Standard name
Human Ortholog
Description Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0.05 0.07 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0.06 0 0 0 0.06 0.06 0.06 0.06 0.08 0.07 0.11 0.09 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.09 0.05 0.07 0.05 0 0 0.05 0 0 0.08 0.13 0.18 0.18 0.12 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.08 0.09 0.08 0 0 0.06 0 0.06 0.06
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.2 0.09 0 0.07 0.05 0.08 0.1 0.09 0.1 0.15 0.13 0.13 0 0 0 0.08 0.06 0 0 0 0 0 0 0
Nucleus 0.05 0 0 0.05 0 0.05 0 0.06 0 0.05 0.06 0.05 0 0 0.05 0 0 0.05 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.54 0.72 0.36 0.28 0.3 0.37 0.38 0.36 0.44 0.46 0.49 0.46 0.52 0.51 0.45 0.44 0.48 0.5 0 0 0 0.05 0.06 0
Peroxisomes 0 0 0.06 0.06 0 0.06 0.05 0.05 0 0 0.07 0.07 0 0 0 0 0 0.05 0 0 0 0 0 0
SpindlePole 0.73 0.63 0.82 0.77 0.84 0.72 0.72 0.72 0.75 0.65 0.73 0.72 0.8 0.77 0.71 0.67 0.74 0.71 0.9 0.88 0.89 0.83 0.77 0.74
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0
Bud 3 0 5 7 4 4 13 18 12 11 11 13 0 0 0 3 0 1 2 1 1 0 5 11
Bud Neck 8 3 3 5 7 6 6 16 11 5 11 19 6 5 5 2 1 3 1 1 1 1 4 7
Bud Site 10 0 3 10 15 16 21 25 27 21 28 29 6 1 2 5 4 4 – – – – – –
Cell Periphery 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 5 2 11 20 12 18 20 12 6 14 4 7 26 51 79 21 15 10 0 0 1 1 5 4
Endoplasmic Reticulum 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 1 2 1 0 0 0 0 0 0
Endosome 0 0 18 9 2 4 7 16 3 2 2 1 14 26 36 9 11 10 2 1 14 9 27 27
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 2 0
Mitochondria 32 4 1 16 12 22 35 39 32 46 34 44 0 1 0 9 7 2 0 0 2 1 6 6
Nucleus 8 2 6 11 10 14 16 24 14 16 15 16 14 12 22 5 4 6 1 1 0 6 6 13
Nuclear Periphery 0 0 0 0 0 0 0 1 1 1 0 0 1 3 1 0 1 0 0 0 0 0 0 2
Nucleolus 85 33 91 65 73 99 137 150 140 141 130 155 177 193 198 51 60 60 4 1 2 12 24 19
Peroxisomes 5 0 15 14 11 17 20 20 11 8 18 22 2 4 9 3 1 6 0 0 1 2 5 5
SpindlePole 115 29 210 179 206 194 262 297 238 197 194 244 273 293 314 78 92 86 143 74 233 206 331 326
Vac/Vac Membrane 0 1 1 1 1 0 1 1 0 0 0 0 4 1 1 5 1 2 0 0 0 0 4 8
Unique Cell Count 157 46 255 233 245 270 365 412 318 304 265 338 341 382 444 117 124 121 159 85 263 248 433 440
Labelled Cell Count 271 74 365 340 353 394 538 619 495 462 447 550 523 591 668 193 199 192 159 85 263 248 433 440


Ambiguous, SpindlePole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.1 5.8 5.2 4.8 5.2 4.6 4.5 4.3 4.4 4.2 4.1 4.1 6.4 6.5 6.3 7.2 6.6 6.9 6.2 6.5 6.8
Std Deviation (1e-4) 0.5 0.9 1.7 1.6 2.2 1.7 1.7 1.5 1.6 1.5 1.5 1.3 1.3 1.5 1.2 2.1 1.5 1.9 1.1 1.4 1.6
Intensity Change (Log2) – – – -0.12 0.0 -0.18 -0.22 -0.26 -0.22 -0.29 -0.33 -0.35 0.3 0.32 0.27 0.48 0.35 0.41 0.25 0.32 0.39


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 3.0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.9 0.3 1.2 0.7 -1.0 -1.7 0.2 -1.9 -1.6 1.7 3.8 5.1 4.4 2.8 1.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 -3.6 0 0 0 0 0 0 0 -1.6 -0.1 0.5 0.2 0.6 0.4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.2 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 1.4 1.1 1.7 1.3 2.1 1.3 1.8 1.9 1.5 1.2 0.6 1.7 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 -1.4 0 0 0 0 0 0 0 3.9 3.7 2.3 1.5 2.4 2.6
Peroxisomes 0 -0.7 0 0 0 0 0 0 0 -3.8 -3.5 -2.7 -1.4 -2.3 -0.4
SpindlePole 0 0.5 0 0 0 0 0 0 0 -0.7 -1.7 -3.4 -3.4 -1.9 -2.5
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.1965 0.2834 0.1321 0.2742 -0.0001 0.3152 1.1758 0.5447 0.7913 0.6731 0.9405 0.6083 0.619 0.4374 0.385 0.7213 0.5815 0.4816
Actin 0.0204 0 0.0004 0 0.0002 0 0.0339 0 0.0054 0.0009 0.0314 0.0044 0.0091 0 0.0056 0.0052 0.001 0.0014
Bud 0.0001 0.0001 0 0 0 0 0.0009 0 0.0001 0.0004 0.0004 0 0.0002 0.0001 0.0002 0.0002 0.0002 0.0001
Bud Neck 0.0009 0.0004 0.0002 0.0004 0.0006 0.0002 0.0019 0.0008 0.0012 0.0007 0.0005 0.0003 0.0005 0.0005 0.0006 0.0007 0.0003 0.0003
Bud Periphery 0.0001 0 0 0 0 0 0.0013 0 0.0002 0.0004 0.0006 0.0001 0.0003 0.0001 0.0003 0.0002 0.0003 0.0001
Bud Site 0.0006 0.0004 0.0001 0.0001 0.0002 0 0.0038 0.0006 0.0013 0.0042 0.001 0.0001 0.002 0.0045 0.0011 0.0028 0.0004 0.0003
Cell Periphery 0.0001 0 0 0 0 0 0.0002 0 0 0.0001 0.0001 0 0.0001 0 0.0001 0 0.0001 0
Cytoplasm 0.0013 0.0001 0.0003 0.0002 0.0001 0 0.0103 0.0003 0.0028 0.0004 0.0013 0 0.0005 0.0001 0.0003 0.0002 0.0009 0
Cytoplasmic Foci 0.0196 0.0062 0.0177 0.0174 0.0555 0.0032 0.0472 0.0066 0.0156 0.0188 0.0519 0.0038 0.0284 0.0056 0.0066 0.0215 0.0226 0.0038
Eisosomes 0.0008 0 0 0 0 0 0.0002 0 0.0001 0 0.0001 0 0.0004 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0015 0 0.0001 0 0 0 0.0061 0 0.0005 0.0002 0.0009 0.0005 0.0004 0 0.0004 0.0002 0.0021 0
Endosome 0.0068 0.0001 0.0018 0.0001 0.0023 0.0001 0.0556 0.0024 0.0099 0.0426 0.0194 0.0016 0.01 0.0001 0.003 0.0058 0.019 0.0017
Golgi 0.0023 0.0003 0.0004 0.0002 0.0019 0.0001 0.0229 0.0002 0.0028 0.0161 0.0283 0.0024 0.005 0.0001 0.0021 0.005 0.0026 0.0023
Lipid Particles 0.0115 0.0053 0.0073 0.0014 0.0263 0.0014 0.0374 0.0016 0.0082 0.028 0.0926 0.0058 0.0259 0.0008 0.0053 0.0292 0.0135 0.0148
Mitochondria 0.0004 0 0.0002 0 0 0 0.0092 0 0.0018 0.004 0.0121 0.0012 0.0073 0 0.0062 0.0022 0.0042 0.002
None 0.0127 0.0001 0.0007 0.0001 0.0001 0.0001 0.0046 0.0001 0.0011 0.0002 0.0005 0.0001 0.0008 0.0001 0.0002 0.0005 0.0005 0.0001
Nuclear Periphery 0.0084 0.0002 0.0013 0.0009 0.0006 0.0001 0.0229 0.0004 0.0013 0.0011 0.0079 0.007 0.0008 0.0001 0.0008 0.0016 0.0047 0.0004
Nucleolus 0.0214 0.0468 0.0328 0.0107 0.0044 0.015 0.0046 0.0883 0.0869 0.0365 0.0035 0.0164 0.0226 0.0468 0.0204 0.0014 0.0032 0.0061
Nucleus 0.0047 0.0156 0.0033 0.0057 0.0005 0.0013 0.0114 0.0649 0.0399 0.0035 0.0011 0.0035 0.0029 0.0155 0.0073 0.0005 0.0019 0.0013
Peroxisomes 0.0046 0.0008 0.0013 0.0006 0.0075 0.0001 0.0172 0.0003 0.0026 0.0123 0.0295 0.0003 0.007 0.0004 0.0035 0.013 0.0158 0.0067
Punctate Nuclear 0.8813 0.9234 0.9318 0.9622 0.8997 0.9784 0.6996 0.8333 0.8172 0.8268 0.7159 0.9518 0.8744 0.9253 0.9358 0.9094 0.8994 0.9584
Vacuole 0.0003 0 0.0001 0 0 0 0.0058 0.0001 0.0007 0.002 0.0005 0.0001 0.0011 0 0.0003 0.0002 0.0046 0.0001
Vacuole Periphery 0.0003 0 0.0001 0 0 0 0.0029 0 0.0003 0.0009 0.0005 0.0005 0.0004 0 0.0001 0.0002 0.0029 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3.335 3.4072 3.7924 6.8912 12.3542 4.7616 8.1818 8.4286 6.2202 9.3212
Translational Efficiency 2.7773 1.8154 1.2495 0.7599 0.6547 1.8387 0.9119 0.6151 1.1078 1.149

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1621 133 774 1533 1535 1496 858 1000 3156 1629 1632 2533

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 760.01 816.31 910.36 882.89 737.53 780.57 931.28 909.59 749.08 783.49 921.36 893.43
Standard Deviation 97.27 116.26 126.45 121.51 94.44 100.79 122.07 132.32 96.56 102.61 124.60 126.57
Intensity Change Log 2 — 0.103099 0.260419 0.216215 — 0.081826 0.336513 0.302515 — 0.092661 0.298397 0.259362

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000226 0.000747 0.000311 0.000461 0.000478 0.000757 0.000117 0.000201 0.000349 0.000756 0.000209 0.000359
Bud Neck 0.003337 0.005818 0.001147 0.001966 0.004715 0.004830 0.001614 0.001299 0.004007 0.004911 0.001393 0.001703
Bud Site 0.005165 0.014789 0.001840 0.005884 0.004803 0.007236 0.003095 0.006232 0.004989 0.007853 0.002500 0.006022
Cell Periphery 0.000123 0.000139 0.000031 0.000045 0.000240 0.000284 0.000027 0.000041 0.000180 0.000272 0.000029 0.000044
Cytoplasm 0.012968 0.022276 0.006768 0.005458 0.033904 0.027284 0.004657 0.006300 0.023151 0.026875 0.005658 0.005791
Cytoplasmic Foci 0.039557 0.040041 0.003962 0.006860 0.067872 0.047714 0.001896 0.012339 0.053329 0.047087 0.002876 0.009023
Eisosomes 0.000095 0.000058 0.000018 0.000012 0.000139 0.000108 0.000016 0.000008 0.000116 0.000104 0.000017 0.000010
Endoplasmic Reticulum 0.001198 0.001225 0.000544 0.000346 0.002349 0.002201 0.000521 0.000204 0.001758 0.002121 0.000532 0.000290
Endosome 0.005606 0.004397 0.001593 0.002548 0.007178 0.010502 0.001546 0.004028 0.006370 0.010004 0.001568 0.003132
Golgi 0.006861 0.005744 0.000847 0.002024 0.010290 0.011926 0.000661 0.003009 0.008529 0.011421 0.000749 0.002413
Lipid Particles 0.011729 0.004012 0.000726 0.001137 0.015129 0.013793 0.000512 0.000606 0.013383 0.012995 0.000613 0.000927
Mitochondria 0.000735 0.000810 0.000110 0.001941 0.002126 0.006451 0.000168 0.003290 0.001412 0.005991 0.000141 0.002474
Mitotic Spindle 0.672549* 0.778255* 0.944146* 0.949511* 0.513718* 0.567499* 0.939805* 0.939358* 0.595298* 0.584706* 0.941864* 0.945503*
None 0.004559 0.012494 0.000327 0.000497 0.009340 0.009816 0.001200 0.000568 0.006884 0.010034 0.000786 0.000525
Nuclear Periphery 0.000515 0.000468 0.000201 0.000290 0.000520 0.001059 0.000240 0.000181 0.000517 0.001010 0.000222 0.000247
Nuclear Periphery Foci 0.096166 0.038422 0.012534 0.007667 0.144641 0.080805 0.009450 0.006535 0.119743 0.077344 0.010913 0.007221
Nucleolus 0.084318 0.036659 0.011443 0.003836 0.110934 0.102464 0.009467 0.003272 0.097263 0.097091 0.010404 0.003613
Nucleus 0.023909 0.013047 0.008493 0.003377 0.040402 0.068395 0.019171 0.005962 0.031931 0.063876 0.014107 0.004397
Peroxisomes 0.029583 0.018895 0.003840 0.002954 0.029514 0.031528 0.001786 0.003831 0.029550 0.030497 0.002760 0.003300
Vacuole 0.000700 0.001557 0.001065 0.002236 0.001255 0.004725 0.003948 0.001597 0.000970 0.004466 0.002581 0.001983
Vacuole Periphery 0.000102 0.000148 0.000055 0.000950 0.000453 0.000623 0.000102 0.001137 0.000273 0.000584 0.000080 0.001024

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.91 -2.52 -1.64 0.53 0.68 -2.65 -1.64 -1.37 0.87 0.07 -4.22 -3.01 -1.81 0.47 0.55
Bud Neck -2.45 -1.53 -1.96 1.84 -0.48 -1.63 -2.32 -3.17 -2.06 -0.17 -2.91 -2.79 -3.37 -0.72 -0.20
Bud Site -2.70 -1.13 -3.86 1.58 -2.86 -1.30 -2.21 -6.12 -5.55 -4.36 -2.75 -2.45 -7.07 -4.67 -4.82
Cell Periphery -0.94 5.78 5.64 2.43 0.42 -0.74 9.03 8.25 6.46 -0.87 -2.48 10.65 9.88 7.32 -0.11
Cytoplasm -0.95 -0.04 -0.87 0.71 -0.58 0.10 3.77 2.06 2.16 -1.75 -1.73 2.62 1.15 2.68 -1.55
Cytoplasmic Foci -0.48 13.22 12.20 3.92 -2.26 3.26 17.00 12.34 9.46 -6.17 1.57 21.51 17.70 12.22 -6.13
Eisosomes 5.09 18.36 26.09 6.32 5.03 3.97 19.37 26.02 24.73 5.19 3.74 26.59 36.94 27.04 7.48
Endoplasmic Reticulum -0.34 0.89 8.90 3.91 3.91 -0.06 3.23 9.40 10.01 3.76 -2.24 2.88 12.96 12.59 5.54
Endosome 0.31 5.36 6.78 2.88 -0.02 -1.30 8.28 4.16 4.49 -1.01 -1.63 9.19 8.06 7.01 -0.59
Golgi 1.90 17.43 14.90 3.95 -0.02 2.31 19.59 13.78 10.33 -1.35 1.43 26.19 20.67 13.08 -0.87
Lipid Particles 4.50 8.42 8.12 3.11 -0.84 0.64 9.28 9.34 10.95 0.17 0.70 12.55 12.22 10.65 -0.97
Mitochondria -0.95 2.91 -1.94 -1.45 -2.26 -2.40 2.15 -1.38 0.42 -2.00 -2.75 2.84 -2.26 0.78 -3.00
Mitotic Spindle -3.23 -21.39* -29.46* -6.87 -3.43 -4.87 -26.97* -31.53* -25.75* -1.97 -2.23 -33.88 -43.72 -31.31* -4.27
None -0.84 6.46 6.70 1.37 0.82 0.41 8.25 10.72 8.32 1.99 -1.69 10.22 12.52 7.64 2.25
Nuclear Periphery 0.94 3.76 1.58 -0.04 -1.28 -1.81 1.06 1.11 2.16 0.02 -1.46 3.19 1.82 2.08 -0.86
Nuclear Periphery Foci 5.50 20.80* 23.83* 4.11 2.74 7.25 22.89* 25.77* 19.15* 2.54 7.23 30.77 35.17 20.76 3.91
Nucleolus 3.10 10.87 17.61 3.66 5.75 1.02 14.05 19.74 18.23 5.37 -0.14 17.59 26.55 19.45 8.05
Nucleus 0.18 -2.23 2.69 1.33 3.67 -4.60 -2.39 1.86 5.59 3.38 -5.77 -3.32 3.50 7.65 5.19
Peroxisomes -0.30 9.54 12.42 4.33 1.86 -0.35 13.59 12.65 12.19 -0.69 -1.35 16.23 18.05 14.23 1.31
Vacuole -3.00 -4.12 -5.01 -2.92 -1.68 -2.35 -3.41 -4.01 -2.45 1.21 -2.87 -4.48 -6.37 -3.56 0.33
Vacuole Periphery -2.59 -3.05 -1.71 -1.46 -1.56 -1.72 0.31 -1.31 -1.03 -1.36 -3.13 -0.67 -2.12 -1.55 -2.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation
Localization
Cell Percentages spindle pole (75%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Kre28

Kre28


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kre28-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available