Standard name
Human Ortholog
Description Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.05 0 0.05 0 0.05 0 0.08 0.11 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.98 0.96 0.96 0.94 0.86 0.8 0.86 0.79 0.85 0.79 0.98 1.0 1.0 0.98 0.97 0.96 0.98 0.95 0.95 0.74 0.83 0.83
Endoplasmic Reticulum 0 0 0 0 0 0 0.11 0.15 0.08 0.09 0.07 0.09 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 7 8 7 6 12 21 0 0 0 0 0 0 0 0 1 5 7 4
Bud 0 0 0 0 3 0 1 2 3 1 3 7 0 1 0 0 0 0 0 0 1 9 10 11
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 14 16 6 17 18 28 15 33 68 49 0 1 1 6 6 12 0 0 0 1 0 0
Cytoplasm 185 214 428 327 258 346 375 442 304 313 510 458 107 219 221 363 344 285 182 212 427 155 277 208
Endoplasmic Reticulum 1 1 7 6 3 14 47 81 27 35 43 52 2 0 0 13 16 9 0 0 4 7 5 6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 0
Golgi 0 0 2 0 1 0 2 3 1 2 1 6 0 0 0 1 2 2 0 0 1 0 0 0
Mitochondria 0 0 0 1 1 0 0 1 9 5 5 10 0 0 0 5 0 1 0 1 3 8 6 3
Nucleus 0 3 2 0 4 0 1 2 0 1 0 4 0 0 0 2 2 0 1 3 2 1 1 2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 1
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 6 1 2 3 5 10 6 23 11 16 0 0 0 2 6 12 0 4 5 13 12 5
Unique Cell Count 186 218 438 340 270 368 435 550 353 394 602 580 109 219 221 369 355 297 187 225 450 210 334 250
Labelled Cell Count 188 219 459 351 278 381 456 577 372 419 653 623 109 221 222 392 376 321 187 225 450 210 334 250


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 28.2 19.2 26.4 26.4 22.7 27.7 26.3 28.4 24.5 25.2 26.6 24.2 27.7 27.1 26.8 24.1 30.0 32.3 22.0 24.6 24.3
Std Deviation (1e-4) 5.3 5.0 4.7 4.9 6.6 5.7 6.2 6.1 5.5 5.9 6.1 5.9 6.2 6.2 5.7 7.3 8.8 11.3 9.8 9.0 9.1
Intensity Change (Log2) – – – -0.0 -0.22 0.07 -0.01 0.1 -0.11 -0.07 0.01 -0.13 0.07 0.03 0.02 -0.13 0.18 0.29 -0.26 -0.1 -0.12

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700010203040WT3HU80HU120HU160010203040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3010203040WT1AF100AF140AF180010203040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 3.0 4.0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.1 -0.8 1.0 0.7 1.5 0.8 3.2 4.8 3.4 0 -2.2 -2.2 -1.4 -1.3 0.6
Cytoplasm -1.3 -1.6 -2.7 -6.3 -8.4 -6.2 -8.4 -7.0 -8.8 0.3 2.3 2.3 0.7 -0.7 -1.4
Endoplasmic Reticulum 0.2 0 2.0 5.6 7.2 4.2 4.8 4.1 5.0 0 0 0 1.8 2.4 1.3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 -0.3 0.6 0.4 3.5 0.6 1.5 0 0 0 0 0.4 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 23.0633 28.2075 27.5857 26.4828 20.1745 26.6803 27.5227 33.6295 30.1226 29.9306 26.7681 29.9137 21.6178 27.5484 25.7175 24.6741 25.6306 24.5964
Actin 0.0083 0.0001 0.0023 0.0454 0.0015 0.0006 0.0099 0.0001 0.0063 0.0002 0.0137 0.0004 0.0099 0.0002 0.0009 0.0002 0.0001 0.0009
Bud 0.0004 0.0001 0.0002 0.0004 0.0035 0.0002 0.0003 0 0.0006 0.0001 0.0007 0.0001 0.0013 0.0001 0.0002 0.0003 0.0001 0.0002
Bud Neck 0.0008 0.0001 0.0003 0.0004 0.0007 0.0007 0.0002 0.0001 0.0003 0.0016 0.0007 0.0005 0.0004 0.0001 0.0003 0.0002 0.0004 0.0005
Bud Periphery 0.0008 0 0.0001 0.0004 0.0019 0.0001 0.0002 0 0.0011 0 0.0011 0 0.0004 0 0 0.0001 0 0.0001
Bud Site 0.0024 0.0001 0.002 0.0006 0.0022 0.0001 0.0004 0 0.0006 0 0.0024 0.0001 0.0054 0.0001 0.0013 0.0001 0.0001 0.0001
Cell Periphery 0.0014 0 0.0001 0.0001 0.0003 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0 0 0 0
Cytoplasm 0.9011 0.9977 0.9836 0.9107 0.7879 0.9622 0.9436 0.9976 0.9735 0.9857 0.8832 0.9749 0.9347 0.995 0.9835 0.9708 0.9896 0.95
Cytoplasmic Foci 0.0057 0.0004 0.0028 0.0043 0.0532 0.0026 0.0045 0.0004 0.0018 0.0027 0.0172 0.0031 0.0083 0.0008 0.0037 0.0008 0.0021 0.005
Eisosomes 0.0018 0 0.0001 0.0002 0.0001 0 0.0001 0 0 0 0.0002 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0043 0.0003 0.0018 0.0012 0.0007 0.0028 0.0072 0.0005 0.0022 0.0033 0.0015 0.0021 0.0046 0.0005 0.0017 0.0034 0.0015 0.007
Endosome 0.0108 0.0001 0.0008 0.0086 0.0199 0.0027 0.0066 0.0001 0.0035 0.0035 0.0104 0.0027 0.0074 0.0004 0.0018 0.0026 0.0015 0.0145
Golgi 0.0031 0 0.0003 0.0088 0.0031 0.0005 0.0029 0 0.0011 0.0004 0.0091 0.0004 0.0015 0.0001 0.0002 0 0.0001 0.0014
Lipid Particles 0.0068 0 0.0017 0.0068 0.0064 0.0003 0.0034 0 0.0002 0 0.0143 0.0043 0.0019 0 0.0002 0 0 0.0012
Mitochondria 0.0199 0 0.0003 0.0026 0.0873 0.0217 0.0051 0 0.0015 0.0001 0.007 0.0005 0.0013 0 0.0001 0.0001 0 0.0011
None 0.0091 0.0001 0.0007 0.0008 0.0017 0.0002 0.0023 0.0001 0.0005 0.0001 0.0118 0.0003 0.0019 0.0002 0.0013 0.0002 0.0002 0.0005
Nuclear Periphery 0.0046 0.0003 0.0006 0.0011 0.0007 0.0009 0.0038 0.0003 0.0015 0.0004 0.0019 0.0011 0.0034 0.0005 0.0009 0.0066 0.0011 0.0103
Nucleolus 0.0009 0 0 0.0001 0.0013 0 0.0009 0 0 0 0.0003 0.0001 0.0002 0 0.0001 0 0 0
Nucleus 0.0059 0.0006 0.0011 0.0013 0.002 0.0021 0.0036 0.0006 0.0016 0.001 0.0015 0.0039 0.0053 0.0015 0.0017 0.0027 0.002 0.0035
Peroxisomes 0.0033 0 0.0004 0.0041 0.0052 0.0009 0.0011 0 0.0003 0 0.0148 0.0043 0.0017 0 0.0002 0 0 0.0001
Punctate Nuclear 0.0045 0 0.0004 0.0008 0.0006 0.0001 0.0009 0 0.0007 0 0.0067 0.0005 0.0051 0.0001 0.0008 0.0001 0.0001 0.0005
Vacuole 0.0033 0.0001 0.0004 0.0008 0.0153 0.0008 0.0019 0.0001 0.0019 0.0007 0.0009 0.0005 0.0043 0.0003 0.0008 0.0094 0.0011 0.0017
Vacuole Periphery 0.0011 0 0.0001 0.0005 0.0047 0.0003 0.0011 0 0.0006 0.0002 0.0005 0.0002 0.0006 0 0.0001 0.0023 0.0002 0.0014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 231.3177 238.2883 255.8793 239.7684 259.205 242.0766 241.5122 281.4466 295.458 249.2304
Translational Efficiency 1.4283 1.4938 1.437 1.8223 1.46 1.3133 1.6399 1.4571 1.4271 1.4361

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2196 1266 1972 1501 2256 2148 1567 1446 4452 3414 3539 2947

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1775.15 2066.26 3141.06 3175.30 1804.32 2124.46 3098.74 3357.79 1789.93 2102.88 3122.32 3264.84
Standard Deviation 289.45 352.13 513.80 610.54 292.32 347.36 524.20 637.39 291.27 350.27 518.86 630.49
Intensity Change Log 2 — 0.219081 0.823311 0.838952 — 0.235641 0.780226 0.896057 — 0.227452 0.801754 0.868020

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000102 0.000257 0.000060 0.000316 0.000081 0.000153 0.000064 0.000158 0.000091 0.000192 0.000062 0.000238
Bud Neck 0.000177 0.000559 0.000732 0.001179 0.000243 0.000244 0.001007 0.001742 0.000211 0.000361 0.000854 0.001455
Bud Site 0.004524 0.005256 0.001877 0.010792 0.003573 0.004867 0.002933 0.007141 0.004043 0.005011 0.002345 0.009001
Cell Periphery 0.000226 0.000366 0.001021 0.005711 0.000150 0.000194 0.000428 0.002063 0.000188 0.000258 0.000759 0.003921
Cytoplasm 0.950600 0.933863 0.909453 0.869559 0.937658 0.950337 0.877001 0.869478 0.944042 0.944228 0.895084 0.869519
Cytoplasmic Foci 0.017958 0.017186 0.004834 0.003650 0.017303 0.016035 0.004149 0.005432 0.017626 0.016462 0.004531 0.004525
Eisosomes 0.000001 0.000002 0.000001 0.000003 0.000001 0.000001 0.000001 0.000002 0.000001 0.000001 0.000001 0.000002
Endoplasmic Reticulum 0.000789 0.000387 0.000101 0.000079 0.000583 0.000493 0.000097 0.000088 0.000685 0.000454 0.000099 0.000083
Endosome 0.000616 0.001464 0.000384 0.000562 0.001176 0.001039 0.000577 0.000921 0.000900 0.001196 0.000470 0.000738
Golgi 0.006375 0.006948 0.004825 0.003263 0.006683 0.005333 0.003050 0.003468 0.006531 0.005932 0.004039 0.003363
Lipid Particles 0.001162 0.003044 0.002943 0.009048 0.000972 0.001484 0.001975 0.006615 0.001065 0.002062 0.002514 0.007854
Mitochondria 0.000095 0.000466 0.000070 0.000089 0.000149 0.000195 0.000069 0.000170 0.000123 0.000295 0.000070 0.000129
Mitotic Spindle 0.000829 0.003070 0.000967 0.000543 0.002742 0.002027 0.000444 0.001489 0.001799 0.002414 0.000736 0.001007
None 0.002052 0.001783 0.001786 0.001342 0.001279 0.001644 0.001365 0.001228 0.001660 0.001695 0.001599 0.001286
Nuclear Periphery 0.000017 0.000055 0.000147 0.000062 0.000048 0.000018 0.000117 0.000115 0.000032 0.000031 0.000134 0.000088
Nuclear Periphery Foci 0.001593 0.004905 0.003368 0.002353 0.001640 0.001808 0.002508 0.003548 0.001616 0.002956 0.002987 0.002939
Nucleolus 0.000034 0.000130 0.000069 0.000171 0.000042 0.000051 0.000155 0.000176 0.000038 0.000080 0.000107 0.000173
Nucleus 0.005169 0.011064 0.027883 0.016881 0.007941 0.006820 0.028289 0.022628 0.006574 0.008394 0.028063 0.019701
Peroxisomes 0.000072 0.000168 0.000016 0.000097 0.000046 0.000074 0.000028 0.000066 0.000059 0.000109 0.000021 0.000082
Vacuole 0.004882 0.007420 0.036610 0.071984 0.011200 0.005473 0.072290 0.070967 0.008084 0.006195 0.052408 0.071485
Vacuole Periphery 0.002726 0.001608 0.002853 0.002317 0.006490 0.001710 0.003453 0.002505 0.004633 0.001672 0.003118 0.002409

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.46 1.54 -3.30 -0.96 -3.58 -2.11 -1.02 -4.61 -1.53 -4.56 -4.22 0.01 -4.65 -1.85 -4.77
Bud Neck -6.40 -10.31 -12.83 -7.95 -2.56 0.07 -9.60 -10.16 -10.20 -2.87 -4.99 -13.79 -14.64 -13.23 -3.97
Bud Site -1.35 4.87 -5.41 -4.44 -7.39 -2.56 -1.04 -4.67 -3.14 -3.88 -2.56 2.63 -7.15 -5.57 -8.33
Cell Periphery -2.94 -6.10 -10.01 -9.70 -7.99 -1.08 -9.09 -10.48 -10.05 -8.40 -2.22 -7.95 -12.78 -12.47 -10.02
Cytoplasm 4.68 15.24 18.78 13.35 5.44 -3.52 17.60 18.63 21.26 1.74 0.35 22.71 26.30 25.26 5.41
Cytoplasmic Foci 0.20 11.63 12.66 10.73 2.35 0.94 10.52 9.89 9.47 -1.87 0.98 15.75 15.99 14.57 -0.02
Eisosomes -1.53 1.52 -5.24 -2.07 -7.36 -2.88 -4.80 -7.65 -5.10 -5.34 -2.34 -0.81 -8.69 -5.11 -9.18
Endoplasmic Reticulum 1.95 3.63 3.81 4.20 1.84 0.63 4.77 4.90 3.63 0.95 1.77 5.49 5.72 4.96 1.97
Endosome -3.69 1.43 0.19 3.32 -0.41 0.72 3.64 1.42 0.64 -1.10 -2.26 4.15 1.27 2.85 -1.18
Golgi -0.69 2.09 4.58 4.47 3.14 1.82 5.93 5.41 3.86 -0.79 1.11 5.32 6.96 5.62 2.70
Lipid Particles -4.85 -6.90 -10.02 -7.10 -6.59 -1.33 -4.77 -11.68 -10.92 -8.90 -3.81 -8.18 -14.86 -12.36 -10.20
Mitochondria -1.14 1.32 0.34 1.16 -0.69 -0.70 3.51 -0.33 0.37 -1.75 -1.35 3.67 -0.14 1.31 -1.90
Mitotic Spindle -2.90 -1.69 0.53 2.99 1.67 0.93 4.21 1.36 0.44 -1.93 -1.33 3.14 1.52 2.39 -0.80
None 0.57 0.66 1.55 2.41 2.73 -1.52 -0.06 0.57 2.17 0.50 -0.13 0.45 1.64 2.88 2.31
Nuclear Periphery -3.53 -12.35 -9.53 -2.30 7.85 3.56 -6.61 -6.88 -10.20 0.79 0.03 -13.15 -10.15 -10.57 5.44
Nuclear Periphery Foci -5.81 -6.55 -4.31 3.85 3.42 -0.53 -4.07 -6.63 -5.54 -2.76 -4.73 -7.65 -7.88 -1.16 0.64
Nucleolus -1.40 -6.11 -3.02 -0.60 -1.97 -0.47 -14.30 -5.47 -4.41 -0.33 -1.51 -14.18 -5.24 -2.68 -2.06
Nucleus -9.33 -20.05 -15.00 -7.95 6.72 2.09 -16.77 -16.20 -17.58 3.94 -5.35 -25.74 -21.89 -19.14 7.24
Peroxisomes -1.42 3.14 -0.97 1.16 -7.94 -2.76 1.65 -1.69 0.66 -2.72 -1.90 3.65 -1.74 1.17 -7.42
Vacuole -3.34 -16.46 -21.95 -20.68 -7.19 5.49 -20.12 -21.42 -23.30 -1.09 2.49 -25.44 -30.51 -31.33 -6.04
Vacuole Periphery 1.85 -0.27 0.95 -1.28 1.76 5.72 4.05 4.78 -0.58 1.67 5.63 3.23 4.58 -1.16 2.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Pro3

Pro3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pro3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available