Standard name
Human Ortholog
Description Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0.05 0 0
Bud 0 0 0.07 0 0 0 0.05 0.05 0.06 0.05 0 0.05 0 0 0 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Cytoplasm 0.5 0.75 0.57 0.65 0.41 0.23 0.25 0.18 0.12 0.18 0.11 0.1 0.9 0.87 0.92 0.52 – – 0.13 0.26 0.15 0.16 0.16 0.28
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Endosome 0.05 0 0 0.06 0.06 0 0 0 0 0 0 0 0 0.05 0 0.07 – – 0.11 0.07 0.07 0.07 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Mitochondria 0.39 0.2 0.32 0.28 0.55 0.83 0.82 0.83 0.88 0.82 0.92 0.92 0 0 0 0.19 – – 0.59 0.49 0.57 0.54 0.54 0.43
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
SpindlePole 0.05 0 0.05 0.08 0.05 0.06 0.05 0.09 0.07 0.09 0.06 0 0 0 0 0.18 – – 0 0 0.05 0 0 0
Vac/Vac Membrane 0.09 0 0 0 0.06 0 0 0 0.06 0 0 0 0 0 0 0 – – 0 0 0 0 0.09 0.1
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 2 0 0 0 0 0 0 0 0 1 0 1 0 3 – – 9 5 7 7 4 7
Bud 1 2 15 6 9 13 24 22 28 20 17 22 1 2 0 8 – – 2 1 2 2 3 1
Bud Neck 0 1 3 0 0 3 0 1 0 1 0 1 1 2 0 6 – – 3 4 2 3 4 6
Bud Site 2 0 0 0 1 5 11 8 13 3 8 5 0 0 0 2 – – – – – – – –
Cell Periphery 3 3 4 2 2 1 2 0 3 0 3 2 2 2 1 8 – – 0 0 0 1 0 2
Cytoplasm 145 138 129 129 116 94 113 81 58 81 48 43 179 192 243 116 – – 53 63 42 26 30 56
Endoplasmic Reticulum 3 1 2 0 5 2 0 3 4 1 3 2 3 1 0 4 – – 2 3 5 1 1 1
Endosome 15 5 5 11 17 0 0 2 5 2 0 1 4 11 8 15 – – 43 17 20 10 8 3
Golgi 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 – – 2 0 0 3 1 1
Mitochondria 113 36 72 56 156 341 372 381 429 364 410 388 2 3 2 43 – – 237 122 164 86 99 87
Nucleus 0 0 0 1 2 10 12 6 6 8 4 3 0 1 1 4 – – 0 1 0 0 0 0
Nuclear Periphery 2 0 0 0 1 0 2 0 3 2 3 2 0 0 0 0 – – 0 0 2 0 0 0
Nucleolus 0 0 0 0 1 2 1 6 0 2 5 2 0 0 1 0 – – 0 0 0 0 0 1
Peroxisomes 5 2 1 10 5 0 5 7 4 2 3 6 4 3 3 2 – – 7 2 4 1 3 1
SpindlePole 14 2 11 16 15 25 22 41 35 41 26 15 3 6 1 40 – – 14 7 13 3 5 6
Vac/Vac Membrane 25 7 5 0 16 13 6 7 29 8 14 6 6 9 9 9 – – 12 10 8 4 17 19
Unique Cell Count 290 184 228 198 284 412 456 461 490 443 444 420 200 221 264 221 401 249 287 160 184 202
Labelled Cell Count 330 198 249 231 347 509 570 565 617 535 544 499 205 233 269 261 401 249 287 160 184 202


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 4.1 3.5 3.7 3.7 3.5 3.1 3.3 3.2 2.9 3.0 3.0 5.2 4.8 4.7 5.1 4.7 4.6 5.4 5.3 5.2
Std Deviation (1e-4) 0.6 0.7 1.0 1.7 2.0 1.5 1.7 1.3 1.6 1.1 1.3 1.1 0.8 0.9 0.7 1.3 0.9 1.1 1.4 1.2 1.0
Intensity Change (Log2) – – – 0.09 0.11 0.0 -0.14 -0.07 -0.12 -0.26 -0.2 -0.19 0.58 0.48 0.45 0.55 0.44 0.43 0.65 0.61 0.6

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 – –
Bud Neck – – – – – – – – – – – – 0 – –
Bud Site – – – – – – – – – – – – 0 – –
Cell Periphery – – – – – – – – – – – – 0 – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 – –
Endosome – – – – – – – – – – – – 0 – –
Golgi – – – – – – – – – – – – 0 – –
Mitochondria – – – – – – – – – – – – 0 – –
Nuclear Periphery – – – – – – – – – – – – 0 – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 – –
Peroxisomes – – – – – – – – – – – – 0 – –
SpindlePole – – – – – – – – – – – – 0 – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 – –
Cytoplasm – – – – – – – – – – – – 0 – –
Nucleus – – – – – – – – – – – – 0 – –
Vacuole – – – – – – – – – – – – 1.1 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0056 0.0076 0.003 0.0053 0.0023 0.0041 0.045 0.0127 0.0167 0.0205 0.0075 0.0195 – – – – – –
Bud 0.0008 0.0025 0.0012 0.0013 0.0007 0.0007 0.0022 0.0064 0.0052 0.002 0.0011 0.0013 – – – – – –
Bud Neck 0.0017 0.0013 0.002 0.0012 0.0006 0.001 0.011 0.002 0.0017 0.0522 0.0016 0.0033 – – – – – –
Bud Periphery 0.0028 0.0061 0.0065 0.0068 0.0034 0.0018 0.005 0.0102 0.0151 0.0093 0.0051 0.0043 – – – – – –
Bud Site 0.0066 0.0179 0.0046 0.0009 0.0021 0.0016 0.0116 0.0724 0.0178 0.0076 0.0022 0.0011 – – – – – –
Cell Periphery 0.0015 0.0013 0.001 0.0012 0.0013 0.0006 0.0019 0.004 0.0052 0.0063 0.0079 0.0016 – – – – – –
Cytoplasm 0.0367 0.0469 0.0266 0.0565 0.0285 0.0244 0.0372 0.0636 0.0665 0.0996 0.1245 0.0662 – – – – – –
Cytoplasmic Foci 0.0882 0.0902 0.0649 0.0513 0.0614 0.0799 0.1366 0.139 0.1076 0.1643 0.0868 0.1132 – – – – – –
Eisosomes 0.0009 0.0007 0.0006 0.0007 0.0009 0.0007 0.0018 0.0011 0.0021 0.0003 0.0016 0.0011 – – – – – –
Endoplasmic Reticulum 0.0053 0.004 0.0053 0.0023 0.0032 0.0014 0.0025 0.0016 0.0026 0.0009 0.002 0.0015 – – – – – –
Endosome 0.1204 0.1404 0.064 0.0731 0.079 0.0789 0.1288 0.1315 0.0963 0.0918 0.0677 0.0864 – – – – – –
Golgi 0.0358 0.0453 0.0248 0.018 0.0498 0.0278 0.0754 0.0645 0.0524 0.0524 0.0426 0.0697 – – – – – –
Lipid Particles 0.0436 0.0323 0.0242 0.019 0.0195 0.0478 0.0331 0.0162 0.0124 0.0096 0.0036 0.0275 – – – – – –
Mitochondria 0.3846 0.4244 0.54 0.5113 0.4265 0.5245 0.3047 0.3447 0.3959 0.1999 0.3353 0.3946 – – – – – –
None 0.1999 0.1121 0.1545 0.2195 0.2894 0.1389 0.1257 0.0625 0.1117 0.1888 0.2461 0.1321 – – – – – –
Nuclear Periphery 0.0024 0.0016 0.0017 0.0006 0.0008 0.0011 0.0007 0.0005 0.0006 0.0006 0.0004 0.0004 – – – – – –
Nucleolus 0.0016 0.0048 0.0027 0.001 0.003 0.001 0.0009 0.001 0.0012 0.0006 0.0006 0.0006 – – – – – –
Nucleus 0.0031 0.0029 0.002 0.001 0.0025 0.001 0.0008 0.0012 0.0012 0.0009 0.0008 0.0007 – – – – – –
Peroxisomes 0.0424 0.0342 0.0541 0.0204 0.0182 0.0527 0.067 0.0492 0.0751 0.08 0.0565 0.0687 – – – – – –
Punctate Nuclear 0.0017 0.002 0.0045 0.0006 0.0014 0.001 0.0012 0.0005 0.0015 0.0039 0.0004 0.0008 – – – – – –
Vacuole 0.0104 0.0159 0.008 0.006 0.0033 0.0058 0.0049 0.0119 0.0079 0.0069 0.0038 0.0035 – – – – – –
Vacuole Periphery 0.0042 0.0054 0.0039 0.0022 0.0022 0.0034 0.0021 0.0032 0.0033 0.0015 0.0019 0.0019 – – – – – –

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.2058 13.0935 7.5568 9.2113 9.4952 11.3858 10.2969 7.9425 13.2151 14.8819
Translational Efficiency 1.7612 0.9239 1.1506 1.7301 1.9307 2.7408 1.7117 2.5825 1.4866 1.9567

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
131 1441 2275 703 2067 2248 1861 1423 2198 3689 4136 2126

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 561.12 682.50 755.26 829.00 668.18 684.94 756.92 797.77 661.80 683.99 756.01 808.10
Standard Deviation 54.18 90.86 88.84 104.00 122.46 87.44 88.04 99.89 122.15 88.80 88.48 102.33
Intensity Change Log 2 — 0.282520 0.428664 0.563063 — 0.035741 0.179904 0.255736 — 0.153640 0.298793 0.404173

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000227 0.001386 0.003078 0.002379 0.000937 0.000874 0.001554 0.003990 0.000895 0.001074 0.002392 0.003457
Bud Neck 0.036091 0.047088 0.042759 0.027322 0.039989 0.037739 0.074591 0.036358 0.039756 0.041391 0.057082 0.033370
Bud Site 0.005926 0.029659 0.062688 0.051111 0.026779 0.023085 0.055432 0.051508 0.025536 0.025653 0.059423 0.051376
Cell Periphery 0.001196 0.000195 0.000151 0.000186 0.000356 0.000182 0.000166 0.000269 0.000406 0.000187 0.000158 0.000242
Cytoplasm 0.179609 0.091331 0.085796 0.345051 0.122062 0.064431 0.159013 0.327869 0.125492 0.074939 0.118740 0.333551
Cytoplasmic Foci 0.340082 0.277037 0.108820 0.079898 0.280920 0.216942 0.105967 0.136042 0.284446 0.240416 0.107536 0.117477
Eisosomes 0.000802 0.000220 0.000103 0.000110 0.000258 0.000212 0.000110 0.000194 0.000290 0.000215 0.000106 0.000166
Endoplasmic Reticulum 0.001081 0.000914 0.006488 0.003182 0.001542 0.000670 0.002661 0.001873 0.001515 0.000765 0.004766 0.002306
Endosome 0.019097 0.072563 0.047364 0.014498 0.072662 0.087109 0.052704 0.017137 0.069470 0.081427 0.049767 0.016264
Golgi 0.020628 0.057525 0.031545 0.011633 0.052203 0.074674 0.011775 0.006860 0.050321 0.067975 0.022649 0.008438
Lipid Particles 0.056534 0.013487 0.005893 0.003789 0.027612 0.010549 0.008572 0.004144 0.029336 0.011697 0.007099 0.004027
Mitochondria 0.152532 0.219286 0.187644 0.004197 0.215903 0.319396 0.099189 0.014487 0.212126 0.280291 0.147843 0.011084
Mitotic Spindle 0.000238 0.020829 0.141395 0.052893 0.009320 0.025304 0.087898 0.022335 0.008779 0.023556 0.117324 0.032440
None 0.001613 0.002686 0.002004 0.004165 0.004676 0.001503 0.002562 0.002291 0.004493 0.001965 0.002255 0.002910
Nuclear Periphery 0.000459 0.000413 0.004287 0.001488 0.000613 0.000269 0.003172 0.000685 0.000604 0.000325 0.003785 0.000951
Nuclear Periphery Foci 0.000116 0.000384 0.001972 0.001486 0.000901 0.000297 0.000792 0.000602 0.000855 0.000331 0.001441 0.000895
Nucleolus 0.000937 0.004015 0.006178 0.001478 0.003188 0.001862 0.007363 0.001364 0.003054 0.002703 0.006711 0.001402
Nucleus 0.068028 0.029917 0.082556 0.189071 0.035346 0.014555 0.126028 0.167733 0.037294 0.020556 0.102117 0.174789
Peroxisomes 0.092616 0.080510 0.048070 0.031859 0.041453 0.069735 0.047266 0.071829 0.044502 0.073943 0.047708 0.058612
Vacuole 0.016592 0.041813 0.116971 0.172483 0.052104 0.040589 0.144767 0.130282 0.049987 0.041067 0.129478 0.144236
Vacuole Periphery 0.005597 0.008743 0.014238 0.001721 0.011177 0.010023 0.008417 0.002148 0.010845 0.009523 0.011619 0.002007

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.74 -13.16 -6.60 -1.23 4.37 0.40 -3.31 -5.96 -6.14 -4.24 -1.10 -8.85 -6.64 -5.96 -1.06
Bud Neck -1.48 -1.26 2.15 7.13 7.98 0.77 -10.09 3.13 2.35 12.43 -0.66 -7.45 4.89 5.99 13.41
Bud Site -9.19 -18.08 -6.30 -0.60 6.68 1.62 -7.47 -4.38 -5.85 2.59 -0.01 -12.55 -4.51 -5.06 6.55
Cell Periphery 2.85 2.97 2.98 2.75 0.36 5.15 6.10 3.35 -1.84 -3.10 5.81 6.85 5.20 -0.78 -3.08
Cytoplasm 4.84 5.03 -6.03 -19.87 -20.73 11.84 -6.51 -23.06 -32.28 -16.90 11.00 0.56 -26.13 -37.50 -28.64
Cytoplasmic Foci 3.17 12.49 14.86 31.96 10.15 9.81 30.46 24.71 16.34 -3.69 7.33 34.36 32.13 30.36 0.94
Eisosomes 3.29 3.96 3.96 5.96 0.21 1.51 7.82 3.51 1.20 -4.92 2.86 8.81 6.08 3.22 -4.87
Endoplasmic Reticulum 0.63 -11.84 -7.84 -10.02 6.29 4.73 -7.10 -3.96 -8.73 3.37 4.77 -12.92 -7.12 -12.98 8.45
Endosome -11.11 -6.76 2.64 18.75 18.63 -3.80 7.14 20.79 24.20 13.51 -3.66 8.09 22.09 30.23 21.28
Golgi -7.24 -1.92 3.48 16.19 10.40 -6.20 15.45 17.54 26.59 5.00 -5.64 11.24 17.66 31.20 13.15
Lipid Particles 5.37 6.35 6.70 8.82 5.26 9.58 11.11 14.60 8.02 6.18 10.29 13.65 16.02 11.80 7.93
Mitochondria -3.00 -1.14 7.53 30.13 33.95 -11.42 17.48 32.51 45.55 18.79 -8.68 11.02 34.05 53.65 36.81
Mitotic Spindle -9.57 -28.69 -7.29 -3.20 13.89 -7.67 -16.87 -4.67 1.62 13.04 -8.80 -30.60 -7.22 -1.18 21.62
None -1.84 -0.80 -2.30 -0.71 -1.62 3.54 2.26 2.88 -1.44 0.90 2.96 2.61 2.35 -1.25 -0.54
Nuclear Periphery 0.34 -7.72 -11.96 -13.64 3.83 3.00 -6.47 -3.99 -10.64 5.56 2.70 -9.63 -8.20 -16.86 7.21
Nuclear Periphery Foci -5.47 -7.45 -10.96 -8.63 1.51 1.76 0.03 0.38 -3.66 0.89 1.64 -2.34 -0.85 -7.87 3.05
Nucleolus -4.54 -11.46 -2.35 3.82 10.25 3.03 -5.40 3.39 0.49 7.74 0.38 -7.33 3.75 3.27 11.98
Nucleus 2.97 -1.80 -9.70 -20.58 -13.07 8.53 -19.88 -24.27 -28.48 -6.34 6.90 -20.61 -29.95 -34.83 -14.54
Peroxisomes 0.76 2.92 4.79 13.45 8.05 -8.35 -1.02 -3.15 3.18 -2.27 -9.78 -0.64 0.55 8.92 1.11
Vacuole -6.01 -21.28 -24.62 -23.15 -14.94 3.75 -22.02 -21.56 -23.73 -3.98 3.22 -26.26 -29.85 -32.54 -13.53
Vacuole Periphery -1.94 -4.82 3.26 12.41 16.72 1.40 4.32 14.08 13.19 8.34 1.91 0.19 15.37 17.46 17.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
Localization
Cell Percentages mitochondrion (67%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Adk2

Adk2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Adk2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available