Standard name
Human Ortholog
Description JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.05 0.08 0 0.05 0 0 0 – 0 0 0 0.06 0.12 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.21 0.27 0.08 0.14 0.08 0.18 0.29 0.2 0.42 – 0.42 0.33 0.06 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.93 0.78 0.88 0.89 0.88 0.86 0.84 0.84 0.84 – 0.82 0.8 0.96 0.91 0.84 0.93 0.91 0.9 0.82 0.78 0.8 0.84 0.7 0.65
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.08 0.09 0 0 0 0 0.05 0.07 0.12 – 0.18 0.12 0 0 0.05 0.05 0 0.05 0.1 0.05 0 0 0.07 0.09
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.06 0.09 0.08 0.16 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 1 0 0 0
Bud 0 0 0 0 2 1 10 5 1 – 7 5 0 0 0 0 0 1 1 3 1 0 1 7
Bud Neck 0 0 1 0 2 2 3 2 0 – 1 5 0 0 0 0 0 0 0 0 0 0 1 2
Bud Site 0 0 2 2 4 8 14 11 14 – 13 15 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 1 0 0 0 1 0 1 0 0 0 0 0 0 0
Cytoplasm 2 8 15 13 13 20 25 16 15 – 9 11 3 15 29 7 9 8 0 2 1 0 1 1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 4 0 2 2 1 0 0 0 0 1 1
Endosome 0 0 4 0 6 5 1 2 0 – 0 0 0 1 3 1 4 1 0 5 1 0 2 4
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 2 1 0 0 0
Mitochondria 23 46 22 23 26 76 170 126 166 – 149 117 9 7 4 1 3 5 1 1 5 0 2 5
Nucleus 100 132 256 141 272 357 497 522 333 – 292 284 144 219 209 297 241 219 101 148 248 85 174 214
Nuclear Periphery 1 2 0 0 1 6 6 15 5 – 6 1 0 0 3 1 2 4 0 1 1 0 0 2
Nucleolus 9 16 3 1 5 12 27 43 48 – 64 42 0 5 12 17 10 11 12 8 11 4 18 28
Peroxisomes 0 0 1 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 1 1 11 4 9 14 13 16 5 – 4 12 1 0 0 0 5 1 0 2 4 0 2 3
Vac/Vac Membrane 0 4 3 1 3 3 2 5 2 – 2 0 0 0 7 9 4 8 3 10 27 7 40 51
Unique Cell Count 108 170 290 159 309 416 590 618 397 355 353 150 241 248 321 266 244 125 191 311 102 250 328
Labelled Cell Count 136 209 318 185 343 504 768 763 590 548 492 157 251 268 336 281 259 125 191 311 102 250 328


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 5.1 5.6 5.3 5.4 4.7 4.8 5.2 4.5 – 4.2 4.4 5.5 5.8 5.9 11.2 10.9 10.9 5.0 5.3 5.7
Std Deviation (1e-4) 1.2 1.5 1.2 1.7 1.1 1.4 1.1 1.1 1.1 – 1.1 1.0 1.2 1.3 1.8 2.7 2.8 2.9 1.2 1.4 1.1
Intensity Change (Log2) – – – -0.08 -0.03 -0.25 -0.23 -0.11 -0.32 – -0.4 -0.35 -0.02 0.05 0.08 1.01 0.96 0.97 -0.16 -0.07 0.03


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 1.3 -0.6 -0.2 -0.6 -2.0 -0.9 – -1.8 -1.3 -1.6 0.5 2.8 -2.0 -1.0 -1.1
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 2.3 0.4 0 0 4.9 0 – 0 0 -0.6 -2.4 -3.2 -4.7 -3.7 -2.9
Nucleus 0.1 -0.1 -1.0 -1.6 -1.5 -1.6 – -2.1 -2.7 2.7 1.0 -1.4 1.8 0.9 0.5
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 3.8 0 – 0 0 0 0 2.7 3.0 2.1 2.5
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole -0.7 -0.6 0 0 -1.0 0 – 0 0 0 0 -3.1 -3.5 -1.3 -2.6
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 1.6 0 1.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8085 2.3752 1.5889 0.968 1.5939 1.7104 0.6565 0.4234 0.4005 0.3393 0.1801 0.3289 -0.0386 -0.2788 -0.4931 -0.4982 -0.6004 -0.4
Actin 0.0072 0.0276 0.0017 0.0007 0 0.0027 0.0166 0 0.0019 0 0.0177 0.0004 0.0373 0.0085 0.0221 0.0332 0.002 0.0027
Bud 0.0004 0.0006 0.0002 0.0002 0 0.0001 0.0006 0 0.0002 0 0.0003 0 0.0002 0.0006 0.0002 0.0001 0.0001 0.0001
Bud Neck 0.0028 0.0008 0.0016 0.0004 0.001 0.0019 0.0021 0.0001 0.0022 0.0001 0.0009 0.0006 0.0005 0.0002 0.0003 0.0002 0.0003 0.0008
Bud Periphery 0.0013 0.0019 0.0005 0.0008 0 0.0004 0.0014 0 0.0007 0 0.0014 0.0001 0.0004 0.0009 0.0002 0.0001 0.0001 0.0005
Bud Site 0.0011 0.0126 0.0119 0.0016 0.0001 0.0003 0.0022 0 0.0005 0 0.0011 0 0.0009 0.001 0.0023 0.0003 0.0002 0.0003
Cell Periphery 0.0005 0.0007 0.0011 0.0002 0 0.0001 0.0003 0 0.0001 0 0.0007 0 0.0001 0.0001 0 0 0 0.0001
Cytoplasm 0.0124 0.0062 0.0042 0.0001 0.0002 0.0005 0.005 0.0001 0.0008 0.0001 0.0018 0.0002 0.0038 0.0004 0.0008 0.0014 0.0022 0.0016
Cytoplasmic Foci 0.0074 0.0014 0.0053 0.0031 0 0.0002 0.0018 0 0.0012 0 0.0066 0.0001 0.0072 0.0001 0.0041 0.0039 0.0012 0.001
Eisosomes 0.0005 0.0004 0.0003 0.0001 0 0 0.0002 0 0 0 0.001 0 0.0012 0.0001 0.0002 0.0001 0 0
Endoplasmic Reticulum 0.0048 0.0043 0.001 0 0 0.0007 0.0016 0 0.0006 0 0.0006 0.0003 0.0013 0.0001 0.0002 0.0001 0.0027 0.0001
Endosome 0.0095 0.0056 0.0042 0.0022 0 0.0018 0.005 0 0.0057 0 0.0033 0.0008 0.0154 0.0002 0.002 0.0015 0.0233 0.0021
Golgi 0.0045 0.0007 0.001 0.0022 0 0.0005 0.0019 0 0.002 0 0.0053 0.0005 0.0049 0.0001 0.0009 0.0067 0.0024 0.0019
Lipid Particles 0.0074 0.0016 0.003 0.0179 0 0.0004 0.0069 0 0.0034 0 0.0163 0.0018 0.0174 0 0.0012 0.007 0.0019 0.0041
Mitochondria 0.0064 0.0083 0.0033 0.0179 0.0001 0.004 0.0044 0 0.0036 0.0001 0.0231 0.0022 0.0073 0.0066 0.0067 0.0006 0.0024 0.0035
None 0.0454 0.0078 0.0058 0.0002 0.0001 0.0011 0.0016 0 0.0007 0.0001 0.0146 0.0002 0.0063 0.0003 0.0113 0.0003 0.0009 0.007
Nuclear Periphery 0.0111 0.0187 0.005 0.0002 0.0011 0.0037 0.0134 0.001 0.0064 0.0008 0.0083 0.0035 0.0125 0.0022 0.0077 0.0017 0.0154 0.0038
Nucleolus 0.0247 0.0222 0.0119 0.007 0.0552 0.037 0.0177 0.0093 0.0111 0.0139 0.0419 0.0314 0.0093 0.0212 0.0081 0.0052 0.0108 0.0194
Nucleus 0.8086 0.8247 0.9154 0.921 0.9262 0.9328 0.8978 0.9857 0.9531 0.9794 0.8159 0.9513 0.8558 0.9559 0.92 0.9267 0.918 0.938
Peroxisomes 0.0088 0.0052 0.0019 0.021 0 0.0003 0.0029 0 0.0008 0 0.0247 0.0005 0.0064 0.0003 0.0038 0.0087 0.0002 0.0028
Punctate Nuclear 0.03 0.006 0.0186 0.0019 0.0158 0.0107 0.0136 0.0038 0.0034 0.0054 0.01 0.0058 0.0099 0.0009 0.0077 0.0023 0.0136 0.0091
Vacuole 0.004 0.0354 0.002 0.0009 0 0.0005 0.002 0 0.0011 0 0.0032 0.0002 0.0008 0.0001 0.0002 0 0.0011 0.0009
Vacuole Periphery 0.001 0.0074 0.0003 0.0003 0 0.0004 0.0009 0 0.0005 0 0.0014 0.0002 0.0009 0.0002 0.0002 0 0.0014 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.1522 8.2507 13.1632 12.438 7.18 8.3021 13.0349 9.7126 9.8459 11.9484
Translational Efficiency 0.7453 1.0657 0.774 0.6527 1.015 0.9549 0.5225 0.7941 0.7556 0.624

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2024 998 134 1224 1429 2154 1352 213 3453 3152 1486 1437

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 653.89 734.12 1128.55 911.50 733.44 758.77 875.93 1022.52 686.81 750.97 898.71 927.96
Standard Deviation 71.72 106.87 141.02 146.34 174.21 108.15 115.55 136.15 130.81 108.36 138.48 150.15
Intensity Change Log 2 — 0.166968 0.787350 0.479195 — 0.048984 0.256137 0.479378 — 0.105797 0.530917 0.479292

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000118 0.000450 0.003147 0.000967 0.000146 0.000335 0.000700 0.001440 0.000130 0.000371 0.000920 0.001037
Bud Neck 0.002264 0.005103 0.013796 0.022962 0.002336 0.007766 0.010548 0.023062 0.002294 0.006923 0.010841 0.022977
Bud Site 0.000469 0.000658 0.002551 0.002307 0.000353 0.001909 0.002120 0.002845 0.000421 0.001513 0.002159 0.002387
Cell Periphery 0.000079 0.000111 0.000084 0.000114 0.000076 0.000107 0.000189 0.000106 0.000077 0.000108 0.000179 0.000113
Cytoplasm 0.016417 0.010466 0.001026 0.002803 0.009052 0.007595 0.010475 0.001436 0.013369 0.008504 0.009623 0.002601
Cytoplasmic Foci 0.002643 0.001772 0.000166 0.000261 0.001478 0.003361 0.001110 0.000028 0.002161 0.002858 0.001024 0.000226
Eisosomes 0.000015 0.000029 0.000098 0.000026 0.000018 0.000028 0.000036 0.000037 0.000016 0.000028 0.000041 0.000028
Endoplasmic Reticulum 0.001158 0.003290 0.010474 0.004917 0.001647 0.003229 0.004280 0.006839 0.001360 0.003248 0.004839 0.005202
Endosome 0.000359 0.000512 0.000369 0.000690 0.000312 0.001250 0.000785 0.000263 0.000339 0.001016 0.000747 0.000626
Golgi 0.000460 0.000243 0.000251 0.000697 0.000320 0.000784 0.000198 0.000118 0.000402 0.000613 0.000202 0.000611
Lipid Particles 0.000879 0.001351 0.000494 0.000095 0.000733 0.002355 0.000571 0.000134 0.000818 0.002037 0.000564 0.000101
Mitochondria 0.001489 0.003471 0.002047 0.002073 0.001508 0.007198 0.001149 0.001810 0.001497 0.006018 0.001230 0.002034
Mitotic Spindle 0.000439 0.001901 0.001090 0.006110 0.001846 0.003787 0.002084 0.008162 0.001022 0.003190 0.001995 0.006415
None 0.015433 0.011424 0.000818 0.002945 0.007919 0.005974 0.013359 0.003280 0.012324 0.007699 0.012228 0.002994
Nuclear Periphery 0.000356 0.000587 0.000484 0.000885 0.000775 0.001534 0.000453 0.000674 0.000529 0.001234 0.000456 0.000853
Nuclear Periphery Foci 0.000389 0.000590 0.000269 0.000199 0.000451 0.000695 0.000892 0.000144 0.000415 0.000662 0.000835 0.000191
Nucleolus 0.018652 0.028990 0.030591 0.009033 0.020713 0.025230 0.014890 0.013764 0.019505 0.026420 0.016306 0.009734
Nucleus 0.937057* 0.926716* 0.925703* 0.940187* 0.949289* 0.921434* 0.932122* 0.933187* 0.942119* 0.923107* 0.931543* 0.939150*
Peroxisomes 0.000725 0.001079 0.001925 0.000233 0.000421 0.002302 0.000767 0.000395 0.000599 0.001915 0.000871 0.000257
Vacuole 0.000425 0.000689 0.004331 0.001615 0.000454 0.002287 0.003009 0.002063 0.000437 0.001781 0.003128 0.001681
Vacuole Periphery 0.000174 0.000569 0.000286 0.000879 0.000153 0.000839 0.000264 0.000214 0.000165 0.000754 0.000266 0.000781

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.61 -13.92 -20.43 -10.70 9.24 -4.53 -10.97 -12.04 -10.37 -7.34 -7.37 -15.09 -23.80 -16.06 -3.63
Bud Neck -4.09 -4.86 -16.23 -13.88 -2.46 -8.50 -11.08 -8.17 -6.44 -4.99 -8.97 -11.91 -18.22 -14.61 -9.67
Bud Site -1.37 -9.87 -7.79 -7.29 0.91 -3.28 -2.95 -5.53 -2.94 -2.44 -3.37 -3.36 -9.52 -3.99 -1.54
Cell Periphery -1.75 -1.33 -1.29 0.25 -0.50 -1.53 -4.88 -1.42 0.33 3.07 -2.05 -5.10 -1.55 0.26 2.69
Cytoplasm 2.94 9.89 8.86 4.73 -2.10 1.08 0.15 5.95 7.02 5.84 3.95 3.25 9.77 6.53 4.45
Cytoplasmic Foci 0.98 4.83 4.64 3.85 -0.56 -2.93 0.88 4.26 5.83 3.22 -1.48 2.71 5.73 6.48 2.65
Eisosomes -7.15 -11.95 -10.90 -0.20 9.82 -5.90 -9.62 -8.89 -5.58 -3.56 -9.20 -14.10 -13.46 -2.33 4.63
Endoplasmic Reticulum -9.65 -11.25 -17.48 -6.45 5.71 -6.39 -11.83 -9.74 -6.73 -4.71 -10.70 -16.59 -19.33 -8.68 -1.89
Endosome -1.03 -0.76 -0.95 -0.25 -0.59 -3.07 -3.23 -1.72 2.68 2.36 -3.13 -3.03 -1.16 1.73 0.87
Golgi 1.10 0.89 -0.08 -0.69 -0.57 -1.93 0.54 0.16 2.83 -1.49 -1.28 1.42 -0.21 0.54 -0.89
Lipid Particles -1.13 1.37 3.00 3.26 4.08 -3.17 0.89 4.21 4.27 3.82 -3.14 1.30 4.37 5.24 5.05
Mitochondria -2.37 -1.74 -2.43 1.35 -1.52 -5.26 0.68 -1.95 4.74 -5.52 -5.86 0.64 -3.10 4.87 -6.73
Mitotic Spindle -1.80 -1.21 -4.52 -3.17 -0.39 -1.75 -0.73 -2.92 -2.58 -2.75 -3.18 -2.02 -5.10 -3.71 -3.55
None 2.30 11.57 9.71 5.80 -7.57 1.52 -1.80 4.15 3.34 4.45 4.42 0.95 10.54 6.76 4.53
Nuclear Periphery -3.61 -3.09 -8.91 -6.13 -5.50 -2.27 2.22 -2.32 0.89 -4.81 -3.26 0.29 -7.25 -0.16 -8.20
Nuclear Periphery Foci -0.82 0.94 0.62 1.23 -0.38 -1.24 -1.55 1.14 3.02 2.63 -1.88 -1.94 1.15 3.07 2.59
Nucleolus -4.19 -3.44 3.44 6.62 4.58 -2.86 2.98 -1.81 -0.86 -2.72 -5.05 1.59 2.37 6.39 0.81
Nucleus 1.96 3.22 2.39 0.20 -1.88 5.94 3.42 4.86 2.32 3.33 5.36 2.79 5.09 0.40 1.93
Peroxisomes -1.38 -2.96 1.90 2.93 7.45 -4.88 -1.13 -1.50 4.31 0.62 -4.35 -0.80 1.83 5.80 1.65
Vacuole -2.15 -4.86 -4.40 -3.68 2.97 -3.59 -5.28 -2.69 -1.57 -1.16 -3.82 -6.20 -5.13 -1.53 1.03
Vacuole Periphery -1.65 -3.99 -1.39 -0.17 -0.96 -4.05 -2.17 -2.81 3.49 0.03 -4.25 -2.30 -1.46 0.56 -1.13
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rph1

Rph1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rph1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available