Standard name
Human Ortholog
Description Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0.15 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0.06 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.07 0.07 0.05 0.07 0 – 0 0 0 0 – – – 0.08 0.05 0.05 0 0 0 0 0.07 0.07
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0.06 0.05
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0.15 0 0 0 0 0.07 0.07 – 0.17 0.13 0.19 0.2 – – – 0 0 0.05 0 0 0 0 0 0
Nucleus 0.93 0.95 0.93 0.91 0.93 0.88 0.89 – 0.82 0.81 0.77 0.77 – – – 0.82 0.87 0.85 0.9 0.91 0.85 0.73 0.52 0.55
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0.06 – 0.16 0.19 0.31 0.26 – – – 0 0 0 0.05 0 0 0.1 0.11 0.05
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0.07 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0.06 0.06 0 0 0 0 0.05 0.21
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 1 1 – 1 0 2 1 – – – 2 1 0 1 0 1 1 0 0
Bud Neck 0 0 0 0 0 0 0 – 2 0 4 2 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 3 – 9 9 7 10 – – – 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 1 5 12 17 14 15 11 – 8 8 11 6 – – – 14 8 6 0 0 0 0 0 1
Endoplasmic Reticulum 0 0 0 0 0 0 1 – 0 0 0 0 – – – 3 1 2 0 1 0 0 0 0
Endosome 0 0 1 0 2 0 1 – 0 1 0 0 – – – 2 1 3 1 1 1 0 0 1
Golgi 0 0 1 1 0 0 2 – 0 0 0 0 – – – 0 0 1 1 1 1 0 0 0
Mitochondria 25 3 1 6 1 15 24 – 35 31 49 53 – – – 6 5 5 1 1 3 0 0 0
Nucleus 156 250 171 214 250 189 298 – 169 196 195 199 – – – 135 138 94 145 254 165 7 7 13
Nuclear Periphery 1 0 0 0 2 1 2 – 2 3 0 4 – – – 1 1 0 0 0 0 0 0 0
Nucleolus 6 4 0 1 12 8 19 – 34 46 79 67 – – – 4 1 2 7 5 5 0 1 1
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 1 3 2 3 – 0 4 0 4 – – – 1 2 0 1 1 1 0 1 0
Vac/Vac Membrane 2 7 2 5 2 1 1 – 1 3 0 1 – – – 6 9 7 2 10 7 0 0 5
Unique Cell Count 167 262 184 236 270 216 336 207 241 252 259 165 159 111 162 281 195 10 15 25
Labelled Cell Count 191 269 190 245 286 232 366 261 301 347 347 174 167 121 162 281 195 10 15 25


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 7.7 7.2 7.2 7.7 6.3 6.5 – 6.3 6.2 5.7 5.8 – – – 8.0 7.9 7.4 – – –
Std Deviation (1e-4) 0.8 1.2 2.0 2.0 2.4 1.9 1.8 – 6.8 1.9 1.8 1.7 – – – 2.2 2.1 2.2 – – –
Intensity Change (Log2) – – – -0.0 0.1 -0.2 -0.15 – -0.21 -0.21 -0.34 -0.32 – – – 0.14 0.12 0.03 – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Bud 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Cytoplasm 0.3 -0.6 0.2 -1.7 – -1.2 -1.5 -1.0 -2.2 – – – 0.7 -0.6 -0.4
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Mitochondria 0 0 3.3 3.4 – 5.6 4.8 6.1 6.3 – – – 0 0 0
Nucleus -0.8 -0.1 -1.8 -1.6 – -3.3 -3.5 -4.4 -4.5 – – – -3.2 -1.9 -2.3
Nuclear Periphery 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Nucleolus 0 0 0 3.3 – 5.8 6.3 8.4 7.5 – – – 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 – – – 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 – – – 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 – – – 0 2.4 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.137 1.4164 1.1657 0.9117 0.9102 0.9329 1.7695 1.8745 1.6912 1.5418 1.5812 1.6108 2.4217 2.347 2.0624 2.156 2.1583 2.0285
Actin 0.0043 0 0.006 0.0228 0.0018 0.0012 0.0283 0 0.0098 0 0.0093 0.0029 0.0006 0 0.0014 0.0037 0.0011 0.0005
Bud 0.0008 0 0.0001 0.0006 0.001 0 0.0006 0 0 0 0.0001 0.0001 0.0002 0.0001 0.0001 0 0.0001 0
Bud Neck 0.0007 0 0.0002 0.0029 0.0013 0.0006 0.0018 0 0.0001 0 0.0009 0.0006 0.001 0 0.0003 0.0002 0.0005 0.0008
Bud Periphery 0.0019 0 0.0002 0.0008 0.0022 0.0001 0.0011 0 0 0 0.0002 0.0002 0.0006 0.0001 0.0002 0 0.0003 0.0001
Bud Site 0.002 0 0.0004 0.0016 0.0052 0.0001 0.0039 0 0.0001 0 0.0004 0.0002 0.0014 0.0002 0.0014 0.0001 0.0006 0.0001
Cell Periphery 0.0005 0 0.0001 0.0002 0.0005 0 0.0003 0 0 0 0 0.0001 0.0002 0 0.0001 0 0.0001 0
Cytoplasm 0.0017 0.0092 0.0004 0.0029 0.0011 0.0003 0.0014 0 0.0001 0 0.0003 0.0001 0.0019 0.0021 0.0032 0.0001 0.0003 0.0002
Cytoplasmic Foci 0.0056 0 0.0057 0.031 0.0115 0.0011 0.023 0 0.0001 0 0.0241 0.0015 0.0114 0.0005 0.0123 0.0061 0.0011 0.0002
Eisosomes 0.0002 0 0.001 0.0001 0.0001 0 0.0003 0 0 0 0.0001 0.0001 0 0 0 0 0 0
Endoplasmic Reticulum 0.0019 0.0002 0.0003 0.0034 0.0005 0.0009 0.0022 0 0 0 0.0004 0.0003 0.0016 0.0009 0.0014 0 0.0011 0.0005
Endosome 0.0157 0.0001 0.0041 0.0368 0.0599 0.0064 0.0071 0 0.0001 0 0.0049 0.0025 0.0228 0.0031 0.0207 0.012 0.0038 0.002
Golgi 0.0035 0 0.0036 0.0236 0.0097 0.0058 0.0048 0 0.0004 0 0.0044 0.0042 0.0035 0.0001 0.0033 0.0251 0.0031 0.0005
Lipid Particles 0.0161 0 0.0114 0.0216 0.0409 0.0126 0.0088 0 0.0001 0 0.0335 0.003 0.0066 0.0001 0.0045 0.001 0.0167 0.0004
Mitochondria 0.0121 0.0002 0.0244 0.0209 0.0505 0.0031 0.0039 0.0001 0.0003 0 0.0022 0.0026 0.0047 0.0002 0.0016 0.0071 0.0039 0.0072
None 0.0009 0.0026 0.005 0.003 0.0004 0.0002 0.0024 0 0 0 0.0009 0.0003 0.0012 0.0001 0.0038 0 0.0003 0
Nuclear Periphery 0.0063 0.0021 0.0008 0.0249 0.0054 0.0223 0.0043 0.0005 0.0003 0.0001 0.009 0.0022 0.0157 0.0017 0.0043 0.0001 0.0129 0.0017
Nucleolus 0.0152 0.0094 0.0104 0.0058 0.0201 0.0336 0.0155 0.0097 0.0101 0.0112 0.0592 0.022 0.0126 0.0095 0.0095 0.0024 0.0834 0.0449
Nucleus 0.8947 0.9753 0.9165 0.7592 0.7405 0.9085 0.8433 0.9894 0.9768 0.9885 0.8061 0.9524 0.8953 0.9778 0.9243 0.9022 0.8632 0.9375
Peroxisomes 0.008 0 0.0079 0.0176 0.03 0.0009 0.023 0 0.0001 0 0.0316 0.002 0.0023 0 0.0023 0.0394 0.0005 0.0001
Punctate Nuclear 0.0008 0.0005 0.0009 0.0162 0.001 0.0008 0.0219 0.0003 0.0014 0.0001 0.0119 0.0022 0.0049 0.0009 0.0016 0.0001 0.0035 0.0029
Vacuole 0.005 0.0001 0.0003 0.002 0.011 0.0004 0.0014 0 0 0 0.0001 0.0003 0.0084 0.0017 0.0032 0.0001 0.0016 0.0002
Vacuole Periphery 0.002 0.0001 0.0003 0.002 0.0053 0.0009 0.0006 0 0 0 0.0004 0.0004 0.0033 0.0004 0.0007 0.0002 0.0018 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.2631 11.2033 8.3133 13.242 10.2439 12.5256 15.1445 10.1384 14.0547 15.9041
Translational Efficiency 1.1186 0.8517 1.0104 0.5888 0.9738 0.9636 0.7162 1.1106 0.8273 0.8304

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1992 172 2447 1233 2401 2180 409 30 4393 2352 2856 1263

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 677.14 882.34 978.00 1061.15 781.94 781.62 1063.57 1134.21 734.42 788.99 990.25 1062.89
Standard Deviation 87.36 137.78 123.20 164.46 105.02 111.33 140.71 211.48 110.50 116.47 129.38 166.10
Intensity Change Log 2 — 0.381881 0.530380 0.648103 — -0.000591 0.443785 0.536558 — 0.189562 0.484620 0.589399

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000079 0.004159 0.000690 0.002584 0.000139 0.000343 0.000763 0.000971 0.000112 0.000622 0.000700 0.002545
Bud Neck 0.002633 0.005903 0.028526 0.030157 0.004949 0.007311 0.016696 0.017563 0.003899 0.007208 0.026832 0.029857
Bud Site 0.000938 0.002383 0.002333 0.008357 0.000370 0.001062 0.001317 0.001028 0.000627 0.001158 0.002187 0.008183
Cell Periphery 0.000154 0.000074 0.000066 0.000159 0.000078 0.000071 0.000070 0.000053 0.000112 0.000072 0.000066 0.000157
Cytoplasm 0.018269 0.000573 0.000497 0.004594 0.001581 0.001463 0.001011 0.000393 0.009148 0.001397 0.000570 0.004494
Cytoplasmic Foci 0.001248 0.002086 0.000103 0.001896 0.000086 0.000441 0.000011 0.000015 0.000613 0.000561 0.000090 0.001851
Eisosomes 0.000011 0.000053 0.000041 0.000038 0.000014 0.000015 0.000038 0.000043 0.000012 0.000017 0.000041 0.000038
Endoplasmic Reticulum 0.001451 0.005860 0.003777 0.004326 0.002492 0.003132 0.002816 0.004026 0.002020 0.003332 0.003639 0.004319
Endosome 0.000247 0.000439 0.000300 0.004185 0.000121 0.000340 0.000095 0.000104 0.000178 0.000348 0.000271 0.004088
Golgi 0.000113 0.002080 0.000225 0.002838 0.000033 0.000206 0.000071 0.000062 0.000069 0.000343 0.000203 0.002772
Lipid Particles 0.000421 0.003166 0.000045 0.000248 0.000069 0.000289 0.000027 0.000056 0.000229 0.000499 0.000042 0.000244
Mitochondria 0.000921 0.003637 0.002020 0.006317 0.000476 0.001203 0.000990 0.001299 0.000678 0.001381 0.001873 0.006198
Mitotic Spindle 0.000380 0.002308 0.004305 0.029361 0.000179 0.001344 0.003024 0.000146 0.000270 0.001415 0.004121 0.028667
None 0.015848 0.002413 0.001132 0.004153 0.002594 0.003008 0.002900 0.001101 0.008604 0.002965 0.001385 0.004081
Nuclear Periphery 0.000676 0.000253 0.000845 0.001945 0.000290 0.001101 0.000219 0.000221 0.000465 0.001039 0.000755 0.001904
Nuclear Periphery Foci 0.000661 0.001205 0.000199 0.000916 0.000072 0.000650 0.000031 0.000060 0.000339 0.000691 0.000175 0.000896
Nucleolus 0.008662 0.027109 0.014789 0.009382 0.015670 0.014017 0.010412 0.009050 0.012492 0.014975 0.014162 0.009374
Nucleus 0.946489* 0.930422* 0.938768* 0.877230* 0.970432* 0.961143* 0.958612* 0.962146* 0.959575* 0.958897* 0.941610* 0.879247*
Peroxisomes 0.000308 0.004669 0.000201 0.000650 0.000131 0.000334 0.000270 0.000389 0.000211 0.000651 0.000211 0.000644
Vacuole 0.000399 0.000720 0.000752 0.006711 0.000131 0.001230 0.000538 0.001155 0.000253 0.001192 0.000722 0.006579
Vacuole Periphery 0.000091 0.000487 0.000385 0.003953 0.000094 0.001297 0.000090 0.000121 0.000093 0.001238 0.000343 0.003862

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.53 -21.13 -3.44 0.74 -2.28 -1.72 -16.35 -3.33 -2.74 -1.59 -2.29 -24.12 -3.45 -2.37 -2.27
Bud Neck -1.84 -23.74 -17.96 -8.22 -1.28 -3.34 -10.79 -3.29 -2.65 0.44 -5.18 -24.57 -17.49 -14.55 -1.98
Bud Site -1.00 -2.59 -4.63 -1.58 -3.23 -2.21 -7.44 -1.65 -1.17 -0.81 -1.55 -4.09 -5.21 -4.56 -3.40
Cell Periphery 2.02 3.13 0.63 -1.99 -4.59 0.37 0.55 -0.57 -0.74 -0.82 2.43 3.04 -1.11 -3.87 -4.66
Cytoplasm 10.39 10.49 8.00 -4.52 -4.77 0.25 0.85 0.52 0.42 -0.01 9.20 10.50 5.28 -3.26 -4.65
Cytoplasmic Foci -0.70 4.94 1.52 1.24 -3.39 -1.96 1.96 -0.04 1.88 -1.14 0.14 4.69 -0.69 -0.67 -3.46
Eisosomes -3.46 -22.18 -17.49 0.95 -0.68 -1.82 -13.10 -2.71 -2.61 -1.33 -4.35 -25.00 -17.47 -11.83 -1.05
Endoplasmic Reticulum -5.29 -15.82 -12.09 1.21 -3.47 -2.97 -4.37 -1.92 -1.47 -1.34 -6.33 -13.99 -10.62 -4.92 -3.91
Endosome -1.09 -0.34 -3.66 -3.05 -3.57 -2.80 0.32 -1.11 1.75 -1.20 -2.21 -1.18 -3.81 -3.44 -3.63
Golgi -1.89 -0.42 -2.36 0.63 -2.22 -1.64 -6.62 -1.53 0.04 -0.99 -2.06 -0.99 -2.49 -1.92 -2.26
Lipid Particles -2.01 2.56 1.34 2.16 -5.11 -1.72 1.61 -1.15 1.00 -1.58 -1.68 2.70 0.11 1.82 -5.25
Mitochondria -2.21 -3.84 -4.91 -0.75 -3.45 -1.98 -7.30 -4.08 -1.19 -1.31 -1.96 -6.26 -5.41 -4.15 -3.61
Mitotic Spindle -1.56 -3.97 -7.11 -5.99 -5.64 -2.38 -1.62 -1.13 -0.61 0.39 -2.48 -4.40 -7.17 -6.76 -5.68
None 8.70 9.96 7.85 -2.17 -5.93 -0.73 -0.29 0.35 0.63 0.46 7.12 10.21 5.91 -1.43 -5.44
Nuclear Periphery 2.01 -0.58 -5.53 -7.06 -3.69 -2.51 -1.70 -1.11 1.79 -0.33 -1.90 -1.39 -7.12 -2.72 -4.13
Nuclear Periphery Foci -0.69 1.11 0.12 0.82 -3.02 -1.57 1.75 -0.87 1.30 -1.23 -0.83 0.86 -1.14 0.12 -3.23
Nucleolus -4.19 -6.58 -2.93 3.16 1.93 1.41 2.34 1.39 0.98 0.39 -2.43 -2.90 -0.26 1.37 1.66
Nucleus 1.50 2.91 9.04 2.83 7.75 3.63 4.96 1.83 1.03 0.23 0.34 8.61 12.10 11.51 8.17
Peroxisomes -1.99 1.05 -0.76 1.93 -2.34 -1.78 -3.13 -1.66 -0.70 -1.24 -2.25 0.13 -2.00 1.11 -2.34
Vacuole -1.29 -2.83 -6.70 -5.63 -6.18 -3.02 -6.39 -1.89 -1.25 -1.42 -2.82 -4.77 -6.94 -5.62 -6.24
Vacuole Periphery -1.41 -1.67 -3.40 -2.34 -2.84 -2.26 -0.74 -1.50 2.12 -1.29 -2.32 -1.68 -3.40 -0.98 -2.91
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Hda2

Hda2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hda2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available