Standard name
Human Ortholog
Description Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.15 0 0.09 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.27 0.15 0.22 0 0 0 0 0 0
Cytoplasm 0 0.05 0.07 0.09 0.13 0.13 0.12 0.12 0.11 0.16 0.17 0.15 0.13 0.17 0.18 0.2 0.28 0.24 0 0 0 0 0 0
Endoplasmic Reticulum 0.21 0.24 0.21 0.08 0.08 0.32 0.3 0.11 0.18 0.12 0.22 0.13 0.38 0.15 0.16 0 0 0 0.36 0.4 0.29 0.67 0.7 0.65
Endosome 0 0 0 0.07 0.08 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.16 0.17 0.07 0 0 0 0 0 0
Mitochondria 0.11 0 0 0.12 0.05 0.18 0.16 0.14 0.2 0.14 0.22 0.11 0 0 0 0 0 0.05 0 0 0 0 0 0
Nucleus 0 0 0.05 0.08 0 0 0 0.09 0.07 0.06 0.06 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.41 0.33 0.34 0.13 0 0.11 0.14 0.1 0.13 0.12 0.1 0.08 0.27 0.16 0.15 0.07 0.09 0.06 0.49 0.43 0.53 0.15 0.1 0.1
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.52 0.58 0.47 0.56 0.74 0.35 0.41 0.52 0.45 0.49 0.35 0.52 0.28 0.5 0.53 0.19 0.36 0.4 0.06 0.07 0.05 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 7 0 5 13 4 9 1 9 6 6 13 10 5 16 5 12 1 0 5 10 28 22
Bud 0 0 0 2 2 5 2 6 7 4 7 6 0 1 0 0 0 0 0 2 4 3 7 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 2
Bud Site 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 2 9 9 5 3 3 5 4 0 6 22 27 29 18 29 0 0 0 0 0 0
Cytoplasm 9 13 22 22 56 55 59 53 48 71 62 60 40 94 91 21 34 31 1 3 5 7 11 9
Endoplasmic Reticulum 44 64 62 19 35 135 149 52 76 53 78 50 118 82 77 1 1 4 90 136 119 282 520 373
Endosome 2 2 13 17 34 12 8 18 14 18 6 22 7 16 21 1 0 0 2 6 9 8 23 30
Golgi 0 2 1 0 0 0 0 0 0 0 0 0 0 1 1 17 20 9 0 5 3 3 7 7
Mitochondria 22 4 2 28 21 75 82 62 86 63 79 42 0 13 1 4 5 7 5 7 18 17 23 18
Nucleus 5 2 16 20 4 14 17 43 29 28 21 35 8 22 13 4 1 0 2 0 1 1 0 0
Nuclear Periphery 84 91 100 32 5 45 68 45 54 54 36 31 83 85 72 7 11 8 123 145 217 62 75 60
Nucleolus 0 3 5 1 0 2 3 4 0 1 4 2 1 1 3 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1
SpindlePole 0 0 0 2 1 0 0 1 0 0 0 0 0 3 1 0 1 0 1 0 1 1 3 2
Vac/Vac Membrane 108 157 138 135 320 146 203 237 190 216 126 204 87 270 260 20 44 51 15 24 18 16 32 36
Unique Cell Count 207 272 295 240 431 418 500 458 420 442 359 390 310 541 494 107 121 129 250 337 410 423 746 578
Labelled Cell Count 274 339 366 280 492 511 601 534 508 522 429 458 363 620 572 120 140 151 250 337 410 423 746 578


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.1 10.8 8.3 7.8 8.5 7.5 7.2 7.7 7.3 7.4 6.7 7.3 8.9 8.9 9.6 14.1 14.1 14.0 9.0 9.4 10.0
Std Deviation (1e-4) 1.1 1.7 1.2 1.4 1.4 1.3 1.3 1.3 1.5 1.6 1.4 1.5 1.4 1.5 1.7 2.7 2.7 2.7 1.8 1.6 1.8
Intensity Change (Log2) – – – -0.08 0.04 -0.15 -0.21 -0.1 -0.19 -0.17 -0.31 -0.19 0.1 0.11 0.22 0.77 0.77 0.76 0.13 0.18 0.27


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0.6 0 -0.4 0 -0.3 -0.6 -0.8 1.3 -0.5 0 4.8 0 3.2
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 3.5 4.1 9.3 6.8 8.4
Cytoplasm 0.7 2.4 2.4 2.0 1.8 1.8 3.4 3.7 3.2 2.2 4.0 4.3 3.5 5.6 4.7
Endoplasmic Reticulum -4.2 -5.0 3.3 2.7 -3.6 -1.0 -3.3 0.2 -2.9 4.6 -2.1 -1.9 -4.9 -5.2 -4.7
Endosome 1.3 1.9 -1.1 -2.4 -0.3 -0.7 -0.2 -2.1 0.7 -1.5 -1.1 -0.1 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 6.8 0
Mitochondria 5.5 3.2 7.3 7.0 6.2 7.9 6.4 8.2 5.3 0 1.8 0 0 0 0
Nucleus 1.3 -3.6 -1.4 -1.4 2.0 0.8 0.5 0.2 1.8 -1.8 -0.9 -2.0 -0.7 0 0
Nuclear Periphery -5.5 -12.3 -7.6 -6.8 -8.2 -6.7 -7.1 -7.5 -8.6 -1.9 -6.1 -6.4 -5.5 -5.2 -6.0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.2 7.5 -3.2 -1.7 1.3 -0.4 0.6 -3.0 1.4 -4.8 0.9 1.6 -5.1 -1.9 -1.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.976 5.4095 5.4274 5.2548 4.3895 5.2397 5.6348 5.9462 5.4248 5.3242 4.784 5.3946 7.3751 6.8241 6.3947 6.5157 5.7732 6.6898
Actin 0.0124 0.0002 0.0002 0.0003 0.0029 0.0003 0.0341 0.0003 0.0006 0.0004 0.0031 0.0008 0.0018 0.0007 0.0088 0.0017 0.0015 0.0007
Bud 0.0001 0.0001 0 0 0.0003 0 0.0002 0 0 0 0.0002 0 0.0001 0.0014 0.0003 0.0014 0 0
Bud Neck 0.0019 0.0003 0.0001 0 0.0015 0.0002 0.0017 0.0002 0.0001 0 0.0009 0.0001 0.0002 0.0001 0.0009 0.0002 0.0001 0.0002
Bud Periphery 0.0001 0.0001 0 0 0.0005 0 0.0003 0 0 0.0001 0.0001 0 0.0002 0.0005 0.0006 0.0005 0 0
Bud Site 0.0011 0.0004 0 0 0.0006 0 0.0007 0.0001 0 0 0.0014 0 0.0003 0.0003 0.0018 0.0005 0.0001 0.0001
Cell Periphery 0.0002 0.0001 0 0 0.0001 0 0.0003 0.0001 0.0001 0.0001 0 0 0.0001 0.0001 0.0001 0.0004 0 0
Cytoplasm 0.0024 0.0178 0.002 0.0006 0.0058 0.0024 0.0085 0.001 0.0005 0.0003 0.0023 0.0006 0.0028 0.0113 0.0026 0.0218 0.0016 0.0011
Cytoplasmic Foci 0.0027 0.0006 0 0 0.0022 0.0002 0.0059 0.0002 0.0015 0 0.004 0.0015 0.0071 0.001 0.0055 0.0025 0.0073 0.0013
Eisosomes 0.0001 0 0 0 0 0 0.0003 0 0 0 0 0 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0289 0.0588 0.0578 0.0733 0.1043 0.0176 0.0417 0.1587 0.1112 0.1351 0.0937 0.0941 0.0447 0.0726 0.0714 0.0713 0.0732 0.0511
Endosome 0.0089 0.0053 0.0012 0.0023 0.0204 0.0027 0.0164 0.0031 0.0035 0.003 0.015 0.0043 0.0143 0.0026 0.0099 0.0336 0.0105 0.005
Golgi 0.0023 0.0001 0 0.0001 0.0015 0.0001 0.0042 0.0002 0.0006 0.0002 0.0018 0.001 0.0048 0.0003 0.0023 0.0042 0.0058 0.0033
Lipid Particles 0.0048 0.0003 0.0002 0.0002 0.0032 0.0003 0.0171 0.0018 0.0027 0.0004 0.0028 0.0052 0.0254 0.0014 0.0018 0.0307 0.042 0.0086
Mitochondria 0.0014 0.0003 0.0003 0.0004 0.0037 0.0003 0.0021 0.0005 0.0007 0.0015 0.0011 0.0007 0.0054 0.0005 0.0021 0.0084 0.0007 0.0013
None 0.0009 0.0002 0.0001 0.0001 0.0033 0.0004 0.0084 0.0001 0.0002 0.0002 0.0017 0.0001 0.0077 0.0003 0.0007 0.0008 0.0002 0.0001
Nuclear Periphery 0.8395 0.7114 0.8131 0.8718 0.7562 0.8773 0.8072 0.7926 0.8363 0.8227 0.8303 0.8692 0.8229 0.788 0.8316 0.7123 0.7916 0.8761
Nucleolus 0.0005 0.0012 0.0004 0.0001 0.0016 0.0004 0.0033 0.003 0.0001 0 0.0009 0.0001 0.0013 0.0006 0.0002 0.0011 0.0003 0.0002
Nucleus 0.0637 0.1669 0.1057 0.0359 0.0672 0.0843 0.0124 0.0112 0.0075 0.0054 0.0193 0.0078 0.0302 0.0817 0.0304 0.0627 0.0099 0.0348
Peroxisomes 0.0033 0 0 0 0.001 0 0.004 0 0.0055 0 0.001 0.0005 0.0036 0.0032 0.0045 0.0007 0.0297 0.0003
Punctate Nuclear 0.0095 0.014 0.0006 0.0005 0.011 0.0035 0.008 0.0017 0.0009 0.0002 0.0099 0.0026 0.0103 0.0161 0.0035 0.0256 0.0148 0.0047
Vacuole 0.0018 0.011 0.0015 0.0014 0.0031 0.0014 0.0033 0.0026 0.002 0.0018 0.002 0.001 0.0026 0.0034 0.0039 0.0057 0.0013 0.0012
Vacuole Periphery 0.0135 0.0109 0.0168 0.0129 0.0097 0.0084 0.0202 0.0226 0.026 0.0287 0.0087 0.0102 0.0142 0.0139 0.0171 0.0139 0.0093 0.0098

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 36.0273 24.0345 21.4016 26.1838 25.0985 32.2454 26.4884 32.1474 24.6573 33.4479
Translational Efficiency 1.1552 1.3745 1.2708 1.1016 1.1782 1.0806 1.35 0.9465 1.3458 1.0672

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1982 1173 2439 1088 1666 1964 1912 847 3648 3137 4351 1935

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 937.41 950.09 1179.30 1294.55 875.58 963.89 1114.06 1226.26 909.17 958.73 1150.63 1264.66
Standard Deviation 128.65 170.43 160.03 234.83 129.42 133.96 160.49 267.50 132.63 148.80 163.47 251.95
Intensity Change Log 2 — 0.019384 0.331179 0.465699 — 0.138630 0.347516 0.485954 — 0.078205 0.339092 0.475516

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000105 0.000397 0.000420 0.018904 0.000252 0.000342 0.003111 0.026831 0.000172 0.000363 0.001603 0.022373
Bud Neck 0.000190 0.000884 0.000330 0.009413 0.000186 0.000254 0.001803 0.010501 0.000188 0.000489 0.000977 0.009889
Bud Site 0.000202 0.002340 0.000290 0.043962 0.000324 0.000594 0.005620 0.063509 0.000257 0.001247 0.002632 0.052519
Cell Periphery 0.000087 0.000287 0.000088 0.011126 0.000189 0.000122 0.000684 0.006417 0.000134 0.000184 0.000350 0.009065
Cytoplasm 0.004985 0.029285 0.007519 0.019725 0.010507 0.011348 0.033023 0.071733 0.007507 0.018055 0.018726 0.042490
Cytoplasmic Foci 0.001082 0.009916 0.000283 0.019030 0.002255 0.005143 0.007510 0.040094 0.001618 0.006928 0.003459 0.028250
Eisosomes 0.000004 0.000017 0.000004 0.001372 0.000113 0.000010 0.000174 0.001028 0.000054 0.000013 0.000079 0.001222
Endoplasmic Reticulum 0.118253* 0.266717* 0.244837* 0.682226* 0.158754* 0.215569* 0.652880* 0.456703* 0.136749* 0.234695* 0.424147* 0.583509*
Endosome 0.005141 0.029987 0.010360 0.021308 0.007183 0.013718 0.021666 0.037725 0.006073 0.019802 0.015328 0.028494
Golgi 0.000588 0.005225 0.000276 0.014825 0.001178 0.003942 0.003673 0.021198 0.000857 0.004422 0.001769 0.017614
Lipid Particles 0.009107 0.027967 0.003007 0.113621* 0.018813 0.023300 0.037843 0.121314* 0.013540 0.025045 0.018315 0.116988*
Mitochondria 0.002472 0.004086 0.000466 0.002420 0.002506 0.004232 0.001418 0.003412 0.002488 0.004178 0.000884 0.002854
Mitotic Spindle 0.003118 0.005287 0.001905 0.008833 0.001193 0.003096 0.007268 0.027022 0.002239 0.003915 0.004261 0.016795
None 0.002027 0.003730 0.001078 0.002265 0.002095 0.002136 0.001515 0.002575 0.002058 0.002732 0.001270 0.002401
Nuclear Periphery 0.356983* 0.119838* 0.285000* 0.000491 0.279311* 0.216851* 0.030684 0.001321 0.321511* 0.180575* 0.173244* 0.000854
Nuclear Periphery Foci 0.486673* 0.471632* 0.439877* 0.013262 0.504274* 0.484012* 0.171434 0.035550 0.494712* 0.479382* 0.321912* 0.023018
Nucleolus 0.001138 0.002426 0.000113 0.000025 0.001571 0.000545 0.000092 0.000124 0.001335 0.001248 0.000104 0.000068
Nucleus 0.004256 0.009702 0.002141 0.000894 0.005854 0.004527 0.005347 0.007774 0.004986 0.006462 0.003550 0.003905
Peroxisomes 0.000176 0.000580 0.000026 0.002685 0.000441 0.000747 0.000791 0.004185 0.000297 0.000684 0.000362 0.003342
Vacuole 0.002188 0.006792 0.001834 0.010414 0.001882 0.006483 0.012492 0.055827 0.002048 0.006598 0.006517 0.030292
Vacuole Periphery 0.001225 0.002905 0.000146 0.003201 0.001120 0.003028 0.000972 0.005159 0.001177 0.002982 0.000509 0.004058

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.81 -0.93 -8.35 -8.22 -8.12 -0.74 -5.58 -9.11 -9.07 -7.89 -2.80 -4.89 -12.31 -12.20 -11.31
Bud Neck -5.09 -2.34 -7.57 -6.97 -7.45 -1.60 -7.73 -10.76 -10.69 -8.69 -5.06 -8.03 -12.08 -11.68 -10.93
Bud Site -3.68 -0.94 -12.20 -11.47 -12.17 -1.47 -6.66 -12.68 -12.63 -11.34 -4.13 -6.67 -17.56 -17.18 -16.56
Cell Periphery -5.11 -0.24 -11.13 -10.92 -11.13 1.30 -5.05 -8.06 -8.17 -7.32 -1.77 -4.89 -13.61 -13.53 -13.24
Cytoplasm -8.83 -2.80 -8.08 2.82 -6.99 -0.50 -9.76 -11.91 -11.85 -7.80 -7.53 -9.74 -13.59 -9.58 -9.43
Cytoplasmic Foci -6.41 2.99 -7.68 -3.47 -8.10 -3.18 -5.83 -11.59 -10.57 -9.71 -7.13 -4.30 -13.61 -10.42 -12.53
Eisosomes -5.42 0.05 -7.78 -7.70 -7.78 1.01 -0.59 -5.25 -7.53 -5.95 0.88 -0.53 -9.30 -10.42 -9.72
Endoplasmic Reticulum -14.70 -16.29 -46.70* -28.90 -34.04* -6.39 -46.59* -17.48 -13.70 13.96 -15.16 -40.39 -43.46 -31.60 -13.27
Endosome -14.04 -7.28 -11.60 3.83 -7.52 -6.25 -13.25 -12.35 -9.16 -5.76 -14.81 -14.63 -16.69 -5.35 -9.04
Golgi -5.50 1.67 -7.36 -4.53 -7.54 -3.78 -5.35 -8.87 -7.18 -7.58 -6.47 -3.88 -11.33 -8.25 -10.65
Lipid Particles -7.78 5.72 -17.07 -13.34 -18.31 -1.85 -6.55 -14.34 -13.68 -11.11 -6.86 -3.39 -22.24 -19.29 -20.99
Mitochondria -1.97 5.32 0.05 1.66 -2.86 -2.67 2.48 -0.67 0.96 -1.73 -3.30 5.66 -0.45 1.98 -3.18
Mitotic Spindle -1.74 1.06 -2.99 -1.73 -3.86 -2.78 -5.64 -6.84 -6.29 -4.78 -2.38 -3.22 -7.33 -6.43 -6.04
None -2.53 1.86 -0.18 1.51 -1.23 -0.05 0.95 -0.31 -0.26 -0.85 -1.42 2.02 -0.34 0.59 -1.48
Nuclear Periphery 30.33* 8.98 58.37* 24.25* 54.19* 7.66 37.57* 43.64* 41.89* 15.84 24.12 25.93 71.92 47.27* 47.82*
Nuclear Periphery Foci 1.42 5.17 69.68* 47.26* 65.52* 2.02 34.82* 56.93* 57.88* 19.66* 2.15 25.03 89.63 77.27* 57.86*
Nucleolus -1.78 3.65 4.01 3.71 1.47 2.32 3.56 3.46 3.57 -1.15 0.22 5.07 5.23 4.68 0.89
Nucleus -3.51 2.51 4.56 6.09 3.19 1.06 -0.06 -3.27 -4.11 -3.39 -1.80 1.66 -0.76 0.96 -2.28
Peroxisomes -2.60 5.16 -5.34 -4.22 -5.69 -0.93 -2.11 -3.94 -3.36 -3.52 -1.81 -0.87 -6.22 -4.88 -6.08
Vacuole -5.12 0.53 -6.28 -2.67 -6.58 -4.81 -9.00 -12.48 -11.58 -10.08 -6.53 -7.89 -13.29 -11.43 -11.11
Vacuole Periphery -3.13 6.87 -2.63 -0.32 -4.16 -3.90 0.43 -3.32 -1.47 -3.39 -4.98 3.78 -4.23 -1.24 -5.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
Localization
Cell Percentages nuclear periphery (25%), ER (19%), mixed (56%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Dfm1

Dfm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dfm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available