Standard name | |
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Human Ortholog | |
Description | Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | – | 0 | 0 | 1 | 1 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 4 | 4 |
Bud Neck | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Bud Site | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 2 | – | 1 | 1 | 0 | 0 | – | 1 | 2 | – | 1 | 0 | 2 | 1 | 3 | 8 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 392 | 612 | – | 30 | 93 | 77 | 145 | – | 116 | 75 | – | 16 | 391 | 818 | 720 | 293 | 300 | 272 | 376 | 600 | 37 | 516 | 656 | 572 |
Endoplasmic Reticulum | 2 | 4 | – | 0 | 0 | 0 | 0 | – | 2 | 1 | – | 0 | 1 | 4 | 2 | 3 | 9 | 4 | 1 | 1 | 0 | 1 | 3 | 1 |
Endosome | 1 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 3 | 1 | 0 | 3 | 2 | 3 |
Golgi | 3 | 1 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 0 | 1 | 0 |
Mitochondria | 1 | 0 | – | 0 | 2 | 17 | 5 | – | 22 | 31 | – | 10 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 1 | 0 | 1 | 2 | 1 |
Nucleus | 1 | 8 | – | 5 | 1 | 3 | 3 | – | 4 | 6 | – | 0 | 0 | 1 | 3 | 1 | 6 | 4 | 0 | 4 | 0 | 2 | 1 | 2 |
Nuclear Periphery | 0 | 0 | – | 1 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | – | 1 | 0 | 0 | 0 | – | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | – | 1 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 1 |
Vac/Vac Membrane | 4 | 2 | – | 3 | 15 | 17 | 42 | – | 19 | 28 | – | 4 | 0 | 4 | 3 | 22 | 16 | 23 | 1 | 6 | 0 | 4 | 1 | 2 |
Unique Cell Count | 400 | 619 | 35 | 103 | 103 | 186 | 154 | 123 | 25 | 392 | 825 | 723 | 304 | 310 | 293 | 396 | 626 | 40 | 536 | 683 | 600 | |||
Labelled Cell Count | 404 | 629 | 42 | 112 | 115 | 196 | 164 | 144 | 31 | 392 | 830 | 729 | 324 | 341 | 309 | 396 | 626 | 40 | 536 | 683 | 600 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 9.2 | 8.0 | – | 11.6 | 9.6 | 6.3 | 9.3 | – | 7.7 | 7.0 | – | 7.3 | 8.4 | 8.6 | 8.6 | 23.0 | 22.9 | 20.4 | 6.8 | 7.0 | 7.2 |
Std Deviation (1e-4) | 1.5 | 1.4 | – | 20.5 | 1.3 | 1.5 | 5.3 | – | 1.9 | 1.6 | – | 1.7 | 1.5 | 1.6 | 1.5 | 5.5 | 5.7 | 5.0 | 1.1 | 1.3 | 1.6 |
Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.3454 | 5.4505 | 5.0486 | 4.3345 | 4.8453 | 4.6614 | 6.5694 | 7.8872 | 7.6556 | 7.0068 | 6.4431 | 7.3554 | 8.5401 | 10.6475 | 9.3152 | 9.2543 | 8.0328 | 9.7738 |
Actin | 0.0041 | 0.0001 | 0.0007 | 0.0012 | 0.0005 | 0.0003 | 0.0109 | 0.0027 | 0.0058 | 0.0004 | 0.0176 | 0.0012 | 0.0233 | 0.0193 | 0.0051 | 0.0523 | 0.0023 | 0.0042 |
Bud | 0.0004 | 0.0001 | 0.0003 | 0.0092 | 0.0025 | 0.0001 | 0.0012 | 0.0053 | 0.0013 | 0.0003 | 0.0004 | 0.0015 | 0.0003 | 0.0001 | 0.0004 | 0.0012 | 0.0002 | 0.0002 |
Bud Neck | 0.0013 | 0.0002 | 0.0009 | 0.0015 | 0.0008 | 0.0062 | 0.0012 | 0.0003 | 0.0006 | 0.0008 | 0.0009 | 0.0014 | 0.0009 | 0.0002 | 0.0012 | 0.0009 | 0.0004 | 0.0009 |
Bud Periphery | 0.0002 | 0 | 0.0001 | 0.0059 | 0.0013 | 0 | 0.0008 | 0.0034 | 0.0012 | 0.0001 | 0.0003 | 0.0008 | 0.0003 | 0.0001 | 0.0003 | 0.0011 | 0.0003 | 0.0001 |
Bud Site | 0.0011 | 0.0005 | 0.0003 | 0.0008 | 0.0008 | 0.0001 | 0.0024 | 0.0025 | 0.0003 | 0.0006 | 0.0007 | 0.0003 | 0.001 | 0.0004 | 0.001 | 0.002 | 0.0002 | 0.0001 |
Cell Periphery | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0004 | 0.0001 | 0.0001 | 0 |
Cytoplasm | 0.9067 | 0.9629 | 0.9477 | 0.9342 | 0.939 | 0.9251 | 0.861 | 0.9275 | 0.9358 | 0.8917 | 0.8591 | 0.8701 | 0.9031 | 0.9582 | 0.933 | 0.8429 | 0.9096 | 0.9425 |
Cytoplasmic Foci | 0.0088 | 0.0025 | 0.0035 | 0.0076 | 0.0047 | 0.005 | 0.0117 | 0.0052 | 0.0044 | 0.0061 | 0.0165 | 0.0111 | 0.008 | 0.0024 | 0.0102 | 0.0144 | 0.0026 | 0.0045 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0039 | 0.0014 | 0.0033 | 0.0023 | 0.0027 | 0.0029 | 0.0049 | 0.0014 | 0.0016 | 0.0013 | 0.003 | 0.0017 | 0.0031 | 0.0014 | 0.0029 | 0.0014 | 0.0066 | 0.002 |
Endosome | 0.012 | 0.001 | 0.0024 | 0.0026 | 0.0023 | 0.0054 | 0.0173 | 0.0023 | 0.0021 | 0.0028 | 0.0172 | 0.0066 | 0.0063 | 0.0008 | 0.002 | 0.0106 | 0.0102 | 0.0042 |
Golgi | 0.0024 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0034 | 0.0004 | 0.0003 | 0.0031 | 0.0043 | 0.0031 | 0.0016 | 0.0005 | 0.0012 | 0.0037 | 0.0008 | 0.0017 |
Lipid Particles | 0.0009 | 0 | 0 | 0 | 0.0001 | 0 | 0.0015 | 0.0008 | 0.0001 | 0.0002 | 0.0057 | 0.0001 | 0.0016 | 0.0001 | 0.0008 | 0.0002 | 0.0004 | 0.0003 |
Mitochondria | 0.0017 | 0.0001 | 0.0002 | 0.0006 | 0.0002 | 0.0002 | 0.0188 | 0.0156 | 0.0147 | 0.0472 | 0.006 | 0.0465 | 0.002 | 0.0002 | 0.0009 | 0.0247 | 0.003 | 0.0014 |
None | 0.0276 | 0.0091 | 0.0194 | 0.0124 | 0.0047 | 0.017 | 0.0212 | 0.0055 | 0.0089 | 0.0093 | 0.0277 | 0.0156 | 0.0139 | 0.0058 | 0.0145 | 0.0065 | 0.0024 | 0.0052 |
Nuclear Periphery | 0.0053 | 0.0013 | 0.0028 | 0.0021 | 0.0026 | 0.0032 | 0.0075 | 0.0019 | 0.002 | 0.0019 | 0.0042 | 0.0026 | 0.0084 | 0.0011 | 0.0012 | 0.0015 | 0.03 | 0.0043 |
Nucleolus | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0001 | 0 | 0 | 0.0004 | 0.0001 | 0.0002 | 0 | 0 | 0.0002 | 0.0002 | 0.0001 |
Nucleus | 0.0187 | 0.0188 | 0.0157 | 0.0133 | 0.0344 | 0.0312 | 0.029 | 0.0173 | 0.0175 | 0.0302 | 0.0181 | 0.031 | 0.0126 | 0.0078 | 0.0137 | 0.0241 | 0.0251 | 0.025 |
Peroxisomes | 0.0005 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.002 | 0.0058 | 0.0005 | 0.0002 | 0.0061 | 0.0023 | 0.0021 | 0.0002 | 0.0093 | 0.0083 | 0.0001 | 0.0006 |
Punctate Nuclear | 0.0025 | 0.0009 | 0.0017 | 0.0038 | 0.0017 | 0.0018 | 0.0023 | 0.0009 | 0.0022 | 0.0027 | 0.0097 | 0.0032 | 0.0098 | 0.0009 | 0.0012 | 0.0022 | 0.001 | 0.002 |
Vacuole | 0.0013 | 0.0007 | 0.0008 | 0.0014 | 0.0014 | 0.0011 | 0.0018 | 0.0009 | 0.0005 | 0.0006 | 0.0014 | 0.0007 | 0.0007 | 0.0003 | 0.0005 | 0.0014 | 0.002 | 0.0006 |
Vacuole Periphery | 0.0003 | 0.0001 | 0.0001 | 0.0003 | 0.0002 | 0.0002 | 0.0007 | 0.0001 | 0.0001 | 0.0004 | 0.0005 | 0.0002 | 0.0006 | 0 | 0.0001 | 0.0005 | 0.0024 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 81.5128 | 49.7631 | 39.564 | 79.037 | 37.3764 | 41.7273 | 48.9677 | 46.6944 | 50.6474 | 49.9952 |
Translational Efficiency | 2.5516 | 2.8322 | 3.6028 | 1.909 | 2.874 | 4.4093 | 2.1512 | 2.1959 | 2.6769 | 2.2224 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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