Standard name
Human Ortholog
Description Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.27 0.4 0.45 0.65 0.35 0.38 0.41 – 0.49 0.59 0.65 0.66 0.87 0.91 0.95 0.25 0.27 0.27 0 0 0.05 0.06 0.11 0.11
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.26 0 0 0 0 0.05 0 – 0 0.05 0.1 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.16 0.14 0.1 0 0.14 0.22 0.25 – 0.16 0.13 0.06 0.07 0.06 0 0 0.26 0.21 0.22 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.55 0.7 0.63 0.55 0.71 0.7 0.6 – 0.61 0.59 0.4 0.48 0.18 0.14 0.05 0.66 0.66 0.68 0.91 0.89 0.86 0.82 0.79 0.72
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2
Bud 0 0 0 0 0 0 1 – 2 2 1 0 0 0 0 0 0 0 0 1 2 0 2 4
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 1 – 0 0 0 2 0 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 33 94 82 108 98 111 167 – 152 196 208 185 117 202 248 49 59 59 2 7 10 4 25 26
Endoplasmic Reticulum 0 0 0 0 0 2 0 – 1 0 9 2 1 1 0 3 10 9 0 0 0 0 0 0
Endosome 0 6 1 3 9 1 3 – 2 1 0 0 0 2 2 12 3 11 3 10 3 0 4 12
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 2 2 0 1 0 1 0 0 1
Mitochondria 32 5 1 1 3 14 12 – 11 16 31 14 0 0 2 7 4 0 1 2 3 2 7 7
Nucleus 20 32 18 5 40 64 103 – 49 44 20 20 8 1 1 51 46 49 1 3 2 1 3 4
Nuclear Periphery 0 1 1 0 0 3 0 – 1 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0
Nucleolus 0 0 0 0 1 1 0 – 0 1 0 0 0 0 0 2 0 0 0 0 1 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 1 0 1 – 0 0 0 1 0 0 0 4 0 0 0 1 0 0 1 2
Vac/Vac Membrane 68 164 115 92 199 205 242 – 189 196 129 134 24 32 13 131 143 148 134 228 177 69 181 182
Unique Cell Count 123 235 183 167 280 291 404 310 334 322 279 135 222 261 199 218 218 149 257 207 84 231 255
Labelled Cell Count 153 302 218 210 351 402 530 407 456 401 358 150 239 266 262 267 276 149 257 207 84 231 255


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 5.2 6.1 6.3 7.6 6.5 6.6 – 6.0 6.1 5.2 5.3 5.5 5.5 5.2 8.0 8.3 7.6 5.4 5.4 6.0
Std Deviation (1e-4) 0.7 0.7 1.4 1.7 2.1 1.6 1.7 – 1.5 2.2 1.2 1.0 1.0 1.5 1.5 1.7 1.9 1.5 0.8 1.2 1.7
Intensity Change (Log2) – – – 0.04 0.32 0.1 0.12 – -0.03 0.01 -0.24 -0.2 -0.15 -0.14 -0.24 0.39 0.45 0.33 -0.16 -0.17 -0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3.7 -2.1 -1.4 -0.8 – 0.9 3.0 4.3 4.6 7.6 10.1 11.9 -4.2 -3.7 -3.7
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 3.0 0 2.6
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 2.6 0 – 0 2.6 4.0 2.7 0 0 0 0 0 0
Nucleus -2.6 1.4 3.4 4.3 – 1.9 1.1 -1.5 -1.0 -1.3 -4.4 -4.8 4.0 3.1 3.4
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -1.5 1.9 1.7 -0.7 – -0.4 -0.9 -4.9 -3.1 -8.0 -10.1 -13.2 0.6 0.6 1.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.3645 0.8425 0.684 0.4677 0.0502 0.7717 -0.3332 1.2714 0.7674 0.5094 0.6093 0.8907 -0.2521 1.0852 0.7957 0.8719 0.3929 0.5861
Actin 0.0117 0.0001 0.004 0.0044 0.0011 0 0.0004 0.0013 0.0015 0.0002 0.0046 0.0015 0.0037 0 0 0.0098 0 0.0009
Bud 0.0006 0.0004 0.0007 0.0007 0.0028 0.0004 0.0012 0.0203 0.0012 0.0114 0.0171 0.0054 0.0007 0.0006 0.0004 0.0004 0.0002 0.0003
Bud Neck 0.0046 0.001 0.0022 0.0006 0.0079 0.0018 0.0014 0.0011 0.0023 0.0031 0.0026 0.0031 0.0017 0.0011 0.0016 0.0032 0.0011 0.0019
Bud Periphery 0.001 0.0007 0.0013 0.0022 0.003 0.0012 0.0021 0.0085 0.0017 0.0095 0.0025 0.0067 0.0014 0.0008 0.0008 0.0006 0.0007 0.0011
Bud Site 0.0094 0.0014 0.0089 0.001 0.0827 0.0008 0.0019 0.0131 0.0016 0.02 0.0071 0.0023 0.0017 0.0035 0.0018 0.0027 0.0005 0.0008
Cell Periphery 0.0018 0.0018 0.0029 0.001 0.0025 0.0025 0.0032 0.0021 0.0028 0.0031 0.0016 0.0038 0.001 0.0015 0.0018 0.0009 0.0027 0.0018
Cytoplasm 0.0132 0.0273 0.0142 0.0019 0.0034 0.0174 0.0273 0.0358 0.0213 0.0052 0.0169 0.0278 0.021 0.0325 0.0244 0.0077 0.0026 0.0134
Cytoplasmic Foci 0.0312 0.016 0.0219 0.0229 0.0225 0.0106 0.0432 0.0341 0.034 0.0501 0.0481 0.0318 0.0207 0.0119 0.0092 0.0101 0.0021 0.0088
Eisosomes 0.0002 0 0.0001 0.0001 0 0 0.0002 0.0001 0 0.0002 0 0.0001 0.0001 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0045 0.0032 0.0048 0.0011 0.0008 0.0041 0.0081 0.0098 0.0032 0.001 0.0044 0.0028 0.0056 0.0092 0.0046 0.0032 0.0012 0.0027
Endosome 0.2735 0.1732 0.2555 0.1884 0.1251 0.2094 0.2698 0.1698 0.213 0.2857 0.1822 0.1552 0.2896 0.1434 0.2284 0.2004 0.1777 0.1847
Golgi 0.018 0.0033 0.011 0.0273 0.0336 0.0052 0.0105 0.0076 0.0067 0.0055 0.0137 0.0052 0.0066 0.0019 0.005 0.0077 0.0015 0.0028
Lipid Particles 0.0385 0.0151 0.0228 0.0498 0.0619 0.031 0.0624 0.0142 0.0174 0.0445 0.0525 0.0251 0.0152 0.0112 0.0113 0.0164 0.0029 0.0061
Mitochondria 0.0302 0.0174 0.0243 0.0759 0.0183 0.0036 0.0108 0.0255 0.0147 0.0092 0.0063 0.0288 0.0114 0.0027 0.0138 0.0073 0.0006 0.003
None 0.0158 0.0217 0.0369 0.0003 0.0003 0.0075 0.0921 0.041 0.0623 0.0435 0.0082 0.0195 0.0173 0.0275 0.0111 0.0006 0.0002 0.0016
Nuclear Periphery 0.0064 0.0043 0.0069 0.0017 0.0021 0.003 0.0056 0.0129 0.0056 0.0013 0.0056 0.0097 0.0121 0.0123 0.0121 0.0063 0.0036 0.0126
Nucleolus 0.0112 0.0021 0.006 0.0012 0.0059 0.0046 0.0044 0.0061 0.0066 0.0097 0.0039 0.0098 0.0025 0.0042 0.0061 0.0026 0.0033 0.0033
Nucleus 0.0096 0.0039 0.0058 0.0013 0.0037 0.011 0.0069 0.0208 0.0253 0.0036 0.0057 0.0221 0.0083 0.0141 0.0113 0.006 0.0256 0.0117
Peroxisomes 0.0131 0.0022 0.0026 0.0227 0.0099 0.0009 0.0147 0.0032 0.0048 0.0051 0.0422 0.0094 0.004 0.0007 0.0015 0.0029 0.0003 0.0022
Punctate Nuclear 0.0009 0.0004 0.0028 0.0005 0.0007 0.0004 0.0047 0.0056 0.0007 0.0013 0.0017 0.0026 0.0082 0.001 0.0007 0.0048 0.0001 0.0023
Vacuole 0.404 0.5919 0.4673 0.4883 0.5529 0.5664 0.3712 0.4893 0.4809 0.4282 0.5154 0.5317 0.4528 0.6303 0.5412 0.5855 0.6697 0.6286
Vacuole Periphery 0.1002 0.1126 0.0971 0.1069 0.059 0.1181 0.0579 0.0778 0.0924 0.0588 0.0575 0.0959 0.1143 0.0897 0.113 0.1206 0.1033 0.1093

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 59.3931 56.0164 49.157 58.4262 50.8662 58.2711 73.8758 82.7696 78.3417 67.4112
Translational Efficiency 0.677 0.6243 0.7572 0.63 0.6131 0.6942 0.6118 0.4709 0.5146 0.5818

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1736 1492 1972 1228 1234 87 1647 88 2970 1579 3619 1316

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 643.26 668.22 798.10 817.74 724.23 801.65 845.92 884.10 676.90 675.57 819.86 822.18
Standard Deviation 80.86 119.16 93.33 121.36 90.06 94.95 100.56 125.05 93.72 121.82 99.57 122.73
Intensity Change Log 2 — 0.054921 0.311168 0.346240 — 0.146525 0.224073 0.287762 — 0.104158 0.265698 0.315565

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000066 0.001725 0.000639 0.009986 0.000113 0.000554 0.000134 0.013926 0.000086 0.001660 0.000409 0.010249
Bud Neck 0.037431 0.048326 0.013369 0.031004 0.015480 0.044928 0.014522 0.028967 0.028311 0.048139 0.013894 0.030868
Bud Site 0.011996 0.101861* 0.024743 0.154987* 0.005473 0.027773 0.014005 0.210175* 0.009286 0.097779 0.019856 0.158677*
Cell Periphery 0.000175 0.024040 0.000183 0.001290 0.000178 0.014626 0.000150 0.003921 0.000176 0.023522 0.000168 0.001466
Cytoplasm 0.323342* 0.356846* 0.391609* 0.354866* 0.076696 0.064734 0.456592* 0.317536* 0.220864* 0.340751* 0.421183* 0.352369*
Cytoplasmic Foci 0.114838 0.070379 0.022215 0.046648 0.024923 0.067641 0.028959 0.073492 0.077479 0.070228 0.025284 0.048443
Eisosomes 0.000128 0.000142 0.000048 0.000192 0.000025 0.000115 0.000041 0.000393 0.000085 0.000141 0.000045 0.000205
Endoplasmic Reticulum 0.001054 0.004466 0.003059 0.001676 0.001603 0.001827 0.001585 0.002636 0.001282 0.004321 0.002388 0.001740
Endosome 0.070131 0.047164 0.008944 0.034749 0.047501 0.135613 0.021572 0.040634 0.060729 0.052037 0.014691 0.035142
Golgi 0.001658 0.002658 0.000301 0.004987 0.000480 0.007675 0.000825 0.001226 0.001168 0.002934 0.000539 0.004736
Lipid Particles 0.006181 0.002605 0.001459 0.002371 0.001457 0.003952 0.001578 0.004354 0.004218 0.002679 0.001513 0.002504
Mitochondria 0.002512 0.003319 0.000830 0.001262 0.000907 0.006343 0.000279 0.000193 0.001845 0.003485 0.000579 0.001190
Mitotic Spindle 0.001581 0.001322 0.005896 0.021164 0.000221 0.000736 0.002504 0.015279 0.001016 0.001290 0.004353 0.020770
None 0.003031 0.003814 0.002862 0.003732 0.000649 0.000036 0.003248 0.000507 0.002042 0.003606 0.003038 0.003517
Nuclear Periphery 0.000357 0.000219 0.003395 0.001076 0.000303 0.000399 0.001734 0.000383 0.000335 0.000229 0.002639 0.001029
Nuclear Periphery Foci 0.000468 0.000292 0.001512 0.002023 0.000327 0.000285 0.001887 0.006136 0.000410 0.000291 0.001683 0.002298
Nucleolus 0.001986 0.001378 0.001511 0.001379 0.000813 0.000690 0.002230 0.000411 0.001499 0.001340 0.001838 0.001314
Nucleus 0.057884 0.027580 0.391403* 0.053773 0.024888 0.022115 0.215930* 0.027522 0.044175 0.027279 0.311546* 0.052018
Peroxisomes 0.003722 0.004129 0.001135 0.007706 0.001032 0.005350 0.000892 0.005153 0.002604 0.004197 0.001024 0.007536
Vacuole 0.358350* 0.289433* 0.124330 0.261374* 0.786800* 0.586936* 0.230687* 0.246521* 0.536366* 0.305825* 0.172733 0.260381*
Vacuole Periphery 0.003109 0.008303 0.000557 0.003756 0.010129 0.007673 0.000645 0.000633 0.006025 0.008268 0.000597 0.003547

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.69 -2.48 -4.30 -2.65 -3.82 -1.65 -0.14 -1.75 -1.62 -1.75 -5.66 -2.39 -4.57 -2.93 -4.30
Bud Neck -2.87 9.56 5.51 7.50 -3.45 -2.50 1.21 -0.36 2.25 -0.90 -6.24 8.86 2.84 7.85 -4.22
Bud Site -18.41 -2.77 -12.02 3.26 -10.47 -2.43 -2.91 -5.04 -3.53 -4.82 -19.32 -3.59 -13.49 2.54 -12.31
Cell Periphery -9.44 1.29 -4.60 9.26 -4.83 -1.70 2.38 -1.62 1.52 -1.70 -9.59 2.62 -4.68 9.37 -5.10
Cytoplasm -3.63 -2.60 0.58 3.85 2.91 0.98 -41.82 -6.24 -6.19 6.29 -14.06 -24.27 -10.47 2.87 7.60
Cytoplasmic Foci 10.05 27.18 20.28 9.23 -8.82 -3.32 -1.31 -3.73 0.46 -3.46 2.06 22.57 13.18 8.93 -8.21
Eisosomes -0.69 8.92 1.09 1.46 -4.70 -4.57 -5.86 -1.60 -0.74 -1.45 -3.96 7.56 -2.17 1.06 -5.11
Endoplasmic Reticulum -4.18 -17.03 -6.83 2.91 10.98 -0.50 -2.39 -1.88 -1.13 -1.25 -3.93 -15.45 -6.14 2.85 7.21
Endosome 6.51 21.31 13.54 7.54 -6.71 -4.25 10.14 1.71 4.60 -0.88 2.94 22.78 13.12 8.60 -4.89
Golgi -1.58 3.55 -0.68 0.41 -2.66 -1.24 -0.06 -0.79 1.21 -0.35 -2.96 2.81 -1.30 0.85 -2.46
Lipid Particles 7.78 11.75 8.75 0.08 -4.48 -2.96 -0.45 -3.69 0.31 -3.74 4.48 10.53 5.50 0.09 -5.46
Mitochondria -0.99 3.02 2.93 4.00 0.06 -0.98 2.21 2.61 1.10 2.20 -2.29 3.66 2.75 4.05 -1.52
Mitotic Spindle 0.26 -5.04 -6.28 -6.41 -3.16 -0.72 -3.80 -1.74 -1.70 -1.40 -0.38 -6.10 -6.83 -6.63 -4.38
None -0.58 0.11 0.06 0.60 -0.02 1.76 -4.96 -0.74 -3.31 4.69 -1.45 -2.12 -0.99 0.58 0.18
Nuclear Periphery 1.40 -20.69 -13.22 -14.37 9.92 -0.82 -15.50 -4.96 -3.77 7.12 1.34 -25.19 -14.43 -14.59 8.01
Nuclear Periphery Foci 1.89 -5.48 -8.63 -10.21 -0.56 0.31 -7.01 -4.78 -4.91 -2.83 1.34 -8.46 -9.79 -11.18 -1.52
Nucleolus 2.29 -1.85 0.28 -1.87 2.04 0.57 -4.43 0.23 -0.19 3.93 0.99 -3.72 -1.12 -1.84 2.07
Nucleus 9.81 -51.10 -8.23 -15.06 41.44 0.45 -34.09 -3.03 -2.99 11.47 6.46 -57.72 -11.83 -15.30 39.17
Peroxisomes -0.38 5.94 -0.87 -0.70 -4.13 -2.50 1.08 -2.31 -0.08 -2.44 -3.56 6.05 -2.41 -0.72 -4.63
Vacuole 6.55 26.62 -1.98 -7.57 -23.77 5.48 52.51* 9.08 2.95 -4.25 23.41 45.01* 14.29 -6.53 -19.16
Vacuole Periphery -8.15 14.51 2.09 7.57 -2.21 1.62 13.46 13.51 5.50 0.92 -3.17 17.13 6.81 8.12 -2.21
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
Localization
Cell Percentages vacuole (79%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ppn1

Ppn1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ppn1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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