Standard name
Human Ortholog
Description Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.08 0.15 0.14 0.16 0.2 0.17 0.25 – 0.23 0.23 0.25 0.18 0.25 0.27 0.35 0.11 0.12 0.14 0.05 0.08 0 0.06 0.05 0.05
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.07 0 0.06 0.06 0 0.05 0 – 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.16 0.31 0 0.09 0.27 0.24 0.3 – 0.72 0.6 0.64 0.62 0 0 0 0.06 0 0 0 0 0 0 0.05 0
Nucleus 0.64 0.57 0.75 0.64 0.52 0.51 0.44 – 0.23 0.23 0.24 0.26 0.7 0.68 0.5 0.82 0.81 0.82 0.48 0.54 0.59 0.51 0.39 0.33
Nuclear Periphery 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.11 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.07 0.05 0.08 0.07 0 – 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0.07 0.15 0.19
Vac/Vac Membrane 0.07 0.1 0 0.07 0.11 0.1 0.07 – 0.08 0.08 0.07 0.07 0.05 0 0.13 0.05 0.06 0 0.28 0.18 0.17 0.2 0.2 0.2
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 1 2 7
Bud 0 0 0 1 0 1 3 – 14 3 4 5 0 0 0 0 0 0 5 4 3 13 12 25
Bud Neck 0 0 3 2 3 0 3 – 3 3 0 0 0 1 0 0 0 0 1 1 0 2 4 8
Bud Site 3 0 0 2 1 2 3 – 13 4 9 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 1 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 19 46 34 36 35 41 73 – 90 55 63 34 154 206 299 57 54 58 16 30 11 40 37 39
Endoplasmic Reticulum 0 2 0 1 0 0 1 – 0 0 0 6 1 0 1 16 10 9 0 0 2 2 4 3
Endosome 16 2 15 13 1 12 11 – 3 1 2 1 6 10 44 6 8 3 14 10 5 13 32 42
Golgi 0 0 1 0 0 0 0 – 0 0 0 0 0 1 0 2 1 2 3 1 1 5 2 4
Mitochondria 38 95 2 20 47 59 87 – 279 142 162 119 4 3 4 32 11 6 5 13 12 29 38 29
Nucleus 154 177 186 144 91 123 127 – 88 55 60 50 427 517 434 435 361 346 159 202 200 339 290 261
Nuclear Periphery 13 1 0 0 0 1 0 – 0 1 1 1 0 0 1 2 3 1 1 0 1 2 4 4
Nucleolus 27 0 0 1 0 2 0 – 3 1 1 0 0 1 1 3 1 1 9 11 11 23 27 28
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 2
SpindlePole 3 3 17 11 14 17 11 – 10 8 9 5 6 20 9 5 5 6 13 24 19 49 114 146
Vac/Vac Membrane 18 32 11 16 20 24 20 – 30 18 17 13 28 34 111 26 27 19 91 69 58 131 148 155
Unique Cell Count 242 308 249 224 174 242 289 386 238 253 191 609 763 860 532 446 424 332 378 340 672 751 791
Labelled Cell Count 292 358 269 248 212 282 339 533 291 328 236 627 793 907 584 481 451 332 378 340 672 751 791


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 3.8 5.6 5.2 4.5 4.6 4.3 – 3.5 3.8 3.7 3.7 5.7 5.7 5.4 5.6 7.2 6.7 6.2 6.3 6.5
Std Deviation (1e-4) 0.8 0.6 1.2 1.4 1.2 1.2 1.2 – 1.4 0.8 1.2 0.7 1.3 1.4 1.4 1.1 1.6 1.3 1.5 1.8 1.7
Intensity Change (Log2) – – – -0.12 -0.31 -0.29 -0.4 – -0.67 -0.55 -0.62 -0.62 0.01 0.03 -0.04 -0.01 0.36 0.25 0.14 0.17 0.2

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 0.3 0.9 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.7344 4.1359 4.0219 3.3829 3.9863 3.7352 3.1707 2.7462 2.7554 2.3951 1.75 2.8099 -0.4389 0.1583 0.0592 0.1054 -0.1915 0.0235
Actin 0.0472 0.0014 0.0169 0.0046 0.0119 0.0069 0.0317 0.0008 0.0013 0.041 0.0007 0.0166 0.045 0.0001 0.0227 0.0046 0.0322 0.0001
Bud 0.0012 0.0019 0.0065 0.0002 0.0004 0.0001 0.001 0.0001 0.0002 0.0003 0.0001 0.0003 0.0007 0.0001 0.0016 0.0012 0.0007 0.0001
Bud Neck 0.007 0.003 0.0025 0.0008 0.0023 0.0038 0.0044 0.0002 0.0008 0.0004 0.001 0.0033 0.0013 0.0006 0.0007 0.0026 0.0019 0.0037
Bud Periphery 0.0021 0.0008 0.0041 0.0002 0.0007 0.0004 0.0017 0.0001 0.0002 0.0008 0.0001 0.0009 0.0012 0 0.0011 0.0012 0.0014 0.0001
Bud Site 0.0151 0.0066 0.0086 0.0008 0.0017 0.0004 0.0071 0.0005 0.0013 0.0006 0.0002 0.0004 0.0031 0.001 0.0099 0.0286 0.006 0.0002
Cell Periphery 0.0006 0.0002 0.0011 0 0.0002 0.0001 0.0004 0.0001 0.0001 0.0001 0 0.0001 0.0004 0.0001 0.0002 0.0004 0.0005 0
Cytoplasm 0.0406 0.0444 0.05 0.0321 0.0188 0.031 0.0765 0.1222 0.1085 0.1208 0.0492 0.0471 0.1051 0.1121 0.0921 0.1014 0.0591 0.0918
Cytoplasmic Foci 0.0234 0.0058 0.0093 0.0137 0.0223 0.0027 0.0436 0.0088 0.0222 0.0087 0.0021 0.0014 0.03 0.0011 0.0144 0.0269 0.0424 0.0015
Eisosomes 0.0008 0.0003 0.0006 0 0.0003 0.0001 0.0005 0.0001 0.0001 0.0005 0 0.0002 0.0005 0.0001 0.0003 0 0.0012 0
Endoplasmic Reticulum 0.0061 0.0016 0.0041 0.0007 0.0026 0.0009 0.0059 0.0037 0.0032 0.0023 0.0023 0.0008 0.0087 0.0026 0.0018 0.0057 0.0027 0.0013
Endosome 0.0188 0.0035 0.0192 0.0084 0.0254 0.0017 0.0618 0.0113 0.0305 0.0049 0.0183 0.0016 0.022 0.0009 0.0046 0.007 0.0331 0.0013
Golgi 0.0084 0.0012 0.0154 0.0049 0.0142 0.0006 0.0289 0.002 0.0114 0.0078 0.0004 0.0007 0.0081 0 0.0035 0.0015 0.0073 0
Lipid Particles 0.0213 0.0137 0.01 0.0098 0.0446 0.0022 0.029 0.0017 0.0143 0.0086 0.0011 0.0004 0.0162 0.0001 0.0086 0.0025 0.0206 0.0002
Mitochondria 0.021 0.0145 0.0194 0.0014 0.0341 0.008 0.0115 0.0021 0.0029 0.0773 0.0009 0.0084 0.0126 0.0004 0.0025 0.0014 0.021 0.0004
None 0.1166 0.159 0.1704 0.1267 0.0835 0.1211 0.1965 0.4509 0.2624 0.348 0.325 0.2169 0.0934 0.1982 0.2086 0.0584 0.108 0.0592
Nuclear Periphery 0.0264 0.0099 0.012 0.0157 0.0246 0.0057 0.0163 0.006 0.0112 0.0418 0.0327 0.0168 0.0262 0.0104 0.0105 0.0329 0.0166 0.0064
Nucleolus 0.0064 0.0225 0.0067 0.0059 0.0069 0.0195 0.009 0.0017 0.0109 0.0026 0.0058 0.0092 0.0049 0.0067 0.0052 0.0038 0.0048 0.0068
Nucleus 0.555 0.645 0.5743 0.6835 0.6311 0.7343 0.3912 0.3743 0.456 0.2997 0.5319 0.6435 0.5631 0.6385 0.571 0.6765 0.5523 0.7997
Peroxisomes 0.0125 0.0074 0.0057 0.0046 0.0207 0.0017 0.0219 0.0019 0.0025 0.0216 0.0002 0.0008 0.0089 0 0.012 0.0065 0.0548 0
Punctate Nuclear 0.0639 0.0553 0.0603 0.0854 0.0508 0.0574 0.0485 0.0099 0.0583 0.0103 0.0249 0.0296 0.0419 0.0257 0.0272 0.0322 0.0303 0.0258
Vacuole 0.0039 0.0016 0.002 0.0005 0.0018 0.0011 0.0096 0.0014 0.0012 0.0012 0.002 0.0006 0.0048 0.0011 0.0012 0.004 0.0021 0.001
Vacuole Periphery 0.0017 0.0005 0.0009 0.0002 0.0012 0.0004 0.0029 0.0003 0.0005 0.0008 0.0012 0.0005 0.0017 0.0002 0.0003 0.0007 0.0011 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.387 17.9341 11.5335 12.4965 13.8726 16.0406 16.3198 17.1341 13.6288 12.6569
Translational Efficiency 0.5445 0.6102 1.0399 0.9068 0.7107 0.8998 0.7413 0.927 0.9885 0.8347

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
66 1447 2797 1699 1795 2425 1488 488 1861 3872 4285 2187

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 559.74 758.77 820.12 879.76 644.53 824.48 800.35 936.28 641.52 799.92 813.25 892.37
Standard Deviation 118.42 86.34 104.01 129.28 77.95 95.55 102.82 135.59 81.26 97.54 104.02 132.82
Intensity Change Log 2 — 0.438906 0.551078 0.652353 — 0.355237 0.312384 0.538693 — 0.394730 0.428253 0.592637

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000142 0.000474 0.000428 0.000870 0.000050 0.000151 0.000283 0.001255 0.000053 0.000272 0.000377 0.000956
Bud Neck 0.003002 0.009968 0.025374 0.026488 0.001905 0.009999 0.016126 0.013383 0.001944 0.009988 0.022162 0.023564
Bud Site 0.001261 0.005334 0.003444 0.005332 0.000856 0.004067 0.003831 0.002698 0.000871 0.004541 0.003578 0.004744
Cell Periphery 0.000333 0.000178 0.000091 0.000142 0.000106 0.000149 0.000245 0.000173 0.000114 0.000160 0.000145 0.000149
Cytoplasm 0.129131 0.112811 0.010111 0.012993 0.205795 0.122076 0.029760 0.010799 0.203076 0.118614 0.016934 0.012503
Cytoplasmic Foci 0.055652 0.028380 0.000173 0.000858 0.019806 0.021097 0.001129 0.000567 0.021077 0.023818 0.000505 0.000793
Eisosomes 0.001948 0.000049 0.000017 0.000024 0.000027 0.000032 0.000024 0.000030 0.000095 0.000039 0.000019 0.000026
Endoplasmic Reticulum 0.000877 0.004817 0.003977 0.007886 0.000652 0.001761 0.002553 0.008007 0.000660 0.002903 0.003482 0.007913
Endosome 0.001575 0.004327 0.000416 0.001815 0.000614 0.002781 0.000895 0.001208 0.000648 0.003359 0.000582 0.001680
Golgi 0.001305 0.002167 0.000095 0.001959 0.000160 0.000854 0.000157 0.000385 0.000200 0.001344 0.000117 0.001608
Lipid Particles 0.006352 0.007032 0.000106 0.000296 0.002481 0.004589 0.000319 0.000273 0.002618 0.005502 0.000180 0.000291
Mitochondria 0.001173 0.009783 0.002060 0.003206 0.000906 0.011199 0.002820 0.001878 0.000916 0.010670 0.002324 0.002910
Mitotic Spindle 0.017759 0.016039 0.003140 0.022124 0.000694 0.009263 0.009264 0.012139 0.001300 0.011795 0.005267 0.019896
None 0.051046 0.009115 0.003321 0.008978 0.017888 0.008072 0.007481 0.014902 0.019064 0.008462 0.004766 0.010300
Nuclear Periphery 0.000453 0.004427 0.001825 0.003220 0.001195 0.003275 0.001604 0.001155 0.001169 0.003705 0.001748 0.002759
Nuclear Periphery Foci 0.007049 0.002612 0.000273 0.001425 0.000351 0.000653 0.000228 0.003016 0.000588 0.001385 0.000258 0.001780
Nucleolus 0.020426 0.011729 0.004397 0.007313 0.003291 0.008027 0.005564 0.012780 0.003899 0.009411 0.004802 0.008533
Nucleus 0.692677 0.755149 0.938545 0.888246 0.740659 0.782588 0.913648 0.908863 0.738957 0.772334 0.929899 0.892847
Peroxisomes 0.003821 0.005792 0.000087 0.000176 0.000510 0.003749 0.000495 0.000328 0.000628 0.004512 0.000229 0.000210
Vacuole 0.003876 0.008662 0.001870 0.005183 0.001958 0.004954 0.003104 0.005360 0.002026 0.006340 0.002299 0.005223
Vacuole Periphery 0.000142 0.001154 0.000250 0.001463 0.000097 0.000665 0.000471 0.000803 0.000099 0.000848 0.000327 0.001316

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.66 -4.95 -11.58 -10.15 -12.71 -4.21 -9.95 -14.03 -13.28 -11.61 -8.39 -18.91 -26.69 -20.99 -17.63
Bud Neck -5.60 -16.64 -16.17 -12.47 -0.47 -10.89 -13.58 -13.53 -6.56 -0.33 -13.94 -24.79 -22.61 -14.40 -1.47
Bud Site -2.96 -2.32 -4.10 -0.25 -2.29 -4.53 -3.62 -5.91 -1.01 -0.50 -5.77 -5.36 -7.74 -1.28 -2.19
Cell Periphery 1.45 2.37 2.00 2.98 -4.39 -3.66 -3.41 -2.41 -0.52 1.17 -4.07 -1.06 -1.81 2.37 -0.47
Cytoplasm 0.47 4.31 4.31 22.77 -0.11 12.39 30.15 33.02 28.00 6.20 13.58 33.65 34.70 37.88 5.40
Cytoplasmic Foci 2.14 4.17 4.14 13.94 -1.88 -0.61 13.60 14.31 15.63 1.84 -1.32 14.76 14.64 20.74 -0.40
Eisosomes 1.13 1.15 1.14 6.15 -9.78 -1.67 0.74 -4.36 -3.94 -6.29 0.89 1.24 0.96 1.91 -10.97
Endoplasmic Reticulum -11.20 -13.85 -20.80 -10.24 -12.02 -7.77 -12.35 -13.22 -11.48 -9.37 -15.78 -25.87 -28.92 -19.91 -15.91
Endosome -2.47 1.62 0.63 4.98 -3.20 -6.51 -0.92 -1.51 4.09 -0.73 -8.95 1.01 -2.53 6.07 -2.96
Golgi -0.32 1.30 0.54 1.42 -1.57 -2.97 0.19 -2.10 1.94 -2.50 -4.04 1.06 -1.45 0.97 -1.69
Lipid Particles -0.44 3.74 3.63 11.94 -4.74 -3.84 6.46 6.06 9.64 -1.25 -6.03 7.38 6.94 15.12 -3.86
Mitochondria -7.55 -2.72 -5.45 5.65 -4.92 -8.78 -3.51 -6.67 7.26 0.44 -11.57 -6.50 -10.36 8.52 -3.16
Mitotic Spindle 0.00 0.90 -0.68 -2.20 -6.44 -6.01 -4.61 -5.36 -3.48 -3.44 -7.60 -5.42 -9.59 -4.78 -7.08
None 2.29 2.60 2.40 1.91 -4.91 5.61 6.50 2.58 -1.32 -2.05 5.96 8.52 6.05 0.74 -4.46
Nuclear Periphery -10.19 -10.12 -12.07 -0.25 -5.96 -5.29 -2.44 -4.69 2.69 -0.87 -8.59 -5.56 -10.05 -0.82 -6.18
Nuclear Periphery Foci 0.84 1.46 0.77 -0.27 -3.76 -2.36 0.90 -2.51 -2.21 -2.58 -3.67 0.33 -4.40 -2.67 -4.58
Nucleolus 1.58 2.18 0.59 -3.29 -5.68 -5.74 -4.03 -6.75 -4.85 -4.80 -7.69 -5.86 -10.58 -6.33 -7.28
Nucleus -1.54 -5.67 -4.31 -12.73 9.76 -4.37 -21.29 -11.42 -8.45 3.97 -3.69 -25.97 -16.33 -15.65 10.14
Peroxisomes -0.50 1.83 1.77 7.51 -4.03 -7.37 0.47 0.14 7.35 -0.39 -9.51 3.27 2.97 10.90 -1.13
Vacuole -3.14 0.45 -2.24 1.63 -5.66 -6.06 -2.22 -4.04 -1.79 -2.78 -8.79 -2.69 -8.19 -0.95 -6.18
Vacuole Periphery -4.71 -1.32 -1.51 0.82 -1.31 -6.19 -2.65 -2.13 0.67 -0.60 -7.71 -3.68 -1.91 0.40 -1.32
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF
Localization
Cell Percentages nucleus (85%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Slx8

Slx8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Slx8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available