Standard name
Human Ortholog
Description Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.06 0 0.05 0.05 0 0 0.06 0 0.07 0.11 0.17 0.1 0.05 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0
Endosome 0 0.06 0.05 0 0.05 0.06 0.11 0.06 0 0.05 0 0 0.05 0.08 0.07 0.13 0.19 0.18 0 0 0.05 0.06 0.14 0.2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.39 0.1 0 0.14 0.06 0.21 0.17 0.19 0.45 0.3 0.5 0.33 0 0.06 0 0.18 0.09 0.09 0 0 0.07 0.09 0.13 0.18
Nucleus 0.08 0.05 0.12 0.08 0.08 0.1 0.1 0.15 0.12 0.18 0.12 0.16 0.06 0.07 0.06 0.07 0.07 0.08 0 0 0 0 0 0
Nuclear Periphery 0.52 0.65 0.47 0.68 0.54 0.55 0.51 0.48 0.47 0.43 0.46 0.51 0.72 0.62 0.55 0.41 0.37 0.32 0.9 0.84 0.79 0.71 0.54 0.43
Nucleolus 0 0 0 0 0.05 0.12 0.11 0.07 0.14 0.08 0.14 0.09 0.07 0.09 0 0.12 0.08 0.1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.32 0.54 0.65 0.27 0.44 0.28 0.27 0.18 0.11 0.18 0.12 0.18 0.26 0.26 0.42 0.48 0.51 0.55 0 0 0 0.05 0.08 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 1 0 1 1 1 0 0 4 3
Bud 0 0 0 0 0 0 0 1 1 0 1 1 0 0 0 0 0 0 1 1 0 0 3 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 1 2 0 0 1 1 0 0 1 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0
Cytoplasm 6 8 0 4 8 7 14 15 8 6 15 8 23 56 115 27 12 20 1 1 0 4 2 4
Endoplasmic Reticulum 1 1 0 5 0 1 0 1 3 1 2 7 0 0 3 8 14 9 1 1 0 0 2 4
Endosome 14 24 3 1 7 11 33 19 6 16 8 4 19 43 48 36 48 34 8 15 4 17 82 124
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 2 1 1 1 0 2 6 11
Mitochondria 135 38 0 13 9 36 50 60 100 88 126 106 10 29 7 52 22 18 11 13 7 25 73 115
Nucleus 29 18 7 7 12 17 28 46 27 53 29 52 21 38 39 21 17 16 1 6 0 8 9 13
Nuclear Periphery 180 249 27 61 77 94 147 152 103 127 117 165 254 315 374 116 93 62 367 358 83 211 310 276
Nucleolus 15 6 1 3 7 21 32 21 30 24 36 29 24 46 20 35 21 19 0 3 0 4 12 13
Peroxisomes 0 1 0 0 0 0 0 1 0 0 0 1 0 1 5 1 3 1 0 0 0 0 1 4
SpindlePole 0 2 2 0 2 3 3 8 2 6 2 5 3 18 21 14 11 5 2 3 0 2 13 11
Vac/Vac Membrane 109 208 37 24 63 48 79 57 25 54 31 59 92 131 288 135 129 106 5 13 3 14 47 41
Unique Cell Count 346 385 57 90 143 171 291 314 220 292 252 326 351 509 683 282 251 194 409 425 105 296 578 636
Labelled Cell Count 489 555 77 118 186 239 387 384 305 375 368 438 446 679 921 448 372 294 409 425 105 296 578 636


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 7.4 7.5 7.1 8.0 6.6 6.7 6.7 5.6 6.1 5.6 6.1 8.1 7.6 7.7 8.1 9.1 7.8 7.6 7.5 7.8
Std Deviation (1e-4) 1.0 1.1 1.2 1.6 1.7 1.4 1.5 1.4 1.3 1.4 1.5 1.7 1.4 1.6 1.8 2.0 6.4 2.0 1.3 1.3 1.4
Intensity Change (Log2) – – – -0.08 0.1 -0.18 -0.15 -0.15 -0.41 -0.29 -0.42 -0.3 0.11 0.03 0.05 0.12 0.28 0.06 0.03 0.0 0.05


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 2.6 3.4 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 1.4 0 0 0 0 0 0 0 0 1.6 2.5 2.3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.0 0 3.8 3.4 3.6 6.4 4.8 6.9 5.1 0 0 0 3.5 0 0
Nucleus -0.9 -0.8 -0.5 -0.6 0.5 0 1.1 -0.2 0.7 0 0 0 0 0 -0.9
Nuclear Periphery 2.5 0.8 1.0 0.4 0.1 -0.1 -0.5 -0.1 0.5 3.8 2.1 1.1 -0.9 -1.4 -2.1
Nucleolus 0 0 2.3 2.2 0 2.5 0 2.6 0 0 0 0 2.4 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -4.6 -2.7 -5.0 -5.5 -7.5 -8.6 -7.3 -8.7 -7.5 -5.8 -6.1 -3.3 -2.3 -1.8 -1.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.6435 3.3391 3.2198 2.8654 2.8421 3.3394 2.7398 2.9052 2.9544 2.6845 2.1794 2.6052 2.465 3.2718 2.4309 2.2671 2.2238 2.2651
Actin 0.0148 0.0004 0.0092 0.0015 0.0151 0.0018 0.0044 0.0005 0.008 0.0011 0.0023 0.0005 0.0017 0.001 0.0051 0.0018 0.0008 0.0008
Bud 0.0003 0.0001 0.0004 0.0008 0.0003 0.0001 0.0003 0 0.0001 0 0.0001 0.0001 0.0001 0 0 0 0 0
Bud Neck 0.0007 0.0001 0.0003 0.0007 0.0015 0.0001 0.0005 0 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0 0 0.0001
Bud Periphery 0.0007 0.0002 0.0013 0.0008 0.0005 0.0003 0.0006 0.0001 0.0003 0.0003 0.0004 0.0002 0.0004 0.0002 0.0001 0.0002 0.0001 0.0001
Bud Site 0.0009 0.0003 0.0028 0.0296 0.0017 0.0001 0.0017 0 0.0006 0 0.0001 0.0002 0.0001 0.0001 0.0001 0 0 0
Cell Periphery 0.0002 0 0.0016 0.0001 0.0001 0 0.0002 0 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0 0 0
Cytoplasm 0.0013 0.0038 0.0109 0.0011 0.0007 0.0001 0.0035 0.0002 0.0018 0.0001 0.0003 0.0002 0.0009 0.0003 0.0003 0.0003 0.0001 0.0002
Cytoplasmic Foci 0.0091 0.0005 0.003 0.0022 0.0099 0.0026 0.0195 0.0005 0.0126 0.0002 0.0013 0.0003 0.0005 0.0003 0.0014 0.0007 0.0001 0.0005
Eisosomes 0.0001 0 0.0009 0 0.0002 0 0.0002 0 0.0003 0.0001 0.0001 0 0.0001 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0041 0.0034 0.0072 0.002 0.0052 0.0008 0.0024 0.004 0.0031 0.0026 0.0025 0.0012 0.0031 0.0059 0.0042 0.0043 0.0016 0.0022
Endosome 0.0218 0.0083 0.0062 0.0031 0.0481 0.0066 0.0146 0.0016 0.0143 0.0026 0.0081 0.0035 0.0062 0.0028 0.0027 0.0019 0.0018 0.0016
Golgi 0.0054 0.0011 0.0033 0.0009 0.0126 0.0025 0.0045 0.0008 0.0089 0.0009 0.0055 0.0008 0.0019 0.0007 0.0006 0.0007 0.0006 0.0004
Lipid Particles 0.0345 0.0069 0.0055 0.0058 0.0268 0.0063 0.0239 0.0106 0.0232 0.0086 0.0402 0.0022 0.0198 0.0053 0.0036 0.0211 0.0042 0.0023
Mitochondria 0.0076 0.0027 0.0087 0.0051 0.0132 0.0057 0.0075 0.011 0.0224 0.0057 0.0438 0.0145 0.0089 0.0039 0.0029 0.0034 0.0024 0.0031
None 0.0018 0.0003 0.0014 0.0006 0.0013 0.0002 0.0079 0.0002 0.0028 0.0006 0.0004 0.0002 0.0028 0.0004 0.0013 0.0005 0.0004 0.0002
Nuclear Periphery 0.8282 0.882 0.8694 0.8997 0.8102 0.9416 0.8319 0.9003 0.8235 0.9184 0.8411 0.9428 0.887 0.9082 0.9023 0.8625 0.9502 0.9543
Nucleolus 0.0037 0.0033 0.0006 0.0011 0.0008 0.0007 0.0038 0.0008 0.0005 0.0013 0.001 0.0023 0.0013 0.0012 0.001 0.0022 0.0018 0.0005
Nucleus 0.0129 0.0483 0.0175 0.0093 0.0078 0.0038 0.0138 0.0075 0.008 0.0075 0.0216 0.0076 0.0136 0.0146 0.0081 0.0416 0.0064 0.0089
Peroxisomes 0.0078 0.0002 0.0063 0.0007 0.0188 0.0069 0.0102 0.0003 0.0077 0.0002 0.0016 0.0001 0.0005 0.0002 0.0027 0.0001 0.0001 0.0001
Punctate Nuclear 0.0116 0.0016 0.0022 0.0025 0.0048 0.0017 0.0101 0.0084 0.0022 0.0016 0.0026 0.0007 0.0034 0.0024 0.0045 0.0093 0.0034 0.004
Vacuole 0.0041 0.0035 0.0032 0.0016 0.0025 0.0008 0.0027 0.0013 0.0027 0.0013 0.002 0.0009 0.0021 0.0021 0.0014 0.0008 0.0007 0.0003
Vacuole Periphery 0.0285 0.0332 0.0378 0.0307 0.018 0.0172 0.0357 0.0519 0.0567 0.0465 0.0249 0.0214 0.0452 0.0503 0.0575 0.0484 0.0252 0.0203

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.5857 11.8841 18.3718 14.7801 11.4909 12.1794 16.7723 18.4164 18.168 15.9614
Translational Efficiency 1.6272 1.3004 0.9278 1.316 1.2168 1.3815 0.9545 1.0337 1.0611 1.0361

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1007 1386 839 1239 1961 2359 383 349 2968 3745 1222 1588

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 661.51 845.03 1012.26 992.68 815.49 819.82 1090.57 1039.70 763.25 829.15 1036.80 1003.01
Standard Deviation 85.51 137.15 120.95 140.68 104.47 118.37 129.84 140.15 122.50 126.24 129.03 141.91
Intensity Change Log 2 — 0.353240 0.613745 0.585566 — 0.007640 0.419343 0.350428 — 0.172722 0.509662 0.460500

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000251 0.000140 0.000425 0.000372 0.000079 0.000153 0.000125 0.000209 0.000137 0.000148 0.000331 0.000336
Bud Neck 0.000322 0.000373 0.000922 0.006159 0.000068 0.000444 0.000698 0.006149 0.000154 0.000418 0.000852 0.006157
Bud Site 0.000183 0.000155 0.000186 0.003797 0.000022 0.000281 0.000195 0.002691 0.000077 0.000234 0.000189 0.003554
Cell Periphery 0.000070 0.000025 0.000031 0.000071 0.000021 0.000050 0.000010 0.000061 0.000038 0.000041 0.000025 0.000069
Cytoplasm 0.008097 0.002141 0.001864 0.002806 0.000455 0.004959 0.000145 0.005465 0.003048 0.003916 0.001325 0.003390
Cytoplasmic Foci 0.007159 0.001632 0.000166 0.009227 0.000860 0.001840 0.000191 0.013871 0.002997 0.001763 0.000174 0.010248
Eisosomes 0.000020 0.000007 0.000011 0.000010 0.000004 0.000010 0.000002 0.000010 0.000010 0.000009 0.000008 0.000010
Endoplasmic Reticulum 0.006008 0.004244 0.007191 0.002758 0.004402 0.006000 0.004657 0.003447 0.004947 0.005350 0.006397 0.002909
Endosome 0.006242 0.003297 0.001053 0.014999 0.002371 0.005488 0.000818 0.022144 0.003684 0.004677 0.000979 0.016569
Golgi 0.002990 0.000891 0.000081 0.006075 0.000510 0.000923 0.002592 0.002255 0.001351 0.000911 0.000868 0.005236
Lipid Particles 0.100149* 0.008664 0.000965 0.005096 0.022965 0.009768 0.000954 0.005023 0.049153 0.009359 0.000962 0.005080
Mitochondria 0.015195 0.003605 0.001638 0.002034 0.003779 0.006622 0.000333 0.003580 0.007652 0.005506 0.001229 0.002374
Mitotic Spindle 0.025514 0.025467 0.032241 0.271026* 0.005688 0.011509 0.019329 0.222518* 0.012415 0.016675 0.028194 0.260366*
None 0.011270 0.001304 0.002070 0.000918 0.000552 0.004076 0.000065 0.000514 0.004189 0.003050 0.001442 0.000829
Nuclear Periphery 0.080677 0.165906* 0.343728* 0.154217* 0.169301* 0.227210* 0.320588* 0.198139* 0.139232* 0.204521* 0.336475* 0.163870*
Nuclear Periphery Foci 0.686007* 0.739424* 0.492345* 0.469212* 0.774856* 0.635099* 0.634323* 0.473548* 0.744711* 0.673709* 0.536844* 0.470165*
Nucleolus 0.025903 0.016955 0.039207 0.015632 0.006077 0.026622 0.005054 0.009552 0.012804 0.023044 0.028503 0.014296
Nucleus 0.020061 0.022610 0.074233 0.015616 0.005805 0.051201 0.008773 0.006991 0.010642 0.040620 0.053717 0.013721
Peroxisomes 0.002291 0.000224 0.000306 0.001226 0.000388 0.000567 0.000138 0.000777 0.001034 0.000440 0.000253 0.001128
Vacuole 0.000686 0.001506 0.001030 0.014170 0.000806 0.004096 0.000693 0.018918 0.000765 0.003138 0.000924 0.015214
Vacuole Periphery 0.000904 0.001433 0.000306 0.004578 0.000991 0.003083 0.000317 0.004138 0.000961 0.002472 0.000309 0.004481

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.87 -4.24 -1.24 -2.08 0.79 -4.73 -1.88 -3.67 -1.83 -2.42 -0.68 -6.28 -2.27 -2.17 0.25
Bud Neck -0.78 -4.91 -8.84 -8.76 -7.21 -7.46 -1.33 -5.82 -5.48 -3.92 -6.31 -3.89 -10.61 -10.17 -7.99
Bud Site 0.38 -2.20 -6.70 -6.73 -6.32 -2.42 -1.04 -5.41 -4.79 -3.88 -2.22 -2.43 -7.93 -7.51 -7.07
Cell Periphery 7.41 3.79 -0.41 -4.11 -2.58 -4.92 4.34 -3.54 -1.41 -4.27 -0.69 1.33 -3.63 -3.22 -4.04
Cytoplasm 3.41 3.59 2.02 -2.48 -3.00 -7.40 2.09 -1.91 -0.31 -2.02 -1.45 2.33 -1.93 -0.94 -3.82
Cytoplasmic Foci 4.64 6.02 -1.03 -6.11 -7.60 -3.27 2.77 -3.96 -3.61 -4.14 2.53 6.51 -5.77 -7.05 -8.53
Eisosomes 7.36 1.60 3.86 -4.51 1.52 -6.17 2.72 -4.07 -0.41 -5.01 0.90 -1.38 -2.27 -3.04 -0.22
Endoplasmic Reticulum 2.91 -2.63 4.54 2.19 6.50 -2.84 -0.41 1.12 2.94 1.30 -1.02 -3.76 3.95 4.74 6.48
Endosome 2.36 4.52 -5.26 -7.96 -10.08 -3.88 3.87 -5.24 -4.34 -5.67 -1.52 5.48 -9.26 -8.39 -11.49
Golgi 3.82 5.71 -1.89 -3.64 -4.31 -1.87 -0.82 -1.81 -1.35 0.12 1.84 0.61 -3.40 -3.85 -3.14
Lipid Particles 15.01 16.54 15.76 2.44 -4.80 6.07 11.28 7.99 3.46 -3.87 15.31 19.24 17.06 4.47 -5.92
Mitochondria 5.88 7.04 6.77 2.65 -1.02 -2.99 5.04 0.14 1.46 -1.52 2.32 7.95 5.53 4.49 -2.09
Mitotic Spindle -0.15 -2.06 -24.19 -24.28* -22.29 -3.74 -3.11 -13.14 -12.72 -12.00 -2.70 -5.40 -29.19 -28.54* -25.64
None 5.55 4.77 5.75 1.12 1.74 -5.41 4.88 0.05 5.09 -1.79 1.70 3.42 5.15 4.70 1.34
Nuclear Periphery -14.01* -25.16 -10.07 2.85 17.57 -9.09 -12.72 -1.63 2.78 8.02 -13.90 -24.04 -2.78 8.09 19.85
Nuclear Periphery Foci -4.77 13.84 16.84 24.80* 2.68 17.66* 11.19 17.92 9.55 8.63 10.60 22.67 30.54 22.98* 7.09
Nucleolus 3.06 -3.04 2.78 -0.16 5.94 -10.18 0.71 -1.97 4.76 -2.25 -5.78 -6.32 -1.49 3.21 4.49
Nucleus -0.80 -9.70 -0.46 0.31 9.33 -13.87 -1.05 -1.33 12.27 0.11 -12.58 -11.04 -3.70 7.45 8.53
Peroxisomes 4.19 3.79 1.66 -3.84 -3.15 -1.37 1.17 -2.52 -1.51 -3.75 2.82 3.51 -0.75 -3.29 -3.86
Vacuole -2.12 -3.01 -8.47 -8.01 -7.74 -5.18 0.33 -4.90 -4.08 -4.91 -5.56 -2.61 -9.74 -8.39 -9.23
Vacuole Periphery -1.14 4.48 -5.37 -3.88 -6.33 -4.52 3.87 -2.91 -0.95 -3.56 -4.45 5.39 -6.00 -3.05 -7.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication
Localization
Cell Percentages nuclear periphery (90%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Heh2

Heh2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Heh2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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