Standard name
Human Ortholog
Description Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0.59 0.6 0.64 0.76 0.76 0.8 0.78 0.78 0.79 0.8 0.78 0.77 0.82 0.89 0.9 – 0.8 0.72 0.07 0 0 0 0.08 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 – 0.06 0.07 0 0 0 0 0 0
Endosome 0 0.07 0.17 0.14 0.1 0 0 0 0 0 0 0 0 0 0.05 – 0.06 0.12 0.16 0.23 0.26 0.24 0.11 0.13
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0.2 0.1 0 0.06 0.08 0.32 0.34 0.3 0.41 0.4 0.43 0.33 0 0 0 – 0.05 0 0.12 0.1 0.11 0.26 0.18 0.16
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.33 0.31 0.27 0.13 0.14 0 0 0 0 0 0 0 0 0 0 – 0.18 0.29 0.55 0.56 0.5 0.38 0.52 0.46
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 5 3 0 0 0 0 1 0 0 0 0 14 3 5 – 2 0 0 3 3 0 1 2
Bud 0 4 0 3 4 4 13 13 21 20 17 18 3 1 2 – 1 0 1 2 3 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 1 0 0 4 1 2 – 1 0 0 1 1 0 1 0
Bud Site 0 0 0 0 0 0 0 2 1 0 3 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 1 1 0 1 0 0 0 0 1 5 0 3 – 0 0 0 0 0 0 0 0
Cytoplasm 27 228 232 179 243 283 345 332 284 372 283 364 204 360 335 – 348 157 6 16 9 3 15 17
Endoplasmic Reticulum 1 17 7 0 0 1 0 0 0 0 0 0 17 3 5 – 25 16 0 3 9 0 5 6
Endosome 0 26 62 34 31 3 8 7 3 5 1 3 9 18 20 – 28 26 14 102 100 20 21 22
Golgi 0 0 3 0 0 0 0 0 0 0 0 0 0 0 1 – 1 0 1 15 12 2 4 6
Mitochondria 9 38 11 13 27 115 150 127 149 186 155 155 0 0 1 – 20 5 10 46 41 23 34 27
Nucleus 1 2 0 0 0 1 1 1 3 1 1 0 1 1 1 – 1 0 0 0 0 0 0 0
Nuclear Periphery 1 1 0 0 1 1 1 0 2 0 2 0 0 0 0 – 0 0 0 0 1 0 0 0
Nucleolus 0 0 1 0 0 0 1 1 0 1 2 1 0 0 0 – 0 0 1 0 0 0 0 0
Peroxisomes 0 0 1 1 2 0 1 2 0 2 0 2 0 1 0 – 1 0 0 1 1 0 0 1
SpindlePole 0 2 7 5 2 3 9 5 9 9 9 19 0 7 4 – 5 1 2 1 2 0 2 1
Vac/Vac Membrane 15 119 98 31 44 13 12 7 4 12 4 8 7 14 8 – 78 63 49 250 195 33 100 79
Unique Cell Count 46 378 361 235 318 354 443 423 360 465 364 470 250 404 372 433 217 89 450 391 88 193 172
Labelled Cell Count 54 442 425 267 355 424 542 498 476 609 477 571 264 409 387 511 268 89 450 391 88 193 172


Ambiguous, Early Golgi, Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.7 5.5 5.2 4.8 4.7 3.5 3.3 3.7 3.1 3.1 3.1 3.0 5.8 5.6 5.7 4.7 5.4 5.9 5.7 6.6 6.9
Std Deviation (1e-4) 0.7 0.8 1.4 1.5 2.0 1.2 1.1 1.3 0.8 1.4 1.1 0.9 0.7 0.8 0.8 0.8 0.9 1.6 0.8 1.5 2.4
Intensity Change (Log2) – – – -0.12 -0.17 -0.56 -0.65 -0.49 -0.76 -0.76 -0.76 -0.81 0.16 0.09 0.13 -0.14 0.06 0.18 0.13 0.34 0.4


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 3.5 0 0 – 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Cytoplasm 3.1 3.4 4.7 4.3 4.4 4.4 5.1 4.0 4.2 4.7 8.2 8.3 – 5.1 2.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 3.0 0 -0.6 – 2.7 3.2
Endosome 0 0 0 0 0 0 0 0 0 -5.1 -5.7 -5.1 – -4.7 -1.7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 -3.5 -3.0 – 1.1 -0.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 -0.2 -1.0 – -0.9 0
Vacuole -4.0 -4.3 -8.7 -10.0 -10.4 -10.0 -10.3 -10.1 -10.9 -7.8 -9.2 -9.6 – -3.1 0.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.0685 1.3522 1.393 1.5778 1.492 1.2089 2.8244 3.7528 3.7512 3.4004 3.1815 4.0331 3.045 3.5138 3.6417 3.5747 3.447 3.8494
Actin 0.0316 0.0009 0.0208 0.023 0.032 0.004 0.0018 0.0031 0.0012 0.0015 0.0003 0.0012 0.0002 0.0002 0.0011 0.0001 0.0001 0.0004
Bud 0.0036 0.0032 0.0007 0.0004 0.0017 0.0002 0.0007 0.0012 0.0012 0.0013 0.0004 0.0004 0.0006 0.0005 0.0003 0.0003 0.0002 0.0002
Bud Neck 0.0029 0.0006 0.0014 0.0018 0.0006 0.0012 0.0053 0.0004 0.0003 0.0005 0.0005 0.0008 0.0003 0.0002 0.0003 0.0074 0.0003 0.0007
Bud Periphery 0.0062 0.0016 0.0008 0.0005 0.0031 0.0004 0.0008 0.0015 0.002 0.0038 0.0005 0.0006 0.0004 0.0007 0.0003 0.0004 0.0002 0.0003
Bud Site 0.0046 0.0081 0.0015 0.0009 0.0036 0.0002 0.0069 0.0061 0.0014 0.0011 0.0005 0.0002 0.0018 0.0007 0.0012 0.0004 0.0003 0.0002
Cell Periphery 0.0004 0.0005 0.0002 0.0002 0.0003 0.0001 0.0004 0.0004 0.0003 0.0003 0.0003 0.0001 0.0003 0.0002 0.0002 0.0002 0.0002 0.0001
Cytoplasm 0.1396 0.247 0.1899 0.15 0.1229 0.2613 0.1924 0.1897 0.1879 0.0678 0.1233 0.18 0.2278 0.2521 0.2267 0.2022 0.2743 0.2338
Cytoplasmic Foci 0.1339 0.1152 0.1442 0.1625 0.1479 0.124 0.1489 0.1025 0.1289 0.1059 0.1694 0.1387 0.1253 0.1201 0.107 0.1635 0.1095 0.1547
Eisosomes 0.0003 0.0003 0.0002 0.0004 0.0004 0 0.0001 0.0002 0.0002 0.0001 0 0.0001 0.0001 0.0001 0.0001 0 0 0.0001
Endoplasmic Reticulum 0.007 0.0043 0.0071 0.0061 0.0056 0.0045 0.0069 0.0043 0.004 0.0027 0.0038 0.0039 0.0049 0.0057 0.0104 0.0028 0.0064 0.0035
Endosome 0.2744 0.2954 0.352 0.4156 0.3644 0.3337 0.3214 0.2442 0.3032 0.5206 0.4077 0.3219 0.3476 0.357 0.3427 0.4634 0.3644 0.3628
Golgi 0.0191 0.0123 0.0183 0.015 0.0208 0.0082 0.0119 0.0096 0.0129 0.0212 0.014 0.0139 0.0202 0.0189 0.0123 0.0203 0.0222 0.0137
Lipid Particles 0.0236 0.0064 0.0091 0.0116 0.0139 0.007 0.0078 0.0095 0.0076 0.0054 0.0054 0.0113 0.0044 0.0057 0.0037 0.0041 0.0029 0.0065
Mitochondria 0.013 0.0077 0.0131 0.0105 0.019 0.0045 0.0032 0.0152 0.008 0.0392 0.0082 0.016 0.0114 0.0063 0.0066 0.0066 0.0064 0.0045
None 0.2583 0.2424 0.1922 0.0877 0.2296 0.1925 0.2392 0.3382 0.2845 0.1587 0.2012 0.2588 0.2189 0.1873 0.2375 0.0517 0.1658 0.184
Nuclear Periphery 0.0091 0.0018 0.0054 0.0151 0.0041 0.0047 0.0053 0.0027 0.0032 0.0035 0.0019 0.0067 0.0013 0.0031 0.0038 0.0012 0.0022 0.0011
Nucleolus 0.0008 0.0012 0.0007 0.0013 0.0005 0.0004 0.0012 0.0005 0.0009 0.0004 0.0005 0.0005 0.0004 0.0003 0.0003 0.0003 0.0002 0.0002
Nucleus 0.0122 0.0023 0.0024 0.0126 0.0022 0.0037 0.0036 0.0016 0.0019 0.001 0.0012 0.0025 0.0013 0.0017 0.0018 0.001 0.0013 0.0008
Peroxisomes 0.013 0.0051 0.004 0.005 0.0053 0.0024 0.0025 0.0041 0.0093 0.003 0.0242 0.0026 0.002 0.0018 0.0026 0.0033 0.0022 0.0035
Punctate Nuclear 0.0077 0.0016 0.0021 0.0083 0.003 0.0042 0.002 0.0011 0.0043 0.0005 0.0012 0.0014 0.0006 0.0007 0.0008 0.0017 0.0004 0.0011
Vacuole 0.0326 0.0359 0.0273 0.0602 0.0151 0.0336 0.0325 0.0543 0.0265 0.0418 0.0281 0.0288 0.0252 0.0301 0.0305 0.0538 0.0345 0.0212
Vacuole Periphery 0.006 0.0063 0.0067 0.0113 0.0042 0.0092 0.0052 0.0098 0.0103 0.0197 0.0073 0.0096 0.005 0.0065 0.0097 0.0154 0.0062 0.0068

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.4465 16.153 6.9597 14.4795 10.5803 12.2338 12.6444 14.0457 13.1786 16.5792
Translational Efficiency 0.3904 0.375 0.7632 0.449 0.5157 0.4622 0.5614 0.4114 0.3864 0.3166

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
132 1111 214 1632 2422 1896 1744 70 2554 3007 1958 1702

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 863.12 779.45 871.23 845.86 732.78 786.31 789.59 912.22 739.52 783.78 798.51 848.59
Standard Deviation 130.22 104.07 89.99 108.24 88.37 99.40 91.54 134.88 95.47 101.20 94.85 110.26
Intensity Change Log 2 — -0.147105 0.013492 -0.029142 — 0.101718 0.107724 0.316002 — -0.027507 0.057525 0.139630

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.007517 0.000957 0.001543 0.002587 0.000229 0.000688 0.004599 0.003071 0.000606 0.000787 0.004265 0.002607
Bud Neck 0.012959 0.009450 0.013024 0.016050 0.012853 0.012679 0.015234 0.007330 0.012859 0.011486 0.014992 0.015691
Bud Site 0.043579 0.012819 0.014493 0.057745 0.010324 0.012658 0.035380 0.032996 0.012042 0.012718 0.033097 0.056727
Cell Periphery 0.001749 0.000121 0.000164 0.000100 0.000070 0.000107 0.000323 0.000791 0.000157 0.000112 0.000305 0.000128
Cytoplasm 0.139890* 0.072461 0.142310* 0.332965* 0.104731* 0.081314 0.120288* 0.132298* 0.106548* 0.078043 0.122695* 0.324712*
Cytoplasmic Foci 0.152289 0.397041* 0.208793* 0.148074 0.295554* 0.340748* 0.326429* 0.328983* 0.288149* 0.361547* 0.313572* 0.155514
Eisosomes 0.000137 0.000164 0.000142 0.000062 0.000095 0.000195 0.000089 0.000310 0.000097 0.000184 0.000094 0.000072
Endoplasmic Reticulum 0.002210 0.001544 0.006122 0.002098 0.002579 0.001565 0.001923 0.001769 0.002560 0.001557 0.002382 0.002085
Endosome 0.094030 0.231853* 0.159781 0.042543 0.225448* 0.236961* 0.160132 0.129167 0.218655* 0.235074* 0.160094 0.046105
Golgi 0.016314 0.092788 0.006393 0.006034 0.037984 0.105738 0.033784 0.012720 0.036864 0.100953 0.030790 0.006309
Lipid Particles 0.009054 0.013331 0.029553 0.006305 0.014209 0.016933 0.017597 0.011674 0.013943 0.015602 0.018904 0.006525
Mitochondria 0.007016 0.017079 0.002323 0.003532 0.019184 0.037794 0.007628 0.006766 0.018555 0.030140 0.007048 0.003665
Mitotic Spindle 0.003704 0.003534 0.038705 0.068555 0.004904 0.004133 0.049423 0.029804 0.004842 0.003912 0.048252 0.066961
None 0.000240 0.000593 0.001306 0.001593 0.000541 0.000276 0.000314 0.000617 0.000525 0.000393 0.000423 0.001553
Nuclear Periphery 0.000932 0.000151 0.005228 0.001798 0.000341 0.000160 0.000830 0.000636 0.000372 0.000157 0.001310 0.001751
Nuclear Periphery Foci 0.001485 0.000342 0.012193 0.002410 0.000234 0.000335 0.001792 0.002473 0.000298 0.000338 0.002929 0.002413
Nucleolus 0.001630 0.000477 0.004296 0.001284 0.000773 0.000500 0.000827 0.000375 0.000817 0.000492 0.001206 0.001246
Nucleus 0.065756 0.002680 0.098082 0.058560 0.007210 0.003493 0.014214 0.018626 0.010236 0.003193 0.023380 0.056917
Peroxisomes 0.012696 0.016339 0.037386 0.023540 0.009029 0.015955 0.047622 0.068378 0.009218 0.016097 0.046503 0.025385
Vacuole 0.410681* 0.105677 0.213108* 0.221616* 0.233607* 0.107124 0.158420 0.209986* 0.242759* 0.106590 0.164397 0.221138*
Vacuole Periphery 0.016130 0.020598 0.005055 0.002551 0.020101 0.020644 0.003154 0.001232 0.019896 0.020627 0.003362 0.002497

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.99 0.86 0.83 -1.91 -0.29 -4.69 -5.90 -2.75 -2.09 2.12 -1.21 -5.32 -3.17 -2.89 3.45
Bud Neck 0.20 -0.70 -1.46 -4.57 -1.17 0.17 -2.77 5.68 4.86 7.35 1.34 -2.75 -2.16 -3.26 0.44
Bud Site 1.92 1.78 -0.21 -7.87 -5.46 -1.80 -8.43 -1.48 -1.24 0.78 -1.00 -7.72 -8.27 -8.08 -1.43
Cell Periphery 1.17 1.12 1.22 2.49 3.99 -4.21 -1.07 -1.14 -1.04 -0.51 0.35 -0.77 0.64 0.88 0.97
Cytoplasm 4.80 0.62 -7.71 -32.59 -11.52 5.29 -4.62 -2.15 -3.03 -1.18 7.51 -4.64 -28.48 -33.90 -23.08
Cytoplasmic Foci -17.62 -3.19 2.02 40.90 7.02 -7.28 -2.00 1.91 3.49 2.36 -13.45 -1.38 31.10 46.91 30.07*
Eisosomes -1.50 -0.99 3.86 4.97 7.59 -8.01 1.30 -0.97 -0.18 -1.03 -7.46 0.56 4.64 9.82 4.35
Endoplasmic Reticulum 1.60 -5.33 0.44 -2.57 6.29 2.57 1.61 1.15 -0.81 0.06 2.89 0.16 1.48 -2.67 2.15
Endosome -11.84 -3.67 3.81 36.14* 9.12 -2.08 14.20 8.01 8.66 3.23 -3.55 13.54 45.93* 54.39* 26.72*
Golgi -11.27 1.04 1.39 20.84 1.59 -17.41 3.72 8.52 20.72 6.10 -20.42 4.57 19.56 34.81 14.67
Lipid Particles -2.61 -4.94 1.55 6.15 6.14 -2.07 -2.90 1.58 2.52 2.80 -1.64 -4.29 11.11 10.62 13.53
Mitochondria -3.17 0.79 0.73 10.53 -0.52 -8.78 10.17 4.07 8.41 0.88 -7.22 10.54 15.59 20.89 7.39
Mitotic Spindle 0.44 -3.86 -11.23 -13.01 -1.46 0.66 -13.05 -1.99 -2.07 2.26 0.93 -13.57 -12.72 -13.19 -0.61
None -0.42 -2.38 -5.85 -2.80 -1.06 1.17 0.89 -0.75 -1.30 -1.18 0.55 0.37 -4.42 -5.60 -6.41
Nuclear Periphery 4.83 -4.43 -6.73 -12.55 2.47 2.41 -4.99 -3.31 -4.45 -0.05 3.11 -6.76 -11.16 -12.73 -5.28
Nuclear Periphery Foci 4.76 -5.45 -1.76 -8.05 5.14 -0.69 -8.33 -3.99 -3.74 -1.29 -0.27 -9.41 -8.57 -7.98 1.85
Nucleolus 2.59 -4.57 -0.61 -6.74 4.80 1.50 -1.21 1.51 0.13 2.72 2.07 -3.19 -4.30 -6.70 -1.35
Nucleus 5.10 -2.68 -1.84 -26.03 1.83 4.95 -7.20 -3.72 -4.30 -1.99 7.76 -8.36 -23.20 -25.99 -15.36
Peroxisomes -1.99 -3.59 -1.23 1.14 3.21 -5.80 -15.19 -3.07 -2.46 0.07 -7.14 -15.66 -4.23 0.41 11.06
Vacuole 12.25 6.90 5.01 -24.39 -4.54 20.67 6.92 -2.72 -6.05 -4.00 24.11 7.92 -7.70 -27.77 -14.39
Vacuole Periphery -1.43 1.06 1.49 14.82 1.91 -0.57 23.43 24.94 22.02 4.60 -1.03 21.20 23.20 25.53 4.11
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
Localization
Cell Percentages vacuole (51%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ynd1

Ynd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ynd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available