Standard name
Human Ortholog
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0.05 0 0.05 0 0.06 0.07 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0 0 0 0 0 0.13 0.12 0.17 0.07 0.09 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.14 0.07 0 0 0 0.14 0.19 0.13 0.14 0.21 0.24 0.19 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.88 0.87 0.87 0.89 0.87 0.8 0.75 0.76 0.73 0.69 0.7 0.71 0.81 0.84 0.77 0.83 0.79 0.79 0.78 0.79 0.72 0.8 0.73 0.72
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.3 0.29 0.21 0.16 0.18 0.25 0.28 0.31 0.35 0.41 0.4 0.39 0.07 0.06 0.1 0.11 0.08 0.17 0.11 0.06 0.2 0.1 0.11 0.14
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.05 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 0 0 0 4 2 3 2 6 4 3 0 0 0 0 0 0 1 0 2 2 3 2
Bud Neck 0 0 0 0 1 1 2 0 1 2 2 0 1 0 0 0 0 0 0 0 1 0 1 0
Bud Site 1 0 2 5 3 14 30 9 24 15 29 36 0 0 1 0 1 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 2 6 9 14 13 13 16 7 15 5 7 26 39 52 9 14 15 0 0 0 2 6 2
Endoplasmic Reticulum 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 4 0 2 0 0 0 0 0 0
Endosome 2 0 3 0 0 0 0 0 0 0 0 0 0 1 4 0 5 0 3 2 5 3 2 4
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2 2 0 2 3 4 0 1 0
Mitochondria 30 5 4 4 6 68 120 82 64 120 114 100 0 0 0 5 6 7 1 1 2 2 2 5
Nucleus 187 66 320 234 249 388 462 469 345 390 336 378 158 279 238 106 118 128 171 72 292 268 214 214
Nuclear Periphery 1 0 6 6 0 16 13 5 10 6 8 12 0 4 1 0 3 1 0 1 0 2 0 2
Nucleolus 63 22 76 42 50 123 175 192 164 233 191 208 14 21 30 14 12 28 24 5 81 32 32 40
Peroxisomes 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 2 2 1 0 2 2 3 1 5 9 2 3 1 4 0 2 3 5 5
Vac/Vac Membrane 2 0 4 0 1 3 4 3 2 3 5 0 1 3 4 2 7 7 7 2 9 11 13 14
Unique Cell Count 213 76 369 263 285 487 616 615 470 567 478 532 194 333 311 127 150 162 220 92 406 335 293 300
Labelled Cell Count 288 95 423 300 325 634 823 781 620 792 696 747 201 352 340 144 171 189 220 92 406 335 293 300


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 7.8 7.2 6.5 6.2 5.5 5.2 5.3 5.2 5.1 4.9 5.0 8.3 7.9 7.7 8.7 8.8 8.3 8.2 8.5 8.9
Std Deviation (1e-4) 1.0 1.7 1.4 1.6 1.6 1.4 1.5 1.4 1.4 1.3 1.4 1.3 2.1 1.5 1.8 1.6 1.8 1.9 1.3 1.5 1.5
Intensity Change (Log2) – – – -0.14 -0.21 -0.39 -0.46 -0.43 -0.45 -0.49 -0.56 -0.52 0.22 0.15 0.1 0.28 0.29 0.21 0.19 0.25 0.31

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 2.5 3.7 0 3.8 2.4 0 4.6 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.5 2.4 1.0 0.5 1.0 -0.2 1.0 0 -0.4 5.7 5.4 7.0 0 4.1 4.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.7 8.4 6.6 6.6 8.9 0 8.2 0 0 0 0 0 0
Nucleus 0.8 0.2 -2.7 -4.4 -4.0 -4.7 -6.3 -5.7 -5.5 -1.7 -1.1 -3.5 -0.9 -2.3 -2.3
Nuclear Periphery 0 0 1.5 0.5 0 0.5 0 0 0.7 0 0 0 0 0 0
Nucleolus -1.5 -1.0 1.6 2.7 3.6 4.5 6.5 0 5.9 -4.1 -5.5 -3.9 -2.4 -3.5 -0.9
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin – – – – – – 0.032 0.0016 0.0139 0.007 0.0517 0.0011 0.0129 0 0.0006 0.0577 0.0063 0
Bud – – – – – – 0.0009 0.0002 0.0004 0.0026 0.0016 0.0002 0.0002 0 0.0001 0.0003 0.0002 0.0001
Bud Neck – – – – – – 0.0034 0.0002 0.001 0.0009 0.0021 0.0006 0.0013 0 0.0002 0.001 0.0009 0.001
Bud Periphery – – – – – – 0.0023 0.0004 0.0008 0.0043 0.0035 0.0002 0.0005 0 0.0002 0.0006 0.0007 0.0002
Bud Site – – – – – – 0.0043 0.0003 0.0044 0.0072 0.0053 0.0002 0.001 0 0.0002 0.0015 0.0006 0.0002
Cell Periphery – – – – – – 0.0008 0.0001 0.0004 0.0008 0.0011 0 0.0002 0 0.0001 0.0002 0.0002 0.0001
Cytoplasm – – – – – – 0.0035 0.0006 0.0008 0.0023 0.0036 0.0002 0.0039 0 0.0001 0.0008 0.0027 0
Cytoplasmic Foci – – – – – – 0.0528 0.0005 0.0182 0.0182 0.0207 0.001 0.0046 0 0.0015 0.0048 0.0032 0
Eisosomes – – – – – – 0.0004 0 0.0001 0.0002 0.0003 0 0.0002 0 0.0001 0.0007 0 0
Endoplasmic Reticulum – – – – – – 0.0045 0.0011 0.0063 0.0016 0.0035 0.0002 0.0029 0 0.0001 0.0052 0.0017 0
Endosome – – – – – – 0.0423 0.0013 0.0177 0.0243 0.0337 0.0067 0.009 0 0.0012 0.0231 0.0051 0.0002
Golgi – – – – – – 0.0091 0.0003 0.0083 0.0177 0.0141 0.003 0.0033 0 0.0004 0.0148 0.0013 0.0001
Lipid Particles – – – – – – 0.0271 0.0005 0.0135 0.0351 0.0422 0.0004 0.0081 0 0.0047 0.0211 0.0008 0.0005
Mitochondria – – – – – – 0.0186 0.0015 0.0188 0.0754 0.0129 0.0011 0.0062 0 0.0057 0.0074 0.004 0.0024
None – – – – – – 0.0028 0.001 0.0002 0.0011 0.0021 0 0.0027 0 0.0001 0.0022 0.0016 0
Nuclear Periphery – – – – – – 0.0168 0.0017 0.0017 0.0218 0.0138 0.0006 0.0215 0.0008 0.0008 0.0069 0.0057 0.0011
Nucleolus – – – – – – 0.05 0.0258 0.0341 0.0169 0.1947 0.1012 0.0511 0.0255 0.02 0.0259 0.1917 0.1445
Nucleus – – – – – – 0.655 0.9551 0.841 0.719 0.5594 0.8767 0.8527 0.9733 0.9558 0.8144 0.7412 0.8479
Peroxisomes – – – – – – 0.0234 0.0003 0.0076 0.0276 0.0117 0.0002 0.0012 0 0.0008 0.0038 0.0003 0
Punctate Nuclear – – – – – – 0.0275 0.0067 0.002 0.0055 0.0089 0.0058 0.0132 0.0002 0.0068 0.0052 0.0293 0.001
Vacuole – – – – – – 0.0163 0.0004 0.0064 0.006 0.0095 0.0003 0.0014 0 0.0004 0.001 0.0011 0.0004
Vacuole Periphery – – – – – – 0.0061 0.0003 0.0023 0.0044 0.004 0.0002 0.0018 0 0.0002 0.0013 0.0014 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.6342 10.7394 7.9691 14.4047 15.5762 5.5417 15.4527 18.0402 12.2125 14.985
Translational Efficiency 1.5782 1.6469 2.1804 0.9302 1.4252 4.5493 1.3034 1.1647 1.7825 1.6557

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2132 957 1639 91 1956 1720 180 128 4088 2677 1819 219

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 784.44 980.76 945.44 1030.38 812.59 934.17 945.78 1434.37 797.91 950.83 945.47 1266.50
Standard Deviation 119.77 154.03 132.42 173.68 112.64 139.71 121.18 343.27 117.26 146.70 131.35 347.91
Intensity Change Log 2 — 0.322237 0.269323 0.393441 — 0.201158 0.218977 0.819818 — 0.261900 0.243926 0.626050

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000315 0.000692 0.000862 0.001664 0.000272 0.000794 0.000668 0.000262 0.000295 0.000758 0.000843 0.000844
Bud Neck 0.003468 0.006814 0.017372 0.013867 0.003934 0.008727 0.002101 0.036501 0.003691 0.008043 0.015861 0.027096
Bud Site 0.001013 0.001302 0.001239 0.007990 0.000401 0.001416 0.000599 0.002681 0.000720 0.001375 0.001176 0.004887
Cell Periphery 0.000090 0.000046 0.000035 0.000071 0.000042 0.000088 0.000107 0.000100 0.000067 0.000073 0.000043 0.000088
Cytoplasm 0.000783 0.000458 0.000209 0.001382 0.000753 0.001255 0.003354 0.009656 0.000768 0.000970 0.000520 0.006218
Cytoplasmic Foci 0.000127 0.000912 0.000016 0.000203 0.000082 0.000843 0.000883 0.000245 0.000106 0.000867 0.000102 0.000228
Eisosomes 0.000033 0.000043 0.000045 0.000040 0.000028 0.000043 0.000053 0.000023 0.000030 0.000043 0.000046 0.000030
Endoplasmic Reticulum 0.002231 0.002171 0.002627 0.005396 0.001668 0.002416 0.002688 0.001406 0.001961 0.002329 0.002633 0.003064
Endosome 0.000234 0.000637 0.000122 0.000708 0.000151 0.001891 0.000118 0.000248 0.000194 0.001443 0.000121 0.000439
Golgi 0.000141 0.000372 0.000142 0.000369 0.000125 0.000926 0.000129 0.000315 0.000133 0.000728 0.000141 0.000337
Lipid Particles 0.000048 0.002014 0.000047 0.000236 0.000090 0.000382 0.000260 0.000045 0.000068 0.000965 0.000068 0.000124
Mitochondria 0.000613 0.001074 0.001549 0.002640 0.000528 0.002976 0.000579 0.002945 0.000572 0.002296 0.001453 0.002818
Mitotic Spindle 0.000621 0.001014 0.002044 0.010266 0.000849 0.006482 0.000365 0.010046 0.000730 0.004527 0.001878 0.010138
None 0.004258 0.001870 0.001413 0.003309 0.002623 0.003181 0.009162 0.004194 0.003475 0.002713 0.002180 0.003826
Nuclear Periphery 0.000317 0.000129 0.000238 0.000604 0.000141 0.000427 0.000104 0.000457 0.000233 0.000321 0.000225 0.000518
Nuclear Periphery Foci 0.001114 0.000764 0.000225 0.000754 0.000527 0.000962 0.000245 0.000218 0.000833 0.000891 0.000227 0.000441
Nucleolus 0.130670 0.129785 0.103614 0.050473 0.109702 0.125514 0.077287 0.023356 0.120637 0.127041 0.101009 0.034624
Nucleus 0.852791 0.847302 0.866699 0.892508 0.877325 0.838415 0.899690 0.904329 0.864530 0.841592 0.869964 0.899417
Peroxisomes 0.000436 0.001627 0.000841 0.000925 0.000373 0.001315 0.001143 0.000148 0.000406 0.001427 0.000871 0.000471
Vacuole 0.000414 0.000627 0.000447 0.005811 0.000238 0.001154 0.000376 0.001893 0.000329 0.000965 0.000440 0.003521
Vacuole Periphery 0.000286 0.000348 0.000211 0.000783 0.000149 0.000790 0.000091 0.000931 0.000221 0.000632 0.000199 0.000869

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.12 -19.40 -6.78 -5.22 -4.39 -3.52 -5.85 -0.72 3.29 5.10 -4.79 -21.45 -5.97 -1.88 -1.06
Bud Neck -4.86 -17.15 -5.35 -4.15 -0.19 -8.51 3.23 -5.41 -4.65 -5.65 -9.99 -16.91 -6.76 -5.64 -3.31
Bud Site -0.73 -1.10 -1.82 -1.73 -1.72 -3.99 -1.20 -2.03 -1.08 -1.82 -2.39 -2.75 -2.37 -1.99 -2.02
Cell Periphery 2.26 3.45 -0.74 -2.50 -3.23 -2.49 -1.49 -1.35 0.03 0.25 -0.54 2.49 -1.30 -0.88 -2.39
Cytoplasm 0.66 2.02 -1.86 -2.13 -2.54 -0.42 -1.51 -1.36 -1.31 -0.94 -0.36 1.40 -1.60 -1.56 -1.75
Cytoplasmic Foci -2.10 2.06 -1.21 1.44 -1.93 -3.17 -1.72 -0.54 2.02 1.31 -3.72 0.39 -1.08 2.48 -1.22
Eisosomes -4.22 -8.69 -2.69 -1.06 -0.64 -8.11 -7.28 2.18 6.95 7.43 -8.57 -12.21 -1.07 2.51 3.72
Endoplasmic Reticulum 0.10 -2.41 -3.48 -3.44 -3.03 -4.95 -4.00 0.98 4.34 4.06 -2.79 -4.39 -2.90 -2.09 -1.37
Endosome -1.64 1.54 -1.25 -0.20 -1.52 -2.90 0.96 -0.92 2.74 -1.73 -3.17 1.65 -1.42 2.29 -1.87
Golgi -1.90 -0.50 -1.65 -0.16 -1.59 -2.35 0.18 -0.91 1.57 -0.96 -2.70 -0.68 -1.63 1.45 -1.54
Lipid Particles -2.03 -0.20 -2.32 1.63 -2.31 -1.57 -1.26 0.85 2.41 3.86 -2.44 0.33 -1.38 2.10 -1.83
Mitochondria -3.57 -6.12 -5.08 -4.15 -3.15 -3.80 -0.86 -2.11 -0.09 -2.06 -4.15 -6.50 -3.57 -1.10 -2.26
Mitotic Spindle -0.81 -3.01 -2.05 -2.01 -1.85 -3.95 1.17 -1.72 -0.99 -1.78 -4.13 -2.80 -2.68 -2.12 -2.37
None 2.75 4.22 0.22 -1.64 -2.21 -0.71 -1.92 -1.15 -0.71 1.38 1.34 2.51 -0.60 -1.41 -2.03
Nuclear Periphery 1.52 0.38 -2.63 -3.35 -2.91 -2.78 1.20 -2.55 -1.15 -2.73 -1.19 -0.22 -3.53 -2.93 -3.53
Nuclear Periphery Foci 0.78 2.09 0.16 -0.60 -1.89 -1.20 1.53 1.24 2.39 -0.07 -0.12 2.48 0.95 1.18 -1.57
Nucleolus 0.26 4.74 8.67 8.03 5.99 -3.53 3.25 9.06 10.77 3.72 -1.84 3.83 12.76 13.35 9.47
Nucleus 0.92 -1.06 -0.22 -0.47 0.04 7.11 -2.01 -0.59 -2.79 0.58 5.63 0.45 -0.77 -2.44 -0.89
Peroxisomes -3.16 -9.54 -4.29 1.42 -1.29 -4.68 -5.60 2.35 5.35 6.14 -5.42 -11.45 -1.55 4.27 3.79
Vacuole -0.75 -0.42 -2.25 -2.17 -2.23 -3.33 -0.92 -2.02 -0.79 -1.89 -3.16 -1.15 -2.80 -2.27 -2.70
Vacuole Periphery -0.60 1.41 -1.13 -0.95 -1.32 -4.89 3.15 -1.82 -0.20 -1.96 -4.36 0.63 -2.09 -0.62 -2.16
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Pgd1

Pgd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pgd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available