2 1.3 3.4 2.4 3.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.993 3.5779 2.9942 2.6619 3.034 3.1395 5.7829 5.4576 5.6152 5.028 5.454 5.7551 2.6438 3.7799 3.1342 3.8879 2.3772 3.1508
Actin 0.0072 0.0001 0.0018 0.0263 0.0143 0.0015 0.0209 0.0015 0.0103 0.0011 0.0072 0.0028 0.0144 0 0.0001 0.0101 0 0
Bud 0.0003 0.0017 0.0012 0.0043 0.0003 0.0012 0.0005 0.0073 0.0056 0.0058 0.0018 0.0006 0.0011 0.0003 0.0004 0.0002 0.0007 0.0002
Bud Neck 0.0006 0.0003 0.0005 0.0017 0.0005 0.0003 0.0007 0.0004 0.0017 0.0007 0.0005 0.0003 0.0004 0.0002 0.0003 0.0006 0.0004 0.0001
Bud Periphery 0.0006 0.0021 0.0018 0.012 0.0005 0.0011 0.0011 0.0108 0.0107 0.0093 0.0037 0.0011 0.0017 0.0004 0.0008 0.0004 0.0009 0.0006
Bud Site 0.0012 0.0014 0.0022 0.0026 0.0003 0.0002 0.0012 0.0041 0.0029 0.0032 0.0015 0.0002 0.0005 0.0013 0.0007 0.0005 0.0006 0.0001
Cell Periphery 0.0005 0.0004 0.0005 0.0004 0.0003 0.0003 0.0007 0.0005 0.0006 0.0003 0.0003 0.0002 0.0006 0.0004 0.0005 0.0002 0.0002 0.0002
Cytoplasm 0.0097 0.0214 0.0199 0.0331 0.0288 0.0082 0.0133 0.074 0.0192 0.0136 0.0179 0.0142 0.01 0.0133 0.0144 0.0036 0.0168 0.0132
Cytoplasmic Foci 0.0294 0.0133 0.0221 0.013 0.0191 0.008 0.0213 0.0215 0.0225 0.0282 0.0151 0.0146 0.0127 0.0092 0.015 0.0066 0.0101 0.0102
Eisosomes 0.0001 0 0.0001 0.0002 0.0001 0 0.0003 0 0.0002 0 0.0001 0 0.0002 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0055 0.0039 0.0038 0.002 0.0056 0.0039 0.0089 0.0059 0.0074 0.0097 0.0044 0.0034 0.0052 0.0037 0.0064 0.005 0.0016 0.0035
Endosome 0.3183 0.2199 0.2897 0.3153 0.2931 0.2436 0.3049 0.2444 0.3061 0.3361 0.2813 0.3296 0.2727 0.2032 0.3154 0.2364 0.2737 0.2944
Golgi 0.0179 0.0081 0.0113 0.0271 0.035 0.0081 0.023 0.0124 0.0152 0.0232 0.0221 0.0142 0.011 0.0057 0.0184 0.0254 0.0084 0.0135
Lipid Particles 0.0214 0.0029 0.01 0.0073 0.0145 0.0044 0.0127 0.0017 0.0088 0.0038 0.0413 0.0039 0.0176 0.0025 0.0143 0.0041 0.0088 0.0039
Mitochondria 0.0114 0.0111 0.0187 0.014 0.0118 0.0157 0.0273 0.0191 0.0387 0.031 0.0311 0.0236 0.0098 0.005 0.0204 0.0326 0.008 0.0088
None 0.0078 0.0141 0.0365 0.0046 0.0181 0.0128 0.0121 0.0496 0.0396 0.0036 0.0084 0.0067 0.0207 0.0014 0.0047 0.0535 0.0004 0.0152
Nuclear Periphery 0.0168 0.0202 0.0126 0.0041 0.0127 0.0286 0.0182 0.0288 0.0093 0.0111 0.0212 0.0155 0.0218 0.019 0.0229 0.0075 0.0216 0.0194
Nucleolus 0.0021 0.0012 0.0012 0.0004 0.0005 0.0006 0.0019 0.0013 0.0019 0.0024 0.0019 0.0004 0.0013 0.0006 0.0005 0.0003 0.0004 0.0003
Nucleus 0.0055 0.0051 0.0034 0.0014 0.0014 0.002 0.0033 0.0044 0.0027 0.0039 0.0043 0.0013 0.0042 0.0022 0.0024 0.0006 0.0009 0.0014
Peroxisomes 0.0074 0.0003 0.0035 0.009 0.0017 0.0004 0.0047 0.0042 0.0041 0.0048 0.005 0.0016 0.0012 0.0002 0.0007 0.0006 0.0002 0.0002
Punctate Nuclear 0.0105 0.0002 0.0012 0.0003 0.0004 0.0006 0.001 0.0008 0.0009 0.0007 0.0033 0.0005 0.0017 0.0001 0.0002 0.0003 0.0001 0.0001
Vacuole 0.3016 0.3926 0.2942 0.2915 0.2444 0.2763 0.259 0.2692 0.244 0.2425 0.1641 0.2218 0.3194 0.3694 0.281 0.2719 0.2442 0.2094
Vacuole Periphery 0.224 0.2797 0.2639 0.2293 0.2965 0.3822 0.2629 0.2382 0.2475 0.265 0.3633 0.3434 0.2719 0.3617 0.2804 0.3394 0.4021 0.4054

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 38.6826 28.3441 26.9217 34.3541 27.1323 27.8867 33.2441 37.138 39.9831 40.1872
Translational Efficiency 1.1824 1.2445 1.0317 0.7658 1.2386 1.6502 1.1947 0.801 0.9622 1.0464

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2476 1692 259 879 1544 1327 2863 1888 4020 3019 3122 2767

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 805.04 843.29 1081.00 858.44 844.20 777.41 887.33 909.74 820.08 814.33 903.40 893.44
Standard Deviation 106.58 139.03 157.30 139.92 137.20 128.99 152.40 142.33 120.78 138.62 161.88 143.57
Intensity Change Log 2 — 0.066968 0.425234 0.092657 — -0.118909 0.071886 0.107869 — -0.025184 0.255171 0.100464

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000038 0.000136 0.000207 0.000461 0.000059 0.000132 0.000334 0.000616 0.000046 0.000134 0.000324 0.000567
Bud Neck 0.001791 0.006955 0.007400 0.012587 0.001829 0.005653 0.014321 0.017550 0.001806 0.006383 0.013747 0.015973
Bud Site 0.005153 0.018557 0.003815 0.027033 0.009459 0.009842 0.020961 0.035013 0.006807 0.014726 0.019539 0.032478
Cell Periphery 0.000263 0.000215 0.000339 0.000196 0.000309 0.000237 0.000148 0.000108 0.000281 0.000225 0.000164 0.000136
Cytoplasm 0.016638 0.068529 0.008880 0.128922* 0.023881 0.048022 0.101445* 0.197594* 0.019420 0.059515 0.093766 0.175779*
Cytoplasmic Foci 0.055302 0.099251 0.012044 0.046129 0.065950 0.086113 0.033828 0.058980 0.059392 0.093476 0.032021 0.054897
Eisosomes 0.000031 0.000038 0.000036 0.000034 0.000031 0.000047 0.000016 0.000028 0.000031 0.000042 0.000018 0.000030
Endoplasmic Reticulum 0.011695 0.004095 0.003739 0.005930 0.005540 0.004177 0.003435 0.002674 0.009331 0.004131 0.003460 0.003709
Endosome 0.115281 0.136785 0.063510 0.089893 0.138863 0.141688 0.089317 0.086538 0.124338 0.138940 0.087176 0.087604
Golgi 0.021044 0.022400 0.005763 0.003861 0.034651 0.021066 0.007478 0.008217 0.026270 0.021814 0.007336 0.006833
Lipid Particles 0.004096 0.004642 0.003995 0.005898 0.003519 0.007676 0.002990 0.003986 0.003875 0.005976 0.003073 0.004593
Mitochondria 0.033856 0.023126 0.003171 0.003465 0.018458 0.031031 0.009117 0.007814 0.027942 0.026601 0.008623 0.006432
Mitotic Spindle 0.000203 0.002546 0.003354 0.021085 0.000472 0.002037 0.014196 0.017853 0.000307 0.002322 0.013297 0.018880
None 0.000194 0.000462 0.000365 0.000934 0.000523 0.000624 0.001173 0.000963 0.000320 0.000533 0.001106 0.000954
Nuclear Periphery 0.000489 0.000354 0.004289 0.003330 0.000263 0.000843 0.003528 0.002334 0.000402 0.000569 0.003591 0.002651
Nuclear Periphery Foci 0.000210 0.000486 0.004107 0.003390 0.000390 0.000659 0.001874 0.001454 0.000279 0.000562 0.002059 0.002069
Nucleolus 0.000253 0.000482 0.008308 0.002121 0.000361 0.000702 0.002316 0.001621 0.000294 0.000579 0.002813 0.001780
Nucleus 0.001420 0.005178 0.031477 0.042751 0.001301 0.003959 0.028238 0.039977 0.001375 0.004642 0.028507 0.040858
Peroxisomes 0.000644 0.002371 0.002884 0.003859 0.000766 0.004384 0.001475 0.003562 0.000691 0.003256 0.001592 0.003656
Vacuole 0.431987* 0.410680* 0.507173* 0.551139* 0.384165* 0.371885* 0.567235* 0.477236* 0.413620* 0.393628* 0.562252* 0.500713*
Vacuole Periphery 0.299411* 0.192712* 0.325144* 0.046979 0.309211* 0.259221* 0.096574 0.035881 0.303175* 0.221946* 0.115536* 0.039406

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.27 -2.04 -3.95 -2.95 -1.59 -2.83 -1.93 -3.13 -2.66 -1.06 -5.15 -2.13 -4.16 -3.39 -1.13
Bud Neck -7.01 -3.28 -9.83 -4.61 -2.78 -4.81 -16.78 -14.93 -9.41 -2.23 -8.47 -17.43 -17.83 -10.43 -1.86
Bud Site -9.88 1.36 -7.24 -2.09 -7.46 -0.33 -7.17 -9.07 -8.91 -3.96 -8.60 -9.83 -12.47 -7.45 -4.53
Cell Periphery 1.32 -0.92 1.78 0.99 1.94 1.48 4.50 5.73 3.77 2.80 1.89 4.66 5.68 4.07 1.95
Cytoplasm -13.69 1.68 -19.02 -10.84 -18.40 -6.14 -20.24 -31.35 -25.22 -15.10 -14.68 -22.66 -37.65 -26.39 -16.11
Cytoplasmic Foci -11.20 12.30 3.53 12.88 -8.11 -4.35 10.32 3.33 7.41 -8.40 -11.40 13.34 3.64 14.08 -9.24
Eisosomes -1.80 -0.78 -1.36 0.21 -0.07 -2.91 3.72 0.55 4.29 -8.19 -3.40 5.17 -0.21 3.81 -7.82
Endoplasmic Reticulum 9.43 7.95 6.24 -1.51 -1.31 2.44 4.24 6.32 4.08 3.33 9.61 11.06 10.74 2.00 0.38
Endosome -4.36 7.46 8.42 11.12 -1.09 -0.44 11.49 13.52 12.92 3.49 -3.77 12.72 15.72 17.57 3.41
Golgi -0.63 7.61 12.71 12.16 1.74 4.91 12.21 11.92 7.55 0.53 2.78 14.84 15.60 12.62 1.80
Lipid Particles -0.90 -0.02 -1.11 -0.56 -0.83 -3.55 0.68 -0.49 3.65 -2.01 -3.40 1.73 -0.88 2.53 -2.57
Mitochondria 4.48 16.38 17.03 11.74 0.39 -4.33 5.88 6.74 9.22 2.10 0.74 14.29 16.10 13.40 3.45
Mitotic Spindle -4.20 -2.50 -6.03 -5.25 -4.58 -1.96 -11.45 -9.29 -7.86 -1.02 -4.31 -11.84 -11.07 -9.51 -1.98
None -4.04 -0.90 -4.23 -2.58 -2.17 -0.40 -2.51 -1.86 -2.01 1.02 -1.90 -5.22 -4.91 -3.66 0.89
Nuclear Periphery 1.25 -3.58 -6.58 -6.94 0.48 -2.99 -11.42 -8.95 -5.82 2.66 -1.58 -11.46 -10.63 -9.78 1.99
Nuclear Periphery Foci -2.93 -3.28 -7.14 -6.44 0.78 -1.71 -4.81 -4.36 -3.28 0.84 -3.35 -6.11 -8.20 -6.78 -0.13
Nucleolus -2.66 -4.59 -5.49 -4.71 3.41 -1.84 -9.06 -8.34 -6.17 2.48 -3.11 -11.26 -11.16 -8.65 3.55
Nucleus -6.14 -3.94 -12.81 -11.81 -2.64 -4.41 -18.10 -20.94 -19.46 -5.45 -7.53 -18.39 -24.25 -22.34 -6.60
Peroxisomes -7.48 -2.82 -3.81 -1.35 -0.37 -5.01 -4.54 -7.07 1.68 -4.65 -7.46 -5.91 -7.79 0.20 -4.58
Vacuole 2.58 -4.77 -10.11 -11.33 -2.23 1.35 -21.24 -10.08 -10.80 9.38 3.25 -21.87 -12.33 -14.23 7.27
Vacuole Periphery 15.30 -1.26 47.06* 25.09* 16.97 5.46 32.94* 43.90* 31.89* 19.07* 14.45 40.99 67.84 41.26* 22.94*
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
Localization
Cell Percentages vacuolar membrane (46%)
Cell Cycle Regulation No
Subcompartmental Group vac memb-1

Dpp1

Dpp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dpp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available