Standard name
Human Ortholog
Description Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 0 0.07 0.08 0 0.08 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 – 0 0.07 0.11 0.08 0.08 0.08 0.05 0.06 0 0 0.08 0.11 0 0.06 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.1 0.1 – 0.05 0 0.12 0.24 0.22 0.41 0.31 0.46 0.23 0.06 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.92 0.9 – 0.83 0.9 0.83 0.79 0.78 0.74 0.77 0.72 0.81 0.84 0.84 0.83 0.85 0.85 0.79 0.9 0.83 0.86 0.77 0.65 0.55
Nuclear Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.16 0.35 – 0.23 0 0.11 0.13 0.17 0.16 0.22 0.19 0.34 0.31 0.05 0 0 0 0.05 0.05 0 0.1 0.05 0.11 0.15
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.07 0.06 0 0 0 0.06 0.15 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 2 4 1 1 0 0 0 0 0 0 0 0 1 2 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 1 0 3 4 3 12 13 2 9 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 0 – 0 9 13 16 14 14 8 8 2 1 10 16 5 6 8 0 1 0 0 3 2
Endoplasmic Reticulum 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 3 1 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 3 1 1 2 0 0 1 1 2
Golgi 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0 0 3
Mitochondria 31 2 – 3 1 15 46 39 75 53 59 27 3 0 0 5 0 4 2 0 0 1 1 5
Nucleus 274 18 – 55 110 100 154 135 134 131 91 94 43 103 124 116 90 86 270 46 41 30 75 68
Nuclear Periphery 2 0 – 0 0 2 0 3 2 1 3 2 0 1 1 2 1 1 0 0 0 0 0 1
Nucleolus 47 7 – 15 3 13 25 30 30 38 24 39 16 6 5 4 1 5 14 1 4 1 12 19
Peroxisomes 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 1 3 0 2 1 0 0 1 1 1 0 0 0 0 0 0 1 1
Vac/Vac Membrane 2 0 – 0 0 1 2 0 2 1 1 1 0 3 6 12 7 7 4 1 0 2 17 11
Unique Cell Count 297 20 66 122 121 195 174 182 171 127 116 51 122 150 137 106 109 299 56 49 40 117 125
Labelled Cell Count 360 27 74 123 147 251 231 270 248 189 174 63 124 154 149 109 115 299 56 49 40 117 125


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.0 8.1 – 5.9 7.2 5.7 5.4 5.6 5.0 4.9 4.7 4.9 6.5 8.6 8.4 9.3 10.5 10.2 – 8.4 8.9
Std Deviation (1e-4) 0.9 1.5 – 0.9 1.6 1.4 1.8 1.8 1.6 1.4 1.5 1.0 1.3 2.1 2.3 2.3 2.3 2.3 – 1.8 2.2
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.6594 3.5855 2.955 3.2476 2.7774 2.9352 3.1694 3.5635 3.0656 2.5934 1.794 3.113 2.5279 3.7102 3.0734 2.8218 1.7041 2.5375
Actin 0.019 0.0081 0.0122 0.0014 0.0007 0 0.1061 0.002 0.0043 0.0025 0.0001 0.0126 0.0618 0.0054 0.0225 0.0007 0.0029 0.0007
Bud 0.0008 0.0008 0.0003 0.0001 0.0002 0 0.0009 0.0002 0.0002 0 0.0003 0.0003 0.0003 0.0002 0.0002 0.0001 0.0015 0
Bud Neck 0.0136 0.0002 0.0007 0.0017 0.0027 0.0012 0.0173 0.0003 0.0002 0.0003 0.0008 0.0026 0.0041 0.0002 0.0007 0.0004 0.0009 0.0012
Bud Periphery 0.0015 0.0013 0.0004 0.0002 0.0003 0.0001 0.0013 0.0005 0.0002 0 0.0008 0.0005 0.0004 0.0002 0.0002 0.0002 0.0029 0.0001
Bud Site 0.0106 0.0012 0.0046 0.0008 0.0002 0 0.0118 0.0036 0.0004 0.0004 0.0008 0.0023 0.0026 0.0029 0.0039 0 0.0037 0.0001
Cell Periphery 0.0011 0.0001 0.0003 0.0004 0.0001 0 0.0007 0.0008 0.0001 0 0.0001 0.0001 0.0003 0.0001 0.0001 0 0.0002 0
Cytoplasm 0.0128 0.0017 0.0048 0.0027 0.091 0 0.0111 0.0089 0.001 0.0522 0 0.0001 0.0162 0.0043 0.0001 0.001 0.0091 0
Cytoplasmic Foci 0.027 0.0051 0.0073 0.0002 0.0008 0 0.0638 0.0019 0.0082 0.0125 0 0.0028 0.0482 0.004 0.0047 0.0008 0.048 0.0004
Eisosomes 0.0016 0 0.0002 0.0001 0 0 0.0015 0 0 0 0 0.0001 0.0003 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0179 0.0004 0.0014 0.0022 0.0008 0 0.0087 0.0033 0.0014 0.0017 0 0.0001 0.0162 0.0004 0.0001 0.0008 0.0055 0
Endosome 0.0497 0.0016 0.0196 0.001 0.0005 0 0.0923 0.0034 0.0133 0.0054 0.0001 0.0019 0.0608 0.0013 0.0036 0.0031 0.0719 0.0008
Golgi 0.0185 0.0017 0.0049 0.0001 0.0001 0 0.039 0.0013 0.0115 0.0005 0 0.0034 0.012 0.001 0.0076 0.0003 0.0102 0.0013
Lipid Particles 0.0297 0.0011 0.005 0.0005 0.0001 0 0.0534 0.0004 0.0019 0.0004 0.0001 0.0036 0.0267 0.004 0.0039 0.0005 0.0282 0.012
Mitochondria 0.0067 0.0015 0.0118 0.0006 0.0012 0.0001 0.0086 0.0011 0.0033 0.0004 0.0009 0.0046 0.0046 0.0028 0.0033 0.0002 0.0406 0.0019
None 0.0402 0.0005 0.0151 0.0009 0.0017 0 0.013 0.0051 0.0002 0.0123 0.0001 0.0001 0.0109 0.0003 0.0001 0.0002 0.006 0
Nuclear Periphery 0.0628 0.0052 0.0344 0.0213 0.0062 0.0005 0.0403 0.0016 0.0182 0.0103 0.0005 0.0022 0.0404 0.0049 0.0015 0.0459 0.0219 0.0065
Nucleolus 0.0288 0.0181 0.016 0.0266 0.1419 0.109 0.0168 0.024 0.0407 0.0095 0.3476 0.1174 0.0161 0.0212 0.0191 0.0201 0.1038 0.1033
Nucleus 0.6047 0.9336 0.8364 0.9292 0.7487 0.8881 0.4479 0.9388 0.8861 0.8386 0.6446 0.8385 0.6009 0.943 0.9238 0.9155 0.6016 0.8695
Peroxisomes 0.0191 0.002 0.0016 0.0001 0 0 0.0218 0.0001 0.0059 0.0008 0.0001 0.0051 0.0333 0.0004 0.0035 0.0001 0.0082 0.0009
Punctate Nuclear 0.018 0.0147 0.0181 0.0078 0.0015 0.0004 0.0371 0.0008 0.0015 0.0521 0.0028 0.0009 0.0396 0.002 0.0007 0.0084 0.0229 0.0008
Vacuole 0.0094 0.0007 0.0034 0.0015 0.0006 0.0003 0.0038 0.0017 0.0006 0.0002 0.0003 0.0005 0.0026 0.0005 0.0002 0.0007 0.0064 0.0001
Vacuole Periphery 0.0062 0.0003 0.0015 0.0007 0.0007 0.0001 0.0026 0.0002 0.0007 0.0001 0.0001 0.0003 0.0018 0.0008 0.0001 0.0009 0.0036 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.6072 12.7973 19.7228 17.9564 17.847 12.1065 14.93 19.1458 23.3192 18.8516
Translational Efficiency 3.551 1.8766 1.1078 1.6459 1.2284 1.9502 1.5948 1.307 1.0936 1.1051

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1820 265 1658 1404 1779 232 264 1260 3599 497 1922 2664

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 949.18 1013.37 1022.84 1068.96 901.33 995.20 1156.31 1139.34 925.53 1004.89 1041.17 1102.25
Standard Deviation 133.64 170.90 158.80 164.91 132.25 148.78 132.00 179.57 135.09 161.21 162.04 175.55
Intensity Change Log 2 — 0.094407 0.107827 0.171454 — 0.142931 0.359401 0.338071 — 0.118246 0.235843 0.255013

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000327 0.000939 0.000724 0.001220 0.000384 0.000867 0.001580 0.001480 0.000355 0.000906 0.000842 0.001343
Bud Neck 0.004984 0.010386 0.023632 0.030645 0.007868 0.012226 0.009074 0.037664 0.006409 0.011245 0.021633 0.033965
Bud Site 0.000423 0.005383 0.001428 0.004716 0.000808 0.002245 0.001255 0.015730 0.000613 0.003918 0.001404 0.009925
Cell Periphery 0.000031 0.000062 0.000047 0.000102 0.000044 0.000036 0.000040 0.000243 0.000037 0.000050 0.000046 0.000168
Cytoplasm 0.000873 0.002338 0.000568 0.004112 0.000570 0.000349 0.000187 0.007975 0.000723 0.001409 0.000515 0.005939
Cytoplasmic Foci 0.000306 0.001393 0.000015 0.001083 0.000134 0.002834 0.000070 0.008699 0.000221 0.002066 0.000023 0.004685
Eisosomes 0.000032 0.000041 0.000039 0.000037 0.000036 0.000037 0.000066 0.000037 0.000034 0.000039 0.000043 0.000037
Endoplasmic Reticulum 0.001975 0.002484 0.001733 0.003458 0.002074 0.002479 0.004779 0.004252 0.002024 0.002481 0.002152 0.003834
Endosome 0.000165 0.000749 0.000090 0.002049 0.000171 0.001326 0.000112 0.008994 0.000168 0.001018 0.000093 0.005334
Golgi 0.000112 0.000331 0.000101 0.003182 0.000111 0.004382 0.000155 0.013093 0.000112 0.002222 0.000109 0.007870
Lipid Particles 0.000059 0.000119 0.000026 0.000171 0.000039 0.002025 0.000126 0.000253 0.000049 0.001009 0.000040 0.000210
Mitochondria 0.000794 0.001039 0.001132 0.004268 0.000657 0.002823 0.001369 0.009347 0.000727 0.001871 0.001165 0.006670
Mitotic Spindle 0.001665 0.011555 0.001155 0.024661 0.000975 0.020398 0.001204 0.064949 0.001324 0.015683 0.001162 0.043716
None 0.001576 0.002765 0.001494 0.004244 0.001173 0.000990 0.001977 0.005448 0.001377 0.001937 0.001561 0.004813
Nuclear Periphery 0.000108 0.000108 0.000181 0.001518 0.000167 0.000219 0.000162 0.001484 0.000137 0.000160 0.000178 0.001502
Nuclear Periphery Foci 0.000317 0.000416 0.000058 0.001058 0.000184 0.000314 0.000122 0.000834 0.000251 0.000368 0.000067 0.000952
Nucleolus 0.095169 0.111833 0.039760 0.028734 0.081711 0.113450 0.047660 0.018823 0.088517 0.112588 0.040845 0.024046
Nucleus 0.890046* 0.845267* 0.926952* 0.873378* 0.901777* 0.830168* 0.926832* 0.783941* 0.895844* 0.838219* 0.926936* 0.831077*
Peroxisomes 0.000486 0.001803 0.000446 0.000440 0.000447 0.001700 0.001904 0.002180 0.000467 0.001755 0.000646 0.001263
Vacuole 0.000294 0.000763 0.000273 0.006322 0.000318 0.000677 0.001167 0.009905 0.000306 0.000723 0.000396 0.008017
Vacuole Periphery 0.000259 0.000226 0.000143 0.004602 0.000353 0.000456 0.000160 0.004668 0.000305 0.000333 0.000145 0.004633

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.66 -19.21 -23.90 -5.42 -12.94 -2.98 -12.93 -16.51 -5.79 -1.31 -6.16 -21.23 -26.31 -7.82 -13.51
Bud Neck -3.89 -21.44 -19.27 -11.65 -5.41 -1.61 -4.13 -18.00 -7.76 -12.77 -3.13 -20.37 -26.16 -12.80 -10.22
Bud Site -1.64 -9.02 -7.68 0.27 -5.32 -1.54 -3.37 -7.64 -5.07 -6.88 -2.02 -6.62 -10.09 -1.93 -8.57
Cell Periphery -1.91 -3.28 -9.06 -2.03 -6.92 0.41 -0.62 -5.66 -5.77 -5.65 -1.35 -2.32 -8.33 -5.71 -7.50
Cytoplasm -0.97 1.11 -3.22 -0.70 -4.17 0.45 1.45 -5.37 -5.43 -5.60 -0.90 1.11 -6.27 -3.79 -6.79
Cytoplasmic Foci -1.01 1.39 -0.20 0.97 -3.05 -1.67 0.26 -3.53 -0.08 -3.58 -1.96 1.63 -3.28 0.44 -4.28
Eisosomes -3.11 -6.10 -8.02 -0.90 -1.70 -0.37 -9.09 -7.11 -3.52 5.25 -2.46 -8.23 -10.56 -3.12 -0.93
Endoplasmic Reticulum -2.08 0.67 -10.94 -5.37 -12.50 -0.90 -7.65 -10.12 -3.88 -0.73 -1.72 -2.71 -14.51 -5.86 -12.62
Endosome -1.27 1.26 -3.67 -0.70 -4.01 -1.94 0.66 -3.76 -1.93 -3.80 -2.29 1.94 -4.78 -2.03 -4.95
Golgi -1.93 -0.32 -2.21 -1.81 -2.20 -1.44 -2.85 -3.39 -0.06 -3.33 -1.53 -1.01 -4.04 -0.49 -4.01
Lipid Particles -1.03 1.06 -2.17 -1.25 -4.26 -1.15 -4.97 -7.96 0.99 -4.69 -1.19 0.49 -5.88 0.95 -7.97
Mitochondria -1.03 -2.11 -7.65 -8.21 -7.85 -1.99 -5.05 -7.66 -2.62 -6.32 -2.20 -4.43 -10.54 -4.84 -9.47
Mitotic Spindle -1.72 0.53 -6.07 -1.11 -6.46 -2.39 -0.88 -8.78 -1.93 -8.35 -2.94 -0.11 -10.64 -2.21 -10.68
None -1.32 0.10 -3.73 -1.59 -4.59 0.50 -2.08 -5.19 -5.29 -3.41 -1.17 -1.15 -6.36 -4.40 -6.28
Nuclear Periphery -0.11 -4.37 -7.85 -7.79 -7.21 -1.00 -1.40 -11.76 -10.25 -11.21 -0.90 -3.12 -13.23 -12.47 -12.62
Nuclear Periphery Foci -0.42 1.33 -1.25 -0.85 -2.98 -0.66 1.02 -2.85 -2.24 -3.59 -0.68 1.87 -2.64 -1.96 -4.76
Nucleolus -2.07 13.72 17.76 10.38 4.71 -3.39 5.50 16.66 9.76 4.36 -3.93 15.07 24.23 14.26 7.06
Nucleus 4.02 -6.55 2.35 -2.62 7.24 4.97 -2.17 9.91 0.27 9.71 6.43 -6.49 8.99 -1.49 13.14
Peroxisomes -3.34 0.21 0.39 3.85 0.73 -4.10 -3.31 -2.25 1.42 1.80 -5.11 -2.09 -1.71 3.69 -0.22
Vacuole -1.26 -0.33 -4.95 -4.27 -4.95 -1.54 -4.67 -7.44 -6.80 -6.55 -1.95 -1.76 -8.83 -7.89 -8.67
Vacuole Periphery 0.32 1.26 -2.83 -2.88 -3.00 -0.35 1.64 -2.41 -2.27 -2.88 -0.13 2.15 -3.70 -3.67 -4.14
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Spt2

Spt2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Spt2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available