Standard name
Human Ortholog
Description Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Cytoplasm 0.98 0.97 0.97 0.88 0.89 0.82 0.72 0.73 0.69 0.7 0.68 0.71 0.96 0.99 0.98 0.95 0.96 0.93 0.97 0.89 0.9 0.95 0.96 0.95
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.08 0.12 0.07 0.15 0.13 0.24 0.18 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0.06 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.13 0.11 0.09 0.19 0.16 0.18 0.15 0.1 0.16 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 0 0 0 0 1 1 1 3 4 2 0 0 0 0 0 1 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 2 1 2 7 3 3 4 4 3 1 0 0 3 10 10 6 0 0 0 0 0 0
Cytoplasm 168 86 139 109 200 212 193 146 125 164 99 120 265 471 414 258 151 137 163 86 142 228 391 472
Endoplasmic Reticulum 0 2 0 1 2 5 3 2 1 4 3 1 3 0 2 7 2 6 0 1 3 0 2 6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 2 0 1 1 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 0
Mitochondria 1 0 0 5 2 20 32 14 27 31 35 31 0 0 0 1 2 1 0 1 1 0 1 3
Nucleus 1 0 4 2 5 6 8 13 3 11 7 6 2 2 0 3 1 3 0 2 2 4 2 0
Nuclear Periphery 1 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 1 2 16 24 24 51 32 32 35 14 27 9 13 10 14 5 5 0 1 1 2 2 1
Unique Cell Count 171 89 144 124 224 258 267 201 180 234 146 170 275 476 424 271 157 147 169 97 159 241 408 496
Labelled Cell Count 172 89 147 135 235 274 291 213 194 253 165 188 282 486 430 293 171 159 169 97 159 241 408 496


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.9 11.7 9.1 9.0 10.0 8.8 7.9 8.5 7.8 7.4 7.1 7.6 10.2 11.3 11.2 14.6 14.8 14.8 10.4 9.9 10.7
Std Deviation (1e-4) 1.2 1.9 1.8 1.7 1.7 1.5 1.6 1.5 1.7 1.3 1.3 1.4 1.6 1.5 1.6 2.6 2.8 2.7 1.6 2.0 1.8
Intensity Change (Log2) – – – -0.02 0.14 -0.05 -0.21 -0.11 -0.23 -0.3 -0.37 -0.26 0.16 0.31 0.29 0.68 0.7 0.7 0.19 0.12 0.24

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 2.2 0
Cytoplasm -2.7 -2.5 -4.1 -6.0 -5.8 -6.2 -6.3 -6.4 -6.0 -0.1 2.0 0.7 -0.6 -0.2 -1.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.4 4.3 3.2 4.9 4.6 6.3 5.4 0 0 0 0 0 0
Nucleus 0 0 0 0 1.6 0 0.9 0.9 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 3.8 3.4 3.1 5.1 4.5 4.8 4.3 3.1 4.4 0 0 0 1.9 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.5071 6.2389 5.2822 4.4352 4.7708 5.4228 5.743 6.9732 6.3329 6.0697 5.7022 6.4657 5.2838 6.7804 6.1338 4.7673 5.1934 6.111
Actin 0.0083 0.0003 0.0044 0.0365 0.0029 0.0002 0.004 0.0003 0.0008 0.0002 0.0059 0.0014 0.0191 0.0003 0.0027 0.0026 0.0129 0.0013
Bud 0.003 0.0002 0.0002 0.0013 0.0001 0.0012 0.0005 0.0004 0.0001 0.0001 0.0005 0.0002 0.0004 0.0001 0.001 0.0004 0.0005 0.0002
Bud Neck 0.0019 0.0002 0.0004 0.0007 0.0005 0.0008 0.0008 0.0005 0.0005 0.0007 0.0027 0.001 0.0017 0.0002 0.0008 0.0006 0.0011 0.0009
Bud Periphery 0.0011 0 0.0001 0.0006 0 0.0003 0.0002 0.0001 0 0.0001 0.0005 0.0001 0.0003 0 0.001 0.0003 0.0006 0.0001
Bud Site 0.0009 0.0005 0.0004 0.0014 0 0.0001 0.0007 0.004 0.0002 0.0002 0.0019 0.0001 0.0007 0.0002 0.0032 0.0019 0.0019 0.0001
Cell Periphery 0.0001 0 0 0.0001 0 0 0 0 0 0 0 0 0.0001 0 0.0001 0.0001 0.0002 0
Cytoplasm 0.8521 0.9526 0.927 0.879 0.9034 0.9282 0.907 0.9546 0.9252 0.9133 0.8707 0.9185 0.8596 0.9794 0.9384 0.768 0.7253 0.9317
Cytoplasmic Foci 0.0127 0.0056 0.011 0.0107 0.0055 0.0051 0.0108 0.0048 0.0076 0.0062 0.022 0.0057 0.0203 0.0027 0.009 0.0528 0.0236 0.0081
Eisosomes 0.0001 0 0 0.0001 0 0 0 0 0 0 0 0 0.0001 0 0 0 0.0002 0
Endoplasmic Reticulum 0.0046 0.0013 0.0021 0.0027 0.0026 0.0023 0.003 0.0011 0.0013 0.0021 0.002 0.0018 0.0038 0.0013 0.0013 0.0024 0.0135 0.0019
Endosome 0.0144 0.0031 0.0046 0.0066 0.0042 0.0036 0.0098 0.0015 0.0022 0.0262 0.0098 0.0049 0.0197 0.0025 0.0025 0.0998 0.0783 0.0052
Golgi 0.0017 0.0001 0.0019 0.0042 0.0014 0.0001 0.0017 0.0001 0.0006 0.0007 0.005 0.0017 0.0069 0.0001 0.0008 0.0163 0.0113 0.0013
Lipid Particles 0.0035 0 0.0012 0.0007 0.0091 0 0.0019 0 0.001 0.0004 0.0107 0.002 0.0048 0 0.0019 0.0098 0.0275 0.0005
Mitochondria 0.0047 0.0002 0.0007 0.0034 0.0006 0.0002 0.001 0.0002 0.0003 0.0004 0.0023 0.0006 0.0168 0.0001 0.0003 0.0027 0.0033 0.0027
None 0.0237 0.0058 0.0069 0.0075 0.0032 0.0047 0.0204 0.0098 0.0128 0.0101 0.0144 0.008 0.0056 0.0029 0.0065 0.0035 0.012 0.0024
Nuclear Periphery 0.0063 0.0027 0.0025 0.0051 0.0048 0.0035 0.0034 0.0014 0.0022 0.0017 0.0026 0.0045 0.0055 0.0013 0.002 0.0063 0.0228 0.003
Nucleolus 0.0006 0.0001 0 0.0001 0 0 0.0001 0 0.0001 0.0001 0.0004 0.0001 0.0001 0 0.0001 0.0007 0.0008 0
Nucleus 0.0466 0.024 0.0308 0.0347 0.0393 0.0467 0.0238 0.0186 0.0396 0.0313 0.0269 0.0454 0.0267 0.008 0.0237 0.0111 0.043 0.0341
Peroxisomes 0.0064 0.0001 0.0032 0.0012 0.0186 0.0001 0.0077 0.0002 0.0025 0.0002 0.0152 0.0003 0.0038 0 0.0022 0.0107 0.0058 0.001
Punctate Nuclear 0.0039 0.0017 0.0013 0.0025 0.0027 0.002 0.0022 0.0016 0.0024 0.0015 0.0052 0.0027 0.0021 0.0003 0.0018 0.0057 0.0106 0.0044
Vacuole 0.0026 0.001 0.0009 0.0008 0.0007 0.0009 0.0008 0.0007 0.0005 0.004 0.0011 0.0008 0.0015 0.0004 0.0006 0.0029 0.0033 0.0007
Vacuole Periphery 0.0008 0.0002 0.0002 0.0002 0.0003 0.0002 0.0002 0.0001 0.0001 0.0006 0.0003 0.0003 0.0006 0.0001 0.0001 0.0014 0.0015 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.7983 36.2063 19.6054 25.6679 12.7733 21.8808 26.2193 30.3842 26.1433 28.0509
Translational Efficiency 1.0052 0.5717 0.987 0.8261 1.5391 0.9713 1.0901 0.8141 0.9743 0.7339

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1496 1461 261 98 2049 1672 295 1171 3545 3133 556 1269

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1026.92 1161.13 1229.95 1106.60 1067.29 1124.35 1213.97 1075.43 1050.25 1141.50 1221.47 1077.84
Standard Deviation 175.40 172.31 147.93 125.23 148.02 157.52 146.84 150.66 161.39 165.60 147.57 149.08
Intensity Change Log 2 — 0.177206 0.260276 0.107810 — 0.075139 0.185781 0.010961 — 0.126091 0.222791 0.059265

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000195 0.000266 0.001168 0.000513 0.000109 0.000298 0.000514 0.001123 0.000146 0.000283 0.000821 0.001076
Bud Neck 0.000921 0.000695 0.004222 0.001826 0.000680 0.001487 0.002580 0.004641 0.000782 0.001117 0.003351 0.004424
Bud Site 0.004048 0.003842 0.005910 0.004724 0.003292 0.007851 0.008058 0.032861 0.003611 0.005982 0.007050 0.030689
Cell Periphery 0.000081 0.000041 0.000303 0.000150 0.000089 0.000054 0.000251 0.000132 0.000085 0.000048 0.000276 0.000133
Cytoplasm 0.806688 0.829502 0.369051 0.394068 0.816888 0.809590 0.454013 0.505407 0.812584 0.818875 0.414130 0.496809
Cytoplasmic Foci 0.060903 0.022543 0.009111 0.009203 0.037266 0.041253 0.029611 0.029983 0.047241 0.032528 0.019988 0.028378
Eisosomes 0.000014 0.000005 0.000042 0.000061 0.000008 0.000010 0.000081 0.000030 0.000010 0.000008 0.000062 0.000032
Endoplasmic Reticulum 0.000930 0.000343 0.006899 0.004737 0.000768 0.000555 0.003474 0.001999 0.000837 0.000456 0.005082 0.002211
Endosome 0.002761 0.001238 0.003029 0.003553 0.000955 0.002532 0.005605 0.015129 0.001717 0.001929 0.004396 0.014235
Golgi 0.002133 0.000834 0.000252 0.000112 0.000592 0.001448 0.000185 0.019346 0.001242 0.001162 0.000216 0.017861
Lipid Particles 0.000645 0.000223 0.001942 0.002176 0.000411 0.000425 0.002193 0.002992 0.000510 0.000331 0.002075 0.002929
Mitochondria 0.001716 0.000298 0.000585 0.000172 0.000428 0.000659 0.000238 0.011519 0.000971 0.000490 0.000401 0.010643
Mitotic Spindle 0.002135 0.002504 0.008008 0.005212 0.000874 0.012876 0.011173 0.101897 0.001406 0.008039 0.009687 0.094431
None 0.004968 0.007682 0.003746 0.003249 0.006445 0.004871 0.005753 0.004927 0.005822 0.006182 0.004811 0.004797
Nuclear Periphery 0.000111 0.000091 0.001902 0.001279 0.000134 0.000132 0.001101 0.000962 0.000124 0.000113 0.001477 0.000986
Nuclear Periphery Foci 0.004108 0.001813 0.005792 0.006006 0.001820 0.002110 0.007258 0.003098 0.002785 0.001972 0.006570 0.003323
Nucleolus 0.000193 0.000202 0.000326 0.000140 0.000142 0.000330 0.000423 0.000300 0.000163 0.000270 0.000378 0.000288
Nucleus 0.066519 0.104714 0.444075 0.165834 0.104856 0.076606 0.243654 0.110143 0.088678 0.089714 0.337737 0.114444
Peroxisomes 0.000354 0.000908 0.000203 0.000171 0.000130 0.001150 0.000621 0.001345 0.000224 0.001037 0.000425 0.001254
Vacuole 0.039815 0.021985 0.133206 0.396685 0.023770 0.034797 0.222980 0.134131 0.030541 0.028823 0.180838 0.154407
Vacuole Periphery 0.000763 0.000272 0.000227 0.000130 0.000342 0.000965 0.000235 0.018036 0.000520 0.000642 0.000231 0.016653

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.84 -6.87 -4.19 -0.71 5.15 -3.77 -9.56 -5.47 -3.28 -0.42 -2.02 -9.42 -5.31 -2.54 2.82
Bud Neck 0.76 -9.79 -5.13 -5.56 4.31 -3.84 -9.72 -9.97 -6.88 -3.37 -3.03 -13.14 -10.09 -8.62 -0.45
Bud Site 0.15 -4.27 -3.48 -3.10 0.48 -3.77 -3.78 -7.11 -4.21 -4.06 -3.32 -5.43 -7.24 -5.53 -4.43
Cell Periphery 6.40 -10.52 -4.02 -6.77 7.31 2.02 -5.16 -1.41 -9.61 5.94 3.48 -10.64 -2.78 -13.20 10.43
Cytoplasm -1.96 34.80 19.84 20.42 0.88 3.63 32.09 46.73 40.49 -3.42 1.48 47.01 50.11 48.22 -5.56
Cytoplasmic Foci 12.90 18.89 13.77 3.93 -1.04 -1.85 9.66 11.23 11.35 -0.51 7.48 20.06 18.26 10.62 -2.44
Eisosomes 7.19 -9.86 -7.97 -9.61 -0.89 -3.68 -13.07 -22.61 -20.02 6.69 2.49 -16.29 -22.29 -24.31 6.65
Endoplasmic Reticulum 5.81 -9.49 -4.61 -5.67 4.17 1.62 -11.12 -7.27 -10.84 8.06 4.45 -13.46 -9.09 -14.13 10.29
Endosome 3.81 -2.02 -0.62 -3.99 1.17 -3.99 -9.14 -6.39 -2.82 0.71 -0.42 -8.57 -4.94 -4.31 0.13
Golgi 1.64 2.41 2.59 1.76 4.82 -1.47 1.11 -2.55 -1.94 -3.06 0.40 2.61 -1.88 -2.14 -3.01
Lipid Particles 6.18 -10.01 -8.61 -10.95 0.96 -1.00 -12.44 -6.85 -6.56 0.21 2.98 -15.76 -7.07 -7.66 0.87
Mitochondria 1.97 1.45 2.04 0.30 7.07 -0.44 0.48 -1.89 -1.73 -2.07 1.41 1.47 -1.29 -1.90 -1.89
Mitotic Spindle -0.79 -1.53 -2.61 -2.55 -2.25 -5.10 -1.46 -10.35 -7.31 -7.96 -5.05 -2.13 -10.59 -8.90 -8.72
None -2.98 2.42 -0.60 0.95 -1.76 2.15 1.23 0.42 -2.48 -1.12 0.04 2.28 -0.50 -0.62 -3.09
Nuclear Periphery 0.03 -17.06 -10.53 -10.53 2.64 -1.92 -16.01 -24.10 -23.66 -0.17 -1.45 -23.15 -25.86 -25.66 2.33
Nuclear Periphery Foci 6.22 -3.54 -2.31 -4.61 0.12 -1.85 -8.37 -6.41 -4.81 4.87 3.36 -8.82 -4.16 -6.55 5.41
Nucleolus -0.25 -1.78 -1.56 -1.22 -0.00 -1.48 -4.25 -4.99 -0.31 -1.14 -1.52 -4.23 -4.89 -1.23 -1.51
Nucleus -11.75 -24.49 -4.20 -1.53 13.76 7.30 -12.22 -13.58 -17.95 5.81 -2.31 -24.29 -17.25 -16.06 14.34
Peroxisomes -1.00 2.03 2.57 1.34 1.28 -3.72 -1.82 -3.12 1.19 -1.84 -2.71 -0.76 -2.52 1.00 -2.17
Vacuole 4.55 -12.34 -13.89 -14.33 -8.68 -8.56 -18.41 -33.05 -29.24 1.71 -3.38 -21.61 -34.24 -33.11 -3.30
Vacuole Periphery 1.42 1.54 1.89 1.08 5.91 -1.59 0.90 -3.24 -2.57 -3.47 -0.27 1.77 -3.00 -2.93 -3.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

His2

His2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (His2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available