Standard name
Human Ortholog
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.07 0.07 0 0.08 0.1 0.09 0.05 0 0.06 0.05 0.06 0.05 0.22 0.19 0.12 0.1 0.11 0 0 0 0.08 0.08 0.05
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0.06 0.08 0.16
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.27 0 0.06 0.36 0.16 0.17 0.19 0.57 0.38 0.55 0.47 0 0 0 0 0.06 0 0 0 0 0 0 0
Nucleus 0.76 0.66 0.73 0.83 0.65 0.63 0.72 0.74 0.63 0.68 0.66 0.68 0.84 0.72 0.67 0.71 0.62 0.67 0.61 0.63 0.59 0.41 0.36 0.28
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.11 0.05 0 0.05 0.12 0.06 0 0.06 0.05 0.06 0.05 0.05 0 0 0.05 0 0.08 0.08 0.16 0.08 0.11 0.07 0.07 0.05
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0.05 0.11 0.09 0.12 0.07
Vac/Vac Membrane 0.14 0.1 0.07 0 0 0.08 0.07 0.1 0 0 0.05 0.05 0.11 0.08 0.14 0.12 0.18 0.13 0.07 0.11 0.08 0.17 0.17 0.26
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 1 4 1 2 2 2 4 7 7 0 0 0 1 0 0 3 4 1 0 3 0
Bud Neck 0 0 1 0 0 1 2 0 0 3 2 1 0 0 0 0 0 0 0 3 0 0 2 0
Bud Site 0 0 0 0 1 0 1 3 5 5 7 17 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 7 32 11 5 5 13 19 13 12 20 13 23 3 8 8 30 23 23 1 12 3 7 13 6
Endoplasmic Reticulum 0 3 0 0 0 1 0 0 0 0 0 0 0 0 0 13 8 6 0 0 0 2 0 0
Endosome 1 3 14 5 1 2 2 4 1 1 2 3 0 0 0 9 10 8 16 18 8 4 12 23
Golgi 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1
Mitochondria 3 121 0 7 24 21 37 45 172 123 143 190 2 0 1 11 13 2 0 12 0 0 4 6
Nucleus 180 298 119 102 43 83 157 176 190 223 170 277 47 26 29 180 140 142 176 332 105 35 57 40
Nuclear Periphery 0 2 0 2 0 0 0 4 2 5 0 1 0 0 0 11 8 1 4 4 2 0 2 2
Nucleolus 25 24 7 6 8 8 7 14 14 21 12 22 1 1 2 9 19 17 45 42 19 5 10 7
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0
SpindlePole 0 5 16 2 2 2 1 6 5 4 0 2 0 0 0 3 4 12 15 25 19 7 20 10
Vac/Vac Membrane 33 45 12 4 2 11 16 23 12 12 14 19 6 3 6 30 41 28 19 58 14 14 27 37
Unique Cell Count 237 451 164 123 66 131 217 239 302 328 259 407 56 36 43 254 225 211 289 528 179 85 161 146
Labelled Cell Count 250 534 180 134 90 143 245 290 415 421 370 562 59 38 46 297 267 240 289 528 179 85 161 146


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 4.5 6.4 6.0 4.3 5.2 5.2 5.5 4.2 4.5 4.2 4.3 6.0 6.2 5.8 6.7 7.9 8.2 6.6 7.5 7.3
Std Deviation (1e-4) 1.0 0.9 1.0 1.0 1.1 1.4 1.1 1.5 0.9 1.0 0.6 0.8 1.0 1.1 1.5 1.7 2.0 1.8 1.6 1.9 1.5
Intensity Change (Log2) – – – -0.09 -0.57 -0.3 -0.31 -0.23 -0.63 -0.51 -0.63 -0.57 -0.11 -0.06 -0.14 0.06 0.3 0.35 0.04 0.21 0.18

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.5 3.1 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.1051 4.1597 4.3964 4.1107 3.7789 4.2914 5.9061 6.2198 5.887 5.908 5.9123 5.7204 2.5288 2.9348 2.9336 3.1077 3.4125 2.7522
Actin 0.0268 0.0002 0.0095 0.0124 0.0193 0.0014 0.0229 0.0001 0.0061 0.003 0.0193 0.0002 0.0352 0.0002 0.0014 0.0002 0.002 0.0002
Bud 0.0007 0.0002 0.0003 0.0007 0.0005 0.0003 0.0007 0.0001 0.0006 0.0002 0.0006 0.0001 0.0003 0.0002 0.0001 0.0002 0.0002 0.0002
Bud Neck 0.0046 0.0011 0.0015 0.0016 0.0054 0.0151 0.0069 0.0019 0.0031 0.0022 0.003 0.0034 0.0006 0.0012 0.0013 0.0025 0.0034 0.0113
Bud Periphery 0.0014 0.0003 0.0008 0.0009 0.0007 0.0006 0.0012 0.0001 0.0011 0.0002 0.0015 0.0002 0.0007 0.0003 0.0002 0.0003 0.0003 0.0003
Bud Site 0.0056 0.0015 0.0021 0.0061 0.0029 0.0017 0.0043 0.0015 0.0086 0.0011 0.002 0.0004 0.0009 0.0033 0.0012 0.0015 0.0007 0.0012
Cell Periphery 0.0007 0.0002 0.0004 0.0004 0.0002 0.0002 0.0007 0 0.0002 0.0001 0.0002 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001
Cytoplasm 0.0127 0.0088 0.0126 0.0123 0.0037 0.0115 0.0325 0.0073 0.0082 0.0045 0.0058 0.0067 0.0444 0.042 0.0028 0.059 0.004 0.0081
Cytoplasmic Foci 0.0064 0.0005 0.0015 0.0152 0.0121 0.0047 0.0042 0.0003 0.0041 0.0161 0.0049 0.0005 0.0092 0.0015 0.0029 0.0003 0.0507 0.0005
Eisosomes 0.0002 0 0.0002 0.0002 0.0003 0 0.0002 0 0.0001 0.0001 0.0001 0 0.0003 0 0 0 0 0
Endoplasmic Reticulum 0.0095 0.002 0.0092 0.0117 0.0015 0.0017 0.0111 0.0006 0.0025 0.0013 0.0017 0.0013 0.0041 0.002 0.0003 0.0032 0.0006 0.0005
Endosome 0.0159 0.0026 0.0081 0.0395 0.0456 0.0112 0.0227 0.001 0.0131 0.0139 0.0065 0.0024 0.0122 0.0034 0.0023 0.0007 0.0428 0.002
Golgi 0.008 0.0001 0.0036 0.0137 0.0204 0.0017 0.0045 0 0.0034 0.0136 0.0045 0.0001 0.0134 0.0001 0.0007 0 0.0432 0.0003
Lipid Particles 0.0089 0.0012 0.004 0.0248 0.0228 0.0092 0.0068 0.0001 0.0076 0.0096 0.0034 0.0006 0.0233 0.0004 0.0033 0.0001 0.0081 0.0006
Mitochondria 0.0057 0.0004 0.0068 0.009 0.0215 0.0055 0.0039 0.0003 0.0026 0.004 0.006 0.0003 0.0047 0.0005 0.0005 0.0005 0.0031 0.0004
None 0.0054 0.002 0.0213 0.0031 0.001 0.0029 0.0285 0.0017 0.0093 0.006 0.0222 0.0105 0.0045 0.0258 0.0211 0.1157 0.0004 0.0191
Nuclear Periphery 0.0253 0.0238 0.0347 0.0311 0.0236 0.0369 0.0521 0.0132 0.0362 0.04 0.014 0.0056 0.033 0.023 0.0095 0.0082 0.0125 0.0097
Nucleolus 0.0198 0.0196 0.0425 0.0817 0.0573 0.0892 0.0559 0.0357 0.1065 0.1564 0.0702 0.0819 0.0095 0.022 0.0373 0.1329 0.0483 0.0688
Nucleus 0.8002 0.9132 0.8102 0.7218 0.712 0.7379 0.7083 0.909 0.7185 0.6082 0.7255 0.855 0.7697 0.8552 0.8656 0.6614 0.7519 0.8394
Peroxisomes 0.0061 0.0001 0.0008 0.0038 0.0125 0.0015 0.002 0 0.0019 0.0023 0.0007 0.0001 0.0077 0.0001 0.0179 0 0.0161 0.0001
Punctate Nuclear 0.0286 0.0188 0.022 0.0051 0.0326 0.0619 0.0203 0.0262 0.0611 0.114 0.1047 0.0293 0.0236 0.0161 0.0304 0.0119 0.01 0.0346
Vacuole 0.006 0.0029 0.0058 0.0031 0.0026 0.0034 0.0067 0.0008 0.0031 0.0025 0.0021 0.0012 0.0012 0.0019 0.001 0.001 0.0011 0.0022
Vacuole Periphery 0.0014 0.0004 0.0021 0.0016 0.0015 0.0016 0.0036 0.0002 0.0021 0.0008 0.0011 0.0002 0.0015 0.0004 0.0002 0.0002 0.0005 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.9382 5.4078 13.6435 14.4023 14.9022 3.6276 15.5832 13.2854 12.9066 18.718
Translational Efficiency 0.8573 1.5712 0.8404 0.6691 0.9084 3.5863 0.6123 0.8394 0.8764 0.5297

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1700 610 714 1509 1825 2025 1684 1701 3525 2635 2398 3210

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 782.55 840.19 947.97 910.10 743.53 909.62 932.77 932.43 762.35 893.55 937.30 921.93
Standard Deviation 108.09 117.38 120.89 127.54 93.76 112.03 116.76 123.04 102.79 117.02 118.21 125.67
Intensity Change Log 2 — 0.102533 0.276658 0.217842 — 0.290873 0.327130 0.326604 — 0.197368 0.301470 0.271858

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000298 0.001309 0.001197 0.001396 0.000218 0.000281 0.000644 0.001084 0.000257 0.000519 0.000808 0.001231
Bud Neck 0.003028 0.012651 0.010700 0.031975 0.009225 0.010215 0.013911 0.029788 0.006236 0.010778 0.012955 0.030816
Bud Site 0.001308 0.003575 0.002364 0.013794 0.001975 0.002824 0.002119 0.011343 0.001653 0.002998 0.002192 0.012495
Cell Periphery 0.000105 0.000159 0.000098 0.000185 0.000122 0.000084 0.000087 0.000138 0.000114 0.000102 0.000090 0.000160
Cytoplasm 0.047014 0.057712 0.012499 0.035222 0.056564 0.040107 0.009541 0.029269 0.051958 0.044183 0.010422 0.032068
Cytoplasmic Foci 0.007279 0.009477 0.000601 0.003204 0.008685 0.008016 0.000169 0.001316 0.008007 0.008355 0.000298 0.002204
Eisosomes 0.000041 0.000063 0.000045 0.000035 0.000037 0.000031 0.000025 0.000032 0.000039 0.000038 0.000031 0.000033
Endoplasmic Reticulum 0.003363 0.010267 0.007050 0.012058 0.002378 0.003509 0.006781 0.010415 0.002853 0.005073 0.006861 0.011188
Endosome 0.001564 0.003356 0.000737 0.003971 0.002286 0.003472 0.001135 0.002612 0.001938 0.003445 0.001016 0.003251
Golgi 0.000750 0.002328 0.000165 0.001836 0.001096 0.001200 0.000391 0.000527 0.000929 0.001461 0.000324 0.001142
Lipid Particles 0.002999 0.003867 0.000607 0.000765 0.002885 0.002755 0.000249 0.000584 0.002940 0.003012 0.000356 0.000669
Mitochondria 0.004736 0.005178 0.001485 0.006271 0.003736 0.008299 0.001606 0.005682 0.004218 0.007576 0.001570 0.005959
Mitotic Spindle 0.004497 0.015472 0.002251 0.038441 0.006566 0.015116 0.003072 0.039118 0.005568 0.015198 0.002828 0.038800
None 0.015328 0.010662 0.005353 0.006565 0.017194 0.006644 0.005045 0.005303 0.016294 0.007574 0.005137 0.005896
Nuclear Periphery 0.003114 0.004187 0.001355 0.007663 0.002607 0.004064 0.001675 0.005485 0.002852 0.004092 0.001580 0.006509
Nuclear Periphery Foci 0.011682 0.019089 0.002421 0.003525 0.008337 0.006884 0.001323 0.003355 0.009950 0.009710 0.001650 0.003435
Nucleolus 0.107179 0.080300 0.052691 0.018078 0.148581 0.070133 0.034509 0.023367 0.128614 0.072487 0.039923 0.020880
Nucleus 0.781669 0.747947 0.893288 0.795093 0.723019 0.808294 0.912440 0.816316 0.751304 0.794324 0.906738 0.806339
Peroxisomes 0.001575 0.002417 0.000636 0.001552 0.001636 0.002998 0.000393 0.000634 0.001607 0.002864 0.000465 0.001065
Vacuole 0.002087 0.009271 0.004221 0.016123 0.002347 0.004295 0.004574 0.012160 0.002222 0.005447 0.004469 0.014023
Vacuole Periphery 0.000385 0.000714 0.000237 0.002248 0.000504 0.000778 0.000310 0.001473 0.000447 0.000763 0.000288 0.001837

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.07 -7.51 -7.69 0.47 0.68 -0.68 -10.12 -10.84 -10.99 -5.04 -4.87 -12.98 -13.09 -8.87 -3.34
Bud Neck -7.79 -9.77 -18.74 -10.62 -8.31 -1.41 -9.35 -16.63 -15.39 -8.50 -6.80 -14.25 -25.03 -19.44 -11.67
Bud Site -3.16 -2.74 -6.62 -3.31 -4.20 -1.15 -1.22 -7.14 -6.43 -7.05 -2.75 -2.94 -9.75 -7.45 -8.38
Cell Periphery -3.45 0.76 -2.14 1.07 -2.51 2.79 2.73 -0.96 -5.01 -4.93 1.17 2.91 -2.26 -3.32 -4.98
Cytoplasm -2.01 11.18 4.66 5.03 -8.12 3.70 14.05 8.25 4.95 -9.38 1.96 18.10 9.25 6.58 -12.54
Cytoplasmic Foci -0.52 8.93 7.56 5.38 -2.33 0.57 9.84 8.98 9.51 -4.05 -0.05 13.39 11.76 10.70 -4.44
Eisosomes -4.45 -1.48 1.72 5.45 2.94 2.40 2.49 -2.51 -4.78 -4.93 0.21 1.84 -0.57 -0.70 -2.41
Endoplasmic Reticulum -9.06 -10.71 -16.27 -1.86 -6.07 -3.89 -17.42 -21.33 -17.35 -8.89 -7.68 -19.54 -26.53 -16.84 -10.84
Endosome -2.93 3.73 -1.30 1.73 -3.61 -1.77 3.46 -0.15 1.65 -3.46 -2.82 4.16 -1.02 2.13 -4.51
Golgi -1.34 3.83 0.17 1.34 -1.58 -0.23 2.39 2.31 2.88 -0.52 -1.26 3.38 1.75 2.49 -1.46
Lipid Particles -1.16 8.92 8.63 6.28 -0.29 -0.08 6.63 5.51 6.52 -6.26 -0.35 10.71 9.42 8.61 -5.01
Mitochondria -0.39 3.06 -0.17 0.32 -6.47 -3.46 3.40 -1.90 2.46 -6.05 -3.06 4.17 -1.22 2.55 -8.51
Mitotic Spindle -3.76 -1.57 -8.96 -3.53 -7.11 -3.29 -0.43 -9.54 -6.86 -9.17 -5.27 -1.61 -13.09 -7.81 -11.57
None 2.65 7.85 6.77 3.20 -2.82 8.93 10.98 10.80 1.57 -1.90 9.11 13.16 12.33 2.59 -3.28
Nuclear Periphery -2.35 3.74 -9.29 -6.45 -12.64 -3.59 0.40 -10.47 -6.87 -11.18 -3.82 2.52 -13.92 -9.46 -16.42
Nuclear Periphery Foci -2.07 5.02 5.72 5.22 0.23 1.36 6.11 3.74 2.21 -4.18 0.61 8.40 6.75 5.19 -3.03
Nucleolus 4.31 7.01 15.93 8.22 6.49 11.93 17.36 19.71 8.78 2.28 11.86 18.32 25.20 12.41 5.95
Nucleus 2.56 -9.10 -2.15 -4.15 7.28 -9.22 -20.35 -6.63 2.67 13.82 -5.90 -21.61 -6.27 0.20 15.74
Peroxisomes -1.68 2.81 2.28 4.03 0.09 -2.26 4.40 4.43 5.16 -0.73 -2.76 5.18 4.55 5.71 -0.61
Vacuole -4.99 -4.42 -11.16 -5.20 -8.12 -3.53 -4.87 -11.91 -10.67 -9.44 -6.05 -6.43 -16.31 -12.94 -12.47
Vacuole Periphery -3.29 1.41 -2.13 -0.98 -2.48 -2.09 2.53 -0.95 -0.09 -1.61 -3.18 2.61 -2.13 -0.65 -2.82
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (84%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Nse3

Nse3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nse3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available