Standard name
Human Ortholog
Description Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.31 0.33 0.31 0.29 0.42 0.34 0.26 0.21 0.21 0.2 0.22 0.17 0.23 0.28 0.48 0.45 0.49 0.43 0.24 0.18 0.16 0.37 0.57 0.71
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0.06 0 0 0 0 0 0
Endosome 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.06 0.08 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.6 0.15 0.32 0.43 0.41 0.7 0.78 0.71 0.78 0.79 0.8 0.85 0 0 0 0.06 0.07 0 0.09 0 0.09 0 0 0
Nucleus 0.15 0.36 0.31 0.28 0.2 0.16 0.19 0.27 0.23 0.24 0.2 0.2 0.72 0.66 0.36 0.27 0.2 0.17 0.27 0.44 0.31 0.2 0.08 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 0.09 0.1 0.09 0.07
Vac/Vac Membrane 0.08 0.26 0.1 0.09 0.09 0.06 0.06 0.06 0 0 0.06 0.07 0 0.08 0.15 0.21 0.21 0.35 0.21 0.18 0.18 0.18 0.11 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 0 1 3
Bud 1 1 3 4 10 14 11 17 11 17 17 9 0 0 0 1 0 0 3 7 7 6 5 5
Bud Neck 0 0 1 0 0 1 0 0 0 0 1 0 3 1 1 1 0 1 1 2 2 3 4 6
Bud Site 0 0 2 1 2 13 8 11 17 29 26 15 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 2 0 0 0 0 0 0 0 0
Cytoplasm 50 52 106 75 146 186 165 115 106 115 113 96 78 102 212 154 142 121 49 37 76 106 168 280
Endoplasmic Reticulum 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 24 18 16 0 0 4 1 1 1
Endosome 0 2 25 8 15 0 3 6 1 0 0 0 5 6 23 20 18 23 5 3 15 6 7 12
Golgi 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 1 0 0 0
Mitochondria 96 24 108 109 143 377 500 389 401 457 410 472 1 0 0 20 20 11 17 5 45 9 11 11
Nucleus 24 57 104 72 71 85 120 148 118 140 100 113 250 245 156 91 59 48 54 91 150 57 23 10
Nuclear Periphery 0 0 0 0 0 1 1 3 0 1 1 6 0 0 0 0 1 0 0 0 3 0 0 0
Nucleolus 0 0 0 0 1 1 3 3 4 10 2 3 0 1 0 1 1 0 1 4 19 4 2 1
Peroxisomes 0 0 0 0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 11 16 2 2 4 8 9 4 4 2 5 9 8 5 10 4 16 11 45 30 27 26
Vac/Vac Membrane 13 41 33 24 32 32 38 35 21 22 31 39 14 30 66 72 62 99 42 36 88 51 32 20
Unique Cell Count 160 159 338 255 348 541 643 550 511 579 511 555 345 369 439 339 291 284 204 208 492 290 298 397
Labelled Cell Count 185 178 393 310 423 713 854 735 688 797 705 756 357 395 467 393 332 323 204 208 492 290 298 397


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.3 4.4 3.9 3.8 3.8 3.2 3.1 3.3 3.0 3.1 2.6 2.8 5.6 5.8 5.4 6.0 5.4 5.6 5.4 5.6 5.4
Std Deviation (1e-4) 0.5 0.7 1.0 1.2 1.5 1.3 1.1 0.9 0.9 0.8 0.8 0.5 0.9 1.0 0.9 1.5 1.4 1.3 1.2 1.7 1.4
Intensity Change (Log2) – – – -0.04 -0.03 -0.26 -0.31 -0.25 -0.36 -0.35 -0.56 -0.46 0.54 0.57 0.46 0.63 0.48 0.53 0.47 0.53 0.48

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 4.1 4.0 7.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.7293 2.413 1.3183 0.8554 1.5197 1.3333 1.0049 0.1419 0.251 0.7255 0.2358 0.3551 -0.211 -0.1852 0.0558 0.7203 -0.2576 -0.0745
Actin 0.0481 0.0005 0.0025 0.0005 0.0004 0.0056 0.0486 0.0023 0.0054 0.0477 0.0212 0.0048 0.0097 0.0003 0.0093 0.0091 0.0001 0.0013
Bud 0.0097 0.0074 0.0055 0.0003 0.0001 0.0023 0.0011 0.0007 0.0004 0.0083 0.0087 0.0005 0.0003 0.0002 0.0002 0.0009 0 0.0001
Bud Neck 0.0064 0.001 0.0016 0.0019 0.0114 0.0182 0.011 0.0008 0.0011 0.0016 0.0012 0.0148 0.0017 0.0007 0.0007 0.004 0.0005 0.0025
Bud Periphery 0.0027 0.0011 0.0008 0.0004 0.0001 0.0022 0.0019 0.0007 0.0005 0.0186 0.0437 0.0008 0.0005 0.0002 0.0002 0.0023 0 0.0002
Bud Site 0.0444 0.009 0.0042 0.0016 0.0002 0.0018 0.017 0.0075 0.0024 0.0099 0.0022 0.0014 0.0036 0.0008 0.0011 0.0023 0.0001 0.0001
Cell Periphery 0.0007 0.0003 0.0001 0 0 0.0001 0.0006 0.0001 0.0001 0.0008 0.0006 0.0001 0.0003 0 0.0001 0.0003 0 0
Cytoplasm 0.0777 0.1448 0.0564 0.067 0.0621 0.0651 0.0896 0.1523 0.0826 0.1386 0.0745 0.0974 0.0871 0.091 0.0681 0.0614 0.0264 0.0554
Cytoplasmic Foci 0.0412 0.0153 0.0253 0.0101 0.0189 0.0039 0.0202 0.0049 0.005 0.006 0.004 0.0081 0.0203 0.0018 0.0103 0.0128 0.0075 0.0025
Eisosomes 0.0004 0.0001 0.0001 0 0.0001 0.0001 0.0006 0 0.0001 0.0001 0.0001 0.0001 0.0002 0 0.0001 0.0001 0 0.0001
Endoplasmic Reticulum 0.0127 0.005 0.0025 0.0012 0.0016 0.0011 0.006 0.003 0.0015 0.0039 0.002 0.0033 0.0048 0.0028 0.0027 0.0051 0.0007 0.0008
Endosome 0.057 0.0059 0.0065 0.0018 0.0543 0.0032 0.0248 0.0034 0.0042 0.0382 0.0034 0.0087 0.0118 0.0019 0.0072 0.0144 0.0014 0.0023
Golgi 0.0203 0.0006 0.0032 0.0007 0.001 0.0009 0.0086 0.0002 0.0007 0.0074 0.0005 0.0016 0.0021 0.0001 0.0022 0.0027 0.0005 0.0008
Lipid Particles 0.0254 0.0023 0.0161 0.001 0.0044 0.0013 0.0077 0.0003 0.0006 0.0012 0.0002 0.0052 0.0076 0.0001 0.0044 0.0019 0.0043 0.001
Mitochondria 0.0114 0.001 0.0017 0.0007 0.0013 0.0032 0.0168 0.0008 0.0139 0.0109 0.0015 0.0026 0.0031 0.0005 0.0053 0.0673 0.0001 0.0035
None 0.1209 0.2891 0.1919 0.172 0.2092 0.1057 0.1776 0.1938 0.1374 0.1612 0.1928 0.0502 0.1178 0.0934 0.0877 0.152 0.0468 0.0755
Nuclear Periphery 0.0356 0.0222 0.0226 0.0107 0.0152 0.0082 0.0409 0.0149 0.0104 0.0099 0.0062 0.0184 0.0218 0.0117 0.0143 0.0174 0.0087 0.0062
Nucleolus 0.009 0.0085 0.007 0.0083 0.0117 0.0137 0.0082 0.0052 0.0066 0.003 0.0101 0.0106 0.0076 0.0062 0.0067 0.0151 0.009 0.0106
Nucleus 0.3638 0.4153 0.566 0.6154 0.5421 0.6989 0.4544 0.5604 0.6854 0.449 0.5895 0.7016 0.631 0.7606 0.6885 0.576 0.7757 0.788
Peroxisomes 0.0106 0.0021 0.0115 0.0051 0.0007 0.0009 0.0055 0.0012 0.0009 0.0014 0.0001 0.0053 0.0069 0 0.0037 0.0051 0.0302 0.0003
Punctate Nuclear 0.0946 0.0645 0.0734 0.1003 0.0593 0.0627 0.0522 0.0437 0.0378 0.0694 0.0357 0.0618 0.0573 0.026 0.0855 0.0454 0.0876 0.0479
Vacuole 0.0049 0.0034 0.0008 0.0009 0.0049 0.0008 0.0044 0.0032 0.0027 0.0104 0.0015 0.0021 0.0035 0.0013 0.0014 0.0032 0.0004 0.0007
Vacuole Periphery 0.0024 0.0007 0.0003 0.0002 0.0011 0.0004 0.0023 0.0005 0.0005 0.0025 0.0004 0.0009 0.001 0.0003 0.0004 0.001 0.0001 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.777 8.3238 8.6473 6.5669 9.0545 7.445 9.6787 10.2247 8.0058 9.8018
Translational Efficiency 0.7859 0.9676 0.9185 0.6499 0.849 1.0391 0.7663 0.7878 0.781 0.9452

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1348 119 2105 40 1093 1572 1302 823 2441 1691 3407 863

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 644.75 792.90 815.25 766.91 682.49 702.49 833.44 807.76 661.65 708.85 822.20 805.87
Standard Deviation 77.60 98.10 96.55 101.50 80.13 84.40 103.24 111.83 80.95 88.51 99.55 111.70
Intensity Change Log 2 — 0.298399 0.338503 0.250317 — 0.041670 0.288270 0.243119 — 0.172093 0.312891 0.246620

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000140 0.001314 0.000272 0.001460 0.000098 0.000255 0.000752 0.000667 0.000121 0.000330 0.000455 0.000704
Bud Neck 0.003494 0.022096 0.008754 0.003303 0.002196 0.008676 0.005086 0.011422 0.002913 0.009620 0.007352 0.011045
Bud Site 0.001220 0.008764 0.006835 0.003760 0.001115 0.003724 0.002338 0.028697 0.001173 0.004078 0.005117 0.027542
Cell Periphery 0.000158 0.000204 0.000134 0.000174 0.000137 0.000186 0.000161 0.000207 0.000149 0.000187 0.000145 0.000206
Cytoplasm 0.242612 0.181597 0.079971 0.189470 0.278870 0.243372 0.075156 0.175541 0.258847 0.239024 0.078131 0.176186
Cytoplasmic Foci 0.052019 0.075583 0.001431 0.013763 0.043436 0.072311 0.003768 0.006906 0.048176 0.072542 0.002324 0.007223
Eisosomes 0.000054 0.000120 0.000023 0.000096 0.000045 0.000063 0.000042 0.000046 0.000050 0.000067 0.000030 0.000049
Endoplasmic Reticulum 0.001193 0.007060 0.003749 0.004694 0.001180 0.001737 0.003154 0.004329 0.001187 0.002112 0.003522 0.004346
Endosome 0.001580 0.014360 0.001200 0.003889 0.001761 0.005205 0.001197 0.004661 0.001661 0.005849 0.001199 0.004625
Golgi 0.000458 0.002229 0.000092 0.008363 0.000249 0.001350 0.000113 0.000473 0.000365 0.001412 0.000100 0.000839
Lipid Particles 0.006109 0.005757 0.000581 0.002963 0.003669 0.007479 0.001191 0.001118 0.005017 0.007358 0.000814 0.001203
Mitochondria 0.003571 0.008306 0.002386 0.002130 0.002015 0.007727 0.001328 0.007309 0.002874 0.007768 0.001982 0.007069
Mitotic Spindle 0.001660 0.009503 0.006314 0.003274 0.000611 0.006820 0.004871 0.025589 0.001190 0.007009 0.005763 0.024555
None 0.019411 0.004750 0.004353 0.002661 0.011145 0.011141 0.012532 0.008674 0.015710 0.010691 0.007479 0.008395
Nuclear Periphery 0.001782 0.001812 0.001828 0.001140 0.001118 0.002292 0.001427 0.002024 0.001485 0.002259 0.001674 0.001983
Nuclear Periphery Foci 0.000724 0.003260 0.000292 0.001282 0.000879 0.000943 0.000422 0.000939 0.000793 0.001106 0.000342 0.000955
Nucleolus 0.006339 0.007732 0.001617 0.003019 0.003434 0.007339 0.002718 0.001540 0.005038 0.007367 0.002038 0.001608
Nucleus 0.649056 0.557748 0.871988 0.710094 0.638104 0.595634 0.871658 0.668330 0.644152 0.592968 0.871862 0.670265
Peroxisomes 0.003053 0.015655 0.000488 0.004016 0.000870 0.007176 0.000842 0.001332 0.002076 0.007773 0.000623 0.001457
Vacuole 0.005067 0.067662 0.007402 0.038660 0.007675 0.015450 0.011079 0.047746 0.006235 0.019124 0.008807 0.047325
Vacuole Periphery 0.000301 0.004487 0.000291 0.001789 0.001390 0.001120 0.000165 0.002450 0.000789 0.001357 0.000243 0.002420

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.13 -5.15 -1.49 0.76 -1.13 -4.63 -3.40 -11.02 -7.50 0.14 -5.24 -4.88 -10.49 -5.30 -2.55
Bud Neck -3.54 -5.90 -1.25 3.05 2.22 -6.58 -4.52 -8.52 -1.34 -3.55 -6.83 -7.52 -7.96 -0.38 -1.72
Bud Site -4.36 -4.65 -1.82 2.65 1.45 -3.86 -2.83 -6.36 -5.15 -5.72 -4.87 -5.30 -6.41 -4.96 -4.75
Cell Periphery -1.38 2.65 0.44 1.44 -0.88 -1.89 -1.07 -0.89 1.17 -0.14 -1.64 1.82 -0.26 1.31 -1.39
Cytoplasm 3.35 23.66 2.61 0.40 -2.72 3.83 23.97 12.10 9.53 -10.06 2.95 33.64 12.55 9.28 -11.15
Cytoplasmic Foci -1.77 17.84 8.16 5.55 -1.95 -6.49 15.06 13.52 19.15 -2.49 -6.04 23.38 19.58 19.97 -4.37
Eisosomes -4.17 10.07 -2.00 0.79 -3.18 -5.18 -1.87 -5.80 -0.56 -3.62 -5.25 6.54 -5.12 0.07 -9.71
Endoplasmic Reticulum -3.88 -9.49 -4.41 0.63 -1.77 -4.64 -14.56 -15.21 -13.64 -5.43 -6.17 -14.75 -15.85 -12.33 -6.26
Endosome -2.58 2.29 -1.73 1.47 -1.98 -5.24 2.35 -1.68 2.86 -2.98 -6.33 3.30 -2.43 3.29 -3.63
Golgi -1.69 2.55 -0.90 -0.51 -1.00 -4.08 1.99 0.14 4.13 -1.78 -3.87 3.15 -0.19 3.11 -1.71
Lipid Particles 0.29 12.58 2.56 1.91 -2.78 -5.24 7.31 7.30 9.48 -0.33 -3.44 14.74 11.89 9.77 -4.98
Mitochondria -1.37 1.97 2.35 2.19 0.87 -4.98 1.09 -1.03 3.15 -1.89 -4.79 2.08 -0.28 3.36 -1.36
Mitotic Spindle -2.58 -3.66 -1.34 0.90 -0.04 -4.25 -3.94 -6.92 -5.30 -5.10 -4.33 -5.44 -6.86 -5.23 -5.46
None 8.06 9.23 10.13 2.31 3.44 -0.15 0.81 2.79 3.25 1.80 3.68 8.32 6.63 3.23 -0.77
Nuclear Periphery -0.45 -2.77 -1.69 -1.23 -0.77 -5.00 -5.54 -11.25 -6.11 -7.32 -3.36 -5.85 -9.91 -6.25 -7.59
Nuclear Periphery Foci -1.48 3.97 -1.52 -0.02 -1.74 -0.91 1.10 -2.46 -2.01 -3.38 -2.20 3.07 -3.18 -1.76 -4.21
Nucleolus -0.40 8.42 3.27 2.58 -0.21 -4.89 1.44 2.38 9.05 2.27 -3.96 6.75 7.28 9.42 1.43
Nucleus 3.08 -25.44 -0.12 -1.86 4.71 3.49 -20.64 0.94 -2.05 18.50 5.19 -32.98 1.40 -2.47 21.36
Peroxisomes -1.94 4.23 0.64 2.06 -0.96 -7.83 1.22 1.46 8.18 -0.05 -6.08 4.45 3.65 8.22 -1.09
Vacuole -5.63 -5.05 -4.05 -1.12 -3.89 -5.03 -6.90 -16.35 -15.16 -13.52 -8.64 -8.20 -17.15 -14.69 -15.72
Vacuole Periphery -1.79 0.98 -0.79 1.36 -0.87 0.38 1.67 0.55 0.37 -1.56 -1.23 1.75 -0.21 0.74 -1.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
Localization
Cell Percentages nucleus (71%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Mig3

Mig3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mig3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available