Standard name
Human Ortholog
Description Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0.07 0 0 0 – – 0.1 0 0 – – – 0 0 0 0 0 0 0.24 0 0
Bud Neck 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0.05 0
Bud Site 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – – 0.05 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 0.89 0.85 0.95 1.0 0.96 0.89 0.91 – – 0.95 0.89 0.82 – – – 0.63 0.77 0.75 0.27 0.33 0.33 0.45 0.45 0.2
Endoplasmic Reticulum 0.1 0.19 0 0 0.08 0.08 0.05 – – 0 0 0.06 – – – 0 0 0 0.33 0.34 0.11 0 0 0.11
Endosome 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0.05 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – – 0 0.11 0.09 – – – 0 0 0 0 0 0.07 0 0 0.08
Nucleus 0 0 0 0 0 0 0 – – 0 0 0.12 – – – 0.05 0 0 0 0 0 0 0 0.15
Nuclear Periphery 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0.08 0
Vac/Vac Membrane 0 0 0.05 0 0 0 0 – – 0 0 0 – – – 0.39 0.25 0.28 0.28 0.19 0.4 0.06 0.18 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 1 4 – – 0 1 0 – – – 1 0 0 2 2 0 0 0 0
Bud 2 0 0 2 0 0 2 – – 2 3 1 – – – 0 0 0 1 1 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 2 4 1 0 0 0
Bud Site 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 1 0 1 – – 1 1 1 – – – 1 3 2 1 0 0 0 0 0
Cytoplasm 154 86 18 27 25 55 86 – – 19 85 27 – – – 130 172 122 53 38 14 1 5 1
Endoplasmic Reticulum 18 19 0 0 2 5 5 – – 0 1 2 – – – 8 1 1 65 39 4 0 0 0
Endosome 0 0 0 0 0 0 0 – – 0 2 0 – – – 7 12 6 4 1 0 0 0 0
Golgi 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 1 2 0 0 0 0 0
Mitochondria 3 0 0 0 0 2 0 – – 0 10 3 – – – 0 2 0 6 2 2 0 0 0
Nucleus 0 0 0 0 0 0 1 – – 0 1 4 – – – 11 5 4 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – – 0 0 1 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – – 0 0 0 – – – 0 0 0 0 0 0 0 1 0
Vac/Vac Membrane 2 0 1 0 0 0 0 – – 0 2 0 – – – 81 55 46 55 21 17 0 2 0
Unique Cell Count 174 101 19 27 26 62 94 20 95 33 206 222 163 199 116 45 4 12 5
Labelled Cell Count 180 106 19 29 28 63 99 22 106 39 239 250 182 199 116 45 4 12 5


Cytoplasm, Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 7.0 7.4 6.6 7.5 6.1 6.3 – – 5.4 4.8 4.9 – – – 8.9 9.3 8.6 – – –
Std Deviation (1e-4) 0.7 1.2 2.3 0.7 0.8 1.0 1.3 – – 0.5 0.9 1.4 – – – 1.5 1.6 1.5 – – –
Intensity Change (Log2) – – – -0.18 0.01 -0.28 -0.23 – – -0.47 -0.63 -0.61 – – – 0.26 0.32 0.21 – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – – 0 0 0 – – – 0 0 0
Bud 0 0 0 0 – – 0 0 0 – – – 0 0 0
Bud Neck 0 0 0 0 – – 0 0 0 – – – 0 0 0
Bud Site 0 0 0 0 – – 0 0 0 – – – 0 0 0
Cell Periphery 0 0 0 0 – – 0 0 0 – – – 0 0 0
Cytoplasm 1.2 0.2 -0.8 -0.5 – – 0 -0.7 -1.3 – – – -2.8 -1.8 -1.9
Endoplasmic Reticulum 0 0 0 0 – – 0 0 0 – – – 0 0 0
Endosome 0 0 0 0 – – 0 0 0 – – – 0 0 0
Golgi 0 0 0 0 – – 0 0 0 – – – 0 0 0
Mitochondria 0 0 0 0 – – 0 0 0 – – – 0 0 0
Nucleus 0 0 0 0 – – 0 0 0 – – – 0 0 0
Nuclear Periphery 0 0 0 0 – – 0 0 0 – – – 0 0 0
Nucleolus 0 0 0 0 – – 0 0 0 – – – 0 0 0
Peroxisomes 0 0 0 0 – – 0 0 0 – – – 0 0 0
SpindlePole 0 0 0 0 – – 0 0 0 – – – 0 0 0
Vacuole 0 0 0 0 – – 0 0 0 – – – 3.0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.6247 2.0165 1.6075 1.6942 1.3942 1.8246 1.4043 2.0542 1.8228 1.2987 1.7551 2.0478 1.0935 1.6405 1.3591 1.6848 1.3012 1.5435
Actin 0.0218 0.0054 0.0071 0.0079 0.0089 0.0107 0.0135 0.0016 0.0046 0.0027 0.0268 0.0159 0.0281 0.0006 0.0176 0.0066 0.1138 0.0147
Bud 0.0012 0.0128 0.0024 0.0018 0.0008 0.0017 0.0006 0.0003 0.0004 0.0003 0.0014 0.0007 0.0003 0.0015 0.0019 0.0005 0.0009 0.0112
Bud Neck 0.0065 0.002 0.0048 0.0034 0.0028 0.0066 0.0014 0.0008 0.0033 0.0058 0.002 0.0034 0.0012 0.0003 0.0014 0.0004 0.0009 0.0016
Bud Periphery 0.0027 0.0028 0.0037 0.0017 0.0013 0.0017 0.0015 0.0008 0.0009 0.0012 0.0032 0.0028 0.0003 0.0006 0.0036 0.0008 0.0012 0.0039
Bud Site 0.008 0.0311 0.0129 0.0009 0.0021 0.0009 0.0067 0.0119 0.0131 0.001 0.0033 0.001 0.0032 0.0243 0.0048 0.0008 0.0034 0.0007
Cell Periphery 0.0045 0.0036 0.0033 0.0012 0.0022 0.0011 0.0051 0.0095 0.0058 0.0085 0.0019 0.0021 0.0023 0.003 0.0022 0.0004 0.0011 0.0009
Cytoplasm 0.4717 0.5863 0.5276 0.6091 0.6218 0.5891 0.4546 0.5685 0.4875 0.602 0.5215 0.5575 0.489 0.616 0.5988 0.4394 0.5345 0.6661
Cytoplasmic Foci 0.0264 0.0213 0.0306 0.0293 0.0407 0.0456 0.0447 0.0225 0.0287 0.0185 0.0255 0.0228 0.033 0.0124 0.0201 0.0629 0.0096 0.0335
Eisosomes 0.0011 0.0006 0.0008 0.0002 0.0001 0.0001 0.0005 0.0002 0.0003 0.0002 0.0002 0.0002 0.0003 0.0001 0.0002 0.0001 0.0005 0.0001
Endoplasmic Reticulum 0.1462 0.12 0.1092 0.0566 0.0895 0.0982 0.1513 0.1524 0.145 0.1512 0.1158 0.1074 0.2049 0.1561 0.1517 0.1984 0.233 0.1365
Endosome 0.0544 0.0392 0.0501 0.0521 0.074 0.039 0.0568 0.0362 0.0357 0.0613 0.0804 0.0272 0.0226 0.0214 0.0186 0.0437 0.0359 0.0194
Golgi 0.0082 0.0023 0.0115 0.0095 0.0069 0.0067 0.0136 0.0023 0.0092 0.0093 0.0133 0.008 0.0067 0.0011 0.0087 0.021 0.0212 0.0119
Lipid Particles 0.0213 0.0121 0.0187 0.0166 0.0124 0.0173 0.0291 0.0235 0.0165 0.0072 0.0368 0.0087 0.0203 0.0056 0.0055 0.0504 0.0064 0.0172
Mitochondria 0.0132 0.0009 0.0089 0.0373 0.004 0.006 0.0116 0.0009 0.0094 0.014 0.0109 0.0131 0.0029 0.0026 0.0061 0.0519 0.0085 0.0036
None 0.1626 0.1217 0.1543 0.1168 0.0618 0.1455 0.1662 0.1364 0.2055 0.1025 0.0677 0.2044 0.1532 0.1336 0.1458 0.0842 0.0138 0.0585
Nuclear Periphery 0.0125 0.0077 0.0074 0.0053 0.0071 0.0032 0.0056 0.0046 0.0038 0.0024 0.0039 0.0059 0.0039 0.0035 0.003 0.0049 0.0051 0.0019
Nucleolus 0.0014 0.0003 0.001 0.0016 0.0019 0.0005 0.0007 0.0002 0.0013 0.0001 0.0011 0.0005 0.0003 0.0009 0.0001 0.0002 0.0001 0.0034
Nucleus 0.0065 0.0037 0.0062 0.0055 0.011 0.0036 0.0022 0.0025 0.0028 0.0015 0.0032 0.0019 0.0014 0.0023 0.001 0.0011 0.0011 0.0022
Peroxisomes 0.0051 0.0029 0.0148 0.005 0.0178 0.007 0.0111 0.0025 0.0091 0.0023 0.0236 0.0034 0.0149 0.0001 0.0015 0.0183 0.0015 0.0027
Punctate Nuclear 0.0063 0.0012 0.0072 0.0144 0.0034 0.0054 0.0035 0.001 0.0016 0.0006 0.0186 0.0031 0.0044 0.0008 0.0006 0.005 0.0009 0.0008
Vacuole 0.0169 0.0208 0.0159 0.0213 0.0258 0.0092 0.0179 0.0207 0.0144 0.0067 0.0355 0.0088 0.0063 0.0129 0.0062 0.0081 0.0055 0.0081
Vacuole Periphery 0.0017 0.0012 0.0015 0.0025 0.0037 0.0008 0.0017 0.0005 0.001 0.0007 0.0034 0.001 0.0004 0.0005 0.0005 0.0012 0.0011 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 36.6569 39.6533 34.3285 41.4292 33.5487 28.9399 44.6875 44.9127 40.8064 50.8998
Translational Efficiency 0.5987 0.5822 0.6428 0.4037 0.4726 0.8397 0.5576 0.4319 0.4676 0.4159

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
262 1332 200 1315 2355 1471 148 304 2617 2803 348 1619

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 759.19 780.53 1059.10 929.41 801.63 798.57 1058.59 1008.50 797.38 790.00 1058.88 944.26
Standard Deviation 121.14 128.16 115.18 128.97 93.89 110.28 113.69 125.21 97.79 119.45 114.55 131.94
Intensity Change Log 2 — 0.039993 0.480306 0.291854 — -0.005518 0.401136 0.331203 — 0.016798 0.440187 0.312197

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000338 0.000712 0.003182 0.008832 0.000244 0.001168 0.001417 0.005507 0.000253 0.000951 0.002431 0.008208
Bud Neck 0.030643 0.013491 0.010222 0.014816 0.011012 0.017863 0.004835 0.018729 0.012977 0.015786 0.007931 0.015550
Bud Site 0.016960 0.009063 0.022442 0.062836 0.003551 0.019203 0.009039 0.054546 0.004893 0.014384 0.016742 0.061280
Cell Periphery 0.000426 0.000329 0.001404 0.004030 0.000390 0.000405 0.001128 0.001581 0.000394 0.000369 0.001287 0.003570
Cytoplasm 0.494889* 0.371027* 0.257033* 0.344978* 0.459881* 0.348295* 0.263139* 0.270426* 0.463386* 0.359097* 0.259630* 0.330980*
Cytoplasmic Foci 0.178606 0.229714* 0.044769 0.056715 0.144735 0.189826* 0.049469 0.073546 0.148126 0.208781* 0.046768 0.059875
Eisosomes 0.000367 0.000341 0.000218 0.001518 0.000572 0.000777 0.000336 0.000730 0.000551 0.000570 0.000268 0.001370
Endoplasmic Reticulum 0.005259 0.019324 0.069432 0.102699* 0.017404 0.038631 0.047531 0.084638 0.016188 0.029456 0.060118 0.099308
Endosome 0.014302 0.037753 0.020400 0.009845 0.017900 0.042264 0.018613 0.015352 0.017540 0.040121 0.019640 0.010879
Golgi 0.001424 0.006290 0.000694 0.003416 0.002792 0.011162 0.000234 0.002421 0.002655 0.008847 0.000498 0.003230
Lipid Particles 0.008863 0.029223 0.017493 0.018406 0.022361 0.044215 0.020036 0.023644 0.021009 0.037091 0.018575 0.019389
Mitochondria 0.001004 0.002693 0.000494 0.002366 0.001072 0.007072 0.000217 0.001363 0.001065 0.004991 0.000377 0.002178
Mitotic Spindle 0.002744 0.001672 0.002327 0.006610 0.001093 0.004511 0.000817 0.009391 0.001258 0.003162 0.001685 0.007132
None 0.001195 0.002779 0.000624 0.001219 0.001112 0.001053 0.001228 0.004067 0.001120 0.001873 0.000881 0.001754
Nuclear Periphery 0.000736 0.001062 0.005642 0.000923 0.001417 0.001854 0.004202 0.001509 0.001349 0.001478 0.005030 0.001033
Nuclear Periphery Foci 0.001695 0.003673 0.052343 0.015133 0.001532 0.001669 0.052158 0.024099 0.001548 0.002621 0.052265 0.016817
Nucleolus 0.001506 0.001544 0.000336 0.000301 0.000662 0.000913 0.000280 0.000380 0.000746 0.001213 0.000313 0.000315
Nucleus 0.112312 0.066056 0.204917* 0.108865 0.137253* 0.064626 0.106896 0.055976 0.134756* 0.065306 0.163230* 0.098934
Peroxisomes 0.003969 0.005311 0.000816 0.003292 0.002420 0.006708 0.000631 0.003196 0.002575 0.006044 0.000737 0.003274
Vacuole 0.121702 0.195586 0.284630* 0.231490* 0.171836 0.193933 0.417597* 0.345905* 0.166817 0.194719 0.341179* 0.252974*
Vacuole Periphery 0.001061 0.002356 0.000581 0.001709 0.000762 0.003851 0.000196 0.002992 0.000792 0.003140 0.000417 0.001950

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.22 -5.01 -8.61 -8.14 -4.45 -4.76 -4.66 -4.05 -2.97 -2.84 -6.06 -6.22 -9.44 -8.35 -5.87
Bud Neck 2.20 2.56 2.15 -0.28 -1.93 -5.16 2.73 -1.27 0.81 -2.50 -2.51 2.87 -1.00 1.37 -3.76
Bud Site 1.75 -0.99 -6.97 -11.42 -5.32 -7.31 -3.67 -5.78 -3.02 -4.45 -7.38 -4.32 -13.72 -10.40 -7.84
Cell Periphery 1.23 -5.31 -7.99 -8.31 -4.89 -0.48 -4.43 -4.62 -4.50 -1.04 0.85 -7.02 -8.55 -8.63 -5.50
Cytoplasm 5.71 10.58 8.23 4.90 -5.34 14.35 11.62 14.30 6.81 -0.69 15.82 18.18 19.89 6.65 -5.67
Cytoplasmic Foci -4.89 12.04 11.49 32.30 -2.53 -8.74 20.75 13.72 18.76 -2.47 -13.94 27.55 27.37 40.56 -3.71
Eisosomes 0.09 1.05 -4.10 -5.18 -6.00 -2.20 5.40 0.76 2.25 -2.16 -0.33 7.28 -3.70 -3.48 -6.11
Endoplasmic Reticulum -4.83 -8.76 -13.19 -10.91 -1.63 -6.82 -2.89 -3.82 -1.20 -1.32 -6.37 -7.64 -12.44 -9.07 -3.18
Endosome -9.97 -1.86 2.88 17.03 5.55 -13.98 1.77 5.28 15.86 2.40 -17.57 0.35 9.43 23.93 6.35
Golgi -6.48 1.75 -1.66 4.80 -3.61 -8.37 10.52 1.76 7.83 -1.39 -9.74 9.20 0.93 9.10 -4.16
Lipid Particles -10.01 -3.89 -4.90 7.01 -0.08 -9.86 3.41 2.29 9.14 -0.57 -10.42 3.77 4.05 13.23 -0.41
Mitochondria -3.34 1.68 -1.18 1.26 -2.07 -7.35 11.88 0.68 6.97 -1.55 -8.16 8.75 -1.02 4.97 -2.40
Mitotic Spindle 0.65 0.07 -1.77 -2.76 -1.59 -2.76 -0.06 -2.48 -1.40 -2.46 -2.29 -0.62 -3.96 -2.44 -2.87
None -1.64 2.28 0.28 1.80 -2.89 0.08 0.41 -1.12 -1.11 -1.20 -1.61 1.84 -0.96 0.85 -2.12
Nuclear Periphery -1.34 -5.95 -1.66 0.17 5.71 -1.61 -4.61 -0.23 1.24 4.37 -0.65 -6.72 1.48 2.38 7.38
Nuclear Periphery Foci -4.03 -8.87 -13.18 -10.90 6.40 -0.96 -7.12 -8.99 -8.91 3.65 -5.80 -11.43 -17.03 -15.19 7.63
Nucleolus 0.03 1.81 1.85 5.75 0.56 -2.47 8.21 3.21 4.21 -0.89 -3.47 5.37 5.07 7.47 -0.12
Nucleus 4.88 -5.14 0.32 -9.84 6.42 20.42 2.26 12.43 0.28 4.09 21.70 -2.97 7.66 -10.37 6.14
Peroxisomes -2.02 4.55 1.42 4.08 -3.03 -6.47 10.76 0.52 5.64 -3.23 -8.57 10.98 0.12 5.83 -3.72
Vacuole -4.21 -8.84 -11.38 -11.55 1.31 -3.61 -13.93 -15.64 -14.18 0.93 -5.38 -15.37 -20.66 -17.08 4.02
Vacuole Periphery -3.69 1.67 -0.39 2.01 -1.39 -5.60 15.90 -0.61 1.55 -1.05 -7.43 4.93 -1.05 3.24 -1.91
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum
Localization
Cell Percentages ER (19%), vacuole (14%), mixed (49%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Yps7

Yps7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yps7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available