Standard name
Human Ortholog
Description Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0.82 0.82 0.89 0.85 0.8 0.72 0.72 0.7 0.57 0.58 0.55 0.59 0.63 0.66 0.79 – 0.64 0.57 0.63 0.63 0.63 0.74 0.73 0.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0.11 0 0 0 0.15 0.14 0.16 0.47 0.37 0.46 0.41 0 0 0 – 0.07 0 0.06 0 0.08 0 0 0.05
Nucleus 0.08 0.07 0 0.09 0.1 0.15 0.13 0.14 0.11 0.16 0.15 0.15 0.32 0.26 0.05 – 0.17 0.26 0.1 0.12 0.07 0.06 0.05 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0
Vac/Vac Membrane 0.1 0.07 0.06 0.05 0.09 0.06 0.06 0.05 0 0 0 0 0.06 0.13 0.18 – 0.2 0.19 0.13 0.1 0.09 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 1 3 3 1 0 1
Bud 1 1 0 0 0 1 3 1 14 6 8 17 0 0 0 – 0 0 2 3 5 0 5 7
Bud Neck 0 0 10 3 4 3 12 8 10 11 10 9 0 0 0 – 0 0 1 1 1 1 0 1
Bud Site 1 0 0 0 0 0 1 0 5 2 4 5 0 0 0 – 0 0 – – – – – –
Cell Periphery 1 1 3 0 1 0 1 3 1 4 2 0 0 0 0 – 0 0 0 0 1 1 0 0
Cytoplasm 163 326 313 287 305 331 504 425 353 352 340 442 53 148 187 – 87 42 139 275 240 128 131 171
Endoplasmic Reticulum 0 1 2 0 1 0 0 0 0 0 1 0 0 1 0 – 4 4 0 0 1 0 0 3
Endosome 0 0 2 4 4 6 5 6 1 0 2 2 0 0 6 – 5 0 2 4 3 2 1 6
Golgi 0 0 0 0 1 0 1 1 0 0 0 0 1 0 0 – 0 1 0 2 1 0 0 2
Mitochondria 7 45 0 11 10 69 97 95 288 227 285 310 0 0 1 – 9 2 13 12 30 5 4 11
Nucleus 16 26 15 30 39 71 90 87 70 95 94 114 27 58 11 – 23 19 21 53 27 10 9 6
Nuclear Periphery 0 1 1 0 1 0 1 1 1 3 1 0 0 0 0 – 1 0 0 0 0 1 0 0
Nucleolus 0 1 1 0 0 1 0 1 1 0 0 1 0 0 1 – 0 0 0 1 0 2 2 4
Peroxisomes 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0
SpindlePole 0 0 2 0 6 4 19 14 7 14 8 20 0 0 0 – 2 0 6 20 15 3 7 7
Vac/Vac Membrane 20 29 20 16 36 28 44 31 12 15 17 25 5 29 43 – 28 14 28 42 35 7 7 15
Unique Cell Count 198 397 352 337 383 459 700 603 618 606 615 754 84 224 238 137 74 222 436 382 173 179 245
Labelled Cell Count 209 432 370 351 408 514 778 673 763 729 772 945 86 236 249 159 82 222 436 382 173 179 245


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 3.2 5.0 4.5 5.4 4.1 4.1 4.3 3.2 3.5 3.4 3.6 4.8 5.0 4.7 4.4 5.0 5.6 5.7 5.6 6.0
Std Deviation (1e-4) 0.5 0.7 1.4 1.5 2.4 1.3 1.4 1.4 0.9 1.0 0.8 0.8 1.3 1.0 1.4 1.7 1.8 1.7 2.7 2.4 2.7
Intensity Change (Log2) – – – -0.13 0.12 -0.3 -0.28 -0.21 -0.64 -0.49 -0.57 -0.47 -0.07 -0.0 -0.08 -0.17 0.01 0.16 0.2 0.18 0.26

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – 0 0
Bud Neck – – – – – – – – – – – – – 0 0
Bud Site – – – – – – – – – – – – – 0 0
Cell Periphery – – – – – – – – – – – – – 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – 0 0
Endosome – – – – – – – – – – – – – 0 0
Golgi – – – – – – – – – – – – – 0 0
Mitochondria – – – – – – – – – – – – – 0 0
Nuclear Periphery – – – – – – – – – – – – – 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – 0 0
Peroxisomes – – – – – – – – – – – – – 0 0
SpindlePole – – – – – – – – – – – – – 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – 0 0
Cytoplasm – – – – – – – – – – – – – 0 0
Nucleus – – – – – – – – – – – – – 0 0
Vacuole – – – – – – – – – – – – – 4.9 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.5989 1.0526 0.7679 0.4673 0.6398 0.6234 2.7724 2.6644 2.8006 2.9788 2.1611 2.4495 -0.4429 0.2152 0.0239 -0.2932 -0.7112 -0.0638
Actin 0.019 0.0087 0.0072 0.0096 0.045 0.0009 0.0332 0.0006 0.0079 0.0215 0.0031 0.0066 0.0205 0.0002 0.0008 0.0003 0.0002 0.0004
Bud 0.0032 0.0006 0.0014 0.0067 0.0002 0.0001 0.0002 0.0001 0.0005 0.0003 0.0002 0.0012 0.0004 0.0002 0.0003 0.0002 0.0009 0.0003
Bud Neck 0.0037 0.0006 0.0008 0.0012 0.0006 0.0013 0.0009 0.0004 0.0006 0.0431 0.0003 0.0018 0.001 0.0008 0.0005 0.0032 0.0002 0.0017
Bud Periphery 0.0122 0.0005 0.0007 0.0022 0.0005 0.0001 0.0002 0.0001 0.0008 0.0003 0.0005 0.0027 0.0009 0.0002 0.0009 0.0005 0.0011 0.0003
Bud Site 0.0094 0.0049 0.0028 0.0021 0.0005 0 0.0012 0.0024 0.0026 0.0028 0.0009 0.0003 0.0017 0.0072 0.0004 0.001 0.0001 0.0001
Cell Periphery 0.0009 0.0002 0.0004 0.0001 0.0002 0.0001 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0004 0.0002 0.0001 0.0004 0.0001 0
Cytoplasm 0.1017 0.1553 0.0959 0.0324 0.1537 0.1583 0.0546 0.1356 0.1193 0.0442 0.0419 0.1296 0.1202 0.161 0.1371 0.1464 0.1228 0.1785
Cytoplasmic Foci 0.0355 0.0059 0.0065 0.0233 0.0385 0.0166 0.0515 0.0054 0.0101 0.03 0.0105 0.0171 0.0055 0.0092 0.0096 0.0057 0.0068 0.0106
Eisosomes 0.0006 0.0003 0.0003 0.0001 0.0005 0.0001 0.0004 0.0001 0.0001 0.0001 0.0002 0.0001 0.0005 0.0001 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0039 0.0043 0.0018 0.0012 0.0038 0.002 0.0016 0.0078 0.0067 0.0006 0.0014 0.0035 0.0039 0.0061 0.0064 0.003 0.0015 0.0033
Endosome 0.0099 0.0021 0.0027 0.0199 0.0126 0.0021 0.0095 0.0052 0.0234 0.004 0.009 0.004 0.0058 0.0064 0.0036 0.006 0.0025 0.0023
Golgi 0.0037 0.0018 0.0012 0.0021 0.0119 0.0003 0.0081 0.0005 0.0053 0.0034 0.0075 0.0007 0.001 0.0005 0.0001 0.0006 0.0001 0.0001
Lipid Particles 0.013 0.001 0.0038 0.0103 0.0492 0.0059 0.0265 0.0021 0.0108 0.0126 0.043 0.0013 0.0009 0.0041 0.0005 0.0055 0.0004 0.0005
Mitochondria 0.0111 0.0062 0.0177 0.0012 0.0109 0.0004 0.0013 0.0004 0.0038 0.0004 0.0229 0.0023 0.0017 0.001 0.0008 0.0035 0.0004 0.0005
None 0.6207 0.6055 0.5915 0.8367 0.5408 0.7299 0.7586 0.6717 0.5979 0.7697 0.8343 0.703 0.7606 0.621 0.6325 0.7623 0.8553 0.6513
Nuclear Periphery 0.0084 0.0091 0.0073 0.0035 0.0051 0.007 0.0026 0.034 0.0109 0.0019 0.0008 0.0072 0.0061 0.0093 0.0098 0.0042 0.001 0.0045
Nucleolus 0.0105 0.0032 0.0055 0.0023 0.0011 0.0012 0.0007 0.0067 0.0019 0.0002 0.0019 0.002 0.0018 0.0022 0.002 0.007 0.0002 0.0017
Nucleus 0.0811 0.1666 0.2341 0.0103 0.0217 0.05 0.0081 0.1146 0.1668 0.0302 0.001 0.1005 0.0542 0.1578 0.1776 0.0383 0.0032 0.1264
Peroxisomes 0.0197 0.0038 0.0031 0.0039 0.0827 0.0015 0.0296 0.0002 0.0142 0.0245 0.0169 0.0014 0.0005 0.0008 0.0023 0.0026 0.0002 0.0002
Punctate Nuclear 0.0245 0.0168 0.0135 0.027 0.0187 0.0209 0.0096 0.009 0.0095 0.0096 0.0009 0.0122 0.0055 0.0075 0.0123 0.0023 0.0015 0.0149
Vacuole 0.0062 0.0023 0.0015 0.0034 0.0013 0.0013 0.0013 0.0021 0.0058 0.0002 0.0017 0.002 0.006 0.0036 0.002 0.0061 0.0013 0.0022
Vacuole Periphery 0.0011 0.0004 0.0003 0.0005 0.0006 0.0002 0.0003 0.0007 0.0009 0.0001 0.0007 0.0005 0.0008 0.0004 0.0004 0.0009 0.0002 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 4.5649 3.4978 2.5955 6.8548 7.6096 7.8212 2.6525 3.9783 4.9839 9.0143
Translational Efficiency 4.2223 1.2072 1.4665 1.4739 2.0215 2.8148 2.2913 1.0645 1.5651 1.3139

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1986 548 2315 1729 2660 1956 173 1736 4646 2504 2488 3465

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 635.62 724.12 804.14 770.25 658.93 768.52 866.67 840.90 648.97 758.80 808.49 805.65
Standard Deviation 67.47 87.28 90.98 109.76 73.20 91.91 98.20 120.46 71.74 92.75 92.87 120.54
Intensity Change Log 2 — 0.188064 0.339282 0.277162 — 0.221958 0.395358 0.351809 — 0.205416 0.368097 0.315640

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000123 0.000628 0.000136 0.000442 0.000050 0.000101 0.000455 0.001485 0.000082 0.000216 0.000158 0.000965
Bud Neck 0.022057 0.021783 0.006317 0.010024 0.006605 0.017057 0.002302 0.008650 0.013210 0.018091 0.006038 0.009336
Bud Site 0.003546 0.007005 0.007602 0.013416 0.001635 0.003914 0.007481 0.018441 0.002452 0.004591 0.007594 0.015934
Cell Periphery 0.000194 0.000175 0.000112 0.000252 0.000121 0.000217 0.000209 0.000147 0.000152 0.000208 0.000119 0.000199
Cytoplasm 0.370257 0.319627 0.208244 0.252794 0.458180 0.376960 0.150831 0.313828 0.420596 0.364413 0.204252 0.283373
Cytoplasmic Foci 0.244895 0.210670 0.002898 0.009798 0.076299 0.111082 0.009935 0.008282 0.148368 0.132877 0.003387 0.009038
Eisosomes 0.000254 0.000140 0.000015 0.000036 0.000055 0.000096 0.000090 0.000028 0.000140 0.000106 0.000020 0.000032
Endoplasmic Reticulum 0.001200 0.001961 0.001715 0.002451 0.000431 0.000692 0.007887 0.002953 0.000760 0.000969 0.002144 0.002702
Endosome 0.004760 0.012687 0.000866 0.003992 0.001603 0.006440 0.002768 0.002838 0.002953 0.007807 0.000999 0.003414
Golgi 0.004032 0.002297 0.000043 0.001101 0.000383 0.002592 0.000069 0.000994 0.001943 0.002527 0.000045 0.001047
Lipid Particles 0.016226 0.008035 0.000354 0.001058 0.004421 0.007752 0.002836 0.000761 0.009467 0.007814 0.000526 0.000909
Mitochondria 0.015063 0.011068 0.000749 0.005265 0.003127 0.008444 0.000391 0.001589 0.008229 0.009018 0.000724 0.003423
Mitotic Spindle 0.000557 0.004505 0.003456 0.039269 0.001777 0.002724 0.000666 0.021884 0.001255 0.003114 0.003262 0.030559
None 0.006666 0.006362 0.005448 0.008193 0.005223 0.008796 0.004376 0.007450 0.005840 0.008263 0.005373 0.007820
Nuclear Periphery 0.000525 0.000808 0.001661 0.002914 0.000667 0.000995 0.001926 0.002502 0.000606 0.000954 0.001680 0.002708
Nuclear Periphery Foci 0.000247 0.000635 0.000158 0.000784 0.000127 0.000215 0.001613 0.000562 0.000179 0.000307 0.000259 0.000673
Nucleolus 0.001906 0.002630 0.000602 0.001451 0.001162 0.002967 0.001040 0.000883 0.001480 0.002893 0.000632 0.001166
Nucleus 0.279574 0.316387 0.749219 0.607414 0.426848 0.421429 0.746998 0.564325 0.363893 0.398441 0.749064 0.585826
Peroxisomes 0.009345 0.022518 0.000105 0.001171 0.002143 0.005933 0.000357 0.001273 0.005222 0.009563 0.000123 0.001222
Vacuole 0.017800 0.048454 0.010110 0.036560 0.008935 0.020550 0.057606 0.038750 0.012725 0.026657 0.013413 0.037657
Vacuole Periphery 0.000772 0.001626 0.000189 0.001616 0.000206 0.001044 0.000167 0.002375 0.000448 0.001172 0.000187 0.001996

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.77 -1.49 -2.79 1.47 -2.34 -1.92 -7.93 -2.55 -2.41 -0.84 -3.91 -4.45 -3.25 -2.45 -2.60
Bud Neck 0.09 9.44 6.94 4.24 -2.97 -7.04 4.31 -2.73 4.94 -6.10 -3.51 6.86 3.78 6.18 -3.53
Bud Site -4.49 -3.01 -5.15 -2.20 -1.82 -3.67 -1.10 -6.78 -5.16 -1.27 -4.34 -4.07 -8.63 -6.14 -2.75
Cell Periphery 1.33 7.59 -0.27 -1.07 -4.34 -5.42 -3.64 -0.35 5.44 3.56 -4.07 3.70 -0.84 2.86 -3.59
Cytoplasm 4.24 23.73 17.07 6.95 -4.87 10.09 19.82 24.83 13.68 -7.16 8.54 38.11 30.47 17.40 -8.75
Cytoplasmic Foci 3.14 47.59 46.11 22.78 -6.80 -8.07 22.64 27.14 28.80 1.73 3.18 50.36 48.46 35.58 -7.05
Eisosomes 6.60 18.46 16.43 8.69 -14.47 -9.56 -5.49 5.33 14.16 6.95 4.86 19.56 16.70 16.34 -11.31
Endoplasmic Reticulum -2.39 -4.07 -7.30 -5.71 -5.48 -3.02 -9.10 -20.02 -18.42 5.37 -1.61 -12.22 -17.90 -19.34 -5.93
Endosome -5.13 11.77 4.06 6.31 -5.04 -7.63 -4.16 -1.24 6.39 2.56 -8.00 9.67 1.83 8.47 -5.11
Golgi 2.94 8.96 7.00 3.40 -2.76 -4.23 4.28 -0.49 3.78 -2.06 -1.20 9.67 5.75 4.48 -3.52
Lipid Particles 5.25 16.19 15.42 5.83 -10.20 -4.85 2.36 9.40 12.30 6.11 2.38 18.57 17.70 13.43 -7.52
Mitochondria 1.82 9.55 7.05 3.56 -4.27 -4.71 4.53 2.74 7.15 -4.25 -0.66 10.18 7.13 7.00 -4.86
Mitotic Spindle -2.84 -4.32 -9.99 -8.26 -8.62 -0.96 1.60 -7.49 -7.02 -8.03 -2.47 -3.26 -12.40 -11.18 -10.51
None 0.25 2.23 -0.98 -0.67 -3.58 -3.63 1.74 -1.76 2.37 -2.84 -2.71 1.89 -2.08 1.49 -3.85
Nuclear Periphery -3.75 -21.12 -10.08 -9.08 -5.56 -3.40 -8.79 -12.19 -10.16 -2.79 -4.61 -22.47 -15.09 -12.79 -7.62
Nuclear Periphery Foci -4.39 0.55 -4.66 -1.82 -4.78 -0.57 -6.13 -6.92 -7.94 4.27 -2.29 -3.23 -7.39 -6.39 -5.68
Nucleolus -1.52 5.01 1.16 2.51 -4.13 -4.36 1.83 0.15 3.89 -1.11 -4.26 5.36 0.70 4.58 -3.78
Nucleus -2.62 -61.29 -34.40 -20.55 16.04 0.69 -12.98 -17.63 -16.79 5.29 -4.65 -58.47 -34.85 -25.06 20.96
Peroxisomes -4.52 14.06 12.25 7.65 -2.25 -5.99 5.93 3.96 8.76 -1.28 -5.26 15.27 12.08 11.31 -3.13
Vacuole -8.80 2.19 -15.13 -4.07 -15.81 -10.04 -7.81 -20.37 -16.49 1.94 -11.43 -6.39 -25.38 -17.93 -19.76
Vacuole Periphery -2.75 8.68 -0.69 1.85 -3.53 -5.06 1.38 -2.07 -0.28 -2.13 -4.89 6.47 -2.33 0.37 -3.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress
Localization
Cell Percentages cytoplasm (24%), nucleus (7%), mixed (49%)
Cell Cycle Regulation Yes
cytoplasm - MA (2e-06)
Subcompartmental Group N/A

Eco1

Eco1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Eco1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available