Standard name
Human Ortholog
Description Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.06 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.94 0.14 0.72 0.6 0.66 – 0.46 0.49 0.36 0.48 0.18 0.37 0.49 0.83 0.89 0.94 0.94 0.91 0.86 0.88 0.82 0.76
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0.09 0.07 – 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.16 0.14 – 0.33 0.34 0.55 0.36 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0.73 0.11 0.09 0.05 – 0.15 0.16 0.12 0.21 0.69 0.49 0.37 0 0 0 0 0 0 0 0.06 0.06
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.14 0.21 0.19 0.17 – 0.17 0.15 0.13 0.1 0.17 0.15 0.13 0.21 0.12 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 1 2 0 0 0
Bud 3 2 0 1 0 1 5 – 4 3 6 4 0 0 0 0 0 0 0 1 1 0 4 9
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2
Bud Site 0 0 0 0 0 0 0 – 0 2 2 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 5 9 0 2 0 2 – 1 0 0 1 0 0 0 4 8 4 0 0 0 0 0 0
Cytoplasm 156 332 146 25 158 143 185 – 111 127 118 143 22 56 85 89 121 98 150 316 141 49 114 137
Endoplasmic Reticulum 0 2 3 1 0 0 0 – 0 0 0 2 0 0 2 8 2 4 2 2 4 0 0 2
Endosome 0 2 0 7 8 21 20 – 9 11 8 4 5 4 8 1 0 0 1 4 1 0 0 1
Golgi 1 0 2 0 0 0 0 – 0 0 0 0 0 0 0 3 2 1 0 0 0 0 0 0
Mitochondria 4 0 0 0 1 38 40 – 79 87 179 108 0 1 0 0 1 0 1 0 2 1 2 1
Nucleus 1 0 4 134 25 22 15 – 37 41 38 63 84 75 65 1 3 2 0 3 1 2 8 11
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 1 0 0 0 1 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 2 0 0 0 – 2 2 3 2 1 3 0 0 0 1 0 0 0 0 0 2
Peroxisomes 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 1 0 0 2 – 2 2 2 4 0 1 1 0 0 0 0 1 0 0 2 4
Vac/Vac Membrane 0 5 3 26 45 46 47 – 42 39 44 29 21 23 23 23 16 7 0 8 2 0 1 3
Unique Cell Count 161 340 155 183 219 240 279 242 259 326 299 122 152 174 107 136 104 161 346 164 56 139 181
Labelled Cell Count 166 349 168 197 239 271 317 287 314 401 364 133 163 185 129 153 117 161 346 164 56 139 181


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 9.9 8.5 8.5 7.7 5.9 5.9 – 5.2 5.1 4.6 4.7 8.7 8.5 7.5 11.7 11.9 11.4 – 8.2 8.4
Std Deviation (1e-4) 0.9 1.4 1.4 2.0 1.7 1.4 1.5 – 1.6 1.3 1.0 1.1 1.4 1.8 1.5 2.4 2.4 2.1 – 1.2 1.7
Intensity Change (Log2) – – – 0.0 -0.15 -0.53 -0.52 – -0.69 -0.73 -0.88 -0.84 0.04 -0.0 -0.17 0.47 0.49 0.42 – -0.04 -0.01


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 -0.8 0 -0.7
Cytoplasm -14.8 -5.4 -7.6 -6.5 – -9.8 -9.4 -11.9 -9.7 -12.9 -10.6 -9.0 -2.9 -1.6 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 3.8 3.4 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.2 4.9 – 7.9 8.1 0 0 0 0 0 0 0 0
Nucleus 13.2 3.1 2.6 1.4 – 4.1 4.2 3.3 5.3 11.8 9.4 7.7 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 4.0 5.3 5.1 4.7 – 4.7 4.3 4.0 3.1 4.5 4.2 3.8 5.2 3.4 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.6476 1.7378 1.4725 1.5875 0.909 1.9452 2.1842 2.8272 2.5393 1.9228 1.9376 2.4551 3.1166 3.827 3.1413 3.5667 3.1434 3.4802
Actin 0.0454 0.0012 0.0034 0.0001 0.0073 0.0055 0.0103 0.0008 0.0126 0.0037 0.006 0.0006 0.0102 0.001 0.0034 0.04 0.0381 0.004
Bud 0.0017 0.0047 0.0018 0.0004 0.0007 0.0014 0.0019 0.004 0.0065 0.0002 0.0058 0.0015 0.0038 0.0044 0.0049 0.0032 0.0006 0.002
Bud Neck 0.0036 0.0008 0.001 0.0011 0.0043 0.0059 0.0079 0.0013 0.0021 0.0011 0.0016 0.0043 0.0029 0.001 0.0024 0.0097 0.0029 0.0083
Bud Periphery 0.0017 0.0015 0.0011 0.0003 0.0011 0.0011 0.0012 0.0013 0.0032 0.0001 0.0024 0.0008 0.0052 0.0022 0.0021 0.0037 0.0007 0.0018
Bud Site 0.0061 0.0071 0.0017 0.0004 0.0007 0.0011 0.0055 0.0252 0.0046 0.0005 0.0017 0.0007 0.0046 0.0099 0.0042 0.009 0.0012 0.0015
Cell Periphery 0.0005 0.0003 0.0001 0.0002 0.0002 0.0001 0.0005 0.0002 0.0005 0.0001 0.0001 0.0001 0.0006 0.0002 0.0002 0.0024 0.0001 0.0001
Cytoplasm 0.5342 0.6442 0.6103 0.6451 0.5547 0.5876 0.4884 0.4786 0.5243 0.5479 0.3666 0.5499 0.5182 0.6125 0.5857 0.4877 0.4333 0.4494
Cytoplasmic Foci 0.023 0.014 0.0101 0.0817 0.0175 0.0096 0.0351 0.008 0.0134 0.0481 0.0465 0.0107 0.0264 0.0109 0.0133 0.0168 0.0179 0.0069
Eisosomes 0.0009 0 0 0 0.0001 0 0.0001 0 0.0001 0.0002 0.0001 0 0.0002 0 0 0.0003 0.0005 0
Endoplasmic Reticulum 0.0079 0.0089 0.005 0.0032 0.0034 0.0058 0.009 0.0029 0.0035 0.003 0.005 0.003 0.0045 0.0018 0.0033 0.0087 0.0057 0.0021
Endosome 0.0251 0.008 0.016 0.0419 0.0661 0.0124 0.0241 0.0031 0.0081 0.0111 0.0288 0.0069 0.0202 0.0049 0.0149 0.0193 0.0252 0.0077
Golgi 0.0116 0.0009 0.0093 0.0013 0.032 0.0049 0.0039 0.0002 0.0038 0.0042 0.0175 0.0002 0.005 0.0004 0.0024 0.0108 0.0067 0.0034
Lipid Particles 0.0082 0.0006 0.0013 0.0092 0.0171 0.0068 0.0144 0.0001 0.0049 0.0061 0.0393 0.0001 0.008 0.0001 0.0048 0.0044 0.0222 0.005
Mitochondria 0.0102 0.0004 0.0102 0.0003 0.0317 0.0146 0.0027 0.0008 0.004 0.001 0.0216 0.0006 0.0045 0.0005 0.0023 0.0052 0.0048 0.0025
None 0.0391 0.0477 0.064 0.0059 0.0664 0.0141 0.068 0.1466 0.0717 0.0908 0.0457 0.039 0.0276 0.0323 0.0243 0.0267 0.054 0.0141
Nuclear Periphery 0.0186 0.0128 0.015 0.0068 0.0097 0.0173 0.0114 0.0054 0.0071 0.0052 0.0184 0.0091 0.0076 0.0047 0.0064 0.0107 0.0311 0.0064
Nucleolus 0.0018 0.0013 0.001 0.0012 0.0117 0.0041 0.0022 0.0018 0.0041 0.0046 0.0022 0.0031 0.0042 0.0021 0.0019 0.0026 0.0054 0.0034
Nucleus 0.2124 0.2291 0.2258 0.1671 0.1639 0.2926 0.2739 0.283 0.2891 0.2288 0.3231 0.3441 0.3092 0.2925 0.2954 0.3116 0.3058 0.4665
Peroxisomes 0.0116 0.0027 0.0014 0.0021 0.0012 0.0023 0.0151 0.0003 0.0077 0.0362 0.0303 0.0002 0.0154 0.0008 0.0042 0.0109 0.0076 0.0026
Punctate Nuclear 0.0225 0.0076 0.0159 0.0016 0.0021 0.007 0.0171 0.0338 0.0177 0.0051 0.0317 0.0212 0.0126 0.0138 0.0177 0.008 0.0321 0.0088
Vacuole 0.012 0.0056 0.0043 0.0254 0.0051 0.0048 0.0063 0.0022 0.01 0.0015 0.0043 0.0028 0.008 0.0035 0.0051 0.007 0.003 0.003
Vacuole Periphery 0.0019 0.0005 0.001 0.0048 0.0029 0.001 0.0011 0.0003 0.001 0.0003 0.0012 0.001 0.0011 0.0005 0.001 0.0014 0.001 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.7478 22.5401 23.9978 26.0016 26.2954 23.0091 21.0563 23.2401 21.3822 26.4608
Translational Efficiency 1.0061 1.0368 0.8789 0.6495 0.977 0.8369 0.8926 0.796 0.983 0.9209

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1623 807 103 1569 1671 2446 1789 177 3294 3253 1892 1746

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 816.40 839.18 1386.57 1271.61 898.25 932.15 1226.21 1244.23 857.92 909.09 1234.94 1268.83
Standard Deviation 120.25 156.00 179.23 184.11 122.09 139.44 168.86 166.72 127.91 149.23 173.30 182.61
Intensity Change Log 2 — 0.039704 0.764172 0.639308 — 0.053445 0.449017 0.470064 — 0.046919 0.607672 0.553126

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000773 0.000550 0.000811 0.000709 0.000190 0.000264 0.000331 0.000223 0.000477 0.000335 0.000358 0.000660
Bud Neck 0.003438 0.010677 0.002278 0.004882 0.002289 0.011028 0.001548 0.005484 0.002855 0.010941 0.001588 0.004943
Bud Site 0.008748 0.022293 0.011321 0.022888 0.005305 0.008723 0.005046 0.013911 0.007002 0.012089 0.005387 0.021978
Cell Periphery 0.000137 0.000180 0.000222 0.000134 0.000091 0.000126 0.000059 0.000097 0.000114 0.000139 0.000068 0.000130
Cytoplasm 0.710226* 0.582588* 0.512469* 0.615212* 0.716361* 0.558254* 0.794107* 0.623168* 0.713338* 0.564291* 0.778775* 0.616019*
Cytoplasmic Foci 0.063972 0.165927 0.060746 0.011116 0.103201 0.037565 0.015415 0.038970 0.083872 0.069408 0.017883 0.013940
Eisosomes 0.000020 0.000054 0.000038 0.000008 0.000022 0.000018 0.000008 0.000018 0.000021 0.000027 0.000009 0.000009
Endoplasmic Reticulum 0.001082 0.001877 0.002354 0.000465 0.001609 0.001495 0.000706 0.000286 0.001349 0.001589 0.000795 0.000447
Endosome 0.004395 0.024544 0.014000 0.001924 0.007523 0.005761 0.001752 0.013042 0.005982 0.010421 0.002418 0.003051
Golgi 0.001514 0.004550 0.000396 0.001624 0.001999 0.001339 0.000250 0.005019 0.001760 0.002136 0.000258 0.001969
Lipid Particles 0.000977 0.003036 0.002865 0.000751 0.001284 0.001101 0.000419 0.000730 0.001133 0.001581 0.000552 0.000749
Mitochondria 0.001636 0.003551 0.000051 0.002144 0.001556 0.002083 0.000149 0.006527 0.001596 0.002447 0.000144 0.002588
Mitotic Spindle 0.001494 0.005491 0.001609 0.039307 0.003022 0.018853 0.004779 0.041878 0.002269 0.015538 0.004607 0.039568
None 0.012735 0.005029 0.000379 0.009889 0.004320 0.011275 0.004738 0.010229 0.008466 0.009726 0.004501 0.009924
Nuclear Periphery 0.000133 0.000304 0.000466 0.000458 0.000228 0.000823 0.000270 0.000275 0.000181 0.000695 0.000281 0.000440
Nuclear Periphery Foci 0.001396 0.002812 0.013315 0.001847 0.001824 0.001257 0.002794 0.002294 0.001613 0.001643 0.003367 0.001893
Nucleolus 0.001207 0.001836 0.000129 0.000213 0.000762 0.005973 0.000199 0.000158 0.000981 0.004947 0.000196 0.000208
Nucleus 0.156066* 0.078787 0.026251 0.248764* 0.104181 0.303484* 0.102775 0.028775 0.129746 0.247741* 0.098609 0.226463*
Peroxisomes 0.000785 0.004910 0.000390 0.000598 0.000613 0.000955 0.000448 0.005529 0.000698 0.001936 0.000444 0.001098
Vacuole 0.028182 0.078781 0.349352* 0.036869 0.042444 0.028367 0.064051 0.193920 0.035417 0.040874 0.079583 0.052790
Vacuole Periphery 0.001080 0.002222 0.000559 0.000198 0.001177 0.001257 0.000155 0.009467 0.001130 0.001496 0.000177 0.001138

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.43 -0.01 0.52 0.31 0.83 -3.57 -0.99 -0.70 2.55 0.66 0.39 0.71 -0.14 -1.83 -1.94
Bud Neck -5.91 1.04 -2.26 4.39 -3.53 -13.89 -0.05 -0.38 9.77 -0.29 -13.97 0.90 -3.43 8.92 -3.59
Bud Site -6.08 -2.66 -1.19 4.77 1.42 -4.54 0.71 -2.41 0.28 -2.69 -5.86 2.20 -2.62 1.29 -3.89
Cell Periphery -1.47 -2.01 0.16 1.92 2.27 -2.97 4.33 0.57 2.89 -2.14 -1.79 3.93 -1.16 0.75 -6.30
Cytoplasm 10.26 8.65 20.09 5.62 -1.72 18.15 -2.06 9.88 2.24 10.76 21.51 -0.56 24.43 4.14 23.12
Cytoplasmic Foci -14.69 1.46 20.96 24.36 8.71 16.82 24.52 15.44 1.97 -4.27 4.76 28.43 31.73 24.12 6.49
Eisosomes -9.55 -5.10 3.32 11.22 6.42 0.80 9.82 0.27 -0.33 -6.74 -5.88 9.86 4.84 10.42 -6.19
Endoplasmic Reticulum -3.26 -2.07 1.02 4.20 2.52 -0.41 4.68 7.60 11.76 3.06 -2.92 3.79 4.19 8.09 -0.59
Endosome -9.24 -5.27 7.77 11.14 8.34 2.17 8.45 2.95 1.66 -1.36 -5.23 8.66 10.92 12.76 3.45
Golgi -2.67 4.60 3.37 3.69 -0.19 1.83 6.53 1.70 0.56 -1.24 -0.79 8.19 4.72 4.00 -1.26
Lipid Particles -5.50 -5.60 -1.07 5.33 5.47 0.79 7.97 -0.13 -0.78 -4.89 -2.31 4.84 -0.30 2.21 -6.05
Mitochondria -1.27 2.37 0.88 1.89 -3.26 -0.74 1.96 0.34 0.96 -1.01 -1.38 2.93 1.04 3.02 -3.00
Mitotic Spindle -2.49 -1.02 -8.51 -5.91 -6.31 -7.73 -2.84 -1.90 0.56 -1.31 -8.60 -3.96 -8.37 -2.10 -6.04
None 5.34 11.25 3.24 -3.69 -18.34 -9.17 -0.82 -1.23 2.57 -1.04 -1.60 6.46 -0.21 1.58 -8.17
Nuclear Periphery -4.98 -6.72 -22.01 -13.79 -6.29 -11.32 -8.49 -5.11 2.98 -1.57 -12.93 -12.25 -21.21 -5.38 -11.94
Nuclear Periphery Foci -3.34 -5.30 -1.25 2.87 5.17 1.04 -2.57 -0.87 -1.96 1.46 -0.81 -5.78 -0.58 0.37 6.01
Nucleolus -1.88 5.07 3.32 4.42 -3.75 -9.98 2.98 4.12 11.37 1.52 -9.95 4.55 4.11 11.52 -0.66
Nucleus 8.58 14.87 -14.53 -22.98 -29.63 -24.45 -3.27 4.01 22.04 6.33 -18.38 1.18 -17.98 -0.33 -18.95
Peroxisomes -5.97 1.94 3.34 7.00 2.56 -3.37 2.01 -0.50 0.02 -0.90 -6.32 2.42 3.14 8.20 0.02
Vacuole -11.30 -13.79 -20.77 -7.96 9.69 5.13 -12.38 -14.23 -14.81 -11.85 -3.29 -17.54 -22.77 -21.03 -6.94
Vacuole Periphery -3.50 4.70 7.43 7.25 5.89 -0.03 4.76 -0.28 -0.28 -0.99 -1.32 7.63 4.44 4.87 -0.75
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages cytoplasm (79%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Dot6

Dot6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dot6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available