Standard name
Human Ortholog
Description Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.93 0.99 0.99 0.99 0.96 0.94 0.87 0.8 0.77 0.71 0.75 0.97 0.99 1.0 – 0.97 0.96 0.92 0.71 0.85 0.88 0.89 0.89
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0.07 0 0 0 0 0.07 0.06 0.26 0.18 0.32 0.24 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.08 0.05 0.05 0.08 0.07 0 0 0 – 0 0 0 0.19 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 2 0 0 0 0 0 0 0 0 0 0 0 – 0 0 1 0 3 0 2 0
Bud 0 0 0 1 0 1 2 0 4 4 2 3 0 0 0 – 0 0 0 0 5 1 10 5
Bud Neck 0 0 2 2 6 4 7 8 4 1 0 0 2 1 0 – 0 1 0 0 0 0 2 2
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 1 0 2 2 0 3 1 1 0 0 0 3 2 0 0 – 1 2 0 0 1 0 0 0
Cytoplasm 127 54 307 283 285 395 434 482 236 211 160 185 180 297 375 – 173 187 127 48 272 170 399 286
Endoplasmic Reticulum 0 0 0 0 1 0 1 0 1 1 0 2 0 0 0 – 10 4 0 0 1 1 0 0
Endosome 0 0 1 0 0 1 0 2 0 1 0 2 0 1 0 – 2 2 0 1 5 1 1 0
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – 1 0 0 0 1 1 0 0
Mitochondria 0 4 0 1 0 17 30 34 78 50 72 59 2 0 0 – 5 2 2 0 8 4 4 7
Nucleus 0 1 2 3 0 5 3 10 6 8 12 8 0 0 2 – 0 3 1 1 0 1 3 0
Nuclear Periphery 1 0 0 0 0 1 0 2 0 1 2 0 0 0 0 – 0 0 0 0 1 0 1 1
Nucleolus 0 0 0 0 0 0 1 0 0 0 1 0 0 1 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 1 3 4 1 1 0 2 0 0 0 – 0 0 1 0 8 3 10 3
Vac/Vac Membrane 3 1 0 2 4 11 12 47 15 15 18 17 6 2 1 – 0 8 1 12 1 3 2 5
Unique Cell Count 130 58 311 286 288 413 461 554 296 275 226 247 185 300 376 179 194 139 68 319 194 447 324
Labelled Cell Count 132 60 316 296 296 439 494 590 345 293 267 281 192 302 378 192 210 139 68 319 194 447 324


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 3.9 5.4 5.3 5.9 4.6 4.6 5.1 4.3 4.8 5.1 5.6 5.0 5.1 4.6 4.6 5.8 6.3 6.1 6.0 6.2
Std Deviation (1e-4) 1.0 1.1 1.2 1.5 1.8 1.5 1.4 1.5 1.5 1.5 1.6 1.7 1.1 1.2 1.0 1.6 2.2 2.2 2.0 1.7 2.0
Intensity Change (Log2) – – – -0.01 0.13 -0.22 -0.22 -0.07 -0.33 -0.15 -0.08 0.05 -0.11 -0.08 -0.21 -0.21 0.1 0.22 0.18 0.16 0.21

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.6316 0.143 0.3614 0.8476 0.3391 0.4403 3.0647 2.9144 3.0175 3.9047 3.3266 3.3081 0.5903 1.1834 0.7154 0.6029 0.5905 0.5169
Actin 0.0306 0.0003 0.0036 0.0523 0.0013 0.0074 0.0232 0.0003 0.0175 0.0016 0.0056 0.0015 0.0191 0.0008 0.0044 0.0003 0.0028 0.0005
Bud 0.0034 0.0016 0.0027 0.0005 0.0019 0.0011 0.0004 0.0003 0.0004 0.0001 0.0001 0.0002 0.0019 0.0015 0.0002 0.0002 0.0001 0.0006
Bud Neck 0.0046 0.0008 0.0019 0.0034 0.0083 0.0037 0.0088 0.0004 0.0004 0.0002 0.0003 0.0011 0.0133 0.0032 0.0005 0.0002 0.0002 0.0043
Bud Periphery 0.003 0.0013 0.0053 0.0007 0.0041 0.0019 0.0007 0.0001 0.0003 0.0001 0.0002 0.0002 0.0041 0.0027 0.0002 0.0002 0.0002 0.0006
Bud Site 0.0017 0.0049 0.002 0.0005 0.0161 0.0003 0.0097 0.0011 0.0265 0.0001 0.0011 0.0002 0.0057 0.0085 0.0006 0 0.0002 0.0017
Cell Periphery 0.0003 0.0002 0.0002 0.0001 0.0003 0.0001 0.0003 0.0001 0.0002 0.0001 0.0001 0 0.0006 0.0008 0.0001 0 0 0
Cytoplasm 0.4723 0.4138 0.4668 0.577 0.5878 0.5639 0.2482 0.3195 0.4252 0.5574 0.4177 0.5366 0.489 0.6165 0.5712 0.6056 0.5749 0.5846
Cytoplasmic Foci 0.0166 0.0151 0.02 0.006 0.0272 0.0192 0.0397 0.0028 0.0057 0.0058 0.0429 0.0043 0.021 0.0045 0.0134 0.0037 0.0065 0.0072
Eisosomes 0.0004 0.0001 0.0001 0.0008 0 0 0.0029 0 0.0002 0.0001 0.0001 0 0.0003 0 0.0001 0.0002 0 0
Endoplasmic Reticulum 0.0064 0.0031 0.0036 0.0031 0.004 0.0024 0.0026 0.0018 0.0033 0.0049 0.0011 0.0026 0.0041 0.0023 0.0036 0.0017 0.0006 0.0016
Endosome 0.0099 0.0062 0.0104 0.0051 0.0055 0.0054 0.0139 0.0007 0.0096 0.0012 0.0118 0.0071 0.0168 0.0047 0.0037 0.0014 0.0024 0.0043
Golgi 0.003 0.0002 0.0011 0.0045 0.0004 0.0006 0.0049 0.0001 0.0036 0.0003 0.013 0.0004 0.0048 0.0002 0.0007 0.0001 0.0028 0.0004
Lipid Particles 0.0016 0.0009 0.0028 0.0058 0.0002 0.0005 0.0245 0.0001 0.0019 0.0001 0.0761 0.0007 0.0079 0.0001 0.0004 0.0014 0.0054 0.0008
Mitochondria 0.0048 0.0006 0.0008 0.0017 0.0003 0.0006 0.0045 0.0001 0.0024 0.0002 0.02 0.0004 0.003 0.0002 0.0005 0.0018 0.0096 0.0002
None 0.3971 0.5078 0.438 0.2515 0.3066 0.3444 0.4877 0.6653 0.4672 0.423 0.3462 0.4296 0.3685 0.3434 0.3843 0.3734 0.3358 0.3717
Nuclear Periphery 0.0062 0.0035 0.0067 0.0058 0.003 0.0025 0.0584 0.0008 0.0237 0.0015 0.0017 0.0047 0.0066 0.0011 0.0024 0.0026 0.0007 0.0024
Nucleolus 0.0005 0.0036 0.0003 0.0003 0.0002 0.0004 0.0049 0.0001 0.0001 0 0.0007 0.0002 0.0016 0.0001 0.0001 0.0002 0 0.0002
Nucleus 0.0229 0.023 0.0213 0.0675 0.0185 0.0344 0.0098 0.0046 0.0035 0.0022 0.004 0.0042 0.0121 0.0073 0.009 0.0052 0.007 0.0161
Peroxisomes 0.0044 0.0007 0.0044 0.0048 0.0005 0.0008 0.0353 0.0001 0.0009 0.0001 0.0533 0.0005 0.0053 0.0001 0.0011 0.0002 0.0497 0.0001
Punctate Nuclear 0.0055 0.0065 0.0057 0.0064 0.0112 0.008 0.0132 0.0016 0.0011 0.0007 0.0023 0.0049 0.0106 0.0009 0.0024 0.0006 0.0005 0.002
Vacuole 0.0039 0.0053 0.0019 0.0018 0.0021 0.0021 0.0019 0.0003 0.0017 0.0003 0.0008 0.0005 0.003 0.0011 0.001 0.0007 0.0003 0.0006
Vacuole Periphery 0.001 0.0005 0.0005 0.0004 0.0004 0.0003 0.0045 0 0.0046 0.0001 0.0008 0.0002 0.0008 0.0002 0.0002 0.0003 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.7654 14.7621 11.9499 17.1962 22.3837 21.0056 14.5867 18.3164 21.9903 20.8312
Translational Efficiency 1.987 1.3574 1.3033 1.325 1.4667 1.5751 0.906 0.597 0.6553 0.8069

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1785 446 1944 1892 1621 1576 1594 1332 3406 2022 3538 3224

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 616.75 753.88 769.69 785.61 613.33 731.65 872.56 801.64 615.12 736.55 816.04 792.23
Standard Deviation 68.88 97.75 114.43 122.74 69.22 112.50 131.53 126.38 69.06 109.81 132.70 124.51
Intensity Change Log 2 — 0.289649 0.319592 0.349127 — 0.254490 0.508591 0.386291 — 0.272226 0.416922 0.367777

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000134 0.000637 0.000368 0.000828 0.000053 0.000183 0.000396 0.000213 0.000095 0.000283 0.000381 0.000574
Bud Neck 0.029118 0.033602 0.006697 0.011175 0.004011 0.025561 0.004598 0.003594 0.017169 0.027335 0.005751 0.008043
Bud Site 0.004432 0.026509 0.016428 0.029454 0.001566 0.008952 0.010088 0.021512 0.003068 0.012825 0.013572 0.026173
Cell Periphery 0.000457 0.000188 0.000181 0.000259 0.000096 0.000139 0.000150 0.000193 0.000285 0.000149 0.000167 0.000232
Cytoplasm 0.426563 0.356009 0.483290 0.480385 0.590726 0.472826 0.471427 0.581511 0.504692 0.447059 0.477945 0.522166
Cytoplasmic Foci 0.294438 0.297802 0.011801 0.026857 0.140850 0.217805 0.009847 0.027443 0.221341 0.235450 0.010920 0.027099
Eisosomes 0.000711 0.000168 0.000030 0.000074 0.000068 0.000181 0.000035 0.000045 0.000405 0.000178 0.000032 0.000062
Endoplasmic Reticulum 0.001675 0.001098 0.002217 0.000906 0.000749 0.000565 0.002691 0.001129 0.001234 0.000682 0.002431 0.000998
Endosome 0.011230 0.028637 0.001684 0.007835 0.005042 0.018978 0.002148 0.003901 0.008285 0.021109 0.001893 0.006210
Golgi 0.007385 0.010490 0.000591 0.002344 0.000900 0.003681 0.000415 0.001543 0.004299 0.005183 0.000512 0.002013
Lipid Particles 0.024753 0.005389 0.000883 0.001897 0.004445 0.007300 0.001107 0.001203 0.015088 0.006878 0.000984 0.001610
Mitochondria 0.015903 0.009256 0.001824 0.004612 0.001663 0.009712 0.000942 0.000551 0.009126 0.009611 0.001426 0.002935
Mitotic Spindle 0.000348 0.004810 0.005201 0.038806 0.000112 0.006924 0.006744 0.014135 0.000236 0.006458 0.005896 0.028613
None 0.006570 0.002942 0.004322 0.007116 0.010961 0.006650 0.006976 0.009290 0.008660 0.005832 0.005518 0.008014
Nuclear Periphery 0.000457 0.000347 0.001504 0.001183 0.000427 0.000466 0.001439 0.000947 0.000443 0.000440 0.001475 0.001086
Nuclear Periphery Foci 0.000370 0.000681 0.000761 0.000689 0.000443 0.000304 0.001518 0.001081 0.000404 0.000387 0.001102 0.000851
Nucleolus 0.001325 0.001206 0.000303 0.001058 0.001202 0.002408 0.000476 0.000723 0.001266 0.002143 0.000381 0.000919
Nucleus 0.135874 0.113316 0.408421 0.285438 0.203849 0.145195 0.415286 0.244996 0.168225 0.138164 0.411514 0.268730
Peroxisomes 0.008367 0.026237 0.000413 0.002042 0.001253 0.009344 0.000481 0.000348 0.004981 0.013070 0.000443 0.001342
Vacuole 0.028055 0.078881 0.052537 0.093899 0.031008 0.061114 0.063004 0.082095 0.029460 0.065033 0.057253 0.089022
Vacuole Periphery 0.001838 0.001794 0.000546 0.003144 0.000578 0.001712 0.000231 0.003544 0.001238 0.001730 0.000404 0.003309

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.92 -3.64 -2.63 0.47 -0.99 -6.11 -4.19 -4.71 -1.06 1.83 -5.38 -5.59 -3.45 -1.33 -0.28
Bud Neck -0.77 11.71 10.01 5.69 -2.57 -13.49 -0.60 0.66 13.68 0.98 -5.47 10.64 9.27 12.62 -2.06
Bud Site -5.22 -4.85 -7.90 1.30 -2.74 -8.03 -4.74 -6.34 -2.71 -3.15 -8.04 -6.64 -10.30 -2.96 -4.21
Cell Periphery 8.73 10.42 9.80 0.68 -0.45 -5.11 -4.91 -5.15 -1.63 -1.43 9.04 8.44 7.02 -1.49 -1.12
Cytoplasm 5.14 -0.64 -0.71 -5.43 -0.08 12.57 21.50 9.34 -2.54 -9.97 7.63 13.90 6.64 -1.79 -6.40
Cytoplasmic Foci -0.06 54.19 51.90 24.55 -6.89 -11.46 32.53 27.75 35.74 -10.58 -2.22 58.69 54.55 43.40 -12.15
Eisosomes 9.87 12.49 11.99 9.35 -8.52 -2.89 7.16 4.10 3.28 -3.66 5.48 12.65 11.97 3.93 -9.04
Endoplasmic Reticulum 1.52 -4.85 1.58 -0.60 10.48 0.75 -10.75 -4.19 -9.31 10.55 2.92 -10.91 -1.62 -7.39 15.02
Endosome -6.09 13.75 7.33 8.43 -5.70 -9.93 6.81 4.06 11.64 -2.30 -10.02 15.24 7.92 13.55 -6.09
Golgi -1.26 13.56 11.20 4.22 -2.20 -4.96 2.71 0.11 4.24 -1.45 -1.10 13.21 9.03 6.03 -2.67
Lipid Particles 14.58 19.50 18.53 6.24 -1.47 -4.68 8.51 8.51 12.26 0.09 10.40 20.39 19.33 12.45 -1.37
Mitochondria 3.17 10.18 9.42 3.31 -1.87 -6.00 2.40 3.48 7.11 2.37 -0.20 10.24 9.49 6.85 -1.66
Mitotic Spindle -1.93 -4.78 -9.99 -6.13 -7.74 -4.24 -5.47 -5.54 -1.94 -2.44 -4.60 -7.21 -11.40 -6.56 -7.90
None 3.05 2.92 0.37 -2.75 -2.56 3.02 4.41 3.00 -0.21 -0.85 2.79 5.29 2.47 -0.69 -2.45
Nuclear Periphery 1.01 -18.93 -15.01 -14.84 -1.30 -0.45 -19.82 -12.35 -11.72 6.95 -0.05 -27.24 -19.07 -17.43 2.19
Nuclear Periphery Foci -1.71 -3.33 -1.20 0.91 3.24 2.36 -10.90 -8.83 -9.69 5.78 0.15 -9.24 -4.11 -5.69 6.65
Nucleolus 0.48 6.02 1.59 1.28 -3.36 -3.76 5.54 5.47 6.03 -0.11 -3.40 8.18 3.37 5.27 -3.05
Nucleus 2.58 -40.99 -24.65 -20.15 14.44 9.18 -29.85 -10.31 -18.17 17.17 6.23 -49.56 -24.40 -27.62 22.02
Peroxisomes -4.99 13.55 11.52 7.17 -3.80 -9.42 3.41 3.67 11.23 0.49 -7.59 13.54 11.57 12.18 -3.49
Vacuole -9.65 -16.59 -25.95 -10.08 -12.80 -11.05 -16.88 -20.26 -13.59 -4.71 -15.42 -23.52 -32.80 -19.71 -12.60
Vacuole Periphery 0.29 6.17 0.31 0.14 -2.46 -6.20 5.91 -1.80 -0.41 -2.29 -2.71 7.22 -1.28 -0.25 -3.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (34%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Grx4

Grx4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Grx4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available