Standard name
Human Ortholog
Description Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.07 0.07 0 0.07 – 0 0.06 0 0 0.05 0.16 0.21 0.09 0.12 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.09 0 0 0 0 0.05 0 – 0.1 0.06 0.23 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.9 0.92 0.94 0.9 0.88 0.89 0.84 – 0.83 0.8 0.79 0.88 0.9 0.78 0.73 0.8 0.76 0.75 0.85 0.88 0.91 0.76 0.8 0.76
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.11 0.13 0 0.05 0 0.06 0.1 – 0.17 0.14 0.28 0.19 0.09 0 0 0.06 0.05 0 0.05 0.05 0 0.11 0.07 0.08
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.1 0.1 0 0 0 0 0.06 0.11
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 1 0 1 1 0 1 0
Bud Neck 0 0 0 0 0 0 1 – 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 4 – 7 2 7 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 6 4 7 17 17 13 24 – 10 21 6 9 5 30 40 16 11 13 0 0 0 0 1 2
Endoplasmic Reticulum 0 1 0 0 0 1 0 – 0 0 0 0 0 0 0 1 0 3 0 0 0 0 0 0
Endosome 0 0 1 1 2 0 0 – 2 2 0 1 1 1 1 1 0 1 5 2 0 2 5 1
Golgi 0 1 0 1 0 0 0 – 0 1 0 0 0 0 0 2 0 1 1 3 0 0 0 0
Mitochondria 25 5 1 1 2 16 13 – 32 21 64 21 2 1 1 4 1 4 4 2 1 0 1 2
Nucleus 248 192 199 219 224 260 308 – 269 284 220 286 87 143 138 135 67 101 232 201 204 73 165 161
Nuclear Periphery 1 0 0 1 1 1 1 – 1 4 2 3 1 0 1 1 0 0 0 0 1 0 0 0
Nucleolus 30 27 4 11 8 17 36 – 55 51 77 61 9 7 6 10 4 5 12 10 4 10 13 16
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 1 1 2 1 2 – 2 0 0 1 1 2 3 0 2 1 1 0 1 1 2 1
Vac/Vac Membrane 2 4 4 2 7 4 5 – 2 6 1 1 0 4 8 7 9 14 8 5 5 2 13 24
Unique Cell Count 276 209 212 244 254 293 368 324 354 278 326 97 183 190 169 88 134 273 229 225 97 206 213
Labelled Cell Count 313 234 218 254 263 314 394 380 392 377 386 107 188 199 178 94 144 273 229 225 97 206 213


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 8.5 8.7 8.2 8.4 7.1 7.2 – 6.3 6.7 5.8 6.3 8.1 9.5 9.6 10.6 13.3 12.0 6.9 8.1 8.7
Std Deviation (1e-4) 1.3 1.6 1.6 1.6 1.7 1.9 1.9 – 1.4 1.6 1.6 1.4 2.1 3.7 4.4 2.7 4.7 3.0 1.3 2.4 2.4
Intensity Change (Log2) – – – -0.08 -0.04 -0.28 -0.27 – -0.45 -0.36 -0.57 -0.45 -0.1 0.14 0.14 0.28 0.61 0.47 -0.32 -0.09 0.01

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.7 1.6 0.6 1.7 – -0.1 1.4 -0.8 -0.4 0 4.5 5.5 2.5 3.1 2.5
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.1 2.3 – 4.4 3.3 7.3 3.4 0 0 0 0 0 0
Nucleus -1.6 -2.1 -2.0 -3.6 – -3.7 -4.4 -4.6 -2.3 -1.3 -4.6 -5.8 -4.1 -4.4 -4.9
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.6 0.9 2.2 3.6 – 5.5 4.9 7.6 5.9 0 1.2 0 2.1 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0.6 0 0 – 0 0 0 0 0 0 1.4 0 0 3.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.0881 2.605 2.46 1.9282 1.6449 2.1382 3.7411 3.8318 3.7822 3.3987 3.6193 3.6026 3.3383 3.7829 3.0924 3.3314 2.9974 3.0425
Actin 0.0023 0.0001 0.0104 0.0096 0.0056 0 0.0013 0 0.0041 0.0014 0.0054 0.001 0.0315 0 0.0378 0 0.0153 0
Bud 0.0005 0 0.0002 0.0003 0.0002 0 0.0005 0 0.0002 0.0001 0.0003 0.0001 0.0002 0 0.0001 0 0.0008 0
Bud Neck 0.0004 0.0001 0.0001 0.0001 0.0006 0.0011 0.0025 0.0001 0.0019 0.0002 0.0004 0.0005 0.0019 0 0.0008 0 0.0031 0.0002
Bud Periphery 0.0009 0.0001 0.0001 0.0005 0.0005 0.0001 0.0015 0 0.0004 0.0001 0.0012 0.0003 0.0003 0 0.0001 0 0.0015 0
Bud Site 0.0022 0.0001 0.0007 0.0015 0.0006 0.0001 0.0029 0.0001 0.0027 0.0005 0.0012 0.0001 0.0006 0 0.0001 0 0.0041 0
Cell Periphery 0.0003 0 0 0.0001 0.0002 0 0.0006 0 0.0003 0.0002 0.0003 0.0001 0.0003 0 0 0 0.0004 0
Cytoplasm 0.0031 0 0.0124 0.0013 0.0013 0 0.0041 0 0.0008 0.0144 0.0002 0.0003 0.0024 0 0.0002 0 0.0038 0
Cytoplasmic Foci 0.0226 0.0035 0.002 0.0049 0.0146 0 0.0074 0 0.0046 0.0028 0.0097 0.0024 0.0006 0 0.0005 0 0.0047 0
Eisosomes 0 0 0.0001 0.0002 0.0001 0 0.0001 0 0.0003 0 0.0001 0 0.0004 0 0.0002 0 0.0003 0
Endoplasmic Reticulum 0.0015 0 0.0005 0.0009 0.0005 0 0.0028 0 0.0014 0.0146 0.0007 0.0003 0.0045 0 0.001 0 0.0044 0
Endosome 0.0313 0.0009 0.0064 0.0109 0.0106 0 0.0063 0 0.006 0.0221 0.0124 0.0099 0.0073 0 0.0028 0 0.0221 0
Golgi 0.0095 0.0008 0.0025 0.0032 0.0067 0 0.0011 0 0.0014 0.0083 0.0052 0.0037 0.0016 0 0.0017 0 0.0029 0
Lipid Particles 0.0237 0.0047 0.0008 0.0096 0.0275 0 0.0064 0 0.0072 0.0035 0.0461 0.0044 0.0006 0 0.0007 0 0.0033 0
Mitochondria 0.0053 0.0004 0.0045 0.0315 0.0469 0.0001 0.0038 0.0002 0.0073 0.0025 0.0087 0.0032 0.0013 0.0001 0.0006 0 0.03 0
None 0.0016 0 0.0003 0.0022 0.0005 0 0.0021 0 0.0009 0.0007 0.0004 0.0004 0.0022 0 0.001 0 0.0045 0
Nuclear Periphery 0.0141 0.0017 0.002 0.0071 0.0092 0.0003 0.0101 0.0004 0.0126 0.0199 0.0129 0.0027 0.018 0.0002 0.0084 0 0.0222 0
Nucleolus 0.0243 0.0156 0.0053 0.0037 0.1038 0.0626 0.0249 0.0172 0.0118 0.0088 0.093 0.0375 0.0192 0.0081 0.0066 0.0068 0.0975 0.024
Nucleus 0.8045 0.9684 0.9498 0.8981 0.7099 0.9352 0.9019 0.9806 0.9255 0.8944 0.7833 0.9277 0.8982 0.9915 0.9354 0.9931 0.7626 0.9755
Peroxisomes 0.0079 0.0031 0.0008 0.0075 0.0226 0 0.0072 0 0.0021 0.0003 0.0078 0.0013 0.0001 0 0.0004 0 0.0011 0
Punctate Nuclear 0.0362 0.0004 0.0005 0.0049 0.0308 0.0003 0.0055 0.0012 0.0055 0.0008 0.0032 0.0027 0.0069 0.0001 0.0012 0 0.0093 0.0001
Vacuole 0.0047 0.0001 0.0005 0.0007 0.0034 0.0001 0.0045 0.0001 0.0019 0.0022 0.0033 0.0007 0.0007 0 0.0001 0 0.0033 0
Vacuole Periphery 0.003 0.0001 0.0003 0.0012 0.0037 0 0.0025 0 0.0013 0.0021 0.0044 0.0006 0.0011 0 0.0003 0 0.0028 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.3002 14.3175 17.4541 17.8066 11.8661 15.4357 14.6057 16.7496 16.6667 20.0103
Translational Efficiency 1.4231 1.1025 1.1507 1.0833 2.0109 1.2803 1.1324 1.1241 1.2086 1.1657

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1647 1202 2632 1788 1321 1610 480 71 2968 2812 3112 1859

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 662.12 799.89 1151.85 1113.92 900.90 895.47 1182.24 1208.70 768.40 854.61 1156.54 1117.54
Standard Deviation 94.56 155.56 165.63 182.98 130.58 140.06 159.20 241.63 163.19 154.31 165.02 186.45
Intensity Change Log 2 — 0.272709 0.798788 0.750481 — -0.008722 0.392084 0.424017 — 0.117255 0.578524 0.571417

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000267 0.000775 0.000360 0.000669 0.000224 0.000457 0.000954 0.000990 0.000248 0.000593 0.000452 0.000681
Bud Neck 0.003311 0.006221 0.020053 0.024726 0.008573 0.009622 0.012576 0.015133 0.005653 0.008168 0.018899 0.024360
Bud Site 0.001741 0.001378 0.000656 0.002648 0.000585 0.001373 0.001210 0.001848 0.001227 0.001375 0.000741 0.002617
Cell Periphery 0.000394 0.000208 0.000037 0.000080 0.000111 0.000052 0.000028 0.000138 0.000268 0.000119 0.000035 0.000082
Cytoplasm 0.004463 0.005380 0.000046 0.000484 0.000228 0.000282 0.000150 0.001634 0.002578 0.002461 0.000062 0.000528
Cytoplasmic Foci 0.001146 0.000422 0.000003 0.000358 0.000025 0.000571 0.000018 0.013821 0.000647 0.000508 0.000005 0.000872
Eisosomes 0.000026 0.000037 0.000057 0.000036 0.000040 0.000044 0.000061 0.000047 0.000032 0.000041 0.000058 0.000036
Endoplasmic Reticulum 0.002771 0.003920 0.001023 0.002112 0.003227 0.003176 0.002665 0.001794 0.002974 0.003494 0.001276 0.002100
Endosome 0.000380 0.000298 0.000023 0.000675 0.000119 0.000624 0.000055 0.000656 0.000264 0.000485 0.000028 0.000675
Golgi 0.000090 0.000501 0.000034 0.000260 0.000033 0.000425 0.000071 0.006349 0.000065 0.000457 0.000040 0.000493
Lipid Particles 0.000251 0.000188 0.000004 0.000205 0.000011 0.000458 0.000048 0.000639 0.000144 0.000343 0.000011 0.000222
Mitochondria 0.000778 0.001468 0.000781 0.003198 0.000463 0.001035 0.001139 0.003083 0.000638 0.001220 0.000836 0.003194
Mitotic Spindle 0.000556 0.000463 0.000102 0.004663 0.000743 0.002685 0.000263 0.003019 0.000639 0.001735 0.000126 0.004600
None 0.024193 0.010922 0.000400 0.001442 0.001100 0.001135 0.001626 0.021303 0.013915 0.005318 0.000589 0.002200
Nuclear Periphery 0.000508 0.000151 0.000078 0.000917 0.000173 0.000513 0.000088 0.000597 0.000359 0.000358 0.000079 0.000905
Nuclear Periphery Foci 0.000575 0.000582 0.000006 0.000248 0.000029 0.000454 0.000038 0.000526 0.000332 0.000509 0.000011 0.000259
Nucleolus 0.065153 0.038300 0.019392 0.012308 0.020620 0.030652 0.024302 0.026682 0.045333 0.033921 0.020150 0.012857
Nucleus 0.892226 0.926781 0.956490 0.942154 0.963296 0.945178 0.953021 0.894614 0.923858 0.937314 0.955955 0.940339
Peroxisomes 0.000304 0.000952 0.000189 0.000324 0.000120 0.000484 0.000930 0.000834 0.000222 0.000684 0.000303 0.000343
Vacuole 0.000546 0.000766 0.000146 0.001759 0.000168 0.000425 0.000654 0.003524 0.000378 0.000571 0.000225 0.001826
Vacuole Periphery 0.000322 0.000286 0.000121 0.000735 0.000110 0.000356 0.000103 0.002770 0.000228 0.000326 0.000118 0.000812

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.50 -3.15 -9.73 0.40 -10.56 -7.23 -13.73 -7.52 -5.68 -1.34 -9.39 -9.36 -13.68 -4.12 -8.15
Bud Neck -4.86 -20.39 -17.53 -15.30 -4.12 -1.34 -4.06 -2.51 -2.19 -1.17 -4.63 -19.04 -16.32 -13.92 -4.90
Bud Site 0.59 1.96 -1.24 -2.21 -3.64 -1.93 -1.85 -2.24 -1.11 -1.16 -0.45 1.38 -2.38 -2.21 -3.54
Cell Periphery 2.56 5.40 4.71 4.41 -4.06 1.70 2.42 -0.32 -1.34 -1.74 3.55 5.84 4.58 2.43 -4.52
Cytoplasm -0.65 5.64 4.80 3.57 -4.35 -0.71 0.77 -1.89 -1.79 -1.98 0.08 5.74 4.12 3.07 -4.60
Cytoplasmic Foci 1.60 2.66 2.12 0.94 -2.29 -2.33 0.45 -1.01 -0.94 -1.01 0.76 2.68 0.58 -0.03 -1.74
Eisosomes -4.46 -6.62 -5.38 0.21 4.44 -0.97 -6.35 -2.00 -1.33 1.71 -3.55 -6.37 -2.62 1.63 5.26
Endoplasmic Reticulum -3.29 5.93 1.78 7.17 -10.10 0.17 1.32 3.38 3.24 1.86 -2.45 9.05 3.67 7.60 -7.52
Endosome 0.98 6.18 -1.06 -1.55 -3.47 -2.15 2.81 -1.12 0.31 -1.29 -1.60 7.03 -1.91 -0.34 -3.54
Golgi -1.45 3.96 -1.63 0.99 -2.31 -2.54 -4.81 -1.04 -0.93 -1.03 -2.55 2.55 -1.85 0.46 -1.98
Lipid Particles 0.70 5.00 0.68 0.26 -1.21 -1.79 -4.39 -1.21 0.11 -1.08 -1.38 4.79 -0.20 0.95 -1.28
Mitochondria -1.71 -0.57 -3.75 -2.24 -3.69 -3.22 -5.91 -3.85 -2.99 -2.83 -2.92 -2.85 -4.18 -3.03 -3.75
Mitotic Spindle 0.34 1.48 -3.98 -4.13 -4.45 -1.90 0.94 -1.36 -1.05 -1.45 -1.85 1.75 -4.12 -3.09 -4.64
None 4.62 9.60 9.09 6.40 -3.62 -0.35 -0.84 -1.21 -1.20 -1.17 5.58 9.52 7.93 3.99 -2.65
Nuclear Periphery 1.87 2.21 -1.48 -3.79 -4.11 -1.17 2.06 -1.56 -0.37 -1.78 0.00 2.51 -2.49 -2.16 -4.21
Nuclear Periphery Foci 0.15 2.62 1.67 1.86 -3.93 -1.81 -0.38 -1.59 -0.13 -1.57 -0.69 2.65 0.91 1.66 -4.11
Nucleolus 9.06 17.24 19.83 11.85 5.02 -5.23 -1.50 -1.23 -0.14 -0.86 5.97 13.99 17.09 12.46 4.98
Nucleus -6.26 -14.00 -8.50 -2.16 5.09 5.59 3.57 2.86 2.12 2.39 -3.84 -10.56 -2.71 0.52 5.53
Peroxisomes -2.11 2.43 -0.32 2.01 -1.70 -5.24 -10.42 -4.17 -2.02 -0.12 -3.34 -3.69 -1.89 2.29 -0.49
Vacuole -1.07 2.50 -2.31 -1.85 -3.10 -2.18 -4.43 -1.62 -1.54 -1.42 -1.59 1.19 -2.97 -2.58 -3.20
Vacuole Periphery 0.39 2.52 -1.74 -2.07 -3.10 -3.41 0.06 -1.07 -0.95 -1.07 -1.69 2.28 -2.62 -2.04 -3.26
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Tfb1

Tfb1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tfb1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available