Standard name
Human Ortholog
Description 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0.05 0.07 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.98 0.98 0.97 0.94 0.89 0.83 0.79 0.76 0.79 0.76 0.98 0.99 0.99 0.86 0.96 0.96 0.97 0.95 0.96 0.95 0.9 0.88
Endoplasmic Reticulum 0 0 0 0 0 0 0 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.08 0.06 0.09 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.07 0.11 0.09 0.12 0.05 0.12 0 0 0 0.1 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 2 1 4 4 1 0 0 0 0 0 0 0 0 1 0 0 3 1
Bud 0 0 1 0 0 0 0 3 1 4 0 1 2 1 0 0 0 0 0 3 0 7 18 22
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 0 0 0 2 3 1 10 13 5 7 3 2 6 4 2 0 0 0 0 0 0 0
Cytoplasm 106 352 122 141 135 185 148 272 171 141 110 105 680 679 772 149 138 132 112 353 113 496 474 451
Endoplasmic Reticulum 0 2 0 1 2 4 4 15 8 5 8 6 6 4 5 5 4 3 0 0 2 2 2 2
Endosome 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 1
Golgi 0 0 0 0 0 0 0 1 0 0 0 1 2 0 1 7 3 1 0 0 0 0 1 1
Mitochondria 0 0 0 0 0 1 3 8 18 12 12 12 1 0 1 0 1 0 0 1 0 0 0 1
Nucleus 0 0 1 0 0 0 0 1 1 2 1 1 1 0 0 0 0 0 0 2 0 2 7 7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 2 0 0
Nucleolus 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2
Vac/Vac Membrane 0 0 3 3 3 6 11 35 20 22 7 17 7 4 5 18 7 4 0 2 0 3 4 13
Unique Cell Count 106 355 125 144 139 196 166 329 217 185 140 139 694 687 783 173 144 137 117 373 119 524 527 514
Labelled Cell Count 106 357 127 145 142 198 171 337 233 203 145 150 702 690 790 185 155 141 117 373 119 524 527 514


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 43.0 37.1 23.8 30.1 38.3 33.3 23.1 19.2 20.7 17.3 21.0 21.8 48.0 52.8 53.3 38.1 49.5 44.7 25.3 27.9 29.9
Std Deviation (1e-4) 10.4 10.8 6.5 9.6 13.7 14.9 11.8 9.0 9.0 8.5 8.1 9.0 20.9 19.8 20.9 19.7 23.5 19.0 8.3 10.1 10.1
Intensity Change (Log2) – – – 0.34 0.69 0.48 -0.04 -0.31 -0.2 -0.46 -0.18 -0.13 1.01 1.15 1.16 0.68 1.06 0.91 0.09 0.23 0.33

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 3.0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 -0.2 -1.4 -2.8 -4.2 -4.8 -5.1 -4.7 -5.2 0.3 1.1 0.8 -3.4 -0.8 -0.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 3.3 0 3.3 3.4 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 1.7 2.8 2.4 3.0 0 3.0 0 0 0 2.7 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 112.1085 154.6099 131.4508 126.2745 125.6057 102.5002 130.3778 189.3147 158.7831 166.8393 131.8205 174.2042 119.5306 170.9516 150.7511 136.6349 125.393 124.9616
Actin 0.0115 0.0002 0.006 0.0003 0.0155 0.0041 0.0045 0.0009 0.0041 0.0045 0.0108 0.0027 0.0083 0.0001 0.0031 0.0158 0.0003 0.0004
Bud 0.0006 0.0002 0.0008 0.0006 0.0004 0.0008 0.0009 0.0003 0.0012 0.0003 0.0017 0.0023 0.0019 0.0003 0.0014 0.0004 0.0005 0.0009
Bud Neck 0.0005 0.0002 0.0007 0.0004 0.0008 0.0014 0.0004 0.0001 0.0003 0.0003 0.0004 0.0009 0.0005 0.0001 0.0002 0.0014 0.0002 0.0008
Bud Periphery 0.0004 0 0.0005 0.0002 0.0005 0.0005 0.0004 0.0001 0.0007 0.0002 0.0021 0.0028 0.001 0.0003 0.0014 0.0003 0.0006 0.0004
Bud Site 0.0009 0.0001 0.0077 0.0001 0.0007 0.0006 0.0007 0.0012 0.0004 0.0013 0.001 0.0009 0.0024 0.0001 0.0011 0.003 0.0001 0.0004
Cell Periphery 0.0004 0.0012 0.0005 0.0001 0.0008 0.0007 0.0017 0.0003 0.0009 0.0004 0.0003 0.0006 0.0012 0.0002 0.0008 0.0003 0.0012 0.0015
Cytoplasm 0.836 0.9809 0.9428 0.9301 0.8401 0.7138 0.8904 0.9823 0.9394 0.9192 0.6964 0.9361 0.8327 0.9862 0.9341 0.8913 0.8578 0.8891
Cytoplasmic Foci 0.0295 0.0002 0.0048 0.0081 0.02 0.0108 0.0061 0.0004 0.0057 0.0009 0.0033 0.0016 0.0352 0.0003 0.0062 0.0142 0.0634 0.0178
Eisosomes 0.0003 0.0001 0.0004 0 0.0008 0.0003 0.0014 0.0023 0.0001 0.0001 0.0002 0.0001 0.0004 0 0.0002 0.0003 0.0002 0.0001
Endoplasmic Reticulum 0.0024 0.0002 0.0003 0.0003 0.0027 0.0094 0.003 0.0001 0.0007 0.0415 0.0032 0.001 0.0023 0.0001 0.0006 0.0054 0.0013 0.0006
Endosome 0.0086 0 0.0008 0.0001 0.0044 0.0374 0.0009 0.0001 0.0006 0.0024 0.024 0.0006 0.0062 0 0.0019 0.0047 0.001 0.0008
Golgi 0.0017 0 0.0004 0 0.0027 0.003 0.0004 0.0002 0.0003 0.0005 0.0024 0.0001 0.0054 0 0.0013 0.0022 0.0002 0.0001
Lipid Particles 0.0064 0.0001 0.0032 0.0002 0.0055 0.0189 0.0013 0.0001 0.0013 0.0005 0.0006 0.0002 0.0078 0 0.0017 0.0031 0.0022 0.0034
Mitochondria 0.0048 0.0003 0.0024 0.0031 0.0226 0.0066 0.0028 0.0048 0.0101 0.0022 0.062 0.0171 0.0121 0.0004 0.0114 0.0036 0.015 0.0046
None 0.0117 0.0009 0.0071 0.0301 0.0089 0.0214 0.0104 0.0006 0.0036 0.0025 0.0087 0.0039 0.0249 0.0006 0.0081 0.0167 0.0213 0.0042
Nuclear Periphery 0.0145 0.0049 0.0019 0.0034 0.0066 0.0597 0.0192 0.0004 0.0054 0.0082 0.0272 0.0032 0.0045 0.0007 0.0025 0.0075 0.0039 0.0032
Nucleolus 0.0094 0.0007 0.0033 0.0019 0.0209 0.0053 0.0085 0.0026 0.0052 0.0008 0.0753 0.0023 0.0152 0.0012 0.0038 0.0087 0.0033 0.0366
Nucleus 0.0345 0.0078 0.0093 0.0178 0.0215 0.0744 0.0385 0.0027 0.0123 0.0107 0.0439 0.0187 0.0215 0.006 0.0064 0.0128 0.009 0.0184
Peroxisomes 0.0023 0 0.0006 0.0002 0.001 0.0011 0.0002 0.0001 0.0002 0.0001 0.0004 0.0004 0.0028 0 0.0004 0.0018 0.0008 0.0007
Punctate Nuclear 0.0198 0.0001 0.0014 0.001 0.0012 0.009 0.0046 0.0001 0.0029 0.0008 0.0021 0.0007 0.0027 0 0.0005 0.0031 0.0034 0.0013
Vacuole 0.0026 0.0014 0.0035 0.0013 0.0105 0.0113 0.0025 0.0002 0.0022 0.0017 0.0137 0.0023 0.0074 0.0024 0.0081 0.0017 0.0105 0.0108
Vacuole Periphery 0.0013 0.0005 0.0016 0.0007 0.012 0.0095 0.0011 0.0003 0.0024 0.0012 0.0203 0.0013 0.0038 0.001 0.0048 0.002 0.004 0.004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 868.4407 461.7643 486.4831 512.2773 366.0486 794.3664 566.7221 524.8219 590.6775 500.2246
Translational Efficiency 1.4938 1.4419 1.2699 1.4796 1.6356 1.8247 1.5155 1.5497 1.4389 1.4651

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2857 1377 243 1363 1457 2123 1018 343 4314 3500 1261 1706

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1889.46 2722.31 3132.66 4050.71 2062.73 2977.91 2986.30 4283.83 1947.98 2877.35 3014.50 4097.58
Standard Deviation 453.18 812.73 632.68 1124.31 553.89 856.49 647.59 1205.52 496.33 848.78 647.33 1144.92
Intensity Change Log 2 — 0.526857 0.729414 1.100201 — 0.529745 0.533804 1.054346 — 0.528365 0.630634 1.076450

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000025 0.000083 0.000370 0.000492 0.000064 0.000083 0.000132 0.000384 0.000038 0.000083 0.000178 0.000470
Bud Neck 0.000286 0.000340 0.005257 0.001869 0.000308 0.000530 0.000877 0.007738 0.000294 0.000456 0.001721 0.003049
Bud Site 0.000638 0.000768 0.002792 0.011116 0.001112 0.001684 0.000757 0.030273 0.000798 0.001324 0.001149 0.014967
Cell Periphery 0.000030 0.000208 0.000749 0.000620 0.000114 0.000118 0.000274 0.000757 0.000059 0.000153 0.000366 0.000648
Cytoplasm 0.846647 0.760974 0.510769 0.705991 0.774316 0.756532 0.567860 0.721978 0.822218 0.758280 0.556858 0.709206
Cytoplasmic Foci 0.002988 0.003161 0.016280 0.009414 0.002879 0.003265 0.004645 0.022947 0.002951 0.003224 0.006887 0.012135
Eisosomes 0.000000 0.000001 0.000004 0.000004 0.000000 0.000000 0.000001 0.000006 0.000000 0.000001 0.000002 0.000004
Endoplasmic Reticulum 0.000059 0.000027 0.000156 0.000027 0.000051 0.000033 0.000063 0.000114 0.000056 0.000031 0.000081 0.000044
Endosome 0.000053 0.000038 0.000514 0.000242 0.000064 0.000120 0.000074 0.006097 0.000057 0.000088 0.000159 0.001419
Golgi 0.000110 0.000313 0.000930 0.000562 0.000343 0.000645 0.000239 0.004522 0.000189 0.000514 0.000372 0.001358
Lipid Particles 0.000053 0.000160 0.002020 0.001813 0.000080 0.000163 0.000411 0.002018 0.000062 0.000162 0.000721 0.001854
Mitochondria 0.000079 0.000106 0.000618 0.000175 0.000104 0.000129 0.000227 0.000685 0.000087 0.000120 0.000303 0.000277
Mitotic Spindle 0.000808 0.000346 0.004063 0.002866 0.000325 0.002033 0.001913 0.010615 0.000645 0.001369 0.002327 0.004424
None 0.022911 0.024919 0.009470 0.012887 0.020954 0.022725 0.011682 0.008883 0.022250 0.023588 0.011256 0.012082
Nuclear Periphery 0.000049 0.000049 0.000892 0.000164 0.000040 0.000084 0.000291 0.000265 0.000046 0.000070 0.000407 0.000184
Nuclear Periphery Foci 0.000396 0.000782 0.002689 0.001672 0.000674 0.000598 0.000782 0.001689 0.000490 0.000671 0.001149 0.001675
Nucleolus 0.000086 0.000089 0.000315 0.000171 0.000060 0.000148 0.000088 0.000342 0.000077 0.000125 0.000132 0.000205
Nucleus 0.122388 0.203924 0.403654 0.233341 0.196928 0.208311 0.401268 0.133858 0.147563 0.206585 0.401728 0.213339
Peroxisomes 0.000010 0.000010 0.000041 0.000071 0.000009 0.000013 0.000008 0.000172 0.000010 0.000012 0.000014 0.000091
Vacuole 0.002003 0.003030 0.038159 0.015852 0.001369 0.002479 0.008352 0.040989 0.001789 0.002696 0.014096 0.020906
Vacuole Periphery 0.000379 0.000671 0.000260 0.000652 0.000207 0.000304 0.000055 0.005666 0.000321 0.000448 0.000094 0.001660

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.18 -7.92 -2.66 -2.17 2.34 -2.36 -8.78 -4.80 -3.69 1.60 -2.53 -10.24 -3.01 -2.51 0.45
Bud Neck -4.41 -10.61 -10.94 -9.54 8.56 -3.43 -12.68 -5.97 -5.53 -3.27 -4.96 -14.65 -11.80 -10.21 3.73
Bud Site -1.65 -9.50 -5.87 -5.43 -0.39 -1.37 -2.95 -4.03 -3.80 -3.69 -2.52 -10.19 -7.02 -6.37 -5.00
Cell Periphery -10.16 -11.67 -13.03 -8.83 5.20 -1.12 -9.91 -8.21 -8.03 -2.43 -8.71 -16.14 -14.74 -12.04 -0.32
Cytoplasm 18.16 32.41 28.46 11.26 -18.81 5.68 33.59 9.26 6.90 -9.00 20.27 52.50 27.09 12.88 -22.85
Cytoplasmic Foci -3.45 -10.26 -9.75 -7.61 6.87 -2.32 -9.85 -8.19 -7.91 -5.39 -3.99 -13.64 -12.63 -11.37 -0.09
Eisosomes -3.43 -11.26 -4.80 -4.33 6.36 -2.81 -12.99 -8.01 -7.59 -1.71 -4.33 -16.52 -6.26 -5.80 1.94
Endoplasmic Reticulum 1.91 -5.19 1.90 -0.06 6.74 2.12 -5.14 0.78 -0.55 5.01 2.08 -5.42 2.25 0.59 9.48
Endosome 0.20 -7.40 -2.38 -2.40 6.30 -1.74 -4.00 -1.45 -1.36 -1.28 -1.89 -9.00 -1.94 -1.64 -0.07
Golgi -3.49 -9.80 -3.02 -0.21 6.57 -1.41 -0.34 -1.19 -0.67 -1.14 -2.96 -7.50 -2.30 0.14 0.61
Lipid Particles -4.30 -8.19 -5.40 -4.87 2.89 -2.52 -11.11 -7.00 -6.69 -4.80 -4.45 -13.12 -7.28 -6.73 -2.20
Mitochondria -3.04 -4.74 -5.49 -3.19 3.96 -2.54 -13.30 -1.53 -1.02 1.14 -4.58 -11.59 -4.38 -2.03 6.39
Mitotic Spindle 1.47 -3.18 -2.56 -3.27 1.25 -3.98 -4.66 -3.54 -1.48 -1.47 -2.88 -4.77 -4.06 -1.75 0.00
None 0.06 18.84 14.29 7.68 -6.28 -0.02 10.33 13.66 14.32 7.69 0.46 19.01 18.13 13.51 0.52
Nuclear Periphery -2.55 -12.81 -16.54 -15.41 11.16 -8.19 -22.51 -13.05 -10.83 2.01 -7.88 -22.89 -20.77 -15.83 14.28
Nuclear Periphery Foci -3.87 -7.58 -5.52 -2.75 4.32 -0.25 -6.85 -6.35 -6.32 -2.92 -3.60 -11.09 -7.12 -5.40 0.97
Nucleolus -0.59 -10.13 -1.93 -1.41 7.33 -3.12 -11.94 -4.26 -0.63 -1.57 -2.76 -13.18 -3.51 -0.26 2.47
Nucleus -17.35 -17.85 -20.34 -4.16 9.29 -3.99 -27.89 6.78 9.97 28.61 -18.49 -42.01 -13.65 0.21 26.63
Peroxisomes -0.40 -8.04 -3.34 -3.17 2.53 -1.83 -5.48 -2.65 -2.47 -2.27 -1.41 -9.05 -4.22 -3.94 -2.14
Vacuole -6.15 -11.89 -16.89 -14.77 7.99 -6.63 -15.05 -13.10 -12.57 -8.95 -8.19 -17.79 -20.28 -18.54 -0.76
Vacuole Periphery -0.39 0.11 0.43 0.59 0.59 -0.46 1.15 -0.92 -0.82 -1.09 -0.33 1.41 -0.37 0.01 -1.46
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Dld3

Dld3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dld3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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