Standard name
Human Ortholog
Description Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0.05
Bud 0 0 0.07 0 0 0 – 0.05 0.06 0.06 0 0.06 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.36 0.16 0.23 0.18 0.22 0.14 – 0.15 0.12 0.08 0.16 0.1 0.49 0.49 0.41 – – – 0.07 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0.05 0.13 0 0 0.11 0 – 0 0 0 0 0 0.13 0.13 0.19 – – – 0.07 0.11 0.07 0.05 0.09 0.08
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.55 0.6 0.79 0.83 0.65 0.89 – 0.87 0.92 0.92 0.88 0.93 0.25 0.31 0.2 – – – 0.65 0.65 0.68 0.71 0.6 0.59
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.09 0 – 0 0 0 0 0 0 0.05 0.1 – – – 0 0 0 0 0.05 0
SpindlePole 0 0 0.08 0 0.08 0 – 0.06 0.06 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.19 0 0 0.05 0 – 0 0 0 0 0 0.1 0.05 0.08 – – – 0.06 0 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 3 1 0 0 0 – 0 0 0 0 0 1 5 0 – – – 12 15 8 6 11 22
Bud 16 4 19 10 10 9 – 28 22 24 9 16 8 5 8 – – – 10 6 2 3 4 8
Bud Neck 0 0 2 0 0 0 – 3 2 1 0 0 2 0 0 – – – 9 4 1 5 7 7
Bud Site 0 0 3 4 1 5 – 7 10 5 2 5 0 0 0 – – – – – – – – –
Cell Periphery 2 11 2 2 1 0 – 1 3 1 5 3 5 7 18 – – – 1 0 0 1 0 1
Cytoplasm 180 43 59 46 69 46 – 80 46 33 43 29 235 171 206 – – – 42 5 12 12 13 19
Endoplasmic Reticulum 14 9 3 2 4 4 – 1 1 2 1 2 10 11 5 – – – 6 2 3 3 1 6
Endosome 24 34 0 2 35 3 – 0 1 0 0 0 65 44 97 – – – 43 39 19 16 30 37
Golgi 0 2 0 0 0 1 – 0 0 0 0 0 6 0 12 – – – 3 11 3 5 9 11
Mitochondria 270 163 203 211 205 288 – 480 364 367 229 268 122 110 102 – – – 390 234 192 225 195 265
Nucleus 3 3 1 2 2 0 – 10 4 1 3 4 1 0 1 – – – 1 0 0 0 1 2
Nuclear Periphery 0 1 0 2 2 2 – 6 7 7 3 2 0 0 1 – – – 3 3 1 4 1 4
Nucleolus 1 1 0 1 3 1 – 6 3 4 1 2 2 0 0 – – – 2 0 0 1 2 3
Peroxisomes 5 7 1 6 30 5 – 4 0 3 1 2 20 18 51 – – – 6 8 9 6 15 14
SpindlePole 18 8 20 6 26 10 – 31 22 18 8 7 20 6 21 – – – 16 5 8 6 9 12
Vac/Vac Membrane 60 52 7 5 16 6 – 12 11 5 2 5 47 18 40 – – – 38 12 7 10 14 21
Unique Cell Count 495 270 257 253 317 324 550 395 400 261 287 484 350 498 601 359 283 318 324 448
Labelled Cell Count 595 341 321 299 404 380 669 496 471 307 345 544 395 562 601 359 283 318 324 448


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 5.0 3.6 3.7 4.1 3.4 – 3.5 3.0 3.1 3.2 3.2 4.8 5.1 5.1 – – – 5.1 5.4 5.3
Std Deviation (1e-4) 0.5 0.9 0.9 2.0 1.7 1.5 – 1.4 1.2 0.9 1.0 1.4 1.1 1.1 1.3 – – – 1.4 1.5 1.9
Intensity Change (Log2) – – – 0.02 0.2 -0.07 – -0.05 -0.25 -0.19 -0.17 -0.17 0.42 0.49 0.51 – – – 0.51 0.58 0.56

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 – 0 0 0 0 0 0 -3.7 -4.1 – – –
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 2.3 – – –
Cytoplasm -1.3 -0.3 -2.7 – -2.9 -3.8 -5.3 -1.9 -4.1 6.8 6.5 5.0 – – –
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 1.6 0 – – –
Endosome 0 0 0 – 0 0 0 0 0 0 5.9 7.6 – – –
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Mitochondria 0 0 0 – 0 0 0 0 0 0 -11.6 -15.5 – – –
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 – 0 0 0 0 0 0 3.3 5.1 – – –
SpindlePole 0 0 0 – 0 0 0 0 0 0 -3.6 -2.0 – – –
Vacuole -0.6 1.4 -0.7 – -0.5 0 0 0 -0.8 3.5 1.5 2.9 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.3919 0.6277 0.5593 0.8562 0.1066 0.7456 -0.0106 0.1147 0.2323 1.0857 0.6773 0.3325 1.5072 1.5885 1.6732 1.6708 1.5839 1.5996
Actin 0.0056 0.006 0.0077 0.0103 0.003 0.0091 0.0054 0.0118 0.0064 0.0612 0.0483 0.0119 0.0041 0.0082 0.0091 0.0454 0.0052 0.0073
Bud 0.0021 0.0052 0.0031 0.0067 0.0014 0.0011 0.0021 0.0064 0.0041 0.0025 0.0101 0.0029 0.0022 0.0046 0.0071 0.0051 0.0025 0.0017
Bud Neck 0.005 0.0022 0.0034 0.0043 0.0032 0.004 0.0025 0.0013 0.0033 0.0049 0.0038 0.0072 0.0048 0.0021 0.0019 0.003 0.0008 0.0062
Bud Periphery 0.0046 0.0079 0.0065 0.0155 0.0025 0.0029 0.0049 0.0131 0.0146 0.0078 0.0172 0.0099 0.0062 0.0112 0.0088 0.0156 0.0117 0.0065
Bud Site 0.0084 0.0488 0.0138 0.0172 0.0026 0.0013 0.0076 0.0311 0.0145 0.0051 0.01 0.0043 0.0096 0.0269 0.0099 0.0045 0.0026 0.0018
Cell Periphery 0.0009 0.0011 0.0021 0.0011 0.0003 0.0005 0.0016 0.0014 0.0015 0.0009 0.0006 0.001 0.0024 0.0018 0.0022 0.0007 0.0005 0.0011
Cytoplasm 0.0341 0.0682 0.0406 0.0413 0.0604 0.051 0.0319 0.0423 0.0579 0.0295 0.0465 0.0548 0.0564 0.0787 0.0667 0.0643 0.0487 0.0643
Cytoplasmic Foci 0.1108 0.1277 0.1065 0.0999 0.1505 0.1217 0.119 0.1111 0.1173 0.0968 0.1603 0.135 0.12 0.1222 0.1113 0.096 0.099 0.1264
Eisosomes 0.0004 0.0004 0.0008 0.0004 0.0001 0.0003 0.0011 0.001 0.0009 0.0016 0.0004 0.0005 0.0006 0.0004 0.0007 0.0006 0.0006 0.0005
Endoplasmic Reticulum 0.0035 0.0057 0.0032 0.0049 0.0044 0.0025 0.0076 0.0024 0.0063 0.0052 0.0034 0.0034 0.0072 0.0027 0.0035 0.0043 0.0022 0.0035
Endosome 0.2099 0.1345 0.1297 0.1381 0.1906 0.1305 0.1335 0.1816 0.0892 0.1226 0.1015 0.0996 0.1581 0.1449 0.1031 0.0847 0.1291 0.1048
Golgi 0.0597 0.0524 0.0416 0.0423 0.0586 0.0458 0.0419 0.0582 0.0308 0.0413 0.0476 0.0358 0.0364 0.0523 0.0398 0.0403 0.0415 0.0356
Lipid Particles 0.0539 0.0283 0.036 0.0098 0.0168 0.0401 0.0482 0.0193 0.0213 0.0586 0.0216 0.0257 0.0369 0.0161 0.0112 0.0084 0.0144 0.0237
Mitochondria 0.344 0.3193 0.4301 0.4573 0.3699 0.4018 0.3156 0.3428 0.3729 0.2227 0.386 0.3398 0.3344 0.3417 0.3795 0.3533 0.2791 0.3591
None 0.0727 0.1259 0.077 0.0694 0.0666 0.0775 0.1773 0.1119 0.1605 0.2155 0.0383 0.1568 0.1409 0.1094 0.1753 0.2067 0.2437 0.1652
Nuclear Periphery 0.0033 0.0039 0.0063 0.0082 0.0007 0.0033 0.008 0.001 0.0087 0.0077 0.0053 0.0046 0.0025 0.0012 0.0014 0.0053 0.0017 0.0026
Nucleolus 0.0023 0.002 0.0027 0.0007 0.0005 0.0017 0.0029 0.0014 0.0027 0.0023 0.002 0.0019 0.0093 0.002 0.001 0.0007 0.0013 0.0014
Nucleus 0.0025 0.0031 0.0033 0.0017 0.0008 0.0028 0.0045 0.0014 0.0068 0.0039 0.0035 0.003 0.0031 0.0023 0.002 0.0037 0.0019 0.0023
Peroxisomes 0.0498 0.0408 0.065 0.0544 0.0518 0.0853 0.0576 0.044 0.057 0.0849 0.0714 0.0842 0.0313 0.048 0.0505 0.041 0.0861 0.0689
Punctate Nuclear 0.0021 0.0023 0.0024 0.0011 0.0017 0.0052 0.0073 0.0013 0.0108 0.0077 0.0127 0.0048 0.003 0.0015 0.0014 0.0019 0.002 0.0035
Vacuole 0.0169 0.0104 0.0136 0.0092 0.0086 0.0074 0.0142 0.0107 0.0086 0.0112 0.0068 0.009 0.0231 0.0171 0.0098 0.0101 0.0176 0.0093
Vacuole Periphery 0.0074 0.0039 0.0048 0.0065 0.005 0.0043 0.0053 0.0047 0.0037 0.0061 0.0029 0.0037 0.0074 0.0047 0.0039 0.0043 0.0077 0.0043

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.3476 21.2124 15.7405 19.5864 17.3058 11.858 21.4478 30.7612 29.7528 21.1311
Translational Efficiency 1.9442 1.3179 2.0798 2.3918 2.3175 4.3369 2.3971 2.0594 2.3338 2.7861

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1669 1723 1250 260 1475 1865 921 1664 3144 3588 2171 1924

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 586.84 711.75 719.58 814.08 616.07 731.49 728.80 786.92 600.55 722.01 723.49 790.59
Standard Deviation 66.36 95.01 92.39 104.11 67.58 95.01 92.38 113.08 68.51 95.52 92.50 112.29
Intensity Change Log 2 — 0.278403 0.294188 0.472203 — 0.247744 0.242429 0.353123 — 0.262783 0.267911 0.412445

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000381 0.001010 0.001459 0.009953 0.000482 0.000578 0.001161 0.006200 0.000428 0.000785 0.001333 0.006707
Bud Neck 0.043722 0.024992 0.024762 0.026275 0.030794 0.032649 0.042577 0.040609 0.037657 0.028972 0.032319 0.038672
Bud Site 0.013800 0.027907 0.045555 0.077930 0.015046 0.021627 0.047814 0.095465 0.014384 0.024643 0.046513 0.093095
Cell Periphery 0.000323 0.000245 0.000194 0.000233 0.000415 0.000286 0.000226 0.000212 0.000366 0.000266 0.000207 0.000215
Cytoplasm 0.076490 0.042418 0.227329 0.238673 0.050620 0.048303 0.305649 0.257027 0.064353 0.045477 0.260555 0.254547
Cytoplasmic Foci 0.216611 0.160659 0.188353 0.173238 0.179494 0.160168 0.179608 0.127063 0.199198 0.160404 0.184643 0.133303
Eisosomes 0.000259 0.000134 0.000112 0.000200 0.000221 0.000158 0.000118 0.000143 0.000241 0.000146 0.000114 0.000150
Endoplasmic Reticulum 0.001085 0.000532 0.004017 0.002860 0.001222 0.000705 0.001507 0.001955 0.001149 0.000622 0.002952 0.002077
Endosome 0.070412 0.083236 0.052464 0.025613 0.091596 0.100386 0.034865 0.030779 0.080351 0.092151 0.044998 0.030081
Golgi 0.053647 0.109072 0.030320 0.010496 0.066151 0.101076 0.015597 0.015975 0.059513 0.104916 0.024074 0.015235
Lipid Particles 0.027548 0.006464 0.007508 0.006087 0.022327 0.014055 0.006358 0.003525 0.025099 0.010410 0.007020 0.003871
Mitochondria 0.366143 0.389024 0.078926 0.019777 0.410137 0.387098 0.050465 0.038824 0.386782 0.388022 0.066852 0.036250
Mitotic Spindle 0.004382 0.034281 0.047669 0.054376 0.007106 0.019818 0.033845 0.070929 0.005660 0.026763 0.041805 0.068692
None 0.002272 0.001484 0.003803 0.001126 0.001823 0.001037 0.001499 0.001570 0.002062 0.001252 0.002825 0.001510
Nuclear Periphery 0.000545 0.000239 0.001226 0.000517 0.000758 0.000502 0.000905 0.001111 0.000645 0.000376 0.001090 0.001031
Nuclear Periphery Foci 0.000239 0.000241 0.002197 0.001870 0.000427 0.000336 0.001228 0.000755 0.000327 0.000290 0.001786 0.000906
Nucleolus 0.003003 0.002228 0.007572 0.000698 0.002689 0.001474 0.002257 0.001864 0.002856 0.001836 0.005317 0.001707
Nucleus 0.022493 0.007789 0.120808 0.092040 0.015806 0.008053 0.123802 0.085770 0.019356 0.007926 0.122078 0.086617
Peroxisomes 0.058262 0.063638 0.048198 0.115889 0.056245 0.054735 0.059010 0.083327 0.057315 0.059010 0.052785 0.087727
Vacuole 0.027316 0.030633 0.090044 0.141211 0.032140 0.032661 0.086762 0.130525 0.029579 0.031688 0.088652 0.131969
Vacuole Periphery 0.011067 0.013772 0.017485 0.000939 0.014500 0.014297 0.004747 0.006373 0.012678 0.014045 0.012081 0.005639

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.50 -8.94 -3.21 -2.94 -2.73 -0.82 -5.06 -6.94 -6.75 -5.89 -3.97 -10.08 -7.70 -7.13 -6.29
Bud Neck 5.91 6.12 3.88 0.30 0.23 -0.61 -3.05 -2.19 -1.52 1.41 3.84 2.33 0.95 -2.78 -1.33
Bud Site -7.02 -9.46 -5.92 -4.17 -2.16 -3.52 -7.17 -15.41 -13.63 -6.10 -7.54 -11.77 -16.94 -13.81 -7.41
Cell Periphery 2.56 4.98 3.42 1.18 -0.69 1.35 2.09 2.50 3.94 1.09 2.10 3.51 3.90 4.36 0.95
Cytoplasm 7.36 -18.16 -9.62 -11.79 -0.35 0.55 -25.25 -30.15 -31.03 3.40 5.93 -30.37 -30.62 -34.40 -0.09
Cytoplasmic Foci 8.45 3.98 5.05 0.16 2.52 3.14 0.38 10.15 7.92 8.32 8.44 3.02 15.36 8.34 11.47
Eisosomes 7.77 9.28 2.51 -2.54 -3.40 2.81 4.80 3.92 2.34 -2.36 6.98 9.57 7.06 0.42 -3.98
Endoplasmic Reticulum 3.13 -8.23 -4.54 -5.99 1.68 1.71 -0.96 -2.77 -5.17 -1.79 3.03 -7.31 -4.78 -7.91 2.93
Endosome -3.25 5.04 11.60 14.71 7.42 -1.79 12.98 16.03 20.75 2.79 -3.74 12.48 20.32 26.05 8.37
Golgi -12.41 7.64 13.25 22.65 6.48 -7.56 15.05 16.46 23.90 1.00 -14.18 15.38 21.55 33.48 6.15
Lipid Particles 12.05 11.78 11.24 0.68 1.57 3.93 8.86 11.45 7.74 3.22 10.56 14.64 18.19 8.19 6.10
Mitochondria -1.89 30.44 34.80 37.69 8.35 1.79 35.84 39.75 43.65 3.29 -0.18 46.25 54.31 59.39 8.93
Mitotic Spindle -12.34 -12.48 -5.00 -1.53 -0.20 -6.10 -7.28 -13.30 -9.42 -5.14 -13.31 -14.19 -14.67 -8.32 -4.23
None 1.14 -2.48 2.18 0.35 5.32 1.73 0.80 0.73 -1.01 0.11 2.00 -1.73 1.53 -0.36 3.37
Nuclear Periphery 1.69 -3.46 -1.19 -4.26 2.92 0.71 -0.79 -1.83 -2.38 -1.38 1.31 -2.92 -2.70 -3.81 -0.57
Nuclear Periphery Foci -0.19 -5.34 -4.70 -4.69 -0.68 0.84 -1.30 -2.14 -3.01 0.73 0.58 -4.49 -5.05 -5.41 2.24
Nucleolus 1.08 -4.68 4.27 2.90 7.66 2.97 0.53 2.19 -1.04 1.68 2.51 -4.28 3.37 0.72 6.82
Nucleus 7.29 -17.22 -8.21 -9.79 1.86 4.16 -17.96 -20.38 -23.16 3.37 8.28 -24.72 -21.66 -25.34 4.03
Peroxisomes -1.25 2.43 -2.73 -2.25 -3.61 0.48 0.08 -2.66 -3.15 -2.37 -0.50 1.89 -3.51 -3.14 -4.66
Vacuole -1.59 -15.61 -12.09 -11.85 -7.47 -0.23 -13.02 -25.64 -26.03 -11.31 -1.32 -20.22 -29.50 -29.18 -14.77
Vacuole Periphery -2.75 -3.83 17.25 16.37 11.90 0.13 8.82 7.69 8.73 -0.52 -1.80 1.26 9.48 11.16 6.64
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog
Localization
Cell Percentages mitochondrion (83%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Mzm1

Mzm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mzm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available