Standard name
Human Ortholog
Description Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.25 0.23 0.42 0.37 0.54 0.58 0.54 0.52 0.56 0.54 0.56 0.49 0.41 0.54 0.58 0.33 0.3 0.26 0.14 0.14 0.22 0.23 0.24 0.19
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.21 0.07 0.47 0.46 0.47 0.54 0.65 0.6 0.68 0.59 0.64 0.67 0 0 0 0.09 0 0 0.07 0 0.08 0.05 0 0.05
Nucleus 0.25 0.48 0.1 0.22 0 0.06 0 0 0 0.05 0 0 0.5 0.33 0.25 0.43 0.31 0.36 0.38 0.49 0.3 0.27 0.26 0.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Vac/Vac Membrane 0.48 0.32 0.16 0.07 0.13 0.05 0 0 0 0.05 0 0 0.12 0.14 0.2 0.25 0.39 0.34 0.27 0.21 0.29 0.37 0.32 0.37
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1
Bud 0 0 2 1 1 7 11 6 5 12 10 14 0 0 0 0 0 0 0 3 2 4 9 11
Bud Neck 0 0 0 0 0 1 0 2 0 4 1 2 1 6 1 0 0 0 0 0 0 2 3 5
Bud Site 0 0 0 1 0 4 2 4 1 4 6 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 1 1 0 0 0 0 1 0 1 0 0 1 0 0 0 0 0 0
Cytoplasm 26 33 77 82 132 258 323 317 261 274 248 257 89 167 229 32 37 28 19 23 51 47 65 63
Endoplasmic Reticulum 0 1 1 0 0 1 0 0 0 1 0 3 1 1 1 4 7 5 0 0 1 1 1 3
Endosome 2 4 6 1 3 0 0 2 0 0 0 0 1 1 5 1 6 4 5 5 4 1 6 4
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 1 2 1 0 0 2
Mitochondria 22 10 87 103 115 239 391 365 316 299 282 350 1 1 1 9 5 4 10 5 18 9 9 17
Nucleus 26 69 19 49 10 28 24 26 15 27 19 17 108 103 98 41 38 38 53 86 69 56 72 66
Nuclear Periphery 0 0 0 0 0 2 1 1 3 0 0 4 0 1 0 1 0 0 0 0 1 0 1 1
Nucleolus 0 1 0 2 0 0 2 2 2 0 1 1 0 1 0 0 0 1 0 1 0 0 1 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 0 0 3 4 1 0 1 5 1 8 2 4 0 2 0 1 0 0 4 5 7 2 10 20
Vac/Vac Membrane 49 46 29 16 31 21 21 14 7 24 16 9 25 43 80 24 47 36 37 36 66 77 90 120
Unique Cell Count 103 145 185 222 243 445 601 607 465 508 439 525 216 311 394 96 122 107 140 176 234 209 278 327
Labelled Cell Count 125 164 225 259 293 562 777 745 611 653 585 664 227 326 418 113 140 117 140 176 234 209 278 327


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 4.5 3.4 3.3 3.2 3.1 2.8 2.8 2.6 2.6 2.5 2.6 5.4 4.9 5.2 5.1 5.1 5.4 5.6 5.8 5.8
Std Deviation (1e-4) 0.9 0.8 0.8 1.5 1.3 1.1 1.6 1.2 1.2 1.1 1.1 1.0 1.5 1.3 1.4 1.0 0.9 1.3 1.6 1.8 2.2
Intensity Change (Log2) – – – -0.03 -0.08 -0.13 -0.27 -0.28 -0.4 -0.39 -0.43 -0.4 0.66 0.53 0.62 0.57 0.58 0.68 0.72 0.77 0.78


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.9 4.5 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.301 0.2089 0.0303 -0.7702 -0.5011 0.1098 0.8829 1.6799 1.5054 1.4427 0.9756 1.3537 -1.6989 -1.0478 -1.6265 -0.5612 -1.9105 -1.5186
Actin 0.0004 0.0002 0.0041 0.0005 0.0005 0.0004 0.0086 0.0001 0.0082 0.0003 0.0004 0.0005 0.0006 0.0002 0.0026 0.1617 0.0004 0.0005
Bud 0.0012 0.0001 0.0017 0 0.0011 0.0009 0.0002 0.0001 0.0002 0 0.0001 0.0001 0.0001 0 0.0005 0.0093 0.0001 0.0001
Bud Neck 0.0006 0.0004 0.0008 0.0005 0.0006 0.0068 0.0015 0.0007 0.0011 0.0004 0.0022 0.0056 0.0001 0.0002 0.0007 0.0199 0.0013 0.0026
Bud Periphery 0.0005 0.0001 0.0005 0 0.0009 0.0007 0.0003 0 0.0003 0 0.0001 0.0001 0.0001 0 0.0005 0.0113 0.0001 0.0001
Bud Site 0.0012 0.0007 0.0006 0.0001 0.0007 0.0002 0.0023 0.0021 0.0004 0.0001 0.0003 0.0001 0.0005 0.0004 0.001 0.0895 0.0001 0.0001
Cell Periphery 0.0001 0 0.0001 0 0.0001 0.0001 0.0002 0.0001 0.0001 0 0 0 0.0001 0.0001 0.0001 0.0019 0 0.0001
Cytoplasm 0.1197 0.1011 0.074 0.045 0.0912 0.089 0.1347 0.1199 0.0946 0.1147 0.1607 0.1065 0.2166 0.2344 0.1569 0.0179 0.0693 0.2305
Cytoplasmic Foci 0.0062 0.0051 0.0085 0.002 0.0043 0.0042 0.0048 0.0017 0.0043 0.0008 0.0039 0.0035 0.0165 0.0279 0.0143 0.0382 0.0004 0.003
Eisosomes 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0004 0 0.0003 0.0002 0 0.0001 0.0002 0.0001 0.0002 0.0012 0 0.0001
Endoplasmic Reticulum 0.0017 0.0025 0.0012 0.0006 0.0009 0.0011 0.0035 0.0033 0.0033 0.0017 0.004 0.0021 0.0044 0.0041 0.0046 0.0012 0.004 0.0034
Endosome 0.0026 0.0051 0.0034 0.0013 0.0012 0.0015 0.0047 0.0023 0.0051 0.0008 0.0038 0.0025 0.0583 0.0072 0.02 0.0364 0.0024 0.0022
Golgi 0.0001 0.0001 0.0005 0.0001 0.0001 0.0001 0.0008 0 0.0012 0 0.0001 0.0001 0.0063 0.001 0.0092 0.0473 0 0.0001
Lipid Particles 0.0004 0.0004 0.0012 0.0005 0.0003 0.0004 0.0016 0.0002 0.002 0 0.0003 0.0004 0.0053 0.008 0.0007 0.0254 0 0.0001
Mitochondria 0.0007 0.0008 0.001 0.0007 0.0007 0.0007 0.0009 0.0006 0.0021 0.0009 0.0011 0.0006 0.0009 0.0003 0.0317 0.0145 0.0008 0.0006
None 0.4627 0.412 0.366 0.3382 0.5554 0.3307 0.3565 0.246 0.3845 0.3506 0.2297 0.2939 0.4804 0.3861 0.2243 0.0014 0.0033 0.2493
Nuclear Periphery 0.0148 0.0207 0.0157 0.0108 0.0131 0.0088 0.0181 0.0209 0.0165 0.0283 0.018 0.0077 0.0186 0.0097 0.0143 0.0023 0.0681 0.0106
Nucleolus 0.0044 0.0067 0.0067 0.0095 0.0054 0.0069 0.005 0.0045 0.0059 0.0018 0.0093 0.0061 0.0047 0.0015 0.0061 0.0022 0.0048 0.0033
Nucleus 0.3415 0.3952 0.4474 0.5273 0.2733 0.4809 0.4129 0.5775 0.4302 0.4764 0.5208 0.536 0.1529 0.3048 0.4676 0.4827 0.8059 0.4659
Peroxisomes 0.0002 0.0002 0.0016 0.0002 0.0002 0.0001 0.0028 0 0.0014 0 0.0002 0.0002 0.001 0.0035 0.0002 0.0254 0 0.0001
Punctate Nuclear 0.0397 0.0463 0.0639 0.0619 0.0491 0.0657 0.0375 0.0171 0.0363 0.0221 0.0426 0.0327 0.0295 0.008 0.039 0.0034 0.0366 0.0259
Vacuole 0.0011 0.0019 0.0008 0.0005 0.0007 0.0007 0.0021 0.0024 0.0017 0.0005 0.002 0.001 0.0023 0.002 0.0041 0.0054 0.0015 0.0014
Vacuole Periphery 0.0003 0.0004 0.0003 0.0002 0.0002 0.0002 0.0004 0.0004 0.0005 0.0003 0.0004 0.0002 0.0007 0.0002 0.0017 0.0014 0.0008 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.7007 4.9496 6.8209 5.756 1.5383 12.6485 4.8258 4.8253 7.8081 7.9899
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1395 1322 1638 1180 1570 1039 144 2068 2965 2361 1782 3248

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 650.46 757.34 845.20 863.77 632.00 692.87 982.04 895.70 640.69 728.97 856.26 884.10
Standard Deviation 77.94 443.31 104.31 117.01 115.75 89.09 112.07 110.42 100.19 338.46 111.39 113.90
Intensity Change Log 2 — 0.219481 0.377832 0.409187 — 0.132660 0.635857 0.503091 — 0.177348 0.510752 0.456227

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000056 0.000320 0.000336 0.000623 0.000060 0.000253 0.000837 0.000812 0.000058 0.000290 0.000377 0.000743
Bud Neck 0.002211 0.009169 0.004192 0.011891 0.004969 0.013007 0.002850 0.011872 0.003671 0.010858 0.004084 0.011879
Bud Site 0.000781 0.003998 0.002252 0.016519 0.002068 0.006297 0.000888 0.013903 0.001463 0.005010 0.002141 0.014853
Cell Periphery 0.000129 0.000160 0.000082 0.000186 0.000371 0.000195 0.000136 0.000139 0.000257 0.000175 0.000086 0.000156
Cytoplasm 0.347461* 0.244558* 0.051239 0.120451* 0.338348* 0.258364* 0.017777 0.104105* 0.342636* 0.250634* 0.048535 0.110044*
Cytoplasmic Foci 0.086042 0.079045 0.000551 0.005056 0.081153 0.125371 0.000747 0.003218 0.083453 0.099432 0.000567 0.003886
Eisosomes 0.000059 0.000060 0.000016 0.000039 0.000541 0.000095 0.000055 0.000023 0.000314 0.000076 0.000019 0.000029
Endoplasmic Reticulum 0.000699 0.002042 0.004361 0.005696 0.001798 0.001065 0.013147 0.004515 0.001281 0.001612 0.005071 0.004944
Endosome 0.002016 0.003184 0.000485 0.006801 0.002437 0.004573 0.000920 0.003754 0.002239 0.003795 0.000520 0.004861
Golgi 0.000566 0.001595 0.000045 0.004178 0.001203 0.002558 0.000056 0.001132 0.000903 0.002019 0.000046 0.002238
Lipid Particles 0.007342 0.006858 0.000330 0.001116 0.009005 0.009328 0.001231 0.000975 0.008223 0.007945 0.000403 0.001027
Mitochondria 0.002762 0.009098 0.001129 0.005180 0.005585 0.016723 0.000620 0.005514 0.004257 0.012453 0.001088 0.005393
Mitotic Spindle 0.001047 0.003429 0.001079 0.027374 0.001474 0.005025 0.000187 0.018898 0.001273 0.004131 0.001007 0.021977
None 0.010559 0.009964 0.003879 0.010643 0.024564 0.007206 0.002367 0.007052 0.017975 0.008750 0.003757 0.008356
Nuclear Periphery 0.000784 0.001700 0.001164 0.002119 0.000972 0.001106 0.001518 0.002241 0.000883 0.001439 0.001193 0.002197
Nuclear Periphery Foci 0.000832 0.000655 0.000399 0.000819 0.001106 0.000774 0.001236 0.000485 0.000977 0.000707 0.000466 0.000606
Nucleolus 0.002491 0.003857 0.000763 0.001354 0.003464 0.004338 0.001465 0.001372 0.003006 0.004069 0.000819 0.001365
Nucleus 0.522599* 0.598407* 0.921017* 0.739074* 0.508351* 0.512921* 0.935146* 0.800778* 0.515055* 0.560787* 0.922159* 0.778361*
Peroxisomes 0.002524 0.005930 0.000245 0.000627 0.002477 0.014366 0.000247 0.000629 0.002499 0.009642 0.000245 0.000628
Vacuole 0.008798 0.014996 0.006290 0.038029 0.009442 0.015512 0.018453 0.016879 0.009139 0.015223 0.007273 0.024563
Vacuole Periphery 0.000241 0.000976 0.000148 0.002226 0.000610 0.000922 0.000117 0.001704 0.000436 0.000952 0.000146 0.001894

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.01 -8.03 -11.38 -3.16 -4.51 -3.23 -6.88 -3.49 -2.56 1.86 -2.99 -9.82 -5.25 -3.23 -2.06
Bud Neck -5.45 -5.67 -8.28 -2.61 -5.60 -5.23 -0.84 -9.44 -1.33 -5.42 -7.23 -3.49 -13.11 -3.26 -9.81
Bud Site -3.64 -3.02 -6.31 -3.97 -4.96 -2.87 -0.69 -5.79 -2.48 -5.38 -4.25 -1.95 -8.49 -4.69 -7.04
Cell Periphery -2.67 5.37 -0.92 1.26 -4.40 3.55 4.14 5.84 3.33 1.60 3.09 6.91 5.54 3.98 -4.18
Cytoplasm 10.58 39.59 30.35 19.26 -7.84 8.09 39.14 34.48 20.26 -11.39 13.35 55.45 46.17 28.40 -11.72
Cytoplasmic Foci 1.61 22.88 22.19 19.77 -4.79 -6.91 24.24 23.84 22.80 -2.82 -3.65 33.41 32.56 29.89 -6.32
Eisosomes -0.02 13.44 2.80 2.58 -12.01 3.74 3.70 4.30 13.98 4.82 3.78 4.58 4.39 13.41 -5.29
Endoplasmic Reticulum -7.27 -18.09 -19.41 -15.38 -7.33 1.93 -8.22 -8.84 -14.02 6.01 -1.68 -15.19 -18.24 -19.25 -1.68
Endosome -3.23 7.84 -1.80 -0.27 -3.85 -4.07 0.76 0.31 3.69 -0.40 -5.02 9.42 -1.10 2.45 -5.28
Golgi -2.01 2.76 -1.28 0.09 -2.04 -1.84 2.74 1.41 3.10 -2.77 -2.51 3.72 -0.06 2.30 -3.09
Lipid Particles 0.63 8.65 7.73 10.28 -4.15 -0.36 7.11 8.92 11.50 2.80 0.39 12.57 11.82 15.45 -2.69
Mitochondria -4.25 2.05 -0.44 4.05 -2.84 -3.81 3.69 1.25 4.86 -5.27 -5.24 3.91 0.75 6.23 -5.04
Mitotic Spindle -1.83 -1.70 -6.72 -5.75 -6.00 -2.12 -0.86 -7.19 -4.70 -2.25 -2.76 -1.82 -9.89 -7.60 -8.08
None 0.39 7.41 2.32 1.61 -3.46 6.39 8.47 6.87 0.90 -5.83 5.67 9.77 7.35 2.20 -5.45
Nuclear Periphery -6.18 -8.33 -18.25 -10.55 -14.26 -1.36 -5.06 -13.64 -12.12 -3.37 -5.70 -8.58 -21.06 -14.61 -15.56
Nuclear Periphery Foci 1.53 -0.25 -1.34 -2.93 -0.68 -0.05 -1.54 0.51 0.28 1.64 0.68 -0.47 -0.49 -1.02 0.23
Nucleolus -1.42 4.38 2.08 3.92 -2.82 -0.74 0.84 0.02 0.63 -0.75 -1.36 6.54 0.58 1.66 -4.07
Nucleus -6.50 -44.46 -20.88 -13.64 17.04 -0.25 -22.19 -31.28 -25.84 4.84 -5.32 -60.14 -37.86 -28.35 20.44
Peroxisomes -3.63 5.23 5.13 7.04 -0.58 -7.42 6.43 6.42 8.95 0.08 -8.15 8.13 7.98 11.26 -0.87
Vacuole -5.15 -1.15 -13.33 -11.43 -12.68 -4.89 -4.26 -10.10 -6.64 1.73 -6.95 -3.05 -16.61 -12.82 -12.78
Vacuole Periphery -6.26 2.70 -2.91 0.17 -3.27 -1.20 1.85 -0.88 0.00 -2.69 -3.48 2.24 -2.14 0.13 -3.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
Localization
Cell Percentages nucleus (28%), cytoplasm (5%), mixed (52%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Kre29

Kre29


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kre29-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available