Standard name
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.07 0.08 0.16 0.27 0.16 0.16 0.12 0.1 0.17 0.15 0.15 0.14 0.09 0.12 0.05 0.2 0.26 0.26 0 0 0 0.08 0.08 0.06
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0.07 0.07 0 0.05 0.05 0 0.1 0.07 0.11 0.09 0.08 0.13 0.22 0.24 0.17 0.2 0 0 0 0 0 0
Cytoplasm 0.05 0.05 0 0.08 0.07 0.07 0.09 0.07 0.06 0.06 0 0.07 0 0 0 0.14 0.24 0.14 0 0 0 0 0 0
Endoplasmic Reticulum 0.89 0.92 0.88 0.57 0.71 0.78 0.62 0.72 0.69 0.6 0.57 0.66 0.91 0.87 0.87 0 0 0 0.92 0.9 0.89 0.77 0.75 0.79
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.1 0.08 0.17 0.5 0.22 0 0.05 0 0 0.08 0 0 0.22 0.17 0 0.48 0.45 0.55 0 0 0 0.08 0.09 0.07
Mitochondria 0 0 0.07 0.21 0.17 0.18 0.21 0.11 0.29 0.21 0.39 0.33 0 0 0 0.08 0.09 0.11 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0 0 0 0 0 0.11 0.12 0.05 0.14 0.08 0 0 0 0 0.08 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 36 25 50 71 58 80 62 64 66 69 41 62 49 66 35 45 50 40 9 11 11 33 38 31
Bud 1 1 3 3 5 9 8 5 10 15 6 7 0 1 1 1 3 2 1 0 0 1 4 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1
Bud Site 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 14 15 21 18 14 26 28 24 38 34 31 40 40 70 140 53 33 31 1 0 2 6 12 10
Cytoplasm 28 14 14 22 24 35 51 47 23 27 10 31 13 12 21 31 46 21 4 5 1 0 3 3
Endoplasmic Reticulum 456 282 274 150 255 394 335 460 274 275 156 292 480 485 559 2 5 2 497 298 293 334 368 420
Endosome 0 0 0 0 1 0 0 0 1 4 0 0 0 0 0 0 0 0 0 3 0 2 2 1
Golgi 52 23 52 130 78 22 25 27 14 35 5 7 114 92 23 108 87 84 7 3 4 34 43 35
Mitochondria 13 1 23 56 62 89 111 73 114 96 109 146 5 0 0 19 18 17 6 2 8 14 8 11
Nucleus 0 0 0 0 0 0 3 1 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Nuclear Periphery 7 1 11 1 2 4 12 24 19 13 11 23 4 2 4 0 1 1 1 0 3 0 0 2
Nucleolus 0 0 0 0 1 1 2 8 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 29 8 5 7 16 22 59 76 20 62 22 13 5 7 6 18 6 4 6 1 1 3 4 5
Unique Cell Count 514 305 313 261 360 507 539 639 397 459 276 443 525 555 639 225 194 153 542 331 331 436 489 530
Labelled Cell Count 636 370 453 458 516 682 696 810 580 635 392 621 710 735 789 278 249 202 542 331 331 436 489 530


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 25.9 30.1 20.1 19.1 17.8 15.5 15.4 15.3 14.3 13.9 12.8 13.1 29.2 27.8 28.4 21.4 20.9 22.0 32.4 33.2 34.9
Std Deviation (1e-4) 6.6 6.8 4.3 4.2 4.1 3.4 3.6 3.4 3.3 3.2 3.2 3.4 5.7 5.6 5.8 6.3 6.2 6.1 7.8 8.1 8.5
Intensity Change (Log2) – – – -0.07 -0.18 -0.37 -0.39 -0.4 -0.5 -0.53 -0.65 -0.62 0.53 0.47 0.5 0.09 0.05 0.13 0.69 0.72 0.8

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700010203040WT3HU80HU120HU160010203040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3010203040WT1AF100AF140AF180010203040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 3.3 0 -0.1 -1.9 -2.7 0.2 -0.4 -0.4 -0.8 -2.9 -1.7 -5.3 1.2 2.7 2.6
Bud 0 0 0 0 0 1.5 2.1 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.1 -1.6 -0.9 -0.9 -2.0 1.4 0.4 1.9 1.2 0.5 2.7 5.9 5.6 3.7 4.4
Cytoplasm 1.9 1.2 1.4 2.6 1.7 0.8 0.9 -0.5 1.4 -1.6 -1.9 -0.9 3.8 6.5 3.6
Endoplasmic Reticulum -8.2 -5.3 -3.5 -7.9 -5.4 -5.8 -8.3 -8.5 -6.8 1.8 -0.1 0 -19.8 -18.7 -17.8
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 8.5 1.7 -6.0 -5.9 -6.5 -6.0 -3.9 -6.1 -7.6 1.8 0 -7.0 7.9 6.9 8.5
Mitochondria 4.9 3.8 4.1 5.1 2.0 7.2 5.1 9.3 8.3 -5.0 -6.5 -6.9 0.5 0.8 1.4
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -2.6 -2.8 -2.8 -1.1 0.2 0.8 -0.5 0.3 1.1 -2.9 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.9 2.1 2.1 5.0 5.3 2.5 5.8 3.7 1.2 0 0 0 3.6 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0246 0.0045 0.005 0.0006 0.0015 0.001 0.0301 0.0006 0.0213 0.0011 0.0003 0.0006 0.0654 0.0058 0.03 0.0964 0 0.002
Bud 0.0006 0.0001 0.0001 0.0001 0 0 0.0006 0 0.0006 0.0001 0 0 0.0022 0.0001 0 0.014 0 0
Bud Neck 0.0004 0.0002 0.0002 0.0003 0.0011 0.0002 0.0012 0.0003 0.0016 0 0.0003 0.0003 0.0015 0.0011 0.0008 0.0008 0 0.001
Bud Periphery 0.0011 0.0003 0.0002 0.0002 0.0002 0.0001 0.0011 0.0001 0.0015 0.0011 0.0003 0.0002 0.0047 0.0003 0.0002 0.0187 0 0.0001
Bud Site 0.0012 0.0004 0.0001 0.0001 0.0001 0 0.0023 0.0001 0.006 0 0 0 0.0025 0.0001 0.0001 0.0178 0 0
Cell Periphery 0.0075 0.0126 0.0138 0.006 0.0084 0.0042 0.0053 0.0158 0.0106 0.0015 0.016 0.0032 0.0057 0.0276 0.0106 0.0097 0.0007 0.0007
Cytoplasm 0.0065 0.0156 0.0149 0.002 0.0057 0.003 0.0161 0.0049 0.0091 0.0006 0.0009 0.0012 0.0296 0.0044 0.0011 0.0013 0.0001 0.001
Cytoplasmic Foci 0.0022 0.0015 0.0014 0.0063 0.0009 0.0006 0.0154 0.0007 0.0014 0 0 0.0002 0.0102 0.0037 0.0013 0.001 0 0
Eisosomes 0.0027 0.001 0.0014 0.0006 0.0011 0.0004 0.007 0.0019 0.0023 0.0002 0.0006 0.0003 0.0004 0.0167 0.002 0.0026 0 0
Endoplasmic Reticulum 0.8323 0.9109 0.9166 0.9298 0.8774 0.9559 0.769 0.9148 0.8818 0.9766 0.9611 0.9579 0.6037 0.7955 0.8611 0.7256 0.996 0.9677
Endosome 0.0085 0.0022 0.0033 0.0113 0.007 0.0028 0.0201 0.0036 0.0108 0.0014 0.0006 0.0029 0.0452 0.0087 0.0063 0.0012 0 0.001
Golgi 0.0084 0.0132 0.0047 0.0087 0.0196 0.0035 0.0147 0.02 0.0113 0.0011 0.0013 0.0129 0.0048 0.071 0.0483 0.0029 0 0.0013
Lipid Particles 0.011 0.0259 0.0157 0.0059 0.0421 0.0086 0.0135 0.0224 0.0033 0.0006 0.001 0.0018 0.0049 0.0131 0.0045 0.0005 0 0.0001
Mitochondria 0.0308 0.0044 0.0093 0.0181 0.0022 0.003 0.0154 0.002 0.0221 0.0054 0.0002 0.0046 0.0052 0.0347 0.0013 0.087 0 0.0002
None 0.0039 0.0002 0.0006 0.0001 0.0007 0.0018 0.0068 0.0002 0.0006 0.0002 0.0001 0.0002 0.0076 0.0004 0.0003 0.0002 0 0
Nuclear Periphery 0.0384 0.004 0.0064 0.0031 0.0222 0.0109 0.057 0.0083 0.0084 0.0075 0.0147 0.0105 0.1333 0.0126 0.0277 0.0149 0.0026 0.0222
Nucleolus 0.0006 0 0 0.0001 0.0001 0.0001 0.0009 0 0.0002 0 0 0 0.0018 0 0 0.0003 0 0
Nucleus 0.007 0.0002 0.0005 0.0002 0.0013 0.0006 0.0044 0.0002 0.0013 0.0002 0.0002 0.0001 0.029 0.0002 0.0004 0.0008 0 0.0009
Peroxisomes 0.002 0 0.0006 0.0012 0.0001 0.0001 0.0065 0 0.0004 0 0 0 0.0006 0 0.0001 0.0011 0 0
Punctate Nuclear 0.0026 0 0.0001 0.0001 0.0002 0.0002 0.0025 0 0.0002 0 0 0 0.0255 0 0.0002 0 0 0
Vacuole 0.0052 0.0027 0.0046 0.0037 0.0058 0.0021 0.0055 0.003 0.0036 0.0008 0.0016 0.0019 0.0092 0.0033 0.0017 0.0019 0.0004 0.001
Vacuole Periphery 0.0028 0.0003 0.0007 0.0014 0.0024 0.001 0.0045 0.0011 0.0019 0.0015 0.0008 0.0009 0.0072 0.0009 0.0018 0.0013 0.0001 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 174.9498 141.1187 139.2617 164.2682 129.7679 161.0274 163.2787 145.4469 136.297 176.9392
Translational Efficiency 1.4815 1.5712 1.4344 1.1626 1.6158 1.7406 1.5595 1.7318 1.6028 1.3306

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1741 1691 2118 151 1938 775 2045 1241 3679 2466 4163 1392

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1145.53 2167.79 2393.74 2420.92 1748.21 1928.67 2447.68 2314.09 1463.01 2092.64 2420.24 2325.68
Standard Deviation 260.07 478.52 526.52 469.93 370.98 437.05 466.31 481.09 441.65 478.93 498.58 481.04
Intensity Change Log 2 — 0.920210 1.063251 1.079540 — 0.141728 0.485536 0.404566 — 0.501442 0.742495 0.710432

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.021912 0.001973 0.002294 0.002713 0.001113 0.002602 0.002059 0.001727 0.010956 0.002171 0.002179 0.001834
Bud Neck 0.000442 0.000276 0.001194 0.010989 0.000156 0.000655 0.000854 0.000601 0.000291 0.000395 0.001027 0.001728
Bud Site 0.006687 0.000940 0.002100 0.009717 0.000669 0.002571 0.001819 0.005257 0.003517 0.001452 0.001962 0.005741
Cell Periphery 0.005529 0.002136 0.004263 0.020350 0.002139 0.002172 0.003552 0.011450 0.003743 0.002147 0.003913 0.012415
Cytoplasm 0.001784 0.000338 0.000630 0.001197 0.000524 0.001707 0.000682 0.000574 0.001120 0.000768 0.000656 0.000641
Cytoplasmic Foci 0.010523 0.000598 0.000547 0.006826 0.002510 0.004043 0.001068 0.001483 0.006302 0.001680 0.000803 0.002062
Eisosomes 0.001047 0.000240 0.000610 0.002036 0.000303 0.000228 0.000334 0.000603 0.000655 0.000236 0.000474 0.000758
Endoplasmic Reticulum 0.875613 0.962634 0.903719 0.717304 0.938855 0.913857 0.929226 0.910829 0.908927 0.947305 0.916249 0.889836
Endosome 0.020093 0.006838 0.012272 0.026544 0.008061 0.021601 0.010587 0.009768 0.013755 0.011478 0.011444 0.011588
Golgi 0.027845 0.011519 0.024416 0.025148 0.020847 0.018356 0.016911 0.017528 0.024159 0.013668 0.020729 0.018355
Lipid Particles 0.013321 0.007307 0.027303 0.096330 0.009079 0.016960 0.020784 0.021391 0.011086 0.010341 0.024101 0.029521
Mitochondria 0.006142 0.000348 0.000334 0.000124 0.004429 0.000967 0.000761 0.001156 0.005240 0.000543 0.000543 0.001044
Mitotic Spindle 0.000226 0.000059 0.000111 0.004908 0.000061 0.000464 0.000538 0.000383 0.000139 0.000186 0.000321 0.000874
None 0.002194 0.000617 0.001067 0.000074 0.000876 0.000561 0.001552 0.000310 0.001500 0.000599 0.001305 0.000285
Nuclear Periphery 0.000347 0.000476 0.001704 0.004090 0.000469 0.000665 0.000831 0.001224 0.000411 0.000535 0.001275 0.001535
Nuclear Periphery Foci 0.001767 0.000945 0.005343 0.030602 0.001669 0.006250 0.001761 0.002921 0.001715 0.002612 0.003583 0.005924
Nucleolus 0.000008 0.000003 0.000006 0.000017 0.000008 0.000455 0.000004 0.000012 0.000008 0.000145 0.000005 0.000012
Nucleus 0.000111 0.000030 0.000063 0.000191 0.000037 0.000404 0.000051 0.000064 0.000072 0.000148 0.000057 0.000078
Peroxisomes 0.001931 0.000221 0.000045 0.000023 0.000330 0.000709 0.000345 0.000173 0.001088 0.000375 0.000192 0.000156
Vacuole 0.000749 0.001487 0.008886 0.037424 0.003926 0.003080 0.004692 0.009186 0.002423 0.001988 0.006826 0.012249
Vacuole Periphery 0.001729 0.001015 0.003093 0.003391 0.003938 0.001693 0.001589 0.003359 0.002893 0.001228 0.002354 0.003363

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 8.05 7.91 7.32 -0.61 -0.32 -1.59 -1.51 -0.77 0.79 0.41 6.86 7.06 6.83 0.37 0.48
Bud Neck 1.55 -4.52 -4.66 -4.72 -4.31 -1.82 -3.41 -5.61 0.14 1.23 -0.98 -5.63 -5.30 -4.67 -2.35
Bud Site 6.01 4.46 -1.26 -3.28 -2.82 -2.36 -2.98 -3.50 -1.83 -2.53 3.79 2.78 -1.90 -3.51 -3.08
Cell Periphery 5.29 1.80 -3.61 -4.49 -3.94 -0.11 -4.29 -7.35 -7.27 -6.16 4.62 -0.59 -6.99 -8.47 -6.96
Cytoplasm 5.16 4.22 0.82 -1.94 -1.35 -2.13 -0.89 -0.28 2.10 0.81 1.44 2.27 2.15 0.45 0.18
Cytoplasmic Foci 9.53 9.62 0.90 -1.54 -1.56 -1.65 2.95 1.82 2.91 -1.09 7.54 9.87 5.58 -0.63 -2.34
Eisosomes 4.70 1.29 -1.15 -2.17 -1.61 0.89 -0.36 -2.54 -3.71 -2.62 4.54 1.03 -0.65 -4.21 -1.44
Endoplasmic Reticulum -13.84 -3.63 5.79 8.90 6.73 3.27 2.23 4.57 0.46 2.89 -8.80 -1.30 3.16 9.10 4.14
Endosome 11.19 6.19 -2.24 -6.69 -4.81 -7.22 -3.12 -1.99 6.11 0.88 2.54 2.95 2.16 -0.23 -0.16
Golgi 7.19 1.26 0.56 -2.81 -0.10 0.90 2.18 1.61 0.30 -0.35 6.57 2.12 3.14 -2.76 1.44
Lipid Particles 4.34 -6.73 -6.14 -6.58 -5.11 -3.30 -6.63 -5.49 -1.50 -0.19 0.65 -9.55 -7.30 -7.45 -2.05
Mitochondria 6.58 6.58 6.86 2.45 2.45 2.64 2.78 2.44 -0.36 -0.68 5.91 5.82 4.79 -1.28 -1.17
Mitotic Spindle 3.85 2.20 -2.27 -2.34 -2.32 -2.16 -1.02 -1.85 0.30 0.30 -0.74 -0.79 -2.68 -2.48 -1.69
None 2.77 1.83 3.81 4.16 3.78 1.06 -1.59 2.10 1.32 3.47 2.90 0.53 3.96 2.36 4.41
Nuclear Periphery -1.74 -7.00 -5.37 -5.19 -3.27 -1.34 -4.93 -7.58 -3.36 -3.46 -1.90 -8.21 -9.52 -7.93 -1.52
Nuclear Periphery Foci 1.36 -4.43 -3.89 -4.00 -3.39 -2.65 -0.29 -1.34 1.76 -1.32 -1.40 -3.94 -3.64 -2.73 -1.97
Nucleolus 6.03 1.51 -1.42 -2.23 -1.66 -1.07 1.94 -1.17 1.06 -3.23 -1.04 2.34 -1.76 1.01 -3.22
Nucleus 9.00 3.69 -2.28 -4.07 -3.16 -1.20 -1.91 -3.31 1.11 -0.88 -0.79 1.22 -1.06 0.68 -1.82
Peroxisomes 5.89 6.64 6.71 3.31 2.02 -1.19 -0.08 1.01 1.89 2.03 3.85 5.53 5.83 2.15 0.74
Vacuole -2.94 -11.10 -5.93 -5.81 -4.56 0.92 -1.12 -3.74 -4.71 -3.04 0.95 -7.19 -7.23 -7.79 -3.77
Vacuole Periphery 3.11 -4.09 -1.78 -2.48 -0.29 3.64 4.12 0.72 -2.70 -3.07 5.04 1.39 -0.89 -4.16 -1.86
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
Localization
Cell Percentages ER (86%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Irc22

Irc22


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Irc22-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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