| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | – | – | 9 | 5 | 7 | 7 | 4 | 7 |
| Bud | 1 | 2 | 15 | 6 | 9 | 13 | 24 | 22 | 28 | 20 | 17 | 22 | 1 | 2 | 0 | 8 | – | – | 2 | 1 | 2 | 2 | 3 | 1 |
| Bud Neck | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 2 | 0 | 6 | – | – | 3 | 4 | 2 | 3 | 4 | 6 |
| Bud Site | 2 | 0 | 0 | 0 | 1 | 5 | 11 | 8 | 13 | 3 | 8 | 5 | 0 | 0 | 0 | 2 | – | – | – | – | – | – | – | – |
| Cell Periphery | 3 | 3 | 4 | 2 | 2 | 1 | 2 | 0 | 3 | 0 | 3 | 2 | 2 | 2 | 1 | 8 | – | – | 0 | 0 | 0 | 1 | 0 | 2 |
| Cytoplasm | 145 | 138 | 129 | 129 | 116 | 94 | 113 | 81 | 58 | 81 | 48 | 43 | 179 | 192 | 243 | 116 | – | – | 53 | 63 | 42 | 26 | 30 | 56 |
| Endoplasmic Reticulum | 3 | 1 | 2 | 0 | 5 | 2 | 0 | 3 | 4 | 1 | 3 | 2 | 3 | 1 | 0 | 4 | – | – | 2 | 3 | 5 | 1 | 1 | 1 |
| Endosome | 15 | 5 | 5 | 11 | 17 | 0 | 0 | 2 | 5 | 2 | 0 | 1 | 4 | 11 | 8 | 15 | – | – | 43 | 17 | 20 | 10 | 8 | 3 |
| Golgi | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | – | 2 | 0 | 0 | 3 | 1 | 1 |
| Mitochondria | 113 | 36 | 72 | 56 | 156 | 341 | 372 | 381 | 429 | 364 | 410 | 388 | 2 | 3 | 2 | 43 | – | – | 237 | 122 | 164 | 86 | 99 | 87 |
| Nucleus | 0 | 0 | 0 | 1 | 2 | 10 | 12 | 6 | 6 | 8 | 4 | 3 | 0 | 1 | 1 | 4 | – | – | 0 | 1 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 2 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 3 | 2 | 3 | 2 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 2 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 6 | 0 | 2 | 5 | 2 | 0 | 0 | 1 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 1 |
| Peroxisomes | 5 | 2 | 1 | 10 | 5 | 0 | 5 | 7 | 4 | 2 | 3 | 6 | 4 | 3 | 3 | 2 | – | – | 7 | 2 | 4 | 1 | 3 | 1 |
| SpindlePole | 14 | 2 | 11 | 16 | 15 | 25 | 22 | 41 | 35 | 41 | 26 | 15 | 3 | 6 | 1 | 40 | – | – | 14 | 7 | 13 | 3 | 5 | 6 |
| Vac/Vac Membrane | 25 | 7 | 5 | 0 | 16 | 13 | 6 | 7 | 29 | 8 | 14 | 6 | 6 | 9 | 9 | 9 | – | – | 12 | 10 | 8 | 4 | 17 | 19 |
| Unique Cell Count | 290 | 184 | 228 | 198 | 284 | 412 | 456 | 461 | 490 | 443 | 444 | 420 | 200 | 221 | 264 | 221 | 401 | 249 | 287 | 160 | 184 | 202 | ||
| Labelled Cell Count | 330 | 198 | 249 | 231 | 347 | 509 | 570 | 565 | 617 | 535 | 544 | 499 | 205 | 233 | 269 | 261 | 401 | 249 | 287 | 160 | 184 | 202 | ||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 3.9 | 4.1 | 3.5 | 3.7 | 3.7 | 3.5 | 3.1 | 3.3 | 3.2 | 2.9 | 3.0 | 3.0 | 5.2 | 4.8 | 4.7 | 5.1 | 4.7 | 4.6 | 5.4 | 5.3 | 5.2 |
| Std Deviation (1e-4) | 0.6 | 0.7 | 1.0 | 1.7 | 2.0 | 1.5 | 1.7 | 1.3 | 1.6 | 1.1 | 1.3 | 1.1 | 0.8 | 0.9 | 0.7 | 1.3 | 0.9 | 1.1 | 1.4 | 1.2 | 1.0 |
| Intensity Change (Log2) | – | – | – | 0.09 | 0.11 | 0.0 | -0.14 | -0.07 | -0.12 | -0.26 | -0.2 | -0.19 | 0.58 | 0.48 | 0.45 | 0.55 | 0.44 | 0.43 | 0.65 | 0.61 | 0.6 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 1.1 | – | – |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | 0.0056 | 0.0076 | 0.003 | 0.0053 | 0.0023 | 0.0041 | 0.045 | 0.0127 | 0.0167 | 0.0205 | 0.0075 | 0.0195 | – | – | – | – | – | – |
| Bud | 0.0008 | 0.0025 | 0.0012 | 0.0013 | 0.0007 | 0.0007 | 0.0022 | 0.0064 | 0.0052 | 0.002 | 0.0011 | 0.0013 | – | – | – | – | – | – |
| Bud Neck | 0.0017 | 0.0013 | 0.002 | 0.0012 | 0.0006 | 0.001 | 0.011 | 0.002 | 0.0017 | 0.0522 | 0.0016 | 0.0033 | – | – | – | – | – | – |
| Bud Periphery | 0.0028 | 0.0061 | 0.0065 | 0.0068 | 0.0034 | 0.0018 | 0.005 | 0.0102 | 0.0151 | 0.0093 | 0.0051 | 0.0043 | – | – | – | – | – | – |
| Bud Site | 0.0066 | 0.0179 | 0.0046 | 0.0009 | 0.0021 | 0.0016 | 0.0116 | 0.0724 | 0.0178 | 0.0076 | 0.0022 | 0.0011 | – | – | – | – | – | – |
| Cell Periphery | 0.0015 | 0.0013 | 0.001 | 0.0012 | 0.0013 | 0.0006 | 0.0019 | 0.004 | 0.0052 | 0.0063 | 0.0079 | 0.0016 | – | – | – | – | – | – |
| Cytoplasm | 0.0367 | 0.0469 | 0.0266 | 0.0565 | 0.0285 | 0.0244 | 0.0372 | 0.0636 | 0.0665 | 0.0996 | 0.1245 | 0.0662 | – | – | – | – | – | – |
| Cytoplasmic Foci | 0.0882 | 0.0902 | 0.0649 | 0.0513 | 0.0614 | 0.0799 | 0.1366 | 0.139 | 0.1076 | 0.1643 | 0.0868 | 0.1132 | – | – | – | – | – | – |
| Eisosomes | 0.0009 | 0.0007 | 0.0006 | 0.0007 | 0.0009 | 0.0007 | 0.0018 | 0.0011 | 0.0021 | 0.0003 | 0.0016 | 0.0011 | – | – | – | – | – | – |
| Endoplasmic Reticulum | 0.0053 | 0.004 | 0.0053 | 0.0023 | 0.0032 | 0.0014 | 0.0025 | 0.0016 | 0.0026 | 0.0009 | 0.002 | 0.0015 | – | – | – | – | – | – |
| Endosome | 0.1204 | 0.1404 | 0.064 | 0.0731 | 0.079 | 0.0789 | 0.1288 | 0.1315 | 0.0963 | 0.0918 | 0.0677 | 0.0864 | – | – | – | – | – | – |
| Golgi | 0.0358 | 0.0453 | 0.0248 | 0.018 | 0.0498 | 0.0278 | 0.0754 | 0.0645 | 0.0524 | 0.0524 | 0.0426 | 0.0697 | – | – | – | – | – | – |
| Lipid Particles | 0.0436 | 0.0323 | 0.0242 | 0.019 | 0.0195 | 0.0478 | 0.0331 | 0.0162 | 0.0124 | 0.0096 | 0.0036 | 0.0275 | – | – | – | – | – | – |
| Mitochondria | 0.3846 | 0.4244 | 0.54 | 0.5113 | 0.4265 | 0.5245 | 0.3047 | 0.3447 | 0.3959 | 0.1999 | 0.3353 | 0.3946 | – | – | – | – | – | – |
| None | 0.1999 | 0.1121 | 0.1545 | 0.2195 | 0.2894 | 0.1389 | 0.1257 | 0.0625 | 0.1117 | 0.1888 | 0.2461 | 0.1321 | – | – | – | – | – | – |
| Nuclear Periphery | 0.0024 | 0.0016 | 0.0017 | 0.0006 | 0.0008 | 0.0011 | 0.0007 | 0.0005 | 0.0006 | 0.0006 | 0.0004 | 0.0004 | – | – | – | – | – | – |
| Nucleolus | 0.0016 | 0.0048 | 0.0027 | 0.001 | 0.003 | 0.001 | 0.0009 | 0.001 | 0.0012 | 0.0006 | 0.0006 | 0.0006 | – | – | – | – | – | – |
| Nucleus | 0.0031 | 0.0029 | 0.002 | 0.001 | 0.0025 | 0.001 | 0.0008 | 0.0012 | 0.0012 | 0.0009 | 0.0008 | 0.0007 | – | – | – | – | – | – |
| Peroxisomes | 0.0424 | 0.0342 | 0.0541 | 0.0204 | 0.0182 | 0.0527 | 0.067 | 0.0492 | 0.0751 | 0.08 | 0.0565 | 0.0687 | – | – | – | – | – | – |
| Punctate Nuclear | 0.0017 | 0.002 | 0.0045 | 0.0006 | 0.0014 | 0.001 | 0.0012 | 0.0005 | 0.0015 | 0.0039 | 0.0004 | 0.0008 | – | – | – | – | – | – |
| Vacuole | 0.0104 | 0.0159 | 0.008 | 0.006 | 0.0033 | 0.0058 | 0.0049 | 0.0119 | 0.0079 | 0.0069 | 0.0038 | 0.0035 | – | – | – | – | – | – |
| Vacuole Periphery | 0.0042 | 0.0054 | 0.0039 | 0.0022 | 0.0022 | 0.0034 | 0.0021 | 0.0032 | 0.0033 | 0.0015 | 0.0019 | 0.0019 | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 12.2058 | 13.0935 | 7.5568 | 9.2113 | 9.4952 | 11.3858 | 10.2969 | 7.9425 | 13.2151 | 14.8819 |
| Translational Efficiency | 1.7612 | 0.9239 | 1.1506 | 1.7301 | 1.9307 | 2.7408 | 1.7117 | 2.5825 | 1.4866 | 1.9567 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | ✘ |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 131 | 1441 | 2275 | 703 | 2067 | 2248 | 1861 | 1423 | 2198 | 3689 | 4136 | 2126 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 561.12 | 682.50 | 755.26 | 829.00 | 668.18 | 684.94 | 756.92 | 797.77 | 661.80 | 683.99 | 756.01 | 808.10 |
| Standard Deviation | 54.18 | 90.86 | 88.84 | 104.00 | 122.46 | 87.44 | 88.04 | 99.89 | 122.15 | 88.80 | 88.48 | 102.33 |
| Intensity Change Log 2 | — | 0.282520 | 0.428664 | 0.563063 | — | 0.035741 | 0.179904 | 0.255736 | — | 0.153640 | 0.298793 | 0.404173 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000227 | 0.001386 | 0.003078 | 0.002379 | 0.000937 | 0.000874 | 0.001554 | 0.003990 | 0.000895 | 0.001074 | 0.002392 | 0.003457 |
| Bud Neck | 0.036091 | 0.047088 | 0.042759 | 0.027322 | 0.039989 | 0.037739 | 0.074591 | 0.036358 | 0.039756 | 0.041391 | 0.057082 | 0.033370 |
| Bud Site | 0.005926 | 0.029659 | 0.062688 | 0.051111 | 0.026779 | 0.023085 | 0.055432 | 0.051508 | 0.025536 | 0.025653 | 0.059423 | 0.051376 |
| Cell Periphery | 0.001196 | 0.000195 | 0.000151 | 0.000186 | 0.000356 | 0.000182 | 0.000166 | 0.000269 | 0.000406 | 0.000187 | 0.000158 | 0.000242 |
| Cytoplasm | 0.179609* | 0.091331 | 0.085796 | 0.345051* | 0.122062* | 0.064431 | 0.159013* | 0.327869* | 0.125492* | 0.074939 | 0.118740* | 0.333551* |
| Cytoplasmic Foci | 0.340082* | 0.277037* | 0.108820 | 0.079898 | 0.280920* | 0.216942* | 0.105967 | 0.136042 | 0.284446* | 0.240416* | 0.107536 | 0.117477 |
| Eisosomes | 0.000802 | 0.000220 | 0.000103 | 0.000110 | 0.000258 | 0.000212 | 0.000110 | 0.000194 | 0.000290 | 0.000215 | 0.000106 | 0.000166 |
| Endoplasmic Reticulum | 0.001081 | 0.000914 | 0.006488 | 0.003182 | 0.001542 | 0.000670 | 0.002661 | 0.001873 | 0.001515 | 0.000765 | 0.004766 | 0.002306 |
| Endosome | 0.019097 | 0.072563 | 0.047364 | 0.014498 | 0.072662 | 0.087109 | 0.052704 | 0.017137 | 0.069470 | 0.081427 | 0.049767 | 0.016264 |
| Golgi | 0.020628 | 0.057525 | 0.031545 | 0.011633 | 0.052203 | 0.074674 | 0.011775 | 0.006860 | 0.050321 | 0.067975 | 0.022649 | 0.008438 |
| Lipid Particles | 0.056534 | 0.013487 | 0.005893 | 0.003789 | 0.027612 | 0.010549 | 0.008572 | 0.004144 | 0.029336 | 0.011697 | 0.007099 | 0.004027 |
| Mitochondria | 0.152532* | 0.219286* | 0.187644* | 0.004197 | 0.215903* | 0.319396* | 0.099189 | 0.014487 | 0.212126* | 0.280291* | 0.147843* | 0.011084 |
| Mitotic Spindle | 0.000238 | 0.020829 | 0.141395* | 0.052893 | 0.009320 | 0.025304 | 0.087898 | 0.022335 | 0.008779 | 0.023556 | 0.117324* | 0.032440 |
| None | 0.001613 | 0.002686 | 0.002004 | 0.004165 | 0.004676 | 0.001503 | 0.002562 | 0.002291 | 0.004493 | 0.001965 | 0.002255 | 0.002910 |
| Nuclear Periphery | 0.000459 | 0.000413 | 0.004287 | 0.001488 | 0.000613 | 0.000269 | 0.003172 | 0.000685 | 0.000604 | 0.000325 | 0.003785 | 0.000951 |
| Nuclear Periphery Foci | 0.000116 | 0.000384 | 0.001972 | 0.001486 | 0.000901 | 0.000297 | 0.000792 | 0.000602 | 0.000855 | 0.000331 | 0.001441 | 0.000895 |
| Nucleolus | 0.000937 | 0.004015 | 0.006178 | 0.001478 | 0.003188 | 0.001862 | 0.007363 | 0.001364 | 0.003054 | 0.002703 | 0.006711 | 0.001402 |
| Nucleus | 0.068028 | 0.029917 | 0.082556 | 0.189071* | 0.035346 | 0.014555 | 0.126028 | 0.167733* | 0.037294 | 0.020556 | 0.102117 | 0.174789* |
| Peroxisomes | 0.092616 | 0.080510 | 0.048070 | 0.031859 | 0.041453 | 0.069735 | 0.047266 | 0.071829 | 0.044502 | 0.073943 | 0.047708 | 0.058612 |
| Vacuole | 0.016592 | 0.041813 | 0.116971 | 0.172483 | 0.052104 | 0.040589 | 0.144767 | 0.130282 | 0.049987 | 0.041067 | 0.129478 | 0.144236 |
| Vacuole Periphery | 0.005597 | 0.008743 | 0.014238 | 0.001721 | 0.011177 | 0.010023 | 0.008417 | 0.002148 | 0.010845 | 0.009523 | 0.011619 | 0.002007 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | -4.74 | -13.16 | -6.60 | -1.23 | 4.37 | 0.40 | -3.31 | -5.96 | -6.14 | -4.24 | -1.10 | -8.85 | -6.64 | -5.96 | -1.06 |
| Bud Neck | -1.48 | -1.26 | 2.15 | 7.13 | 7.98 | 0.77 | -10.09 | 3.13 | 2.35 | 12.43 | -0.66 | -7.45 | 4.89 | 5.99 | 13.41 |
| Bud Site | -9.19 | -18.08 | -6.30 | -0.60 | 6.68 | 1.62 | -7.47 | -4.38 | -5.85 | 2.59 | -0.01 | -12.55 | -4.51 | -5.06 | 6.55 |
| Cell Periphery | 2.85 | 2.97 | 2.98 | 2.75 | 0.36 | 5.15 | 6.10 | 3.35 | -1.84 | -3.10 | 5.81 | 6.85 | 5.20 | -0.78 | -3.08 |
| Cytoplasm | 4.84 | 5.03 | -6.03 | -19.87 | -20.73 | 11.84 | -6.51 | -23.06 | -32.28 | -16.90 | 11.00 | 0.56 | -26.13 | -37.50 | -28.64 |
| Cytoplasmic Foci | 3.17 | 12.49 | 14.86 | 31.96 | 10.15 | 9.81 | 30.46 | 24.71 | 16.34 | -3.69 | 7.33 | 34.36 | 32.13 | 30.36 | 0.94 |
| Eisosomes | 3.29 | 3.96 | 3.96 | 5.96 | 0.21 | 1.51 | 7.82 | 3.51 | 1.20 | -4.92 | 2.86 | 8.81 | 6.08 | 3.22 | -4.87 |
| Endoplasmic Reticulum | 0.63 | -11.84 | -7.84 | -10.02 | 6.29 | 4.73 | -7.10 | -3.96 | -8.73 | 3.37 | 4.77 | -12.92 | -7.12 | -12.98 | 8.45 |
| Endosome | -11.11 | -6.76 | 2.64 | 18.75 | 18.63 | -3.80 | 7.14 | 20.79 | 24.20 | 13.51 | -3.66 | 8.09 | 22.09 | 30.23 | 21.28 |
| Golgi | -7.24 | -1.92 | 3.48 | 16.19 | 10.40 | -6.20 | 15.45 | 17.54 | 26.59 | 5.00 | -5.64 | 11.24 | 17.66 | 31.20 | 13.15 |
| Lipid Particles | 5.37 | 6.35 | 6.70 | 8.82 | 5.26 | 9.58 | 11.11 | 14.60 | 8.02 | 6.18 | 10.29 | 13.65 | 16.02 | 11.80 | 7.93 |
| Mitochondria | -3.00 | -1.14 | 7.53 | 30.13* | 33.95* | -11.42 | 17.48 | 32.51* | 45.55* | 18.79* | -8.68 | 11.02 | 34.05 | 53.65* | 36.81* |
| Mitotic Spindle | -9.57 | -28.69* | -7.29 | -3.20 | 13.89 | -7.67 | -16.87 | -4.67 | 1.62 | 13.04 | -8.80 | -30.60 | -7.22 | -1.18 | 21.62* |
| None | -1.84 | -0.80 | -2.30 | -0.71 | -1.62 | 3.54 | 2.26 | 2.88 | -1.44 | 0.90 | 2.96 | 2.61 | 2.35 | -1.25 | -0.54 |
| Nuclear Periphery | 0.34 | -7.72 | -11.96 | -13.64 | 3.83 | 3.00 | -6.47 | -3.99 | -10.64 | 5.56 | 2.70 | -9.63 | -8.20 | -16.86 | 7.21 |
| Nuclear Periphery Foci | -5.47 | -7.45 | -10.96 | -8.63 | 1.51 | 1.76 | 0.03 | 0.38 | -3.66 | 0.89 | 1.64 | -2.34 | -0.85 | -7.87 | 3.05 |
| Nucleolus | -4.54 | -11.46 | -2.35 | 3.82 | 10.25 | 3.03 | -5.40 | 3.39 | 0.49 | 7.74 | 0.38 | -7.33 | 3.75 | 3.27 | 11.98 |
| Nucleus | 2.97 | -1.80 | -9.70 | -20.58 | -13.07 | 8.53 | -19.88 | -24.27 | -28.48 | -6.34 | 6.90 | -20.61 | -29.95 | -34.83 | -14.54 |
| Peroxisomes | 0.76 | 2.92 | 4.79 | 13.45 | 8.05 | -8.35 | -1.02 | -3.15 | 3.18 | -2.27 | -9.78 | -0.64 | 0.55 | 8.92 | 1.11 |
| Vacuole | -6.01 | -21.28 | -24.62 | -23.15 | -14.94 | 3.75 | -22.02 | -21.56 | -23.73 | -3.98 | 3.22 | -26.26 | -29.85 | -32.54 | -13.53 |
| Vacuole Periphery | -1.94 | -4.82 | 3.26 | 12.41 | 16.72 | 1.40 | 4.32 | 14.08 | 13.19 | 8.34 | 1.91 | 0.19 | 15.37 | 17.46 | 17.53 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background |
| Localization | |
| Cell Percentages | mitochondrion (67%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | mito-1 |
Adk2
Adk2
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Adk2-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
