Standard name
Human Ortholog
Description Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.07 0 0 0 0 0 0 0 0 0 0 0.09 0.07 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.07 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.08 0 0 0 0 0 0 0 0 0.06 0.06 0.1 0.17 0.15 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.06 0 0 0 0 0 0 0 0 0 0 0.19 0.12 0.08 0 0 0.05 0 0 0 0 0 0
Endosome 0.06 0 0.12 0.13 0.12 0 0 0 0 0 0 0 0.06 0.08 0.17 0.23 0.31 0.19 0.07 0.09 0.07 0.08 0.05 0.05
Golgi 0.49 0.4 0.34 0.17 0.15 0 0 0 0 0 0 0 0.52 0.52 0.42 0.33 0.31 0.49 0.83 0.75 0.77 0.63 0.72 0.76
Mitochondria 0.83 0.87 0.81 0.79 0.81 0.95 0.96 0.91 0.97 0.97 0.96 0.96 0.4 0.31 0.21 0.08 0.1 0.08 0.05 0.09 0.05 0.16 0.11 0.07
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.05 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0 0 0 0 0 0 0 0 0 0 0 0.06 0.12 0.24 0.12 0.13 0.1 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 14 28 1 2 2 2 0 2 1 1 0 2 14 11 2 6 4 7 8 15 10 6 17 17
Bud 2 4 2 4 3 10 7 23 12 17 14 22 1 1 2 19 4 4 0 1 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 3 3 3 3 4 6 4 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 2 0 0 2 2 4 0 4 5 2 9 0 0 2 4 1 4 0 0 0 0 0 0
Cytoplasm 8 8 4 18 12 12 4 10 7 5 5 7 10 9 18 46 22 20 0 1 1 1 2 2
Endoplasmic Reticulum 16 23 14 4 7 6 6 11 4 4 10 2 30 20 14 5 5 8 0 0 1 4 1 7
Endosome 29 7 44 29 42 4 10 22 2 3 3 3 9 13 31 61 47 33 37 37 26 23 24 24
Golgi 243 159 120 39 50 3 5 0 3 1 1 2 81 84 77 87 46 84 443 330 300 172 335 339
Mitochondria 409 346 285 178 272 365 520 511 322 505 352 465 62 50 39 20 15 14 27 38 19 43 53 30
Nucleus 0 2 1 0 0 4 2 4 0 2 0 0 0 2 0 2 2 0 0 0 0 0 0 0
Nuclear Periphery 0 4 3 2 1 0 9 3 8 3 3 3 0 1 3 0 0 2 0 1 0 0 0 2
Nucleolus 5 0 7 3 2 6 9 6 6 10 6 9 0 0 1 2 1 0 0 0 0 0 0 0
Peroxisomes 1 1 3 8 9 1 7 25 5 4 2 4 0 0 0 4 2 0 5 2 18 16 23 14
SpindlePole 1 0 3 3 2 1 2 17 1 5 5 10 1 3 3 10 12 5 1 0 2 0 0 0
Vac/Vac Membrane 45 15 10 2 15 11 4 18 8 11 5 7 10 20 45 32 20 17 8 9 3 3 3 5
Unique Cell Count 494 397 354 224 336 384 541 563 333 519 366 482 156 162 185 264 150 171 535 440 389 274 465 449
Labelled Cell Count 773 599 497 292 419 430 592 655 386 580 414 549 218 214 237 299 181 198 535 440 389 274 465 449


Early Golgi, Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.6 8.8 7.8 7.5 7.1 5.9 5.6 5.9 5.6 5.0 5.1 5.2 8.1 8.2 8.6 6.8 7.2 8.6 8.4 9.2 9.3
Std Deviation (1e-4) 0.9 1.1 1.2 2.4 1.7 1.5 1.0 1.2 1.0 0.9 0.9 1.0 0.8 0.9 1.0 1.1 1.2 1.5 1.6 1.4 1.4
Intensity Change (Log2) – – – -0.06 -0.14 -0.39 -0.48 -0.4 -0.49 -0.63 -0.61 -0.58 0.06 0.07 0.14 -0.19 -0.12 0.14 0.1 0.24 0.25

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 2.2 0 3.2 2.8 2.7 3.0 3.4 0 0 0 4.5 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4.2 2.1 1.9 0 0.8 1.0 0 0 0 0 0 4.8 7.3 6.3 5.4
Endoplasmic Reticulum -1.5 -1.4 -2.0 -2.8 -1.8 -2.3 -3.3 -0.9 -3.7 5.7 3.6 1.8 -1.5 -0.3 0.4
Endosome 0.2 0 -6.3 -6.5 -4.9 -6.2 -7.6 -6.3 -7.3 -2.3 -1.5 1.4 3.5 5.0 2.1
Golgi -4.3 -5.8 -12.1 -13.9 -14.8 -11.3 -14.2 -12.1 -13.5 3.8 3.9 1.8 -0.2 -0.7 3.4
Mitochondria -0.3 0.1 6.1 7.6 4.5 6.6 8.3 6.6 7.5 -9.1 -11.0 -13.4 -17.9 -14.7 -15.7
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 1.6 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 -0.4 -0.3 -1.1 -0.2 -0.1 -0.3 -0.1 0 0 0 0 0 0
Peroxisomes 0 1.8 0 0 3.1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 2.2 0 0 0 1.4 0 0 0 2.5 0 0
Vacuole 0 1.2 0 -2.5 0.3 -0.3 -0.7 -1.4 -1.4 1.9 4.3 7.8 4.5 4.6 3.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.6551 3.7198 3.5872 3.3294 2.6888 3.6274 5.4011 5.8386 5.3879 5.6954 5.7209 5.5186 5.4956 5.7905 5.8183 5.7536 5.6926 6.0507
Actin 0.1022 0.0066 0.0301 0.0044 0.0074 0.0114 0.0078 0.0081 0.0046 0.0422 0.0015 0.0121 0.0275 0.009 0.0045 0.0003 0.0154 0.0152
Bud 0.001 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001
Bud Neck 0.004 0.0003 0.0005 0.0025 0.0003 0.0005 0.0004 0.0002 0.0003 0.0004 0.0001 0.0005 0.0004 0.0002 0.0002 0.0001 0.0001 0.0003
Bud Periphery 0.0018 0.0003 0.0002 0.0001 0.0003 0.0002 0.0002 0.0001 0.0002 0.0002 0.0001 0.0001 0.0002 0.0001 0.0001 0 0 0.0001
Bud Site 0.0035 0.001 0.0008 0.0005 0.0007 0.0002 0.0003 0.0005 0.0005 0.0029 0.0001 0.0001 0.0011 0.0002 0.0002 0.0001 0.0001 0.0002
Cell Periphery 0.0004 0.0003 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0 0.0002 0 0 0 0 0
Cytoplasm 0.003 0.0026 0.0022 0.0032 0.0027 0.0024 0.0024 0.0062 0.0024 0.0078 0.002 0.0023 0.0017 0.0022 0.0014 0.002 0.001 0.0016
Cytoplasmic Foci 0.0634 0.0693 0.0653 0.0686 0.0705 0.0491 0.1013 0.1119 0.0811 0.0873 0.0952 0.0722 0.0865 0.1201 0.0815 0.0796 0.1115 0.0762
Eisosomes 0.0008 0.0013 0.0001 0.0001 0.0002 0.0001 0 0.0001 0 0.0001 0 0.0001 0.001 0 0 0 0 0.0001
Endoplasmic Reticulum 0.0024 0.0016 0.0008 0.0026 0.0031 0.0017 0.0021 0.0009 0.0006 0.0011 0.0008 0.0006 0.0006 0.0009 0.0005 0.0005 0.0002 0.0006
Endosome 0.2138 0.2583 0.2201 0.2704 0.2402 0.1975 0.2098 0.2203 0.2022 0.3109 0.2591 0.1737 0.1863 0.244 0.1749 0.2673 0.1773 0.1373
Golgi 0.4702 0.5992 0.6357 0.5652 0.4959 0.6812 0.5672 0.5933 0.6285 0.4841 0.5705 0.653 0.6519 0.5579 0.6932 0.6068 0.5938 0.702
Lipid Particles 0.0184 0.0047 0.0077 0.0175 0.0203 0.0059 0.0165 0.0063 0.008 0.0054 0.0439 0.0084 0.0079 0.0069 0.0075 0.0013 0.0394 0.0128
Mitochondria 0.0731 0.0423 0.0206 0.0205 0.1084 0.0328 0.043 0.0321 0.0563 0.0254 0.0078 0.051 0.0157 0.031 0.0223 0.0385 0.0068 0.0289
None 0.003 0.0002 0.0003 0.0024 0.0007 0.0004 0.0005 0.0004 0.0002 0.0091 0.0003 0.0001 0.0018 0.0002 0.0001 0 0.0001 0.0019
Nuclear Periphery 0.0039 0.0006 0.0005 0.0232 0.0008 0.0048 0.0094 0.0001 0.0002 0.0004 0.0003 0.0001 0.0003 0.0002 0.0001 0.0001 0.0001 0.0001
Nucleolus 0.0005 0 0 0.0004 0.0001 0.0001 0.0001 0 0.0002 0.0003 0 0 0.0001 0 0 0 0 0
Nucleus 0.0023 0.0001 0.0001 0.0011 0.0002 0.001 0.0009 0 0.0001 0.0004 0.0001 0 0.0001 0 0 0 0 0
Peroxisomes 0.0238 0.0057 0.0069 0.0028 0.0415 0.0048 0.0329 0.0172 0.0081 0.0117 0.0151 0.0233 0.0145 0.0243 0.0117 0.0008 0.0524 0.0206
Punctate Nuclear 0.0026 0.0001 0.0008 0.0076 0.0014 0.0009 0.0017 0.0001 0.0005 0.003 0.0003 0.0001 0.0006 0.0001 0.0001 0 0.0002 0.0002
Vacuole 0.0028 0.0024 0.0042 0.0025 0.002 0.0017 0.0013 0.0008 0.0028 0.0027 0.0011 0.0007 0.0006 0.0009 0.0007 0.0008 0.0006 0.0008
Vacuole Periphery 0.0032 0.0029 0.0029 0.0041 0.0031 0.0029 0.002 0.0011 0.0027 0.0042 0.0016 0.0014 0.0009 0.0014 0.0011 0.0017 0.001 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.2805 15.1687 14.9064 17.8197 13.9731 11.4588 18.9641 19.5839 15.553 20.6757
Translational Efficiency 0.6505 0.8245 0.6853 0.6012 0.7027 0.8636 0.8138 0.6227 0.7983 0.6605

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
842 1190 1465 1053 2264 1770 2631 1299 3106 2960 4096 2352

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 967.19 943.43 1044.82 1005.53 851.80 927.97 1056.83 988.95 883.08 934.19 1052.53 996.37
Standard Deviation 131.41 148.89 125.56 147.97 106.86 127.03 124.63 138.96 125.05 136.45 125.09 143.30
Intensity Change Log 2 — -0.035884 0.111383 0.056085 — 0.123563 0.311157 0.215383 — 0.040980 0.208385 0.132875

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003742 0.003443 0.001019 0.007746 0.001126 0.001922 0.003911 0.001452 0.001835 0.002533 0.002877 0.004270
Bud Neck 0.000421 0.000065 0.000225 0.000235 0.000041 0.000099 0.000068 0.000382 0.000144 0.000085 0.000124 0.000316
Bud Site 0.004223 0.000847 0.001576 0.005186 0.000487 0.000703 0.001402 0.002897 0.001500 0.000761 0.001464 0.003922
Cell Periphery 0.000114 0.000064 0.000047 0.000062 0.000058 0.000068 0.000032 0.000052 0.000073 0.000066 0.000037 0.000057
Cytoplasm 0.001949 0.000963 0.000655 0.001850 0.000440 0.000476 0.000678 0.001347 0.000849 0.000672 0.000670 0.001572
Cytoplasmic Foci 0.176298 0.205422 0.215447 0.167860 0.130491 0.154133 0.162609 0.193023 0.142908 0.174753 0.181508 0.181757
Eisosomes 0.000058 0.000060 0.000018 0.000047 0.000064 0.000051 0.000030 0.000022 0.000062 0.000054 0.000026 0.000033
Endoplasmic Reticulum 0.001015 0.000420 0.001301 0.000565 0.000378 0.000259 0.000496 0.000430 0.000551 0.000324 0.000784 0.000491
Endosome 0.237080 0.134820 0.142837 0.189615 0.140554 0.189790 0.120753 0.275045 0.166721 0.167691 0.128651 0.236798
Golgi 0.475915 0.608362 0.571620 0.563326 0.684311 0.591095 0.676813 0.453415 0.627817 0.598037 0.639189 0.502623
Lipid Particles 0.003157 0.007288 0.004762 0.001286 0.002822 0.008431 0.000912 0.004401 0.002913 0.007971 0.002289 0.003006
Mitochondria 0.025864 0.024957 0.005113 0.013546 0.029790 0.038630 0.007050 0.010240 0.028725 0.033133 0.006357 0.011720
Mitotic Spindle 0.010270 0.002370 0.008458 0.009279 0.000577 0.000600 0.002844 0.011815 0.003204 0.001311 0.004852 0.010680
None 0.000041 0.000338 0.000030 0.000022 0.000024 0.000022 0.000011 0.000067 0.000029 0.000149 0.000018 0.000047
Nuclear Periphery 0.000342 0.000027 0.000253 0.000125 0.000018 0.000052 0.000047 0.000242 0.000106 0.000042 0.000121 0.000190
Nuclear Periphery Foci 0.001376 0.000151 0.001579 0.000449 0.000055 0.000192 0.000215 0.001592 0.000413 0.000175 0.000703 0.001080
Nucleolus 0.000199 0.000021 0.000008 0.000008 0.000021 0.000014 0.000002 0.000082 0.000070 0.000017 0.000004 0.000049
Nucleus 0.000311 0.000017 0.000040 0.000026 0.000096 0.000015 0.000007 0.000290 0.000154 0.000016 0.000019 0.000172
Peroxisomes 0.003842 0.002386 0.000775 0.003456 0.001628 0.003114 0.000520 0.003069 0.002228 0.002821 0.000611 0.003243
Vacuole 0.030989 0.002689 0.025121 0.022820 0.002042 0.003520 0.011732 0.026824 0.009889 0.003186 0.016521 0.025031
Vacuole Periphery 0.022794 0.005291 0.019115 0.012490 0.004979 0.006814 0.009867 0.013313 0.009809 0.006202 0.013175 0.012945

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.28 2.87 -2.00 -2.29 -3.77 -2.07 -3.11 -0.50 0.65 2.28 -1.60 -1.63 -2.67 -1.87 -1.34
Bud Neck 5.29 2.42 2.30 -4.63 -0.36 -2.33 -1.48 -2.72 -2.24 -2.49 2.44 0.73 -2.40 -3.25 -2.67
Bud Site 6.27 4.71 -1.04 -4.98 -4.09 -1.28 -4.21 -4.24 -3.83 -2.55 3.88 0.16 -4.70 -6.29 -4.81
Cell Periphery 3.11 4.15 3.20 0.20 -2.01 -0.63 1.86 0.28 1.14 -2.36 0.53 3.22 1.31 1.11 -3.34
Cytoplasm 1.53 3.45 0.12 -1.55 -4.16 -0.26 -1.48 -3.36 -3.31 -2.47 0.67 1.18 -3.36 -3.30 -4.49
Cytoplasmic Foci -4.82 -6.53 1.38 6.57 8.40 -6.62 -9.84 -12.98 -7.49 -6.10 -10.19 -13.10 -10.66 -1.80 -0.04
Eisosomes -0.17 5.58 1.31 1.89 -5.52 2.10 4.91 6.68 6.82 1.44 1.57 7.03 5.55 5.58 -2.01
Endoplasmic Reticulum 3.40 -1.01 2.31 -1.19 3.11 0.92 -0.85 -0.43 -2.24 0.65 2.18 -1.74 0.51 -2.42 2.72
Endosome 14.29 13.18 5.92 -9.12 -7.80 -10.76 6.20 -20.76 -11.98 -24.45 -0.26 12.08 -14.47 -14.09 -24.33
Golgi -12.81 -9.09 -7.60 4.78 0.95 14.10 1.40 27.55 14.94 26.50 5.27 -2.16 18.65 14.16 21.23
Lipid Particles -2.58 -1.62 2.88 4.02 4.32 -3.66 2.88 -1.77 2.57 -4.98 -4.46 1.08 -0.20 4.51 -1.51
Mitochondria 0.22 6.92 3.60 3.47 -4.12 -2.60 11.23 8.34 9.04 -2.10 -1.72 13.31 8.73 9.28 -4.31
Mitotic Spindle 3.73 0.84 0.22 -3.76 -0.64 -0.08 -4.31 -7.11 -7.18 -5.58 2.85 -1.96 -5.92 -7.86 -4.74
None -1.00 1.08 2.70 1.06 0.79 0.29 1.99 -1.50 -1.60 -1.98 -1.01 1.85 -1.15 0.84 -1.83
Nuclear Periphery 3.34 0.90 1.89 -1.74 1.79 -1.97 -4.15 -4.94 -3.96 -4.29 2.31 -0.51 -1.95 -3.98 -1.88
Nuclear Periphery Foci 3.15 -0.43 2.11 -2.37 4.29 -2.76 -3.00 -4.93 -4.47 -4.39 2.15 -2.14 -3.34 -5.00 -2.15
Nucleolus 1.83 1.97 1.96 1.01 -0.28 0.35 1.00 -1.83 -2.37 -2.82 1.73 2.19 0.55 -1.97 -2.87
Nucleus 1.89 1.75 1.83 -0.96 0.56 0.94 1.04 -0.89 -1.30 -1.34 1.89 1.85 -0.14 -1.34 -1.32
Peroxisomes 2.18 5.74 0.42 -1.25 -3.53 -2.25 3.37 -2.04 0.03 -3.98 -1.26 5.77 -1.83 -0.69 -5.37
Vacuole 11.99 2.05 2.54 -10.39 0.75 -4.90 -12.41 -12.76 -11.97 -7.31 9.43 -6.42 -9.94 -15.81 -5.54
Vacuole Periphery 9.46 1.68 4.93 -5.91 3.92 -3.33 -7.86 -7.66 -5.63 -2.90 5.59 -4.22 -3.35 -8.03 0.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
Localization
Cell Percentages Golgi (10%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Cog3

Cog3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cog3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available